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  1. Article ; Online: Mini-review: Interaction between intestinal microbes and enteric glia in health and disease.

    Seguella, Luisa / Palenca, Irene / Franzin, Silvia Basili / Zilli, Aurora / Esposito, Giuseppe

    Neuroscience letters

    2023  Volume 806, Page(s) 137221

    Abstract: Enteric glia are a unique population of peripheral neuroglia associated with the enteric nervous system (ENS) throughout the digestive tract. The emerging data from the latest glial biology studies unveiled enteric glia as a heterogenic population with ... ...

    Abstract Enteric glia are a unique population of peripheral neuroglia associated with the enteric nervous system (ENS) throughout the digestive tract. The emerging data from the latest glial biology studies unveiled enteric glia as a heterogenic population with plastic and adaptative abilities that display phenotypic and functional changes upon distinct extrinsic cues. This aspect is essential in the dynamic signaling that enteric glia engage with neurons and other neighboring cells within the intestinal wall, such as epithelial, endocrine, and immune cells to maintain local homeostasis. Likewise, enteric glia sense signals from luminal microbes, although the extent of this active communication is still unclear. In this minireview, we discuss the recent findings that support glia-microbes crosstalk in the intestine in health and disease, pointing out the critical aspects that require further investigation.
    MeSH term(s) Humans ; Biodiversity ; Disease ; Enteric Nervous System/cytology ; Enteric Nervous System/physiology ; Enteric Nervous System/physiopathology ; Gastrointestinal Microbiome/physiology ; Health ; Host Microbial Interactions ; Inflammation/microbiology ; Neuroglia/physiology ; Probiotics ; Animals
    Chemical Substances S100B protein, human
    Language English
    Publishing date 2023-04-07
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2023.137221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Intranasal administration of Escherichia coli Nissle expressing the spike protein of SARS-CoV-2 induces long-term immunization and prevents spike protein-mediated lung injury in mice.

    Sarnelli, Giovanni / Del Re, Alessandro / Palenca, Irene / Franzin, Silvia Basili / Lu, Jie / Seguella, Luisa / Zilli, Aurora / Pesce, Marcella / Rurgo, Sara / Esposito, Giovanni / Sanseverino, Walter / Esposito, Giuseppe

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 174, Page(s) 116441

    Abstract: While current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and ... ...

    Abstract While current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and innovation. To tackle these constraints, our research group developed a bacterial-based vaccine using a non-pathogenic E. coli Nissle 1917 (EcN) strain genetically modified to express the SARS-CoV-2 spike protein on its surface (EcN-pAIDA1-SP). We intranasally delivered the EcN-pAIDA1-SP in two doses and checked specific IgG/IgA production as well as the key immune mediators involved in the process. Moreover, following the initial and booster vaccine doses, we exposed both immunized and non-immunized mice to intranasal delivery of SARS-CoV-2 SP to assess the effectiveness of EcN-pAIDA1-SP in protecting lung tissue from the inflammation damage. We observed detectable levels of anti-SARS-CoV-2 spike IgG in serum samples and IgA in bronchoalveolar lavage fluid two weeks after the initial treatment, with peak concentrations in the respective samples on the 35th day. Moreover, immunoglobulins displayed a progressively enhanced avidity index, suggesting a selective binding to the spike protein. Finally, the pre-immunized group displayed a decrease in proinflammatory markers (TLR4, NLRP3, ILs) following SP challenge, compared to the non-immunized groups, along with better preservation of tissue morphology. Our probiotic-based technology provides an effective immunobiotic tool to protect individuals against disease and control infection spread.
    MeSH term(s) Animals ; Administration, Intranasal ; Spike Glycoprotein, Coronavirus/immunology ; Escherichia coli ; Mice ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/administration & dosage ; COVID-19/prevention & control ; COVID-19/immunology ; Mice, Inbred BALB C ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin A/immunology ; Lung Injury/prevention & control ; Lung Injury/immunology ; Female ; SARS-CoV-2/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Lung/immunology ; Lung/pathology ; Lung/microbiology ; Lung/metabolism ; Immunization/methods
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; COVID-19 Vaccines ; Immunoglobulin G ; Immunoglobulin A ; Antibodies, Viral
    Language English
    Publishing date 2024-03-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Oral Immunization with

    Sarnelli, Giovanni / Del Re, Alessandro / Pesce, Marcella / Lu, Jie / Esposito, Giovanni / Sanseverino, Walter / Corpetti, Chiara / Basili Franzin, Silvia / Seguella, Luisa / Palenca, Irene / Rurgo, Sara / De Palma, Fatima Domenica Elisa / Zilli, Aurora / Esposito, Giuseppe

    Biomolecules

    2023  Volume 13, Issue 3

    Abstract: As of October 2022, the COVID-19 pandemic continues to pose a major public health conundrum, with increased rates of symptomatic infections in vaccinated individuals. An ideal vaccine candidate for the prevention of outbreaks should be rapidly scalable, ... ...

    Abstract As of October 2022, the COVID-19 pandemic continues to pose a major public health conundrum, with increased rates of symptomatic infections in vaccinated individuals. An ideal vaccine candidate for the prevention of outbreaks should be rapidly scalable, easy to administer, and able to elicit a potent mucosal immunity. Towards this aim, we proposed an engineered
    MeSH term(s) Humans ; Animals ; Mice ; Spike Glycoprotein, Coronavirus/genetics ; Escherichia coli/genetics ; COVID-19 Vaccines ; Antibody Formation ; Pandemics ; COVID-19/prevention & control ; SARS-CoV-2 ; Immunization/methods ; Antibodies, Viral
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13030569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intrarectal Administration of Adelmidrol plus Hyaluronic Acid Gel Ameliorates Experimental Colitis in Mice and Inhibits Pro-Inflammatory Response in Ex Vivo Cultured Biopsies Derived from Ulcerative Colitis-Affected Patients.

    Palenca, Irene / Seguella, Luisa / Zilli, Aurora / Basili Franzin, Silvia / Del Re, Alessandro / Pepi, Federico / Troiani, Anna / Pesce, Marcella / Rurgo, Sara / De Palma, Fatima Domenica Elisa / Luglio, Gaetano / Tropeano, Francesca Paola / Sarnelli, Giovanni / Esposito, Giuseppe

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Improving clinical outcomes and delaying disease recrudescence in Ulcerative Colitis (UC) patients is crucial for clinicians. In addition to traditional and new pharmacological therapies that utilize biological drugs, the development of medical devices ... ...

    Abstract Improving clinical outcomes and delaying disease recrudescence in Ulcerative Colitis (UC) patients is crucial for clinicians. In addition to traditional and new pharmacological therapies that utilize biological drugs, the development of medical devices that can ameliorate UC and facilitate the remission phase should not be overlooked. Drug-based therapy requires time to be personalized and to evaluate the benefit/risk ratio. However, the increasing number of diagnosed UC cases worldwide necessitates the exploration of new strategies to enhance clinical outcomes. By incorporating medical devices alongside pharmacological treatments, clinicians can provide additional support to UC patients, potentially improving their condition and slowing down the recurrence of symptoms. Chemically identified as an azelaic acid derivative and palmitoylethanolamide (PEA) analog, adelmidrol is a potent anti-inflammatory and antioxidant compound. In this study, we aimed to evaluate the effect of an intrarectal administration of 2% adelmidrol (Ade) and 0.1% hyaluronic acid (HA) gel formulation in both the acute and resolution phase of a mouse model of colitis induced via DNBS enema. We also investigated its activity in cultured human colon biopsies isolated from UC patients in the remission phase at follow-up when exposed in vitro to a cytomix challenge. Simultaneously, with its capacity to effectively alleviate chronic painful inflammatory cystitis when administered intravesically to urological patients such as Vessilen, the intrarectal administration of Ade/HA gel has shown remarkable potential in improving the course of colitis. This treatment approach has demonstrated a reduction in the histological damage score and an increase in the expression of ZO-1 and occludin tight junctions in both in vivo studies and human specimens. By acting independently on endogenous PEA levels and without any noticeable systemic absorption, the effectiveness of Ade/HA gel is reliant on a local antioxidant mechanism that functions as a "barrier effect" in the inflamed gut. Building on the findings of this preliminary study, we are confident that the Ade/HA gel medical device holds promise as a valuable adjunct in supporting traditional anti-UC therapies.
    MeSH term(s) Humans ; Animals ; Mice ; Colitis, Ulcerative/drug therapy ; Hyaluronic Acid ; Antioxidants ; Colitis ; Biopsy ; Cystitis ; Dicarboxylic Acids ; Palmitic Acids
    Chemical Substances Hyaluronic Acid (9004-61-9) ; adelmidrol (1BUC3685QU) ; Antioxidants ; Dicarboxylic Acids ; Palmitic Acids
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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