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  1. Article ; Online: A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy.

    Li, Jun / Zong, Qingyu / Zhao, Zhongyi / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 21, Page(s) 3142–3145

    Abstract: In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug ... ...

    Abstract In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH
    MeSH term(s) Prodrugs/pharmacology ; Reactive Oxygen Species ; Drug Liberation ; Nanoparticles ; Drug Delivery Systems ; Doxorubicin/pharmacology ; Cell Line, Tumor
    Chemical Substances Prodrugs ; Reactive Oxygen Species ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00052d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy

    Zong, Qingyu / Xiao, Xuan / Li, Jisi / Yuan, Youyong

    Biomaterials science. 2022 July 26, v. 10, no. 15

    2022  

    Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a ... ...

    Abstract The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a reactive oxygen species (ROS)-sensitive polyprodrug (TSCA/DOX) with cascade amplification of triggering agents and drug activation by incorporating both an ROS signal amplifier (TACA) and a drug activation amplifier (SIPDOX) into a delivery system. Endogenous ROS as a triggering mechanism kicked off the initial circulation phase to increase intracellular ROS signals. Subsequently, the enhanced ROS initiated the second degradation step, allowing the polyprodrug SIPDOX to fracture spontaneously in a domino-like fashion, resulting in self-accelerated drug activation in tumor tissue. Therefore, the polyprodrug created in this study with cascade amplification of drug activation holds great promise for effective cancer treatment.
    Keywords biocompatible materials ; cancer therapy ; drugs ; neoplasms ; polymers ; reactive oxygen species
    Language English
    Dates of publication 2022-0726
    Size p. 4228-4234.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00647b
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy.

    Zong, Qingyu / Xiao, Xuan / Li, Jisi / Yuan, Youyong

    Biomaterials science

    2022  Volume 10, Issue 15, Page(s) 4228–4234

    Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a ... ...

    Abstract The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we rationally created a reactive oxygen species (ROS)-sensitive polyprodrug (TS
    MeSH term(s) Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Liberation ; Humans ; Nanoparticles ; Neoplasms/drug therapy ; Polymers/metabolism ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Reactive Oxygen Species/metabolism
    Chemical Substances Polymers ; Prodrugs ; Reactive Oxygen Species ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00647b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging.

    Zhao, Zhongyi / Zong, Qingyu / Li, Jun / Jiang, Maolin / Wang, Kewei / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 26, Page(s) 3878–3881

    Abstract: In this study, we combined low pH and cathepsin B dual-stimulus-triggered delivery carriers with a bioorthogonal reaction-activated prodrug to achieve regulated activation of the prodrug. A workable method for precise tumor therapy and imaging is ... ...

    Abstract In this study, we combined low pH and cathepsin B dual-stimulus-triggered delivery carriers with a bioorthogonal reaction-activated prodrug to achieve regulated activation of the prodrug. A workable method for precise tumor therapy and imaging is provided by the bioorthogonal reaction, which activates the prodrug and fluorescent probe.
    MeSH term(s) Prodrugs/therapeutic use ; Fluorescent Dyes ; Optical Imaging/methods
    Chemical Substances Prodrugs ; Fluorescent Dyes
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc00177f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Self-amplified chain-shattering cinnamaldehyde-based poly(thioacetal) boosts cancer chemo-immunotherapy.

    Zong, Qingyu / Li, Jisi / Xiao, Xuan / Du, Xiaojiao / Yuan, Youyong

    Acta biomaterialia

    2022  Volume 154, Page(s) 97–107

    Abstract: The selective activation of stimuli-responsive polymers in the tumor microenvironment is a great concern to achieve intelligent cancer therapy, but most of them show inadequate response due to insufficient endogenous triggering agents. Herein, we ... ...

    Abstract The selective activation of stimuli-responsive polymers in the tumor microenvironment is a great concern to achieve intelligent cancer therapy, but most of them show inadequate response due to insufficient endogenous triggering agents. Herein, we rationally designed a reactive oxygen species (ROS)-responsive cinnamaldehyde (CA)-based poly(thioacetal), consisting of ROS-responsive thioacetal (TA) and ROS-generating agent CA, with self-amplified chain-shattering polymer degradation. The mechanism of self-amplified chain-shattering is that endogenous ROS as a triggering agent facilitates chain cleavage of TA with the release of CA, which in turn produces more ROS through mitochondrial dysfunction, resulting in an exponential polymer degradation cascade. The polymer can be further modified with anticancer drug doxorubicin (DOX) for cooperative amplification of oxidative stress and immunogenic cell death (ICD) of tumor cells, thereby boosting the effect of chemo-immunotherapy. The self-amplified chain-shattering polymer designed in this work holds great promise in developing stimuli-responsive polymers for efficient drug delivery. STATEMENT OF SIGNIFICANCE: This study presented an approach to utilize self-amplified chain-shattering cinnamaldehyde-based poly (thioacetal) as a drug delivery system to restrain tumor growth and boost chemo-immunotherapy. The endogenous ROS as a triggering agent initiates the chain cleavage with the release of CA, which in turn produces ROS through mitochondria dysfunction, resulting in an exponential polymer degradation cascade and rapid drug release.
    Language English
    Publishing date 2022-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.09.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Synergistic Chemoimmunotherapy System Leveraging PD-L1 Blocking and Bioorthogonal Prodrug Activation.

    Wang, Kewei / Jiang, Maolin / Li, Tao / Liu, Ye / Zong, Qingyu / Xu, Qing / Ullah, Ihsan / Chen, Yahui / Xue, Wei / Yuan, Youyong

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2402322

    Abstract: Novel strategies to facilitate tumor-specific drug delivery and restore immune attacks remain challenging in overcoming the current limitations of chemoimmunotherapy. An antitumor chemoimmunotherapy system comprising bioorthogonal reaction-ready group ... ...

    Abstract Novel strategies to facilitate tumor-specific drug delivery and restore immune attacks remain challenging in overcoming the current limitations of chemoimmunotherapy. An antitumor chemoimmunotherapy system comprising bioorthogonal reaction-ready group tetrazine (TZ) modified with an anti-PD-L1 antibody (αPD-L1
    Language English
    Publishing date 2024-05-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202402322
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  7. Article: Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer

    Li, Jisi / Zong, Qingyu / Liu, Ye / Xiao, Xuan / Zhou, Jielian / Zhao, Zhongyi / Yuan, Youyong

    Chemical communications. 2022 Mar. 8, v. 58, no. 20

    2022  

    Abstract: In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of ... ...

    Abstract In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.
    Keywords cancer therapy ; ferrocenes ; ferroptosis ; neoplasms ; polymers
    Language English
    Dates of publication 2022-0308
    Size p. 3294-3297.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06742g
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Self-immolative polyprodrug-based tumor-specific cascade amplificated drug release nanosystem for orchestrated synergistic cancer therapy

    Wang, Kewei / Xiao, Xuan / Liu, Ye / Zong, Qingyu / Tu, Yalan / Yuan, Youyong

    Biomaterials. 2022 Oct., v. 289

    2022  

    Abstract: Reactive oxygen species (ROS)-activated prodrugs can potentially improve the selectivity of chemotherapeutics. However, the inability to release sufficient drugs at tumor sites due to the paucity of ROS, which is required for prodrug activation usually ... ...

    Abstract Reactive oxygen species (ROS)-activated prodrugs can potentially improve the selectivity of chemotherapeutics. However, the inability to release sufficient drugs at tumor sites due to the paucity of ROS, which is required for prodrug activation usually limits the antitumor potency. Herein, a delivery nanosystem with self-amplifiable drug release pattern is constructed by encapsulating a tumor specificity ROS inducer NAD(P)H: quinone oxidoreductase-1 (NQO1)-responsive hemicyanine fluorescent dye (NCyNH₂) in a ROS-responsive self-immolative polyprodrug nanoparticle for orchestrated oxidation-chemotherapy. In response to ROS stimulation, the self-immolative polyprodrug can degrade and release doxorubicin (DOX) through a domino-like fragmentation, which can impart advanced attributes of this nanosystem such as minimum cleavage events required and maximum cleavage speed for disintegration. Thus, the NCyNH₂-loaded self-immolative polyprodrug nanoparticle (SIPN) could be dissociated in response to endogenous ROS, triggering the release of DOX and NCyNH₂. Subsequently, the NCyNH₂ could be activated by intratumoral overexpressed NQO1 to generate additional ROS, which further induces the amplifiable degradation of self-immolative polyprodrug to release sufficient drugs. The in vitro and in vivo studies consistently demonstrate that SIPN amplifies the drug release efficiency of ROS-responsive polyprodrug by specifically upregulating intratumoral ROS levels, resulting in significant antitumor efficacy with minimal side effects.
    Keywords biocompatible materials ; cancer therapy ; doxorubicin ; drug therapy ; fluorescent dyes ; nanoparticles ; neoplasms ; quinones ; reactive oxygen species
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121803
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Cinnamaldehyde-based poly(thioacetal): A ROS-awakened self-amplifying degradable polymer for enhanced cancer immunotherapy

    Tu, Yalan / Xiao, Xuan / Dong, Yansong / Li, Jisi / Liu, Ye / Zong, Qingyu / Yuan, Youyong

    Biomaterials. 2022 Oct., v. 289

    2022  

    Abstract: Although stimuli-responsive polymers have emerged as promising strategies for intelligent cancer therapy, limited polymer degradation and insufficient drug release remain a challenge. Here, we report a novel reactive oxygen species (ROS)-awakened self- ... ...

    Abstract Although stimuli-responsive polymers have emerged as promising strategies for intelligent cancer therapy, limited polymer degradation and insufficient drug release remain a challenge. Here, we report a novel reactive oxygen species (ROS)-awakened self-amplifying degradable cinnamaldehyde (CA)-based poly(thioacetal) polymer. The polymer consists of ROS responsive thioacetal (TA) group and CA as the ROS generation agent. The self-amplified polymer degradation process is triggered by endogenous ROS-induced cleavage of the TA group to release CA. The CA released then promotes the generation of more ROS through mitochondrial dysfunction, resulting in amplified polymer degradation. More importantly, poly(thioacetal) itself can trigger immunogenic cell death (ICD) of the tumor cells and its side chains can be conjugated with indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor to reverse the immunosuppressive tumor microenvironment for synergistic cancer immunotherapy. The self-amplified degradable poly(thioacetal) developed in this work provides insights into the development of novel stimulus-responsive polymers for enhanced cancer immunotherapy.
    Keywords biocompatible materials ; cancer therapy ; cell death ; drugs ; immunosuppression ; immunotherapy ; indoleamine 2,3-dioxygenase ; mitochondria ; neoplasms ; polymers ; reactive oxygen species
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121795
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer.

    Li, Jisi / Zong, Qingyu / Liu, Ye / Xiao, Xuan / Zhou, Jielian / Zhao, Zhongyi / Yuan, Youyong

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 20, Page(s) 3294–3297

    Abstract: In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of ... ...

    Abstract In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.
    MeSH term(s) Catalysis ; Cell Line, Tumor ; Ferroptosis ; Humans ; Metallocenes ; Neoplasms ; Polymers ; Reactive Oxygen Species
    Chemical Substances Metallocenes ; Polymers ; Reactive Oxygen Species
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06742g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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