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Article ; Online: Glycyrol Prevents the Progression of Psoriasis-like Skin Inflammation via Immunosuppressive and Anti-Inflammatory Actions

Yuanyuan Liu / Yanxia Fu / Ziwei Zhu / Shanzao Chen / Li Tong / Qun Wei

International Journal of Molecular Sciences, Vol 24, Iss 24, p

2023 Volume 17335

Abstract: Glycyrol (GC) is one natural active product. Imiquimod-induced psoriasis-like Balb/c mouse models were established. The model mice were intraperitoneally injected with cyclosporine A (CsA) and GC for 8 days followed by a series of biological detections. ... ...

Abstract	Glycyrol (GC) is one natural active product. Imiquimod-induced psoriasis-like Balb/c mouse models were established. The model mice were intraperitoneally injected with cyclosporine A (CsA) and GC for 8 days followed by a series of biological detections. GC had little toxicity according to the levels of peripheral blood cells, hemoglobin, blood urea nitrogen (BUN), and serum creatinine (CRE), while CsA significantly increased the levels of BUN and CRE. GC decreased the splenic index and reduced the expressions of IL-6, IL-23, and CXCL-3 in the model mice and IL-6, CXCL-1, and CXCL-2 in the inflammatory HaCaT cells. The half inhibition concentration (IC 50 ) of GC on HaCaT cells was 29.72 μmol/L, resulting in improved apoptosis, enhanced expressions of p21, BAX, and BIK, and reduced expressions of BCL-2. GC is an immunosuppressive agent against psoriasis-like symptoms by anti-inflammatory effects, which provides a strategy for the discovery of anti-psoriatic natural products.
Keywords	cyclosporine A ; imiquimod ; immunosuppression ; inflammation ; nephrotoxicity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptomic Analysis of Three Differentially Senescing Maize ( Zea mays L.) Inbred Lines upon Heat Stress

Xiaokang Han / Dingyu Zhang / Haibo Hao / Yong Luo / Ziwei Zhu / Benke Kuai

International Journal of Molecular Sciences, Vol 24, Iss 9782, p

2023 Volume 9782

Abstract: Maize, one of the world’s major food crops, is facing the challenge of rising temperature. Leaf senescence is the most significant phenotypic change of maize under heat stress at the seedling stage, but the underlying molecular mechanism is still unknown. ...

Abstract	Maize, one of the world’s major food crops, is facing the challenge of rising temperature. Leaf senescence is the most significant phenotypic change of maize under heat stress at the seedling stage, but the underlying molecular mechanism is still unknown. Here, we screened for three inbred lines (PH4CV, B73, and SH19B) that showed differentially senescing phenotypes under heat stress. Among them, PH4CV showed no obviously senescing phenotype under heat stress, while SH19B demonstrated a severely senescing phenotype, with B73 being between the two extremes. Subsequently, transcriptome sequencing showed that differentially expressed genes (DEGs) were generally enriched in response to heat stress, reactive oxygen species (ROS), and photosynthesis in the three inbred lines under heat treatment. Notably, ATP synthesis and oxidative phosphorylation pathway genes were only significantly enriched in SH19B. Then, the expression differences of oxidative phosphorylation pathways, antioxidant enzymes, and senescence-related genes in response to heat stress were analyzed in the three inbred lines. In addition, we demonstrated that silencing ZmbHLH51 by virus-induced gene silencing (VIGS) inhibits the heat-stress-induced senescence of maize leaves. This study helps to further elucidate the molecular mechanisms of heat-stress-induced leaf senescence at the seedling stage of maize.
Keywords	heat stress ; maize ; leaf senescence ; transcriptome sequencing ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Short‐term commercial load forecasting based on peak‐valley features with the TSA‐ELM model

Mengran Zhou / Ziwei Zhu / Feng Hu / Kai Bian / Wenhao Lai / Tianyu Hu

Energy Science & Engineering, Vol 10, Iss 8, Pp 2622-

2022 Volume 2636

Abstract: Abstract Commercial buildings are consuming an increasing amount of energy, and accurate load demand forecasting is critical for the reliable operation of power systems and the efficient use of resources. Therefore, in this paper, a short‐term commercial ...

Abstract	Abstract Commercial buildings are consuming an increasing amount of energy, and accurate load demand forecasting is critical for the reliable operation of power systems and the efficient use of resources. Therefore, in this paper, a short‐term commercial load forecasting model based on tunicate swarm algorithm (TSA) combined with an extreme learning machine (ELM) under peak‐valley features is proposed as a research case for a shopping mall in Romania. This paper's overall structure is divided into two steps. In the first step, the 24‐h day is divided into six periods by analyzing the daily load characteristics of the training set, and the peak and valley loads are obtained. The ELM optimized by TSA (TSA‐ELM) algorithm is then used to forecast the peak and valley values of the test set one day ahead. In the second step, the actual load, peak, and valley for the previous week of historical load are chosen using the maximum information coefficient (MIC). Following that, the MIC ≥ 0.8 features are added to the TSA‐ELM to achieve short‐term commercial electricity load forecasting. The results show that the PV (Peak & Valley)‐TSA‐ELM model proposed in this paper has higher prediction accuracy compared with other models. Taking ELM as an example, compared with the traditional ELM, the mean absolute error, root mean square error, and mean absolute percentage error of PV‐TSA‐ELM are reduced by 20.59%, 20.13%, and 19.19% on average in the three commercial data sets. The proposed model is validated with an industrial data set, and ideal results are obtained, which verifies the effectiveness and superiority of the proposed method.
Keywords	commercial electricity demand ; extreme learning machine ; peak and valley loads ; short‐term load forecasting ; tunicate swarm algorithm ; Technology ; T ; Science ; Q
Subject code	621
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biogeography and Diversification of the Tropical and Subtropical Asian Genus Gastrochilus (Orchidaceae, Aeridinae)

Yang Li / Weitao Jin / Liguo Zhang / Peng Zhou / Yan Luo / Ziwei Zhu / Xiaoguo Xiang

Diversity, Vol 14, Iss 396, p

2022 Volume 396

Abstract: Tropical and subtropical Asia are major orchid diversity and endemism centers. However, the evolutionary dynamics of orchids in these areas remain poorly studied. Gastrochilus D. Don, a species-rich orchid genus from tropical and subtropical Asian ... ...

Abstract	Tropical and subtropical Asia are major orchid diversity and endemism centers. However, the evolutionary dynamics of orchids in these areas remain poorly studied. Gastrochilus D. Don, a species-rich orchid genus from tropical and subtropical Asian forests, was employed to investigate the issue. We firstly used eight DNA regions to reconstruct the phylogeny and estimate the divergence times within Gastrochilus . We inferred the ancestral ranges and conducted a diversification analysis based on empirical and simulated data. Subsequently, we assessed the ancestral niche state and tested for phylogenetic signals in the evolution of niche conditions. Our results suggested that the most recent common ancestor of Gastrochilus occurred in the subtropical area of the East Asiatic region in the late Miocene (8.13 Ma). At least eight dispersal events and four vicariant events were inferred to explain the current distribution of Gastrochilus , associated with the global cooling from the Plio-Pleistocene. The genus experienced a slowly decreasing diversification rate since its origin, and no significant correlation between current niches and phylogenetic relatedness was observed. The diversification of Gastrochilus was attributed to accumulation through time, integrated with the intensification of the Asian Monsoon system during the Plio-Pleistocene, pollination, and epiphytism.
Keywords	Gastrochilus ; biogeography ; diversification ; niche ; Asian Monsoon ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An often-overestimated ecological risk of copper in Chinese surface water

Wei Liao / Yutao Zheng / Chenglian Feng / Wenjun Zhong / Ziwei Zhu / Huiyu Xie / Wenpan Li / Xiaowei Jin / John P. Giesy

Environmental Sciences Europe, Vol 35, Iss 1, Pp 1-

bioavailable fraction determined by multiple linear regression of water quality parameters

2023 Volume 14

Abstract: Abstract Background Risks of adverse ecological effects of copper (Cu) consider of water quality parameters were not fully understood in China. Here, a national-scale exposure of Cu in Chinese surface water was investigated, and the first report using ... ...

Abstract	Abstract Background Risks of adverse ecological effects of copper (Cu) consider of water quality parameters were not fully understood in China. Here, a national-scale exposure of Cu in Chinese surface water was investigated, and the first report using multiple linear regression approach to predict and correct toxicity data based on water chemistries in China. Risk of Cu was overestimated without considering water quality parameters in the previous studies. Results Under prevalent water quality conditions of hardness = 150.0 mg/L, pH = 7.8, and dissolved organic carbon (DOC) = 3.0 mg/L, across China, the predicted no effect concentration for total, dissolved Cu was 9.71 μg/L. Based on results of the preliminary risk quotients method, 1.19% (a total of 43 in 3610 sites) were classified as “high risk”, only one sixth of the percentage of sites with “high risk” than the proportion predicted when not considering water quality parameters, which was 7.51%. Similar results were obtained by application of both the margin of safety method (0.71% compared to 2.81%) and joint probability curve method (3.34% compared to 16.29%), both of which overestimated risks posed by Cu to aquatic organisms in China. Conclusion After correcting for bioavailability based on water quality parameters, consider both concentrations and frequencies during ecological risk assessment, regions of China at greatest risk from adverse effects of Cu were the Hai River (Haihe), Huai Rivers (Huaihe) and Chao Lake. These findings provide a comprehensive method for a more accurate assessment of risks of adverse effects of Cu to aquatic life in surface waters.
Keywords	Metal bioavailability ; Ecological risk assessment ; Simulation models ; Water quality ; Available fraction ; Chemical activity ; Environmental sciences ; GE1-350 ; Environmental law ; K3581-3598
Subject code	333
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy

Jiaying Yang / Yongjun Yao / Li Tong / Ziwei Zhu / Lei Wang / Jinju Yang

European Journal of Inflammation, Vol

2021 Volume 19

Abstract: Gliomas are very malignant brain tumors that are difficult to treat. CD47 is an antiphagocytic molecule that binds to SIPRα on phagocytes. It is overexpressed on the plasma membranes of multiple human tumor cell types and is an important diagnostic and ... ...

Abstract	Gliomas are very malignant brain tumors that are difficult to treat. CD47 is an antiphagocytic molecule that binds to SIPRα on phagocytes. It is overexpressed on the plasma membranes of multiple human tumor cell types and is an important diagnostic and prognostic biomarker in many types of cancer. However, the association between CD47 protein expression in glioma tissue and clinicopathological stage has not been investigated in detail. A total of 80 surgical glioma specimens were stained with anti-CD47 antibody to assess the relationship between CD47 protein expression and clinicopathological stage of the glioma. Wound healing assays were performed to analyze the influence of CD47 on the migration and invasion of glioma cells, and near-infrared fluorescence localization assays in a U-87 MG-bearing xenograft model were used to determine the distribution of anti-CD47 antibody in vivo. MTT assays and administration of anti-CD47 to a U251-bearing xenograft model were used to analyze the inhibitory effects of the antibody on gliomas. CD47 expression was higher in high-grade gliomas than in low-grade gliomas, and high CD47 expression was positively correlated with histology and tumor clinicopathological stage. CD47 over-expression promoted the growth and motility of two glioma cell lines (U-87 MG and U251) and a laboratory-developed anti-CD47 antibody accumulated at the glioma site. Proliferation of U251 and U-87 MG cells was not significantly inhibited by the anti-CD47 antibody in vitro, but the antibody significantly inhibited U251 growth in vivo. It also enhanced inhibition capacity by Taxol. Our results suggest that CD47 plays a critical role in the progression of gliomas from stage I to IV and may be a potential target for the treatment of gliomas. CD47 appears to play a critical role in the progression of gliomas from stage I to IV and an anti-CD47 antibody prepared in the laboratory may inhibit the growth of gliomas.
Keywords	Medicine ; R
Subject code	570
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

Kai Wang / Xian Shi / Ziwei Zhu / Xingjie Hao / Liangkai Chen / Shanshan Cheng / Roger S. Y. Foo / Chaolong Wang

Genome Medicine, Vol 14, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Background Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. While many genetic loci have been identified to associate with CAD, the intermediate ... ...

Abstract	Abstract Background Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. While many genetic loci have been identified to associate with CAD, the intermediate causal risk factors and etiology have not been fully understood. This study assesses the causal effects of 37 heritable clinical factors on CAD in East Asian and European populations. Methods We collected genome-wide association summary statistics of 37 clinical factors from the Biobank Japan (42,793 to 191,764 participants) and the UK Biobank (314,658 to 442,817 participants), paired with summary statistics of CAD from East Asians (29,319 cases and 183,134 controls) and Europeans (91,753 cases and 311,344 controls). These clinical factors covered 12 cardiometabolic traits, 13 hematological indices, 7 hepatological and 3 renal function indices, and 2 serum electrolyte indices. We performed univariable and multivariable Mendelian randomization (MR) analyses in East Asians and Europeans separately, followed by meta-analysis. Results Univariable MR analyses identified reliable causal evidence (P < 0.05/37) of 10 cardiometabolic traits (height, body mass index [BMI], blood pressure, glycemic and lipid traits) and 4 other clinical factors related to red blood cells (red blood cell count [RBC], hemoglobin, hematocrit) and uric acid (UA). Interestingly, while generally consistent, we identified population heterogeneity in the causal effects of BMI and UA, with higher effect sizes in East Asians than those in Europeans. After adjusting for cardiometabolic factors in multivariable MR analysis, red blood cell traits (RBC, meta-analysis odds ratio 1.07 per standard deviation increase, 95% confidence interval 1.02–1.13; hemoglobin, 1.10, 1.03–1.16; hematocrit, 1.10, 1.04–1.17) remained significant (P < 0.05), while UA showed an independent causal effect in East Asians only (1.12, 1.06–1.19, P = 3.26×10−5). Conclusions We confirmed the causal effects of 10 cardiometabolic ...
Keywords	Mendelian randomization ; Clinical factors ; Coronary artery disease ; Causal inference ; Red blood cells ; Uric acid ; Medicine ; R ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine

Shuchen Zhang / Pingyuan Xu / Ziwei Zhu / Lingyan Zhou / Jiao Li / Ruonan Zhou / Yue Kan / Yaru Li / Xizhong Yu / Juan Zhao / Yu Jin / Jing Yan / Penghua Fang / Wenbin Shang

Redox Biology, Vol 62, Iss , Pp 102704- (2023)

2023

Abstract: Nuclear factor (NF)-κB plays a pivotal role in the regulation of inflammatory response in macrophages. Berberine (BBR), which is an active constituent isolated from Coptis rhizome, possesses a prominent anti-inflammatory activity. Here we show that BBR ... ...

Abstract	Nuclear factor (NF)-κB plays a pivotal role in the regulation of inflammatory response in macrophages. Berberine (BBR), which is an active constituent isolated from Coptis rhizome, possesses a prominent anti-inflammatory activity. Here we show that BBR changes the global acetylation landscape in LPS-induced protein acetylation of macrophages and reduces the acetylation of NF-κB subunit p65 at site Lys310(p65Lys310), leading to the inhibition of NF-κB translocation and transcriptional activity to suppress the expressions of inflammatory factors. BBR resists the inflammatory response in acute LPS-stimulated mice through downregulation of p65Lys310 acetylation in peritoneal macrophages. In obese mice, BBR alleviates the metabolic disorder and inflammation with the reduced acetylation of p65Lys310 in white adipose tissue. Furthermore, we demonstrate that BBR acts as a regulator of p65Lys310 by inhibiting the expression of p300 in macrophages. Our findings elucidate a new molecular mechanism for the anti-inflammatory effect of BBR via the p300/p65Lys310 axis.
Keywords	Berberine ; p65 ; p300 ; Inflammatory response ; Macrophages ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Quercitrin extracted from Tartary buckwheat alleviates imiquimod-induced psoriasis-like dermatitis in mice by inhibiting the Th17 cell response

Chen, Shanzao / Hu Li / Qun Wei / Yuanyuan Liu / Ziwei Zhu

Journal of functional foods. 2017 Nov., v. 38

2017

Abstract: Quercitrin (YDHH) is a natural dietary flavonoid extracted from Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.). Psoriasis is a chronic immune-mediated dermatosis. In this study, we report that YDHH had no obvious cytotoxicity and inhibited the ... ...

Abstract	Quercitrin (YDHH) is a natural dietary flavonoid extracted from Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.). Psoriasis is a chronic immune-mediated dermatosis. In this study, we report that YDHH had no obvious cytotoxicity and inhibited the proliferation of LPS-stimulated HaCaT keratinocytes. Furthermore, oral administration of YDHH alleviated imiquimod-induced psoriasis-like dermatitis in mice, significantly attenuating the excessive proliferation and abnormal differentiation of keratinocytes, and reducing inflammatory cell infiltrates. YDHH treatment lowered the expression of cytokines related to psoriasis, especially those on the IL-23/Th17 axis. Furthermore, it dramatically inhibited the Th17 cell response regulated by the JAK/STAT signalling pathway. In addition, it was less toxic to the liver and kidneys of mice than the classical immunosuppressant cyclosporine A. Taken together, these findings indicate that YDHH could be useful as a functional food supplement for protection against psoriasis.
Keywords	buckwheat ; cyclosporine ; cytokines ; cytotoxicity ; dermatitis ; dietary supplements ; Fagopyrum tataricum ; functional foods ; keratinocytes ; kidneys ; liver ; mice ; oral administration ; psoriasis ; quercitrin ; signal transduction
Language	English
Dates of publication	2017-11
Size	p. 9-19.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2017.08.034
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Automated synthesis and preliminary evaluation of [18F]FDPA for cardiac inflammation imaging in rats after myocardial infarction

Tiantian Mou / Jing Tian / Yi Tian / Mingkai Yun / Junqi Li / Wei Dong / Xia Lu / Ziwei Zhu / Hongzhi Mi / Xiaoli Zhang / Xiang Li

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 10

Abstract: Abstract A translocator protein 18 kDa targeted radiotracer, N,N-diethyl-2-(2-(4-[18F]fluorophenyl)-5,7-dimethylpyrazolo[1,5-a] pyrimidin-3-yl) acetamide ([18F]FDPA), was automated synthetized and evaluated for cardiac inflammation imaging. Various ... ...

Abstract	Abstract A translocator protein 18 kDa targeted radiotracer, N,N-diethyl-2-(2-(4-[18F]fluorophenyl)-5,7-dimethylpyrazolo[1,5-a] pyrimidin-3-yl) acetamide ([18F]FDPA), was automated synthetized and evaluated for cardiac inflammation imaging. Various reaction conditions for an automated synthesis were systematically optimized. MicroPET/CT imaging were performed on normal rats and rats with myocardial infarction (MI). Normalized SUV ratios of [18F]FDPA to [13N]NH3 (NSRs) in different regions were calculated to normalize the uptake of [18F]FDPA to perfusion. The amount of TBAOMs and the volume/proportion of water were crucial for synthesis. After optimization, the total synthesis time was 68 min. The non-decay corrected radiochemical yields (RCYs) and molar activities were 19.9 ± 1.7% and 169.7 ± 46.5 GBq/μmol, respectively. In normal rats, [18F]FDPA showed a high and stable cardiac uptake and fast clearance from other organs. In MI rats, NSRs in the peri-infarct and infarct regions, which were infiltrated with massive inflammatory cells revealed by pathology, were higher than that in the remote region (1.20 ± 0.01 and 1.08 ± 0.10 vs. 0.89 ± 0.05, respectively). [18F]FDPA was automated synthesized with high RCYs and molar activities. It showed a high uptake in inflammation regions and offered a wide time window for cardiac imaging, indicating it could be a potential cardiac inflammation imaging agent.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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