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Article ; Online: Impact of adenoid hypertrophy on the open bite in children.

Poddębniak, Justyna / Zielnik-Jurkiewicz, Beata

Otolaryngologia polska = The Polish otolaryngology

2019 Volume 73, Issue 4, Page(s) 8–13

Abstract: Nasal obstruction caused by adenoid hypertrophy can lead to malocclusion. The research material consisted of children aged 7-12 years with adenoid hypertrophy qualified for adenoidectomy. On the basis of the conducted tests (laryngological, orthodontic, ... ...

Abstract	Nasal obstruction caused by adenoid hypertrophy can lead to malocclusion. The research material consisted of children aged 7-12 years with adenoid hypertrophy qualified for adenoidectomy. On the basis of the conducted tests (laryngological, orthodontic, pediatric), the occurrence of open frontal bite in children with pharyngeal tonsil hypertrophy, in particular in boys, was confirmed in comparison to children without hypertrophy correctly breathing through the nose.
MeSH term(s)	Adenoidectomy/methods ; Adenoids/pathology ; Adenoids/surgery ; Child ; Female ; Humans ; Hypertrophy/complications ; Hypertrophy/surgery ; Male ; Nasal Obstruction/etiology ; Nasal Obstruction/surgery
Language	English
Publishing date	2019-08-31
Publishing country	Poland
Document type	Journal Article
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.5604/01.3001.0013.1536
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Article ; Online: Bacterial lysates in the prevention of respiratory tract infections.

Jurkiewicz, Dariusz / Zielnik-Jurkiewicz, Beata

Otolaryngologia polska = The Polish otolaryngology

2018 Volume 72, Issue 5, Page(s) 1–8

Abstract: Bacterial lysates stimulate the general immunity of the body in a non-specific way. They act on non-specific defense mechanisms, leading to an increase in type A antibody in mucous membranes, phagocytic activity and INF-ƴ production. They can also ... ...

Abstract	Bacterial lysates stimulate the general immunity of the body in a non-specific way. They act on non-specific defense mechanisms, leading to an increase in type A antibody in mucous membranes, phagocytic activity and INF-ƴ production. They can also stimulate the production of specific antibodies against the bacterial antigens that make up the preparation. The oral immunomodulatory preparations with the best documented clinical efficacy available on the Polish market are Ismigen, Broncho-Vaxom, Ribomunyl and Luivac. They are all lysates of bacterial strains that most often cause respiratory tract infections. In many clinical trials, oral bacterial lysates have been shown to minimize the risk of recurrent respiratory infections in children and adults and reduce the need for antibiotics.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antigens, Bacterial/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/immunology ; Bacterial Vaccines/therapeutic use ; Cell Extracts/therapeutic use ; Child ; Child, Preschool ; Drug Dosage Calculations ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Poland ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/immunology ; Young Adult
Chemical Substances	Adjuvants, Immunologic ; Antigens, Bacterial ; Bacterial Vaccines ; Broncho-Vaxom ; Cell Extracts ; LW 50020 ; Ribomunyl
Language	English
Publishing date	2018-11-20
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.5604/01.3001.0012.7216
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Article ; Online: Antibiotic resistance of Streptococcus pneumoniae in children with acute otitis media treatment failure.

Zielnik-Jurkiewicz, Beata / Bielicka, Anna

International journal of pediatric otorhinolaryngology

2015 Volume 79, Issue 12, Page(s) 2129–2133

Abstract: Objectives: The emergence of antibiotic-resistant bacteria is a major cause of treatment failure in children with acute otitis media (AOM). This study aimed to analyze the types of bacterial strains in fluid isolated from the middle ear of children with ...

Abstract	Objectives: The emergence of antibiotic-resistant bacteria is a major cause of treatment failure in children with acute otitis media (AOM). This study aimed to analyze the types of bacterial strains in fluid isolated from the middle ear of children with AOM who did not respond to oral antibiotic treatment. We also determined the antibiotic resistance of the most frequently isolated bacterial strain (Streptococcus pneumoniae) found in these children. Methods: This was a prospective study of 157 children with AOM aged from 6 months to 7 years admitted due to unsuccessful oral antibiotic treatment. All children underwent a myringotomy, and samples of the middle ear fluid were collected for bacteriological examination. Results: Positive bacterial cultures were obtained in 104 patients (66.2%), with Streptococcus pneumoniae (39.69%), Haemophilus influenzae (16.03%) Staphylococcus aureus (16.03%), Staphylococcus haemolyticus (6.9%) and Streptococcus pyogenes (5.34%) found most frequently. The majority (65.4%) of S. pneumoniae strains were penicillin-intermediate-resistant or penicillin-resistant, and 67.2% strains of S. pneumoniae were multidrug-resistant. Conclusions: We identified S. pneumoniae as the most frequently isolated pathogen from the middle ear in children with AOM treatment failure and determined that the majority of strains were antibiotic-resistant. We propose that the microbiological identification of bacterial strains and their degree of antibiotic resistance should be performed prior to therapy in order to choose the most appropriate antibiotic therapy for children with AOM treatment failure.
MeSH term(s)	Acute Disease ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial ; Female ; Haemophilus Infections/complications ; Haemophilus Infections/drug therapy ; Haemophilus influenzae/isolation & purification ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Ear Ventilation ; Otitis Media with Effusion/drug therapy ; Otitis Media with Effusion/microbiology ; Otitis Media with Effusion/surgery ; Penicillin Resistance ; Pneumococcal Infections/complications ; Pneumococcal Infections/drug therapy ; Prospective Studies ; Staphylococcal Infections/complications ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/isolation & purification ; Staphylococcus haemolyticus/isolation & purification ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/isolation & purification ; Streptococcus pyogenes/isolation & purification ; Treatment Failure
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2015-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2015.09.030
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Article: Evaluation of the Interleukin-1 Receptor Antagonist and Immunoregulatory Interleukin-10 in the Middle Ear in Chronic Otitis Media With Effusion in Children With and Without Atopy.

Zielnik-Jurkiewicz, Beata / Stankiewicz-Szymczak, Wanda

Clinical and experimental otorhinolaryngology

2016 Volume 9, Issue 2, Page(s) 104–108

Abstract: Objectives: The role of pro-inflammatory cytokines in the course of chronic otitis media with effusion (COME) has been documented. However, there are fewer studies on the action of anti-inflammatory cytokines in the middle ear. We sought determine ... ...

Abstract	Objectives: The role of pro-inflammatory cytokines in the course of chronic otitis media with effusion (COME) has been documented. However, there are fewer studies on the action of anti-inflammatory cytokines in the middle ear. We sought determine whether there is an association between COME and anti-inflammatory cytokines and whether there are any differences in the cytokine profile in COME children with and without atopy. Methods: Eighty-four children were divided into 3 groups: 32 nonatopic children with COME (group NA), 31 atopic children with COME (group A), and 21 children without COME and without atopy (control group C). Specimens from the middle ear were collected and evaluated by enzyme-linked immunosorbent assay for the cytokines interleukin-1 receptor antagonist (IL-1Ra) and immunoregulatory IL-10. Results: Significantly higher IL-10 concentrations were found in both nonatopic and atopic children with COME compared to controls. No significant differences in IL-1Ra levels were found between atopic and nonatopic children with COME and the control group. Conclusion: We found no differences in the levels of IL-1Ra in atopic and nonatopic children with COME compared to controls. However, we found elevated IL-10 levels in the middle ear effusions from children with COME, with or without atopy. These elevated immunoregulatory cytokine levels suggest a role for new immunomodulatory treatments to prevent disease progression in COME, regardless of atopy.
Language	English
Publishing date	2016-04-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2491719-9
ISSN	2005-0720 ; 1976-8710
ISSN (online)	2005-0720
ISSN	1976-8710
DOI	10.21053/ceo.2015.00129
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Article ; Online: Pro-inflammatory interleukins in middle ear effusions from atopic and non-atopic children with chronic otitis media with effusion.

Zielnik-Jurkiewicz, Beata / Stankiewicz-Szymczak, Wanda

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2016 Volume 273, Issue 6, Page(s) 1369–1378

Abstract: Chronic otitis media with effusion (OME) is associated with irreversible changes in the middle ear, sometimes leading to hearing loss and abnormal language development in children. While the pathogenesis of OME is not fully understood, inflammatory and ... ...

Abstract	Chronic otitis media with effusion (OME) is associated with irreversible changes in the middle ear, sometimes leading to hearing loss and abnormal language development in children. While the pathogenesis of OME is not fully understood, inflammatory and allergic factors are thought to be involved. The study aimed to investigate the role of cytokines in the local development of chronic OME, and assess differences in the cytokine profiles between atopic and non-atopic children. 84 atopic and non-atopic children with chronic OME (mean age of 6 years 7 months) were studied. Age-matched children with hypertrophy of the adenoids and Eustachian tube dysfunction served as the control group. The number of past acute otitis media (AOM) episodes, their age, and the type of effusion were recorded for all children. Pro-inflammatory cytokine concentrations (TNF-α, IL-1β, IL-6 and IL-8) were determined and the presence of pathogenic bacteria in the patients' effusions was examined. High concentrations of TNF-α, IL-1β, IL-6 and IL-8 were found in the effusions in all children with chronic OME, with the highest levels observed in the non-atopic group. The atopic group showed persistently high IL-1β levels, while in the non-atopic children, IL-1β and TNF-α levels positively correlated with the patient's age and the number of past AOM episodes. Pathogenic bacteria were more frequently isolated from effusions in non-atopic children. In both atopic and non-atopic children, pro-inflammatory cytokines are found at high concentrations. This argues in favor of instituting anti-inflammatory management for treating OME, regardless of atopy.
MeSH term(s)	Case-Control Studies ; Child ; Child, Preschool ; Chronic Disease ; Ear, Middle ; Female ; Hearing Loss/etiology ; Humans ; Interleukin-1beta/analysis ; Interleukin-1beta/metabolism ; Interleukin-6/analysis ; Interleukin-6/metabolism ; Interleukin-8/analysis ; Interleukin-8/metabolism ; Interleukins/analysis ; Interleukins/metabolism ; Male ; Otitis Media with Effusion/etiology ; Otitis Media with Effusion/metabolism ; Otitis Media with Effusion/microbiology ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Interleukin-1beta ; Interleukin-6 ; Interleukin-8 ; Interleukins ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2016-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-015-3683-9
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Article: Zakazenia górnych dróg oddechowych u dzieci wywołane przez bakterie atypowe.

Zielnik-Jurkiewicz, Beata

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2008 Volume 25, Issue 149, Page(s) 415–419

Abstract: Unlabelled: It encounters despite solid progress in development of diagnostic methods diagnostics the diseases of upper respiratory tract and ears in children called out by atypical bacteria's on the ground clinical symptoms and their treatment is ... ...

Title translation	Upper respiratory tract infections in children caused by atypical bacteria.
Abstract	Unlabelled: It encounters despite solid progress in development of diagnostic methods diagnostics the diseases of upper respiratory tract and ears in children called out by atypical bacteria's on the ground clinical symptoms and their treatment is difficulty still. Aim: The performance of accessible review of current literature was on the aim of work opinion of the atypical bacteria's part in evocation the infections the upper respiratory tract and ears in children, and performance of characteristic symptoms of clinical diseases these organs the bacteria's also. Conclusions: The quoted in work results of investigations do not it let on the unambiguous opinion the atypical bacteria part in contagions of infections the upper respiratory tract and ears in children. It seems however, that Mycoplasma pneumoniae answers first of all for evocation the acute infections of upper respiratory tract; however Chlamydophila pneumoniae plays the larger part in illnesses chronic as well as co-existent pathogen in illnesses sharp. Atypical bacteria can cause upper respiratory tract infections significantly more often than previously thought. These infections often occur in patients with history of respiratory recurrences.
MeSH term(s)	Atypical Bacterial Forms/classification ; Atypical Bacterial Forms/isolation & purification ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; Child ; Chlamydophila pneumoniae/isolation & purification ; Humans ; Mycoplasma pneumoniae/isolation & purification ; Otitis/microbiology ; Respiratory Tract Infections/microbiology
Language	Polish
Publishing date	2008-11
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
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Article ; Online: Treatment strategy of allergic rhinitis in the face of modern world threats.

Rapiejko, Piotr / Jurkiewicz, Dariusz / Pietruszewska, Wioletta / Zielnik-Jurkiewicz, Beata / Woroń, Jarosław / Lipiec, Agnieszka

Otolaryngologia polska = The Polish otolaryngology

2018 Volume 72, Issue 2, Page(s) 1–12

Abstract: Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater ... ...

Abstract	Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater the risk of developing bronchial asthma. One of the factors affecting the severity of symptoms and the degree of their control is air pollution. In some patients, despite proper treatment, persistence or only partial remission of symptoms (uncontrolled allergic rhinitis) is observed. This can lead to an increase in comorbidities - inflammation of the paranasal sinuses, otitis media and asthma - both in children and in adults. The treatment of allergic rhinitis, in accordance with the standards, consists in: education of the patient, elimination of the allergen from the environment and factors intensifying the course of the disease, selection of proper pharmacotherapy and specific allergen immunotherapy. Many factors influence the selection of the antihistamine used, e.g., the opportunity of safe increase of the dosage.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Air Pollutants/adverse effects ; Anti-Allergic Agents/therapeutic use ; Child ; Child, Preschool ; Desensitization, Immunologic/standards ; Female ; Histamine Antagonists/therapeutic use ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Practice Guidelines as Topic ; Rhinitis, Allergic/etiology ; Rhinitis, Allergic/therapy ; Young Adult
Chemical Substances	Air Pollutants ; Anti-Allergic Agents ; Histamine Antagonists
Language	English
Publishing date	2018-05-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.5604/01.3001.0011.8057
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Article: Wybrane czynniki zapalne w materiale z ucha środkowego w przewlekłym wysiekowym zapaleniu ucha środkowego u dzieci.

Zielnik-Jurkiewicz, Beata

Otolaryngologia polska = The Polish otolaryngology

2007 Volume 61, Issue 1, Page(s) 102–104

Title translation	Selected inflammatory factors in material from the middle ear in chronic otitis media with effusion in children.
MeSH term(s)	Acute Disease ; Child ; Child, Preschool ; Cytokines/metabolism ; Female ; Humans ; Inflammation Mediators/metabolism ; Male ; Otitis Media with Effusion/immunology ; Otitis Media with Effusion/microbiology
Chemical Substances	Cytokines ; Inflammation Mediators
Language	Polish
Publishing date	2007
Publishing country	Poland
Document type	Comparative Study ; Journal Article
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.1016/S0030-6657(07)70392-X
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Article: Rola zakazenia bakteryjnego w podgłtośniowym zapaleniu krtani u dzieci.

Zielnik-Jurkiewicz, Beata

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2005 Volume 18, Issue 104, Page(s) 141–145

Abstract: The aim of this study is to assess the impact of some selected bacteriological factors on the occurrence of subglottic laryngitis in children. The research covered 72 children hospitalized in the Children's Hospital in Warsaw with the following symptoms: ...

Title translation	The role of the bacterial inflammation in subglottic laryngitis in children.
Abstract	The aim of this study is to assess the impact of some selected bacteriological factors on the occurrence of subglottic laryngitis in children. The research covered 72 children hospitalized in the Children's Hospital in Warsaw with the following symptoms: dry barking cough, stridor, inspiratory dyspnoea with the participation of auxiliary respiratory muscles, agitation and change of colour of skin. Subglottic laryngitis is one of the acute children's diseases, directly caused by a violently growing odema of the subglottic area. The disease constitutes 5-8% of all severe airways inflammations and states that subglottic laryngitis is responsible for 6.5% off all lower airways inflammation cases. Based on preliminary examinations, the patients were divided into two groups--one of them composed of 41 patients with simultaneous atopy, the other--of 31 patients with no atopy symptoms. The examination of each patient included subjective, objective (pediatric and laryngological) and auxiliary (primary-blood cell count, OB and specialized-bacteriological tests) examinations. Own research showed that out of 72 patients with subglottic laryngitis 56.95% had bacterial symptoms. 90.32% in non atopic group have higher NBT test, in atopic children it was 39.02%. We observed that 50.51% of the patients suffering from subglottic laryngitis had an inflammation of upper airways (otitis media, rhinitis, pharyngitis) and 13.89% of lower respiratory tract (bronchitis, pneumonitis). Many authors incline to say that bacteria may be a conductive factor for subglottic laryngitis to develop. However, many factors seem to suggest that the occurrence and symptoms of subglottic laryngitis are primarily caused by the reaction to an infection. The impact of bacteria onto the etiopathogenesis of subglottic laryngitis has been discussed for many years. Some experts are of the opinion that the disease develops on the bacteriologic background.
MeSH term(s)	Child ; Child, Preschool ; Cough/microbiology ; Epiglottitis/microbiology ; Female ; Haemophilus influenzae/isolation & purification ; Humans ; Infant ; Male ; Moraxella (Branhamella) catarrhalis/isolation & purification ; Nitroblue Tetrazolium ; Respiratory Tract Infections/microbiology ; Staphylococcus aureus/isolation & purification
Chemical Substances	Nitroblue Tetrazolium (298-83-9)
Language	Polish
Publishing date	2005-02
Publishing country	Poland
Document type	English Abstract ; Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
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Article ; Online: Acute subglottic laryngitis. Etiology, epidemiology, pathogenesis and clinical picture.

Mazurek, Henryk / Bręborowicz, Anna / Doniec, Zbigniew / Emeryk, Andrzej / Krenke, Katarzyna / Kulus, Marek / Zielnik-Jurkiewicz, Beata

Advances in respiratory medicine

2019 Volume 87, Issue 5, Page(s) 308–316

Abstract: In about 3% of children, viral infections of the airways that develop in early childhood lead to narrowing of the laryngeal lumen in the subglottic region resulting in symptoms such as hoarseness, abarking cough, stridor, and dyspnea. These infections ... ...

Abstract	In about 3% of children, viral infections of the airways that develop in early childhood lead to narrowing of the laryngeal lumen in the subglottic region resulting in symptoms such as hoarseness, abarking cough, stridor, and dyspnea. These infections may eventually cause respiratory failure. The disease is often called acute subglottic laryngitis (ASL). Terms such as pseudocroup, croup syndrome, acute obstructive laryngitis and spasmodic croup are used interchangeably when referencing this disease. Although the differential diagnosis should include other rare diseases such as epiglottitis, diphtheria, fibrinous laryngitis and bacterial tracheobronchitis, the diagnosis of ASL should always be made on the basis of clinical criteria.
MeSH term(s)	Acute Disease ; Airway Obstruction/etiology ; Bacterial Infections/complications ; Child ; Croup/etiology ; Dyspnea/etiology ; Humans ; Laryngitis/complications ; Laryngitis/diagnosis ; Laryngitis/therapy ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/diagnosis
Language	English
Publishing date	2019-11-01
Publishing country	Poland
Document type	Journal Article ; Practice Guideline
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.5603/ARM.2019.0056
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