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  1. Article ; Online: Copper - a novel stimulator of autophagy.

    Zischka, Hans / Kroemer, Guido

    Cell stress

    2020  Volume 4, Issue 5, Page(s) 92–94

    Abstract: Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper ... ...

    Abstract Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang
    Language English
    Publishing date 2020-04-24
    Publishing country Austria
    Document type Journal Article ; Comment
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2020.05.218
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  2. Article ; Online: Amyotrophic lateral sclerosis associated disturbance of iron metabolism is blunted by swim training-role of AKT signaling pathway.

    Halon-Golabek, Małgorzata / Flis, Damian Jozef / Zischka, Hans / Akdogan, Banu / Wieckowski, Mariusz Roman / Antosiewicz, Jedrzej / Ziolkowski, Wiesław

    Biochimica et biophysica acta. Molecular basis of disease

    2024  Volume 1870, Issue 3, Page(s) 167014

    Abstract: Swim training has increased the life span of the transgenic animal model of amyotrophic lateral sclerosis (ALS). Conversely, the progress of the disease is associated with the impairment of iron metabolism and insulin signaling. We used transgenic hmSOD1 ...

    Abstract Swim training has increased the life span of the transgenic animal model of amyotrophic lateral sclerosis (ALS). Conversely, the progress of the disease is associated with the impairment of iron metabolism and insulin signaling. We used transgenic hmSOD1 G93A (ALS model) and non-transgenic mice in the present study. The study was performed on the muscles taken from trained (ONSET and TERMINAL) and untrained animals at three stages of the disease: BEFORE, ONSET, and TERMINAL. In order to study the molecular mechanism of changes in iron metabolism, we used SH-SY5Y and C2C12 cell lines expression vector pcDNA3.1 and transiently transfected with specific siRNAs. The progress of ALS resulted in decreased P-Akt/Akt ratio, which is associated with increased proteins responsible for iron storage ferritin L, ferritin H, PCBP1, and skeletal muscle iron at ONSET. Conversely, proteins responsible for iron export- TAU significantly decrease. The training partially reverses changes in proteins responsible for iron metabolism. AKT silencing in the SH-SY5Y cell line decreased PCBP2 and ferroportin and increased ferritin L, H, PCBP1, TAU, transferrin receptor 1, and APP. Moreover, silencing APP led to an increase in ferritin L and H. Our data suggest that swim training in the mice ALS model is associated with significant changes in iron metabolism related to AKT activity. Down-regulation of AKT mainly upregulates proteins involved in iron import and storage but decreases proteins involved in iron export.
    MeSH term(s) Mice ; Animals ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Superoxide Dismutase-1/metabolism ; Neuroblastoma ; Signal Transduction ; Iron/metabolism ; Disease Models, Animal ; Ferritins/metabolism ; RNA-Binding Proteins/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Superoxide Dismutase-1 (EC 1.15.1.1) ; Iron (E1UOL152H7) ; Ferritins (9007-73-2) ; PCBP2 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.167014
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  3. Article ; Conference proceedings: Bioenergetic depression in platelets of Head and Neck cancer patients

    Mogl, Madeleine / Weiser, Tobias / Sailer, Judith / Eberhagen, Carola / Zischka, Hans / Wollenberg, Barbara

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
    Language English
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1784688
    Database Thieme publisher's database

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  4. Article ; Online: Copper Directly Affects Intestinal Lipid Turnover.

    Weiss, Karl Heinz / Zischka, Hans

    Gastroenterology

    2018  Volume 154, Issue 1, Page(s) 15–17

    MeSH term(s) Copper ; Humans ; Intestines ; Lipids ; Liver
    Chemical Substances Lipids ; Copper (789U1901C5)
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2017.11.016
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  5. Article ; Online: Mitochondrial copper homeostasis and its derailment in Wilson disease.

    Zischka, Hans / Einer, Claudia

    The international journal of biochemistry & cell biology

    2018  Volume 102, Page(s) 71–75

    Abstract: In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent ... ...

    Abstract In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent on adequate copper supply for proper respiratory function, and the molecular mechanisms for metalation of the cytochrome c oxidase have been largely characterized. On the other hand, copper overload impairs mitochondria and uncertainties exist concerning the molecular mechanisms for mitochondrial metal uptake, storage and release. The latter issue is of fundamental importance in Wilson disease, a genetic disease characterized by dysfunctional copper excretion from the liver. Prime consequences of the progressive copper accumulation in hepatocytes are increasing mitochondrial biophysical and biochemical deficits. Focusing on this two-sided aspect of mitochondrial copper, we review mitochondrial copper homeostasis but also the impact of excessive mitochondrial copper in Wilson disease.
    MeSH term(s) Animals ; Copper/metabolism ; Hepatolenticular Degeneration/metabolism ; Hepatolenticular Degeneration/pathology ; Homeostasis ; Humans ; Liver/pathology ; Mitochondria/metabolism
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2018-07-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2018.07.001
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    Zs.A 431: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Extending the mode of action of triethylenetetramine (trientine): Autophagy besides copper chelation.

    Pietrocola, Federico / Castoldi, Francesca / Zischka, Hans / Kroemer, Guido

    Journal of hepatology

    2020  Volume 73, Issue 4, Page(s) 970–972

    MeSH term(s) Autophagy/drug effects ; Chelating Agents/pharmacology ; Copper/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Hepatolenticular Degeneration/drug therapy ; Hepatolenticular Degeneration/metabolism ; Hepatolenticular Degeneration/pathology ; Humans ; Trientine/pharmacology
    Chemical Substances Chelating Agents ; Copper (789U1901C5) ; Trientine (SJ76Y07H5F)
    Language English
    Publishing date 2020-07-16
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.05.046
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    Zs.A 2027: Show issues Location:
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  7. Article ; Online: Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets.

    Fontes, Adriana / Ramalho-Santos, João / Zischka, Hans / Azul, Anabela Marisa

    European journal of clinical investigation

    2021  Volume 52, Issue 3, Page(s) e13667

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets.
    MeSH term(s) Agaricales ; Humans ; Non-alcoholic Fatty Liver Disease/diet therapy ; Non-alcoholic Fatty Liver Disease/metabolism
    Language English
    Publishing date 2021-09-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13667
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    Zs.A 677: Show issues Location:
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  8. Article: Mitochondrial copper homeostasis and its derailment in Wilson disease

    Zischka, Hans / Claudia Einer

    international journal of biochemistry & cell biology. 2018,

    2018  

    Abstract: In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent ... ...

    Abstract In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent on adequate copper supply for proper respiratory function, and the molecular mechanisms for metalation of the cytochrome c oxidase have been largely characterized. On the other hand, copper overload impairs mitochondria and uncertainties exist concerning the molecular mechanisms for mitochondrial metal uptake, storage and release. The latter issue is of fundamental importance in Wilson disease, a genetic disease characterized by dysfunctional copper excretion from the liver. Prime consequences of the progressive copper accumulation in hepatocytes are increasing mitochondrial biophysical and biochemical deficits. Focusing on this two-sided aspect of mitochondrial copper, we review mitochondrial copper homeostasis but also the impact of excessive mitochondrial copper in Wilson disease.
    Keywords copper ; cytochrome-c oxidase ; excretion ; hepatocytes ; hepatolenticular degeneration ; homeostasis ; liver ; lung function ; mitochondria ; uncertainty
    Language English
    Size p. .
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2018.07.001
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism.

    Knoop, Paul / Yilmaz, Dilay / Paganoni, Rossana / Steele-Perkins, Peter / Gruber, Andreas / Akdogan, Banu / Zischka, Hans / Leopold, Kerstin / Vujić Spasić, Maja

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Mutations in ... ...

    Abstract Mutations in the
    MeSH term(s) Mice ; Animals ; Kupffer Cells/metabolism ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Hemochromatosis Protein/genetics ; Hemochromatosis Protein/metabolism ; Membrane Proteins/metabolism ; Liver/metabolism ; Hepcidins/genetics ; Hepcidins/metabolism ; Hemochromatosis/genetics ; Hemochromatosis/metabolism ; Iron/metabolism ; Mice, Knockout
    Chemical Substances Histocompatibility Antigens Class I ; Hemochromatosis Protein ; Membrane Proteins ; Hepcidins ; Iron (E1UOL152H7) ; Hfe protein, mouse
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108948
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  10. Article ; Online: Author Correction: A fluorometric assay to determine labile copper(II) ions in serum.

    Maares, Maria / Haupt, Alessia / Schüßler, Christoph / Kulike-Koczula, Marcel / Hackler, Julian / Keil, Claudia / Mohr, Isabelle / Schomburg, Lutz / Süssmuth, Roderich D / Zischka, Hans / Merle, Uta / Haase, Hajo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8859

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59455-z
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