Article ; Online: Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain.
Small (Weinheim an der Bergstrasse, Germany)
2019 Volume 15, Issue 45, Page(s) e1904203
Abstract: Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon ( ... ...
| Abstract | Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon (PSiO |
|---|---|
| MeSH term(s) | Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Cell Survival/drug effects ; Mice ; Microscopy, Confocal ; Microscopy, Fluorescence ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Nerve Growth Factor/chemistry ; Nerve Growth Factor/pharmacokinetics ; Nerve Growth Factor/therapeutic use ; PC12 Cells ; Porosity ; Rats ; Silicon/chemistry ; X-Ray Microtomography |
| Chemical Substances | Nerve Growth Factor (9061-61-4) ; Silicon (Z4152N8IUI) |
| Language | English |
| Publishing date | 2019-09-04 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1613-6829 |
| ISSN (online) | 1613-6829 |
| DOI | 10.1002/smll.201904203 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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