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  1. Article: A 5-year retrospective study of

    Ali, Maisa / Razok, Almurtada / Ziglam, Hisham

    Annals of medicine and surgery (2012)

    2022  Volume 76, Page(s) 103583

    Abstract: Introduction and importance: Manifestations of infection by : Methods: We are reporting 15 cases with isolated : Outcomes: We are reporting 15 cases with isolated : Conclusion: 12 of the 15 reported cases were considered significant and ... ...

    Abstract Introduction and importance: Manifestations of infection by
    Methods: We are reporting 15 cases with isolated
    Outcomes: We are reporting 15 cases with isolated
    Conclusion: 12 of the 15 reported cases were considered significant and received a complete course of antimicrobial therapy. The patients presented with a wide variety of clinical pictures and were of variable age.
    Language English
    Publishing date 2022-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103583
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  2. Article: Actinomyces odontolyticus

    Razok, Almurtada / Ali, Maisa / Aker, Loai / Ziglam, Hisham

    New microbes and new infections

    2022  Volume 45, Page(s) 100956

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2022.100956
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  3. Article ; Online: Exploring determinants of antimicrobial prescribing behaviour using the Theoretical Domains Framework.

    Talkhan, Hend / Stewart, Derek / McIntosh, Trudi / Ziglam, Hisham / Abdulrouf, Palli Valappila / Al-Hail, Moza / Diab, Mohammad / Cunningham, Scott

    Research in social & administrative pharmacy : RSAP

    2024  Volume 20, Issue 4, Page(s) 401–410

    Abstract: Background: Few theoretically-based, qualitative studies have explored determinants of antimicrobial prescribing behaviour in hospitals. Understanding these can promote successful development and implementation of behaviour change interventions (BCIs).!# ...

    Abstract Background: Few theoretically-based, qualitative studies have explored determinants of antimicrobial prescribing behaviour in hospitals. Understanding these can promote successful development and implementation of behaviour change interventions (BCIs).
    Objective: (s): To use the Theoretical Domains Framework (TDF) to explore determinants of clinicians' antimicrobial prescribing behaviour, identifying barriers (i.e., impediments) and facilitators to appropriate antimicrobial practice.
    Methods: Semi-structured interviews with purposively-sampled doctors and pharmacists with a wide range of specialties and expertise in Hamad Medical Corporation hospitals in Qatar. Interviews based on previous quantitative research and the TDF were audio-recorded, transcribed and independently analysed by two researchers using the TDF as an initial coding framework.
    Results: Data saturation was achieved after interviewing eight doctors and eight pharmacists. Inter-related determinants of antimicrobial prescribing behaviour linked to ten TDF domains were identified as barriers and facilitators that may contribute to inappropriate or appropriate antimicrobial prescribing. The main barriers identified were around hospital guidelines and electronic system deficiencies (environmental context and resources); knowledge gaps relating to guidelines and appropriate prescribing (knowledge); restricted roles/responsibilities of microbiologists and pharmacists (professional role and identity); challenging antimicrobial prescribing decisions (memory, attention and decision processes); and professional hierarchies and poor multidisciplinary teamworking (social influences). Key facilitators included guidelines compliance (goals and intentions), and participants' beliefs about the consequences of appropriate or inappropriate prescribing. Further education and training, and some changes to guidelines including their accessibility were also considered essential.
    Conclusions: Antimicrobial prescribing behaviour in hospitals is a complex process influenced by a broad range of determinants including specific barriers and facilitators. The in-depth understanding of this complexity provided by this work may support the development of an effective BCI to promote appropriate antimicrobial stewardship.
    MeSH term(s) Humans ; Pharmacists ; Anti-Infective Agents/therapeutic use ; Qualitative Research ; Physicians ; Inappropriate Prescribing
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2192059-X
    ISSN 1934-8150 ; 1551-7411
    ISSN (online) 1934-8150
    ISSN 1551-7411
    DOI 10.1016/j.sapharm.2023.12.009
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  4. Article ; Online: A Case of Fulminant Liver Failure in a 24-Year-Old Man with Coinfection with Hepatitis B Virus and SARS-CoV-2.

    Ali, Elrazi / Ziglam, Hisham / Kohla, Samah / Ahmed, Mohanad / Yassin, Mohamed

    The American journal of case reports

    2020  Volume 21, Page(s) e925932

    Abstract: BACKGROUND Coronavirus disease 2019 (COVID-19) is a newly emerging disease that is still not fully characterized. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that can be transmitted easily from human to ... ...

    Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) is a newly emerging disease that is still not fully characterized. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that can be transmitted easily from human to human mainly by the respiratory route. Currently, there is no specific treatment for COVID-19 or a vaccine for prevention. The disease has various degrees of severity. It often presents with nonspecific symptoms such as fever, headache, and fatigue, accompanied by respiratory symptoms (e.g., cough and dyspnea) and other systemic involvement. Severe disease is associated with hemophagocytic syndrome and cytokine storm due to altered immune response. Patients with severe disease are more likely to have increased liver enzymes. The disease can affect the liver through various mechanisms. CASE REPORT We report an unusual case of SARS-CoV-2 infection in a 24-year-old man with no previous medical illness, who presented with mild respiratory involvement. He had no serious lung injury during the disease course. However, he experienced acute fulminant hepatitis B infection and cytokine release syndrome that led to multiorgan failure and death. CONCLUSIONS It is uncommon for SARS-CoV-2 infection with mild respiratory symptoms to result in severe systemic disease and organ failure. We report an unusual case of acute hepatitis B infection with concomitant SARS-CoV-2 leading to fulminant hepatitis, multiorgan failure, and death.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Hepatitis B/epidemiology ; Hepatitis B virus ; Humans ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/etiology ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.925932
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  5. Article ; Online: Daptomycin and tigecycline: a review of clinical efficacy in the antimicrobial era.

    Ziglam, Hisham

    Expert opinion on pharmacotherapy

    2007  Volume 8, Issue 14, Page(s) 2279–2292

    Abstract: There is a clinical need for new treatment options as a result of continued increase in the expression of resistance among bacterial pathogens. A number of compounds currently in development show promise. However, in some cases, there is concern that ... ...

    Abstract There is a clinical need for new treatment options as a result of continued increase in the expression of resistance among bacterial pathogens. A number of compounds currently in development show promise. However, in some cases, there is concern that resistance may develop quickly to new compounds that are based on existing antimicrobial agents. Therefore, daptomycin, a novel lipopeptide with a unique mode of action, is of particular interest. It has rapid bactericidal activity against growing and stationary-phase bacteria, once-daily dosing regimen, and has a low potential for the development of resistance. It has been approved for the treatment of complicated skin and soft tissue infections caused by Gram-positive bacteria, and registration for treatment of infective endocarditis and bacteraemia is anticipated. Daptomycin is a welcome addition to the antimicrobial armamentarium for the treatment of bacterial infections. Tigecycline is a new glycyclcycline antimicrobial recently approved for use in the USA, Europe and elsewhere. While related to the tetracyclines, tigecycline overcomes many of the mechanisms responsible for resistance to this class. It is a novel broad spectrum glycylcycline with good activity against Gram-positive, many Gram-negative, anaerobic, and some atypical pathogens that has been developed to address this need. It is efficacious in complicated skin and soft tissue infections and in intra-abdominal infections. This review aims to summarise the key clinical data of daptomycin and tigecycline which hold promise for widespread clinical use in the next decade.
    MeSH term(s) Anti-Infective Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Cardiovascular Infections/drug therapy ; Cardiovascular Infections/microbiology ; Daptomycin/pharmacology ; Daptomycin/therapeutic use ; Humans ; Minocycline/analogs & derivatives ; Minocycline/pharmacology ; Minocycline/therapeutic use ; Tigecycline
    Chemical Substances Anti-Infective Agents ; Tigecycline (70JE2N95KR) ; Minocycline (FYY3R43WGO) ; Daptomycin (NWQ5N31VKK)
    Language English
    Publishing date 2007-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.8.14.2279
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Typhoid fever: misuse of Widal test in Libya.

    Zorgani, Abdulaziz / Ziglam, Hisham

    Journal of infection in developing countries

    2014  Volume 8, Issue 6, Page(s) 680–687

    Abstract: The worldwide gold standard of diagnosing of enteric fever depends on the isolation of Salmonella enterica serovar Typhi from a patient's bone marrow and/or blood culture. In Libya clinicians are heavily dependent on the Widal test for diagnosis of ... ...

    Abstract The worldwide gold standard of diagnosing of enteric fever depends on the isolation of Salmonella enterica serovar Typhi from a patient's bone marrow and/or blood culture. In Libya clinicians are heavily dependent on the Widal test for diagnosis of enteric fever which has been used without determining the locally appropriate threshold titer, because the laboratories lack the skilled, experienced personnel and appropriate facilities to detect and serotype Salmonella isolates. To improve the diagnosis process, clinical management and reliability of public health measures, there is an urgent need for the effective training of laboratory technicians and to provide resources to culture Salmonella species according to published guidelines. Clinicians should understand the limitations of Widal test and recognize that it cannot be expected to give a reliable diagnosis.
    MeSH term(s) Agglutination Tests/methods ; Agglutination Tests/statistics & numerical data ; Antibodies, Bacterial ; Bacteriological Techniques/methods ; Bacteriological Techniques/statistics & numerical data ; Developing Countries ; Diagnostic Errors ; Humans ; Libya ; Reproducibility of Results ; Salmonella typhi/immunology ; Salmonella typhi/isolation & purification ; Typhoid Fever/diagnosis ; Typhoid Fever/microbiology
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2014-06-11
    Publishing country Italy
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.3700
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  7. Article: Antemortem diagnosis of human rabies: A case report.

    Goravey, Wael / Husain, Ahmed / Ali, Gawahir A / Al Maslamani, Muna A / Ziglam, Hisham

    Clinical case reports

    2020  Volume 9, Issue 2, Page(s) 711–713

    Abstract: Antemortem diagnosis of rabies is challenging, and usually, more than one test modality is needed to confirm the diagnosis. No effective treatment exists so far, and the Milwaukee Protocol is debatable. ...

    Abstract Antemortem diagnosis of rabies is challenging, and usually, more than one test modality is needed to confirm the diagnosis. No effective treatment exists so far, and the Milwaukee Protocol is debatable.
    Language English
    Publishing date 2020-12-05
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3615
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  8. Article: A Case of Fulminant Liver Failure in a 24-Year-Old Man with Coinfection with Hepatitis B Virus and SARS-CoV-2

    Ali, Elrazi / Ziglam, Hisham / Kohla, Samah / Ahmed, Mohanad / Yassin, Mohamed

    Am J Case Rep

    Abstract: BACKGROUND Coronavirus disease 2019 (COVID-19) is a newly emerging disease that is still not fully characterized. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that can be transmitted easily from human to ... ...

    Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) is a newly emerging disease that is still not fully characterized. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that can be transmitted easily from human to human mainly by the respiratory route. Currently, there is no specific treatment for COVID-19 or a vaccine for prevention. The disease has various degrees of severity. It often presents with nonspecific symptoms such as fever, headache, and fatigue, accompanied by respiratory symptoms (e.g., cough and dyspnea) and other systemic involvement. Severe disease is associated with hemophagocytic syndrome and cytokine storm due to altered immune response. Patients with severe disease are more likely to have increased liver enzymes. The disease can affect the liver through various mechanisms. CASE REPORT We report an unusual case of SARS-CoV-2 infection in a 24-year-old man with no previous medical illness, who presented with mild respiratory involvement. He had no serious lung injury during the disease course. However, he experienced acute fulminant hepatitis B infection and cytokine release syndrome that led to multiorgan failure and death. CONCLUSIONS It is uncommon for SARS-CoV-2 infection with mild respiratory symptoms to result in severe systemic disease and organ failure. We report an unusual case of acute hepatitis B infection with concomitant SARS-CoV-2 leading to fulminant hepatitis, multiorgan failure, and death.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #854650
    Database COVID19

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  9. Article ; Online: Injured Libyan combatant patients: both vectors and victims of multiresistance bacteria?

    Zorgani, Abdulaziz / Ziglam, Hisham

    The Libyan journal of medicine

    2013  Volume 8

    MeSH term(s) Animals ; Civil Disorders ; Communicable Diseases/microbiology ; Disease Reservoirs/microbiology ; Disease Vectors ; Drug Resistance, Multiple, Bacterial ; Europe/epidemiology ; Humans ; Libya/ethnology ; Warfare ; Wounds and Injuries/microbiology
    Language English
    Publishing date 2013-02-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2273005-9
    ISSN 1819-6357 ; 1993-2820
    ISSN (online) 1819-6357
    ISSN 1993-2820
    DOI 10.3402/ljm.v8i0.20325
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  10. Article ; Online: Drug-resistant tuberculosis: an experience from Qatar.

    Ali, Maisa / Howady, Faraj / Munir, Waqar / Karim, Hanfa / Al-Suwaidi, Zubaida / Al-Maslamani, Muna / Alkhal, Abdullatif / Elmaki, Nada / Ziglam, Hisham

    The Libyan journal of medicine

    2020  Volume 15, Issue 1, Page(s) 1744351

    Abstract: This study was conducted to evaluate the characteristics, treatment outcome and risk factors associated with 223 drug-resistant tuberculosis (DR-TB) cases in the State of Qatar. A descriptive records-based retrospective study was conducted on patients ... ...

    Abstract This study was conducted to evaluate the characteristics, treatment outcome and risk factors associated with 223 drug-resistant tuberculosis (DR-TB) cases in the State of Qatar. A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the period January 2010 - March 2015. Demographic, clinical data, drug-resistance pattern of isolated mycobacteria and treatment outcome was assessed for the patient who completed their treatment in Qatar. Of 3301 patients with positive M. tuberculosis culture were analyzed; 223 (6.7%) were resistant to at least one drug. The overall prevalence of multi-d rug resistant TB (MDR-TB) was 1.2% (n = 38) of patients. A former resident of Indian sub contents was the most common demographic characteristic observed (64.1%). The outcome of treatment was assessed for 85 resistant cases with follow-up after completion of treatment. Cure and relapse rates were 97.6%, and 2.4%, respectively. Drug-resistant TB in Qatar is influenced by migration where the patients were probably infected. Rapid sputum sampling performed in the early stages of the disease, patient isolation, and drug-susceptibility testing should be the standard of care.
    MeSH term(s) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Female ; Humans ; Male ; Microbial Sensitivity Tests/standards ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/growth & development ; Mycobacterium tuberculosis/isolation & purification ; Patient Isolation/standards ; Prevalence ; Qatar/epidemiology ; Recurrence ; Retrospective Studies ; Risk Factors ; Sputum/microbiology ; Transients and Migrants/statistics & numerical data ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/microbiology ; Tuberculosis, Multidrug-Resistant/prevention & control
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2273005-9
    ISSN 1819-6357 ; 1819-6357
    ISSN (online) 1819-6357
    ISSN 1819-6357
    DOI 10.1080/19932820.2020.1744351
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