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  1. Article ; Online: Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases 2.0.

    Kaminska, Joanna / Zoladek, Teresa

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: One of the goals of human genetics is to discover the variants that contribute to human diseases [ ... ]. ...

    Abstract One of the goals of human genetics is to discover the variants that contribute to human diseases [...].
    Language English
    Publishing date 2022-12-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232415821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases.

    Kaminska, Joanna / Zoladek, Teresa

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Neurodegenerative diseases are a group of age-related diseases and a growing problem in an aging society [ ... ]. ...

    Abstract Neurodegenerative diseases are a group of age-related diseases and a growing problem in an aging society [...].
    MeSH term(s) Aging ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Humans ; Models, Biological ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Fungal Proteins
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Yeast as a Model to Find New Drugs and Drug Targets for

    Kaminska, Joanna / Soczewka, Piotr / Rzepnikowska, Weronika / Zoladek, Teresa

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Mutations in ... ...

    Abstract Mutations in human
    MeSH term(s) Calcium Signaling ; Calcium-Binding Proteins/metabolism ; Copper/metabolism ; Copper Transport Proteins ; Humans ; Iron/metabolism ; Iron-Binding Proteins/metabolism ; Neuroacanthocytosis ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Calcium-Binding Proteins ; Copper Transport Proteins ; FET4 protein, S cerevisiae ; Iron-Binding Proteins ; RCN2 protein, human ; Saccharomyces cerevisiae Proteins ; VPS13 protein, S cerevisiae ; Copper (789U1901C5) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095106
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  4. Article ; Online: The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.

    Kolakowski, Damian / Kaminska, Joanna / Zoladek, Teresa

    Biochimica et biophysica acta. Biomembranes

    2020  Volume 1862, Issue 9, Page(s) 183349

    Abstract: Chorein is a protein of the Vps13 family, and defects in this protein cause the rare neurodegenerative disorder chorea-acanthocytosis (ChAc). Chorein is involved in the actin cytoskeleton organization, calcium ion flux, neuronal cell excitability, ... ...

    Abstract Chorein is a protein of the Vps13 family, and defects in this protein cause the rare neurodegenerative disorder chorea-acanthocytosis (ChAc). Chorein is involved in the actin cytoskeleton organization, calcium ion flux, neuronal cell excitability, exocytosis and autophagy. The function of this protein is poorly understood, and obtaining this knowledge is a key to finding a cure for ChAc. Chorein, as well as the Vps13 protein from yeast, contains the APT1 domain. Our previous research has shown that the APT1 domain from yeast Vps13 (yAPT1v) binds phosphatidylinositol 3-phosphate (PI3P) in vitro. In this study, we showed that although the APT1 domain from chorein (hAPT1) binds to PI3P it could not functionally replace yAPT1v. The hAPT1 domain binds, in addition to PI3P, to phosphatidylinositol 5-phosphate (PI5P). The binding of hAPT1 to PI3P, unlike the binding of yAPT1v to PI3P, is regulated by the bivalent ions, calcium and magnesium. Regulation of PI3P binding via calcium is also observed for the APT1 domain of yeast autophagy protein Atg2. The substitution I2771R, found in chorein of patient suffering from ChAc, reduces the binding of the hAPT1 domain to PI3P and PI5P. These results suggest that the ability of APT1 domains to bind phosphoinositides is regulated differently in yeast and human protein and that this regulation is important for chorein function.
    MeSH term(s) Autophagy/genetics ; Autophagy-Related Proteins/genetics ; Calcium/chemistry ; Humans ; Ions/chemistry ; Magnesium/chemistry ; Mutation/genetics ; Neuroacanthocytosis/genetics ; Neuroacanthocytosis/metabolism ; Neuroacanthocytosis/pathology ; Neurons/metabolism ; Neurons/pathology ; Phosphatidylinositol Phosphates/genetics ; Protein Binding/genetics ; Protein Domains/genetics ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Thiolester Hydrolases/chemistry ; Thiolester Hydrolases/genetics ; Vesicular Transport Proteins/chemistry ; Vesicular Transport Proteins/genetics
    Chemical Substances ATG2 protein, S cerevisiae ; Autophagy-Related Proteins ; Ions ; Phosphatidylinositol Phosphates ; Saccharomyces cerevisiae Proteins ; VPS13A protein, human ; Vesicular Transport Proteins ; phosphatidylinositol 3-phosphate ; phosphatidylinositol 5-phosphate ; LYPLA1 protein, human (EC 3.1.2.-) ; Thiolester Hydrolases (EC 3.1.2.-) ; YLR118C protein, S cerevisiae (EC 3.1.2.-) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-05-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2020.183349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
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  5. Article ; Online: Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency.

    Wardaszka, Patrycja / Soczewka, Piotr / Sienko, Marzena / Zoladek, Teresa / Kaminska, Joanna

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: Regulation of calcineurin, a ... ...

    Abstract Regulation of calcineurin, a Ca
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Binding Sites ; Calcineurin/metabolism ; Gene Dosage ; Gene Expression Regulation ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Vesicular Transport Proteins/deficiency
    Chemical Substances Adaptor Proteins, Signal Transducing ; Vesicular Transport Proteins ; Calcineurin (EC 3.1.3.16)
    Language English
    Publishing date 2021-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031193
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  6. Article ; Online: The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.

    Kolakowski, Damian / Rzepnikowska, Weronika / Kaniak-Golik, Aneta / Zoladek, Teresa / Kaminska, Joanna

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: VPS13 proteins are evolutionarily conserved. Mutations in the four human genes ( ...

    Abstract VPS13 proteins are evolutionarily conserved. Mutations in the four human genes (
    MeSH term(s) ADP-Ribosylation Factor 1/genetics ; ADP-Ribosylation Factor 1/metabolism ; Clathrin/metabolism ; Golgi Apparatus/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Microscopy, Confocal ; Mitochondria/genetics ; Mitochondria/metabolism ; Models, Biological ; Mutation ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Protein Binding ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Temperature
    Chemical Substances Clathrin ; Saccharomyces cerevisiae Proteins ; VPS13 protein, S cerevisiae ; Green Fluorescent Proteins (147336-22-9) ; ADP-Ribosylation Factor 1 (EC 3.6.5.2)
    Language English
    Publishing date 2021-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212274
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  7. Article ; Online: Targeting Copper Homeostasis Improves Functioning of

    Soczewka, Piotr / Tribouillard-Tanvier, Déborah / di Rago, Jean-Paul / Zoladek, Teresa / Kaminska, Joanna

    International journal of molecular sciences

    2021  Volume 22, Issue 5

    Abstract: Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes and Wilson's diseases, respectively, and iron imbalance is observed in Parkinson's and ... ...

    Abstract Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes and Wilson's diseases, respectively, and iron imbalance is observed in Parkinson's and Alzheimer's diseases. To better understand human diseases,
    MeSH term(s) Copper/pharmacology ; Copper Transport Proteins/genetics ; Copper Transport Proteins/metabolism ; Gene Expression Regulation/drug effects ; Homeostasis ; Humans ; Mutation ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Copper Transport Proteins ; Saccharomyces cerevisiae Proteins ; VPS13 protein, S cerevisiae ; Copper (789U1901C5)
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22052248
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  8. Article: Nagroda Nobla z chemii, czyli o systemie degradacji białek komórkowych.

    Zoładek, Teresa

    Postepy biochemii

    2004  Volume 50, Issue 4, Page(s) 294–295

    Title translation Nobel prize in chemistry, degradation system and cellular protein.
    MeSH term(s) Animals ; Chemistry/history ; History, 20th Century ; History, 21st Century ; Humans ; Nobel Prize ; Proteins/history ; Proteins/metabolism
    Chemical Substances Proteins
    Language Polish
    Publishing date 2004
    Publishing country Poland
    Document type Historical Article ; Journal Article
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Molecular Basis of the Pathogenic Mechanism Induced by the m.9191T>C Mutation in Mitochondrial

    Su, Xin / Dautant, Alain / Godard, François / Bouhier, Marine / Zoladek, Teresa / Kucharczyk, Roza / di Rago, Jean-Paul / Tribouillard-Tanvier, Déborah

    International journal of molecular sciences

    2020  Volume 21, Issue 14

    Abstract: Probing the pathogenicity and functional consequences of mitochondrial DNA (mtDNA) mutations from patient's cells and tissues is difficult due to genetic heteroplasmy (co-existence of wild type and mutated mtDNA in cells), occurrence of numerous mtDNA ... ...

    Abstract Probing the pathogenicity and functional consequences of mitochondrial DNA (mtDNA) mutations from patient's cells and tissues is difficult due to genetic heteroplasmy (co-existence of wild type and mutated mtDNA in cells), occurrence of numerous mtDNA polymorphisms, and absence of methods for genetically transforming human mitochondria. Owing to its good fermenting capacity that enables survival to loss-of-function mtDNA mutations, its amenability to mitochondrial genome manipulation, and lack of heteroplasmy,
    MeSH term(s) Adenosine Triphosphate/metabolism ; DNA, Mitochondrial/genetics ; Membrane Potential, Mitochondrial/genetics ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Proton-Translocating ATPases/chemistry ; Mitochondrial Proton-Translocating ATPases/genetics ; Mitochondrial Proton-Translocating ATPases/metabolism ; Models, Chemical ; Mutation ; Oxidative Phosphorylation ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances ATP6 protein, S cerevisiae ; DNA, Mitochondrial ; Saccharomyces cerevisiae Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
    Language English
    Publishing date 2020-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21145083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Flavonoids as Potential Drugs for

    Soczewka, Piotr / Flis, Krzysztof / Tribouillard-Tanvier, Déborah / di Rago, Jean-Paul / Santos, Cláudia N / Menezes, Regina / Kaminska, Joanna / Zoladek, Teresa

    Genes

    2020  Volume 11, Issue 7

    Abstract: Several rare neurodegenerative diseases, including chorea acanthocytosis, are caused by mutations in ... ...

    Abstract Several rare neurodegenerative diseases, including chorea acanthocytosis, are caused by mutations in the
    MeSH term(s) Biological Products/chemistry ; Biological Products/pharmacology ; Cell Proliferation/drug effects ; Copper Transport Proteins/genetics ; Copper Transport Proteins/metabolism ; Drug Discovery/methods ; High-Throughput Screening Assays/methods ; Iron/metabolism ; Iron-Binding Proteins/genetics ; Iron-Binding Proteins/metabolism ; Luteolin/chemistry ; Luteolin/pharmacology ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Suppression, Genetic
    Chemical Substances Biological Products ; Copper Transport Proteins ; FET4 protein, S cerevisiae ; Iron-Binding Proteins ; Neuroprotective Agents ; Saccharomyces cerevisiae Proteins ; Small Molecule Libraries ; VPS13 protein, S cerevisiae ; Iron (E1UOL152H7) ; Luteolin (KUX1ZNC9J2)
    Language English
    Publishing date 2020-07-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11070828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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