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  1. Article ; Online: Application of PET imaging delta radiomics for predicting progression-free survival in rare high-grade glioma.

    Ahrari, Shamimeh / Zaragori, Timothée / Zinsz, Adeline / Oster, Julien / Imbert, Laetitia / Verger, Antoine

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3256

    Abstract: This study assesses the feasibility of using a sample-efficient model to investigate radiomics changes over time for predicting progression-free survival in rare diseases. Eighteen high-grade glioma patients underwent two L-3,4-dihydroxy-6-[ ...

    Abstract This study assesses the feasibility of using a sample-efficient model to investigate radiomics changes over time for predicting progression-free survival in rare diseases. Eighteen high-grade glioma patients underwent two L-3,4-dihydroxy-6-[
    MeSH term(s) Humans ; Progression-Free Survival ; Radiomics ; Glioma/diagnostic imaging ; Positron-Emission Tomography ; Retrospective Studies
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53693-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions.

    Zinsz, Adeline / Pouget, Celso / Rech, Fabien / Taillandier, Luc / Blonski, Marie / Amlal, Samir / Imbert, Laetitia / Zaragori, Timothée / Verger, Antoine

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Background: Amino acid PET is recommended for the initial diagnosis of brain lesions, but its value for identifying aggressive lesions remains to be established. The current study therefore evaluates the added-value of dynamic [18 F]FDOPA PET as an ... ...

    Abstract Background: Amino acid PET is recommended for the initial diagnosis of brain lesions, but its value for identifying aggressive lesions remains to be established. The current study therefore evaluates the added-value of dynamic [18 F]FDOPA PET as an adjunct to conventional MRI for determining the aggressiveness of presumed glial lesions at diagnosis.
    Methods: Consecutive patients, with a minimal 1 year-follow-up, underwent contrast-enhanced MRI (CE MRI) and dynamic [18 F]FDOPA PET to characterize their suspected glial lesion. Lesions were classified semi-automatically by their CE MRI (MRI-/+), and PET parameters (static tumor-to-background ratio, TBR; dynamic time-to-peak ratio, TTP
    Results: Of the 109 patients included, 46 had aggressive lesions (45 confirmed by histo-molecular analyses). CE MRI identified aggressive lesions with an accuracy of 73%. TBR
    Conclusion: Dynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06720-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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