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  1. Article ; Online: Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease.

    Spiegel, Jonathan / Pirraglia, Elizabeth / Osorio, Ricardo S / Glodzik, Lidia / Li, Yi / Tsui, Wai / Saint Louis, Leslie A / Randall, Catherine / Butler, Tracy / Xu, Jinfeng / Zinkowski, Raymond P / Zetterberg, Henrik / Fortea, Juan / Fossati, Silvia / Wisniewski, Thomas / Davies, Peter / Blennow, Kaj / de Leon, Mony J

    Journal of Alzheimer's disease : JAD

    2015  Volume 49, Issue 1, Page(s) 93–100

    Abstract: Cerebrospinal fluid (CSF) measures of phosphorylated-tau (P-tau) 231 and P-tau181 are two biomarkers for the identification of tau pathology as related to Alzheimer's disease (AD). While both are pathologically validated, their relative diagnostic ... ...

    Abstract Cerebrospinal fluid (CSF) measures of phosphorylated-tau (P-tau) 231 and P-tau181 are two biomarkers for the identification of tau pathology as related to Alzheimer's disease (AD). While both are pathologically validated, their relative diagnostic performances are not well known. This cross-sectional diagnostic study of 87 normal (NL) subjects and 28 AD subjects compared CSF P-tau231 with CSF P-tau181. Logistic regression modeling demonstrated that the P-tau231 was superior to the P-tau181 in the diagnostic classifications. At a fixed 85% sensitivity cutoff, the ROC analysis shows that P-tau231 has greater overall specificity than P-tau181. While both P-tau analytes demonstrated equivalent negative predictive accuracies, P-tau231 yielded significantly fewer false positives. Moreover, P-tau231, but not P-tau181, demonstrated sensitivity to the E4 genotype. A postmortem validation with 9 AD subjects confirmed the superiority of the CSF P-tau231 specificity. This study suggests that P-tau231 has the potential to improve the CSF tau biomarker diagnosis of AD.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Phosphorylation ; ROC Curve ; Sensitivity and Specificity ; tau Proteins/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; tau Proteins
    Language English
    Publishing date 2015-03-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-150167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.

    Glodzik-Sobanska, Lidia / Pirraglia, Elizabeth / Brys, Miroslaw / de Santi, Susan / Mosconi, Lisa / Rich, Kenneth E / Switalski, Remigiusz / Saint Louis, Leslie / Sadowski, Martin J / Martiniuk, Frank / Mehta, Pankaj / Pratico, Domenico / Zinkowski, Raymond P / Blennow, Kaj / de Leon, Mony J

    Neurobiology of aging

    2007  Volume 30, Issue 5, Page(s) 672–681

    Abstract: While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+ ...

    Abstract While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Aging/genetics ; Aging/metabolism ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/analysis ; Amyloid beta-Peptides/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Biomarkers/analysis ; Biomarkers/cerebrospinal fluid ; DNA Mutational Analysis ; Dinoprost/analogs & derivatives ; Dinoprost/analysis ; Dinoprost/cerebrospinal fluid ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Middle Aged ; Oxidative Stress/genetics ; Peptide Fragments/analysis ; Peptide Fragments/cerebrospinal fluid ; Phosphorylation ; Polymorphism, Genetic/genetics ; tau Proteins/analysis ; tau Proteins/cerebrospinal fluid
    Chemical Substances 8,12-iso-isoprostane F2alpha-VI ; Amyloid beta-Peptides ; Apolipoprotein E4 ; Apolipoproteins E ; Biomarkers ; Peptide Fragments ; amyloid beta-protein (1-40) ; amyloid beta-protein (1-42) ; tau Proteins ; Dinoprost (B7IN85G1HY)
    Language English
    Publishing date 2007-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2007.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1685: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 10: Show issues

    Order via subito

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