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Article ; Online: Hematological and biochemical markers in determining the diagnosis and stage prediction of endometrial cancer.

Petric, Aleksandra Nadezda / Živadinović, Radomir / Mitić, Dejan / Stanojević, Marko / Živadinović, Aleksandar / Kostić, Ivana

Ginekologia polska

2022 Volume 94, Issue 4, Page(s) 283–290

Abstract: Objectives: To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish ... ...

Abstract	Objectives: To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish whether hematological and biochemical parameters may be useful in predicting the stages of endometrial malignancy and in differentiating premalignant and malignant endometrial changes. Material and methods: A retrospective study included 100 patients (70 with endometrial carcinoma diagnosis and 30 with atypical hyperplasia). We compared hematological and biochemical parameters in both groups. Results: CRP, granulocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) are statistically significantly higher in patients with malignant changes. Lymphocyte count is statistically significantly lower in patients with malignant changes. Platelet count is statistically significantly lower in patients with stages I and II in comparison to patients with higher disease stage. NLR and PLR have good discriminatory power for carcinoma presence. Patients with advanced changes have statistically significantly higher CRP values, higher granulocyte and platelet count, as well as higher values of NLR and PLR, and statistically significantly lower values of lymphocytes and MPV in comparison to benign changes. Conclusions: There is a possibility of using hematological and biochemical parameters in the assessment of endometrial changes as well as in the prediction of stages, in confirmed malignant changes of the endometrium.
MeSH term(s)	Female ; Humans ; Retrospective Studies ; Biomarkers ; Blood Platelets/pathology ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Lymphocytes/pathology ; Lymphocyte Count ; Prognosis ; Neutrophils/pathology ; Precancerous Conditions
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-07-27
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2022.0038
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Article ; Online: Predictors of poor neonatal outcomes in fetuses diagnosed with congenital urinary tract anomalie.

Pop-Trajkovic Dinic, Sonja / Zivadinovic, Radomir / Stefanovic, Milan / Trenkic, Milan / Milosevic, Jelena / Mitic, Dejan

Ginekologia polska

2021

Abstract: Objectives: Urinary tract anomalies account for approximately one-quarter of all antenatally detected anomalies. The aim of this study was to identify factors associated with severe adverse neonatal outcomes of a prenatally diagnosed urinary tract ... ...

Abstract	Objectives: Urinary tract anomalies account for approximately one-quarter of all antenatally detected anomalies. The aim of this study was to identify factors associated with severe adverse neonatal outcomes of a prenatally diagnosed urinary tract anomaly. Material and methods: A retrospective-prospective study included 101 pregnant women with prenatally diagnosed fetal urinary tract anomalies presented to the Council for Fetal Anomalies. Prenatal diagnoses were compared with autopsy findings in cases of terminated pregnancy or with clinical and operative findings of the infants. Results: The mortality rate in the group of patients with fetal obstructive uropathy (60 patients) was 10% and in the group of patients with fetal multicystic dysplastic kidney (38 patients) 15.7%. Surgery was performed on 53.4% of the children, whereas more than half of the operations involved resolving associated urinary tract anomalies. Postoperative renal function deterioration occurred in 19% of the children. Conclusions: The prognosis of renal function in obstructive uropathies is excellent if oligoamnios does not develop prenatally and in case of timely provided surgical care is provided postnatally. The finding of the bilateral multicystic dysplastic kidney is associated with poor prognosis. The prognosis in fetal unilateral multicystic dysplastic kidney depends primarily on the condition of the contralateral kidney and the existence of associated anomalies.
Language	English
Publishing date	2021-04-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2021.0032
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Article ; Online: Unruptured tubal pregnancy in early second trimester

Petrić Aleksandra / Živadinović Radomir / Mitić Dejan / Vukomanović Predrag / Trenkić Milan

Srpski Arhiv za Celokupno Lekarstvo, Vol 146, Iss 9-10, Pp 588-

2018 Volume 592

Abstract: Introduction. Most ectopic pregnancies are tubal pregnancies. They are potentially life-threatening conditions with a high mortality rate if unrecognized. The diagnosis is established when the first warning symptoms occur, or during the first prenatal ... ...

Abstract	Introduction. Most ectopic pregnancies are tubal pregnancies. They are potentially life-threatening conditions with a high mortality rate if unrecognized. The diagnosis is established when the first warning symptoms occur, or during the first prenatal visits to a gynecologist. The diagnosis in the second trimester is extremely rare, since clinical presentation resulting either from the expulsion of the fetus into the peritoneal cavity or from the tubal rupture is manifested by that time. If there is no rupture or the expulsion of the fetus, the pregnancy is allowed to continue and ectopic pregnancy diagnosis may be established in the second trimester. Case outline. We present a case of a 31-year-old second gravida with a vital intrauterine pregnancy confirmed at the first examination. In the early second trimester, the patient visited her doctor due to vaginal bleeding. After a gynecological examination and ultrasonography, ectopic pregnancy was suspected, so the patient underwent laparotomy. Ectopic pregnancy was confirmed and adnexectomy was performed. Conclusion. Early ultrasound examinations have to confirm whether eutopic pregnancy is present. A misdiagnosis and monitoring of ectopic pregnancy as eutopic one is potentially life-threatening for a pregnant woman.
Keywords	unruptured pregnancy ; tubal pregnancy ; early second trimester ; Medicine ; R
Subject code	150
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Persistent human papillomavirus infection in the etiology of cervical carcinoma

Živadinović Radomir / Petrić Aleksandra / Lilić Goran / Lilić Vekoslav / Đorđević Biljana

Srpski Arhiv za Celokupno Lekarstvo, Vol 142, Iss 5-6, Pp 378-

The role of immunological, genetic, viral and cellular factors

2014 Volume 383

Abstract: The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response can be ... ...

Abstract	The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response can be better understood. Early E region of the viral genome encodes proteins that are directly involved in carcinogenesis. The E6 protein binds to p53 protein (product of tumor-suppressor gene) blocking and degrading it, which in turn prevents cell cycle arrest and apoptosis induction. E6 is also capable of telomerase activation, which leads to cell immortalization; it also reacts with host proto-oncogene c-jun, responsible for transcription, shortens G1 phase and speeds up the transition from G1 to S phase of the cells infected by HPV. E7 forms bonds with retinoblastoma protein (product of tumor-suppressor gene) and inactivates it. It can inactivate cyclin inhibitors p21, p27, and abrogate the mitotic spindle checkpoint with the loss of protective effect of pRB and p53. The immune system cannot initiate early immunological reaction since the virus is non-lytic, while the concentration of viral proteins - antigens is low and has a basal intracellular position. Presentation through Langerhans cells (LC) is weak, because the number of these cells is low due to the effect of HPV. E7 HPV reduces the expression of E-cadherin, which is responsible for LC adhesion to HPVtransformed keratinocytes. Based on these considerations, it may be concluded that the process of cervical carcinogenesis includes viral, genetic, cellular, molecular-biological, endocrine, exocrine and immunological factors.
Keywords	human papillomavirus (HPV) ; cervical carcinogenesis ; cell cycle ; Medicine ; R
Subject code	572
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Metastatic malignant melanoma of the uterus diagnosed by colposcopy

Živadinović Radomir / Mijović Žaklina / Petrić Aleksandra / Popović Jasmina / Vukomanović Predrag / Trenkić Milan / Krtinić Dane

Srpski Arhiv za Celokupno Lekarstvo, Vol 144, Iss 5-6, Pp 329-

2016 Volume 333

Abstract: Introduction. Primary and metastatic malignant melanomas represent a rare diagnosis with a small number of described cases. The aggressive nature of the tumor, non-specific symptoms, difficult diagnosis, and no official protocol about the treatment ... ...

Abstract	Introduction. Primary and metastatic malignant melanomas represent a rare diagnosis with a small number of described cases. The aggressive nature of the tumor, non-specific symptoms, difficult diagnosis, and no official protocol about the treatment result in poor disease prognosis. Case Outline. The authors presented a 41-year-old multigravida patient. She had an operation of malignant melanoma in the occipital area of the head. She went to her gynecologist because of increased pale pink vaginal secretion. Gynecological examination didn’t show any significant abnormalities apart from a slightly enlarged uterus. Papanicolaou test and vaginal secretion examination were normal. Colposcopically, a significant dark brown hyperpigmented area around 1 cm in size was observed on the posterior lip of the cervix, near the orifice and cervical canal, suspicious of melanoma, which was proven on targeted biopsy of the hyperpigmented change on the cervix, and by magnetic resonance imaging of the lesser pelvis. Classic hysterectomy with adnexectomy and regional pelvic lymphadenectomy were performed. Conclusion. This case report pointed out the significance of applying colposcopy in diagnosing suspected metastatic melanoma of the uterine cervix, along with other diagnostic methods and anamnestic data.
Keywords	malignant melanoma ; uterus ; colposcopy ; metastases ; Medicine ; R
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Influence of air pollution on pregnant women’s health and pregnancy outcomes

Stanković Aleksandra / Mitrović Vladimir / Živadinović Radomir

Medicinski Pregled, Vol 64, Iss 5-6, Pp 279-

2011 Volume 284

Abstract: Summary Outdoor and indoor air pollution pollutants can be a potential cause to a lot of negative effects on the health of pregnant women and outcome of pregnancy. The objective of this paper was to estimate the influence of outdoor and indoor air ... ...

Abstract	Summary Outdoor and indoor air pollution pollutants can be a potential cause to a lot of negative effects on the health of pregnant women and outcome of pregnancy. The objective of this paper was to estimate the influence of outdoor and indoor air pollution on the health of pregnant women and outcome of pregnancy. Material and Methods The study subjects were the pregnant women, non-smokers, who were not professionally exposed to air pollution. They were divided into the exposed group (n=189) and control group (n=178) during the exposure to outdoor air pollution. The data on exposure to sources of indoor air pollution (smoke produced by burning fossil fuels and passive smoking) during pregnancy were obtained from the questionnaire. Data on health condition and outcome of pregnancy were obtained from medical records of tested pregnant women. Results. The research results have shown that the frequency of anemia (OR=6.76; 95% CI=1.28-7.72), upper respiratory symptoms (OR=9.53; 95% CI=1.32-3.8) and bleeding (OR=20.5; 95% CI=2.03-6.97) was significantly higher in pregnant women exposed to outdoor air pollution as compared with the control group. The occurrence of upper respiratory symptoms (OR=40.42; 95% CI=2.96-8.91) and bleeding (OR=53.21; 95% CI=4.3-15.73) was significantly higher in pregnant women who had been exposed to fossil fuel smoke. Exposure to passive smoking had significant influence on the development of upper respiratory symptoms (OR=34.58; 95% CI=3.05-11.66).
Keywords	Air Pollution ; Pregnancy Outcome ; Pregnancy ; Female ; Questionnaires ; Tobacco Smoke Pollution ; Fossil Fuels ; Respiratory Tract Infections ; Hemorrhage ; Anemia ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	333 ; 150
Language	Serbian
Publishing date	2011-01-01T00:00:00Z
Publisher	Serbian Medical Society, Society of Physicians of Vojvodina, Novi Sad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of air pollution on birth weight

Stanković Aleksandra / Mitrović Vladimir / Živadinović Radomir

Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 9-10, Pp 651-

2011 Volume 656

Abstract: Introduction. Epidemiological studies point out that exposure to air pollution during pregnancy is a risk for low birth weight. Objective. The aim of this study was to evaluate the effects of outdoor and indoor air pollution on the occurrence of low ... ...

Abstract	Introduction. Epidemiological studies point out that exposure to air pollution during pregnancy is a risk for low birth weight. Objective. The aim of this study was to evaluate the effects of outdoor and indoor air pollution on the occurrence of low birth weight. Methods. The measurement of outdoor air pollutants, sulphur dioxide and black smoke was carried out daily at the Institute for Public Healthcare of Niš at two measuring locations, in Niš and Niška Banja during 2003. Subjects were 367 pregnant women, nonsmokers and who were not profesionally exposed to air pollution. Data on exposure to source of indoor air pollution (passive smoking and mode of heating) was determined on the basis of a questionnaire. Data on the characteristics of newborns were taken from the register of Obstetrics and Gyanecology Clinic of Niš. Results. We determined that exposure of pregnant women to outdoor air pollution and wood heating systems had influence on the occurence of low birth weight. Exposure to passive smoking had no influence on neonatal low birth weight. Conclusion. Exposure of pregnant women to outdoor and indoor air pollutants can have negative influence on the occurrence of low birth weight.
Keywords	air pollution ; pregnant women ; newborn ; low birth weight ; wood smoke ; Medicine ; R
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: T lymphocytes in the third trimester decidua in preeclampsia.

Milosevic-Stevanovic, Jelena / Krstic, Miljan / Stefanovic, Milan / Zivadinovic, Radomir / Vukomanovic, Predrag / Trajkovic-Dinic, Sonja Pop / Stojnev, Slavica

Hypertension in pregnancy

2019 Volume 38, Issue 1, Page(s) 52–57

Abstract: Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia.: Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all ...

Abstract	Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia. Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. Results: The group with preeclampsia included a significantly higher number of CD3+ (p < 0.01) and CD8+ (p < 0.05) T lymphocytes. Conclusion: It is certain that thebalance dysregulation of T cell of the immune milieu of deciduais of importance in etiopathogenesis and manifestations of preeclampsia.
MeSH term(s)	Adult ; CD3 Complex/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Case-Control Studies ; Decidua/metabolism ; Female ; Humans ; Lymphocyte Count ; Placenta/metabolism ; Pre-Eclampsia/metabolism ; Pregnancy ; Pregnancy Trimester, Third/metabolism ; Prospective Studies ; T-Lymphocytes/metabolism ; Young Adult
Chemical Substances	CD3 Complex
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1151886-8
ISSN	1525-6065 ; 1064-1955
ISSN (online)	1525-6065
ISSN	1064-1955
DOI	10.1080/10641955.2019.1575393
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Article ; Online: Diagnostic performance of human epididymis protein 4 compared to a combination of biophysical and biochemical markers to differentiate ovarian endometriosis from epithelial ovarian cancer in premenopausal women.

Nikolova, Tanja / Zivadinovic, Radomir / Evtimovska, Nina / Klisarovska, Violeta / Stanojevic, Marko / Georgievska, Jadranka / Nikolova, Natasha

The journal of obstetrics and gynaecology research

2017 Volume 43, Issue 12, Page(s) 1870–1879

Abstract: Aim: This study is a comparison of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125), using the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), Risk of Malignancy Index (RMI) and Morphology Index (MI) to ... ...

Abstract	Aim: This study is a comparison of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125), using the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), Risk of Malignancy Index (RMI) and Morphology Index (MI) to differentiate ovarian endometriosis from epithelial ovarian cancer (EOC) in premenopausal women. Methods: The study was performed at the University Clinic of Obstetrics and Gynecology in Skopje. One hundred and sixty-four premenopausal patients were divided into three study groups, including ovarian endometriosis (37), other benign pelvic masses (57) and EOCs (11), and a control group (59). After ultrasonography, all subjects underwent blood sampling. Surgery and histological verification was performed. Pelvic masses were classified based on histological findings. Mann-Whitney, receiver operating characteristic-area under the curve (AUC), sensitivity, specificity and Kruskal-Wallis tests were used for statistical analysis. The level of significance α was set at 5%. Results: For each of the tested markers, sensitivity, specificity and accuracy to distinguish ovarian endometriosis from EOC were as follows: HE4 (81.82%, 100%, 95.83%); CA125 (81.82%, 48.65%, 56.25%); ROMA (90.91%, 83.78%, 85.42%); CPH-I (81.82%, 97.30%, 93.75%); RMI (90.91%, 35.14%, 47.92%); and MI (100%, 75.68%, 81.25%), respectively. The AUC for ovarian endometriosis compared to EOC for tested markers was as follows: HE4 (AUC = 0.934), CA125 (AUC = 0.821), ROMA (AUC = 0.929), CPH-I (AUC = 0.924) and RMI (AUC = 0.880), respectively. Conclusion: HE4 and CPH-I perform best to discriminate ovarian endometriosis from EOC in premenopausal women. MI has maximal sensitivity to detect EOC.
MeSH term(s)	Adult ; Algorithms ; Biomarkers, Tumor/blood ; CA-125 Antigen/blood ; Carcinoma, Ovarian Epithelial ; Diagnosis, Differential ; Endometriosis/diagnosis ; Endometriosis/pathology ; Female ; Humans ; Middle Aged ; Neoplasms, Glandular and Epithelial/diagnosis ; Neoplasms, Glandular and Epithelial/pathology ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Premenopause ; Proteins/analysis ; ROC Curve ; Risk Factors ; Sensitivity and Specificity
Chemical Substances	Biomarkers, Tumor ; CA-125 Antigen ; Proteins ; WFDC2 protein, human
Language	English
Publishing date	2017-10-13
Publishing country	Australia
Document type	Comparative Study ; Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.13466
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Article: [Persistent human papillomavirus infection in the etiology of cervical carcinoma: the role of immunological, genetic, viral and cellular factors].

Zivadinović, Radomir / Petrić, Aleksandra / Lilić, Goran / Lilić, Vekoslav / Djordjević, Biljana

Srpski arhiv za celokupno lekarstvo

2014 Volume 142, Issue 5-6, Page(s) 378–383

Abstract	The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response can be better understood. Early E region of the viral genome encodes proteins that are directly involved in carcinogenesis. The E6 protein binds to p53 protein (product of tumor-suppressor gene) blocking and degrading it, which in turn prevents cell cycle arrest and apoptosis induction. E6 is also capable of telomerase activation, which leads to cell immortalization; it also reacts with host proto-oncogene c-jun, responsible for transcription, shortens G1 phase and speeds up the transition from G1 to S phase of the cells infected by HPV. E7 forms bonds with retinoblastoma protein (product of tumor-suppressor gene) and inactivates it. It can inactivate cyclin inhibitors p21, p27, and abrogate the mitotic spindle checkpoint with the loss of protective effect of pRB and p53. The immune system cannot initiate early immunological reaction since the virus is non-lytic, while the concentration of viral proteins--antigens is low and has a basal intracellular position. Presentation through Langerhans cells (LC) is weak, because the number of these cells is low due to the effect of HPV. E7 HPV reduces the expression of E-cadherin, which is responsible for LC adhesion to HPV-transformed keratinocytes. Based on these considerations, it may be concluded that the process of cervical carcinogenesis includes viral, genetic, cellular, molecular-biological, endocrine, exocrine and immunological factors.
MeSH term(s)	Carcinogenesis/genetics ; Carcinogenesis/immunology ; Carcinogenesis/pathology ; Cyclins/metabolism ; Female ; Host-Pathogen Interactions/physiology ; Humans ; Organ Specificity ; Papillomaviridae/pathogenicity ; Papillomaviridae/physiology ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/genetics ; Papillomavirus Infections/immunology ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms/etiology ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/virology
Chemical Substances	Cyclins ; Retinoblastoma Protein ; Tumor Suppressor Protein p53
Language	Serbian
Publishing date	2014-07-11
Publishing country	Serbia
Document type	Journal Article ; Review
ZDB-ID	128567-1
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
ISSN	0370-8179 ; 0354-2793 ; 0049-0210
DOI	10.2298/sarh1406378z
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