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  1. Book ; Online: La didactique des langues dans la formation initiale des enseignant.e.s en Suisse / Fremdsprachendidaktik in der Schweizer Lehrer*innenbildung

    Robin, Jésabel / Zimmermann, Martina

    Quelles postures scientifiques face aux pratiques de terrain? / An welchen wissenschaftlichen Positionen orientiert sich die Praxis?

    (Transversales)

    2022  

    Series title Transversales
    Keywords Language teaching theory & methods ; Teacher training ; Bildungspolitik ; didactique ; enseignant ; enseignement ; Epistemologie ; épistémologie ; face ; formation ; Fremdsprachendidaktik ; initiale ; innenbildung ; langues ; Lehrer ; Mehrsprachigkeit ; orientiert ; plurilinguisme ; politiques éducatives ; politiques linguistiques ; Positionen ; postures ; pratiques ; Praxis ; Robin ; Schweizer ; scientifiques ; Sprachpolitik ; Suisse ; terrain ; Unterricht ; welchen ; wissenschaftlichen
    Language fra
    Size 1 electronic resource (248 pages)
    Publisher Peter Lang International Academic Publishing Group
    Publishing place Bern
    Document type Book ; Online
    Note French ; German
    HBZ-ID HT030379991
    ISBN 9782807619340 ; 2807619347
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The Diseased Brain and the Failing Mind

    Zimmermann, Martina

    Dementia in Science, Medicine and Literature of the Long Twentieth Century

    (Explorations in Science and Literature)

    2020  

    Series title Explorations in Science and Literature
    Keywords Literary studies: from c 1900 ; Literary theory ; History of science ; Disability ; dementia ; alzheimer's disease ; identity ; ageing ; literature and science ; medical humanities
    Language 0|e
    Size 1 electronic resource (240 pages)
    Publisher Bloomsbury Academic
    Publishing place London
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620617
    ISBN 9781350121812 ; 1350121819
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The Poetics and Politics of Alzheimer's Disease Life-Writing

    Zimmermann, Martina

    2017  

    Keywords Alzheimers ; medicine ; biography ; autobiography ; Alzheimer's
    Size 1 electronic resource (167 pages)
    Publisher Palgrave Macmillan
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021043842
    ISBN 9783319443881 ; 3319443887
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: The Poetics and Politics of Alzheimer’s Disease Life-Writing

    Zimmermann, Martina

    (Palgrave Studies in Literature, Science and Medicine)

    2017  

    Author's details by Martina Zimmermann
    Series title Palgrave Studies in Literature, Science and Medicine
    Keywords Literature ; Literature, Modern/20th century ; British literature
    Subject code 809.04
    Language English
    Size 1 Online-Ressource (VIII, 167 p)
    Publisher Springer International Publishing ; Imprint: Palgrave Macmillan
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019374580
    ISBN 978-3-319-44388-1 ; 9783319443874 ; 3-319-44388-7 ; 3319443879
    DOI 10.1007/978-3-319-44388-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Informal dementia care: The carer's lived experience at the divides between policy and practice.

    Britton, Anthony / Zimmermann, Martina

    Dementia (London, England)

    2022  Volume 21, Issue 7, Page(s) 2117–2127

    Abstract: Support for informal dementia care at a local community level is not working for most carers today. Carers looking after a person with dementia have long lamented the absence of an empowered named support and an effectively actioned care plan. Drawing on ...

    Abstract Support for informal dementia care at a local community level is not working for most carers today. Carers looking after a person with dementia have long lamented the absence of an empowered named support and an effectively actioned care plan. Drawing on literary writing and social research, we argue in this article that these challenges have existed since dementia emerged as a major condition in the West during the 1980s. Based on this historical context, we ask: Why has this issue persisted over the last four decades? How have healthcare politics and policy initiatives responded to these requests? And what can we learn from this for the current, COVID-19 exacerbated crisis of care? This article focuses on the English context, to discuss these ongoing challenges in the light of a series of policy papers, and to ask what is hampering the implementation of such policy initiatives. In England, local authorities are responsible for dementia support. This article focuses on the situation in a county in the Midlands where one of us (AB) has been lobbying local government for over a decade. The discussion contextualises the lived experience of dementia care within the situation exacerbated by the COVID-19 pandemic, ensuing politics of crises and persistent emphasis on cure over care. We find that the absence on two points centrally challenges care: a joined-up approach between health and social care and adequate information on available care support services, accessible through an empowered named contact. To enhance the lived experience of dementia care, consistent provision of individual named support and professional care support, as and when required, should become essential to local implementation of the care policy.
    MeSH term(s) COVID-19 ; Caregivers ; Dementia/epidemiology ; Dementia/therapy ; Health Services Accessibility ; Humans ; Pandemics ; Policy
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2084045-7
    ISSN 1741-2684 ; 1471-3012
    ISSN (online) 1741-2684
    ISSN 1471-3012
    DOI 10.1177/14713012221112234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Alzheimer's Disease Metaphors as Mirror and Lens to the Stigma of Dementia.

    Zimmermann, Martina

    Literature and medicine

    2017  Volume 35, Issue 1, Page(s) 71–97

    Abstract: This essay gives an overview of the metaphors that patients in comparison to caregivers employ to conceptualize their experience with the chronic degenerative, cognitive, and incurable aspects of Alzheimer's disease. It explores how the images (such as ... ...

    Abstract This essay gives an overview of the metaphors that patients in comparison to caregivers employ to conceptualize their experience with the chronic degenerative, cognitive, and incurable aspects of Alzheimer's disease. It explores how the images (such as the journey, darkness, the death sentence, and torture) relate to the narration of cognitive decline and memory loss, and how these personal accounts negotiate with the culturally dominant dementia narrative that centers on the patient's passivity and dependence and is, usually, found in caregiver stories. This analysis, based on English, French, and German language texts, argues that the metaphors of this mainstream dementia narrative are, first, grounded in medico-scientific dementia discourse and, second, encapsulated in "Alzheimer's disease" as metaphor itself.
    MeSH term(s) Aged ; Alzheimer Disease/psychology ; Dementia/psychology ; Female ; Humans ; Literature, Modern ; Male ; Medicine in Literature ; Metaphor ; Narration ; Sick Role ; Social Stigma
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 0278-9671
    ISSN 0278-9671
    DOI 10.1353/lm.2017.0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Über die lymphomatoide Granulomatose (Liebow)

    Zimmermann, Martina

    Darstellung eines eigenen Falles und Übersicht über die Literatur

    1990  

    Author's details vorgelegt von Martina Zimmermann
    Size 109 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1990
    HBZ-ID HT003616378
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    91 D 1884 order for loan Magazin

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  8. Article: S-Sulfocysteine – Investigation of cellular uptake in CHO cells

    Zimmermann, Martina / Kolmar, Harald / Zimmer, Aline

    Journal of biotechnology. 2021 July 20, v. 335

    2021  

    Abstract: For the generation of therapeutic proteins in cell culture, high producing clones are used. These clones have a high demand in amino acids to support cell growth and productivity. l-cysteine (Cys) is critical in highly concentrated feeds due to low ... ...

    Abstract For the generation of therapeutic proteins in cell culture, high producing clones are used. These clones have a high demand in amino acids to support cell growth and productivity. l-cysteine (Cys) is critical in highly concentrated feeds due to low stability of Cys and low solubility of the oxidation product cystine at neutral pH. S-sulfocysteine (SSC) was developed to substitute the Cys source and fed-batch experiments using SSC showed good cellular performance regarding viable cell density and titer, indicating uptake and metabolization of SSC by Chinese hamster ovary cells. However, the responsible transporter allowing cellular uptake remains unclear and was studied in this work. Due to the structure similarity of SSC with cystine and glutamate, it was proposed that the cystine/glutamate antiporter (xc-) allows cellular uptake of SSC. The uptake was assessed via transporter inhibition using sulfasalazine and transporter overexpression using either sulforaphane or sulforaphane-N-acetylcysteine during fed-batch experiments. Following daily addition of 50 μM and 100 μM sulfasalazine, the extracellular SSC concentration was increased by 65 % and 177 % respectively, suggesting a reduced uptake due to xc- inhibition. In contrast, enhanced transporter activity through 15 μM sulforaphane and sulforaphane-N-acetylcysteine treatment, induced a 60 % and 52 % reduced extracellular SSC concentration, respectively. These inverse uptake results strongly suggest that xc- is facilitating the transport of SSC.
    Keywords Cricetulus griseus ; antiporters ; biotechnology ; cell culture ; cell growth ; cell viability ; cysteine ; cystine ; glutamic acid ; oxidation ; pH ; solubility ; sulfasalazine ; sulforaphane ; therapeutics
    Language English
    Dates of publication 2021-0720
    Size p. 27-38.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 843647-2
    ISSN 1873-4863 ; 0168-1656 ; 1389-0352
    ISSN (online) 1873-4863
    ISSN 0168-1656 ; 1389-0352
    DOI 10.1016/j.jbiotec.2021.06.003
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2299: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Understanding the Impact of Active-to-Passive Area Ratio on Deformation in One-Dimensional Dielectric Elastomer Actuators with Uniaxial Strain State.

    Liebscher, Hans / Koenigsdorff, Markus / Endesfelder, Anett / Mersch, Johannes / Zimmermann, Martina / Gerlach, Gerald

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 21

    Abstract: There is increasing interest in the use of novel elastomers with inherent or modified advanced dielectric and mechanical properties, as components of dielectric elastomer actuators (DEA). This requires corresponding techniques to assess their electro- ... ...

    Abstract There is increasing interest in the use of novel elastomers with inherent or modified advanced dielectric and mechanical properties, as components of dielectric elastomer actuators (DEA). This requires corresponding techniques to assess their electro-mechanical performance. A common way to test dielectric materials is the fabrication of actuators with pre-stretch fixed by a stiff frame. This results in the problem that the electrode size has an influence on the achievable actuator displacement and strain, which is detrimental to the comparability of experiments. This paper presents an in-depth study of the active-to-passive ratio with the aim of investigating the influence of the coverage ratio on uniaxial actuator displacement and strain. To model the effect, a simple lumped-parameter model is proposed. The model shows that the coverage ratio for maximal displacement is 50%. To validate the model results, experiments are carried out. For this, a rectangular, fiber-reinforced DEA is used to assess the relation of the coverage ratio and deformation. Due to the stiffness of the fibers, highly anisotropic mechanical properties are achieved, leading to the uniaxial strain behavior of the actuator, which allows the validation of the one-dimensional model. To consider the influence of the simplifications in the lumped-parameter model, the results are compared to a hyperelastic model. In summary, it is shown that the ratio of the active-to-passive area has a significant influence on the actuator deformation. Both the model and experiments confirm that an active-to-passive ratio of 50% is particularly advantageous in most cases.
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16216897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Photostress Recovery Time as a Potential Predictive Biomarker for Age-Related Macular Degeneration.

    Brandl, Caroline / Zimmermann, Martina E / Herold, Janina M / Helbig, Horst / Stark, Klaus J / Heid, Iris M

    Translational vision science & technology

    2023  Volume 12, Issue 2, Page(s) 15

    Abstract: Purpose: The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort.: Methods: We analyzed ... ...

    Abstract Purpose: The purpose of this study was to assess recovery time following photostress and its association with age-related macular degeneration (AMD) cross-sectionally and longitudinally in an elderly population-based cohort.
    Methods: We analyzed photostress recovery time (PRT) and AMD in >1800 AugUR study participants aged 70+ years. On color fundus images from baseline and 3-year follow-up, presence of AMD was graded manually (Three Continent AMD Consortium Severity Scale). Visual acuity (VA) was assessed via Early Treatment Diabetic Retinopathy Study (ETDRS) charts. After a 30-second bleaching of the macular region via direct ophthalmoscope, PRT was measured as the seconds to regain VA.
    Results: First, we analyzed 1208 AugUR participants cross-sectionally (288 with early AMD, and 78 with late AMD). Prolonged PRT was associated with early and late AMD versus no AMD (median PRT = 119.5, 198.0 versus 80.0 seconds, respectively; logistic regression odds ratio [OR] = 1.109-1.165 per 10 seconds, P values < 0.0001). Sensitivity analyses using alternative models or restricting to participants after cataract surgery revealed similar ORs. Second, the association was confirmed in an independent cross-sectional AugUR sample (n = 486). Third, in longitudinal analysis of 233 AugUR participants without AMD, prolonged PRT was associated with incident AMD ascertained 3 years later (follow-up time = 3.2 ± 0.2 years, OR = 1.112-1.162 per 10 seconds, P < 0.05). Overall, we demonstrate a significant association of prolonged PRT with AMD cross-sectionally and longitudinally in elderly individuals.
    Conclusions: Prolonged PRT might capture retinal function impairment after cell damage before early AMD is visible via color fundus imaging.
    Translational relevance: Our results suggest PRT as quantitative predictive biomarker for incident AMD, making it potentially worthwhile also for clinical care.
    MeSH term(s) Humans ; Aged ; Cross-Sectional Studies ; Macular Degeneration/diagnosis ; Retina ; Visual Acuity ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.12.2.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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