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Article ; Online: Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy.

Zou, Jing

2023 Volume 19, Issue 1, Page(s) 55–58

Abstract: The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of Meniere's disease (MD) and sudden sensorineural hearing loss ( ...

Abstract	The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of Meniere's disease (MD) and sudden sensorineural hearing loss (SSHL). Gelation occurred shortly after mixing dexamethasone-containing fibrinogen with thrombin. Dexamethasone was constantly released for at least 16 d at a stable level after 7 d in protocol 1 (low-dose), while it was robustly released within 4 d and slowed afterward until 10 d in protocol 2 (high-dose). There were significant differences among the time points in Protocol 2 (p < 0.01, ANOVA), and the exponential model with the formula y = 15.299 * e
Language	English
Publishing date	2023-11-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2621477-5
ISSN	2524-1753 ; 1672-2930
ISSN (online)	2524-1753
ISSN	1672-2930
DOI	10.1016/j.joto.2023.11.002
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Article ; Online: The effect of parenting pressure on children's internalizing problem behaviors and its mechanism.

Zou, Jing

Work (Reading, Mass.)

2021 Volume 69, Issue 2, Page(s) 675–685

Abstract: Background: in the process of raising children, parents will inevitably have inappropriate measures and behaviors, which will bring greater pressure on the children's psychology and physiology.: Objective: in the field of children's development, ... ...

Abstract	Background: in the process of raising children, parents will inevitably have inappropriate measures and behaviors, which will bring greater pressure on the children's psychology and physiology. Objective: in the field of children's development, parenting pressure has always been one of the hotspots of worldwide scholars. In order to further understand the causes of children's psychological problems, the effect of parenting pressure on children's internalizing problem behaviors and its mechanism are explored. Methods: based on previous literature, the parenting pressure and children's internalizing related problems in China are investigated. Based on the characteristic discussion of parenting styles in China, the parenting pressure and internalizing problems of children is deeply analyzed. The sample survey is used to sample the parents of kindergarten children, and a total of 679 children's parents are selected. Results: the results show that the parents of boys have more serious parenting pressure than the parents of girls. In the process of raising children, the mother bears more pressure than the father. For the internalizing problems of children, the psychological aggression behavior of parents shows a relatively serious effect. There is a certain causal relationship between parenting pressure and parents' strict discipline behavior. Therefore, parenting pressure is used as an intermediary variable to affect children's internalizing behavior. Parenting pressure does not show a significant correlation with children's internalizing problems, but indirectly affects the generation of children's internalizing behaviors by affecting parents' strict discipline behaviors. Conclusion: it enriches the investigations on parenting pressure and children's education in China, and provides a certain theoretical basis for the development of children's mental health.
MeSH term(s)	Child ; Child Behavior ; China ; Female ; Humans ; Male ; Parent-Child Relations ; Parenting ; Parents ; Problem Behavior
Language	English
Publishing date	2021-05-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1394194-x
ISSN	1875-9270 ; 1051-9815
ISSN (online)	1875-9270
ISSN	1051-9815
DOI	10.3233/WOR-213508
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Zs.A 4810: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Missing perilymph but leaking blood-endolymph and vestibulocochlear nerve barriers in idiopathic sudden sensorineural hearing loss: A case study.

Zou, Jing

Journal of otology

2020 Volume 15, Issue 4, Page(s) 171–173

Abstract: Objectives: To evaluate the pathological changes in the blood-perilymph, blood-endolymph, and blood-nerve barriers of a patient with idiopathic sudden sensorineural hearing loss (SSNHL).: Methods: Potential ossification or fibrosis in the inner ear ... ...

Abstract	Objectives: To evaluate the pathological changes in the blood-perilymph, blood-endolymph, and blood-nerve barriers of a patient with idiopathic sudden sensorineural hearing loss (SSNHL). Methods: Potential ossification or fibrosis in the inner ear was evaluated using temporal bone CT and MRI acquired using the 3-dimensional T2-weighted sampling perfection with application-optimized contrasts using a flip angle evolution sequence. Pathological changes in the barriers were analyzed by MRI obtained 4 h after a single-dose intravenous injection of gadolinium chelate using a medium inversion-time inversion recovery imaging with magnitude reconstruction sequence. Results: The perilymph was absent, while significant enhancements of the vestibulocochlear nerve and the endolymphatic compartments were detected. Conclusion: Significant injuries in the blood-endolymph and blood-vestibulocochlear nerve barriers and disabled perilymph production may contribute to the development of SSNHL with poor response to treatments.
Language	English
Publishing date	2020-08-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2621477-5
ISSN	2524-1753 ; 1672-2930
ISSN (online)	2524-1753
ISSN	1672-2930
DOI	10.1016/j.joto.2020.08.002
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Article ; Online: Inhibitory neurons: VIP neurons expect rewards.

Zou, Jing / Hires, Samuel Andrew

Current biology : CB

2023 Volume 33, Issue 17, Page(s) R909–R911

Abstract: Inhibitory neurons which express vasoactive intestinal polypeptide, VIPs, are a small subset of the mammalian cortex but in importance live up to their acronym. New research shows that these critical control knobs of cortical activity are specifically ... ...

Abstract	Inhibitory neurons which express vasoactive intestinal polypeptide, VIPs, are a small subset of the mammalian cortex but in importance live up to their acronym. New research shows that these critical control knobs of cortical activity are specifically activated by actions taken when rewards are anticipated rather than consummated.
MeSH term(s)	Animals ; Vasoactive Intestinal Peptide ; Reward ; Neurons ; Mammals
Chemical Substances	Vasoactive Intestinal Peptide (37221-79-7)
Language	English
Publishing date	2023-09-10
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.07.059
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Zs.A 3208: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Inhibition of Ceramide Kinase Is Effective against Cisplatin-Resistant Ovarian Cancer Cells by Regulating Ceramide and C1P Levels.

Zou, Jing / Jian, Long

Gynecologic and obstetric investigation

2023 Volume 88, Issue 1, Page(s) 61–70

Abstract: Objective: Chemoresistance in ovarian cancer results in treatment failure, yet underlying mechanisms that regulate chemoresistance remain largely unclear. There is emerging evidence relating ovarian cancer drug resistance with bioactive sphingolipids ... ...

Abstract	Objective: Chemoresistance in ovarian cancer results in treatment failure, yet underlying mechanisms that regulate chemoresistance remain largely unclear. There is emerging evidence relating ovarian cancer drug resistance with bioactive sphingolipids and regulation of sphingolipid metabolism. This work investigated the expression and function of ceramide kinase (CerK), a lipid kinase that regulates central bioactive sphingolipids, in ovarian cancer, as well as the therapeutic potential of targeting CERK. Design: The levels of ceramide, ceramide 1-phosphate (C1P), and Cerk in ovarian cancer and normal counterparts were measured. Functions of Cerk in ovarian cancer were examined. Materials, setting, methods: Immunohistochemistry, ELISA, and mass spectrometry methods were used to measure the level of ceramides, C1P, and CerK in primary tissues. Proliferation and apoptosis assays were performed in ovarian cancer cells after CERK depletion, CERK overexpression, and NVP-231 treatment in the absence or presence of cisplatin. Results: Compared to normal ovarian cells, CerK and its mediating bioactive sphingolipids ceramide and C1P were decreased in ovarian cancer tissues. Interestingly, cisplatin-resistant ovarian cancer cells displayed increased CerK, decreased ceramide, and increased C1P, and furthermore, that CerK level was closely associated with ceramide and C1P levels in ovarian cancer cells. Functional analysis demonstrated that CerK overexpression was sufficient to promote growth and confer chemoresistance in ovarian cancer cells. CerK inhibition via both genetic and pharmacological approaches suppressed growth and induced apoptosis in cisplatin-resistant cells, and furthermore, this significantly augmented cisplatin's efficacy. Limitations: The functional analysis of C1P was performed on in vitro ovarian cancer cells. In vivo studies were needed to further confirm the effects of CERK inhibition. Conclusions: Our work is the first to show the critical role of CerK as the underlying mechanism of ovarian cancer chemoresistance, through regulating ceramide and C1P.
MeSH term(s)	Humans ; Female ; Cisplatin/pharmacology ; Ovarian Neoplasms/drug therapy ; Ceramides/metabolism ; Ceramides/pharmacology ; Sphingolipids
Chemical Substances	ceramide 1-phosphate ; Cisplatin (Q20Q21Q62J) ; ceramide kinase (EC 2.7.1.138) ; Ceramides ; Sphingolipids
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	800003-7
ISSN	1423-002X ; 0378-7346
ISSN (online)	1423-002X
ISSN	0378-7346
DOI	10.1159/000528869
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Zs.A 688: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Autoinflammatory characteristics and short-term effects of delivering high-dose steroids to the surface of the intact endolymphatic sac and incus in refractory Ménière's disease.

Zou, Jing

Journal of otology

2019 Volume 14, Issue 2, Page(s) 40–50

Abstract: Objective: To investigate immune-related genetic background in intractable Meniere's disease (MD) and the immediate results of a novel therapy by delivering steroids to the surface of the intact endolymphatic sac (ES) and incus in a sustainable manner.!# ...

Abstract	Objective: To investigate immune-related genetic background in intractable Meniere's disease (MD) and the immediate results of a novel therapy by delivering steroids to the surface of the intact endolymphatic sac (ES) and incus in a sustainable manner. Case report and methods: Candidate genes involved in immune regulation were sequenced using a next-generation sequencing method in a patient with intractable MD. Mutations were confirmed using the Sanger sequencing method. The ES was exposed, and gelatin sponge particles were immersed in high-dose methylprednisolone solution and placed onto the surface of ES. "L"-shaped gelatin sponge strips were immersed in dexamethasone solution and served as a guiding device for the steroids by touching the incus and gelatin sponge particles on the surface of the ES. Gelatin sponge particles immersed in dexamethasone solution were placed around the gelatin sponge strips and sealed using fibrin glue. Results: Autoinflammation in the refractory MD case was indicated by genotype, including novel heterozygous mutations of PRF1, UNC13D, SLC29A3, ITCH, and JAK3, as well as phenotype. The vertigo was fully relieved immediately after operation. Tinnitus and aural fullness were resolved 3 weeks after operation, whereas hearing improved in 2 mon postoperation. No recurrence was noted during the 5-monfollow-up, and the final MRI supported the novel therapeutic hypothesis. Conclusion: Autoinflammation was involved in a refractory MD. This novel therapy, which involves the delivery of steroids to the surface of the intact ES and incus, is effective in relieving vertigo and tinnitus and improves hearing function of refractory MD.
Language	English
Publishing date	2019-01-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2621477-5
ISSN	2524-1753 ; 1672-2930
ISSN (online)	2524-1753
ISSN	1672-2930
DOI	10.1016/j.joto.2019.01.001
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Article ; Online: Projection domain decomposition denoising algorithm based on low rank and similarity-based regularization.

Lu, Chang / Han, Zhenye / Zou, Jing

Journal of X-ray science and technology

2024

Abstract: Background: Projection Domain Decomposition (PDD) is a dual energy reconstruction method which implements the decomposition process before image reconstruction. The advantage of PDD is that it can alleviate beam hardening artifacts and metal artifacts ... ...

Abstract	Background: Projection Domain Decomposition (PDD) is a dual energy reconstruction method which implements the decomposition process before image reconstruction. The advantage of PDD is that it can alleviate beam hardening artifacts and metal artifacts effectively as energy spectra estimation is considered in PDD. However, noise amplification occurs during the decomposition process, which significantly impacts the accuracy of effective atomic number and electron density. Therefore, effective noise reduction techniques are required in PDD. Objective: This study aims to develop a new algorithm capable of minimizing noise while simultaneously preserving edges and fine details. Methods: In this study, a denoising algorithm based on low rank and similarity-based regularization (LRSBR) is presented. This algorithm incorporates the low-rank characteristic of tensors into similarity-based regularization (SBR) framework. This method effectively addresses the issue of instability in edge pixels within the SBR algorithm and enhances the structural consistency of dual-energy images. Results: A series of simulation and practical experiments were conducted on a dual-layer dual-energy CT system. Experiments demonstrate that the proposed method outperforms exiting noise removal methods in Peak Signal-to-noise Ratio (PSNR), Root Mean Square Error (RMSE), and Structural Similarity (SSIM). Meanwhile, there has been a notable enhancement in the visual quality of CT images. Conclusions: The proposed algorithm has a significantly improved noise reduction compared to other competing approach in dual-energy CT. Meanwhile, the LRSBR method exhibits outstanding performance in preserving edges and fine structures, making it practical for PDD applications.
Language	English
Publishing date	2024-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012019-9
ISSN	1095-9114 ; 0895-3996
ISSN (online)	1095-9114
ISSN	0895-3996
DOI	10.3233/XST-230248
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Article ; Online: Use of serum KL-6 and chest radiographic severity grade to predict 28-day mortality in COVID-19 patients with pneumonia: a retrospective cohort study.

Zou, Jing / Shi, Yiping / Xue, Shan / Jiang, Handong

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 187

Abstract: Background: Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. Therefore, the aim of this study was ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. Therefore, the aim of this study was to develop a simple nomogram model to categorize patients who might have a poor short-term outcome. Methods: A retrospective cohort study of 189 COVID-19 patients was performed at Shanghai Ren Ji Hospital from December 12, 2022 to February 28, 2023. Chest radiography and biomarkers, including KL-6 were assessed. Risk factors of 28-day mortality were selected by a Cox regression model. A nomogram was developed based on selected variables by SMOTE strategy. The predictive performance of the derived nomogram was evaluated by calibration curve. Results: In total, 173 patients were enrolled in this study. The 28-day mortality event occurred in 41 inpatients (23.7%). Serum KL-6 and radiological severity grade (RSG) were selected as the final risk factors. A nomogram model was developed based on KL-6 and RSG. The calibration curve suggested that the nomogram model might have potential clinical value. The AUCs for serum KL-6, RSG, and the combined score in the development group and validation group were 0.885 (95% CI: 0.804-0.952), 0.818 (95% CI: 0.711-0.899), 0.868 (95% CI: 0.776-0.942) and 0.932 (95% CI: 0.862-0.997), respectively. Conclusions: Our results suggested that the nomogram based on KL-6 and RSG might be a potential method for evaluating 28-day mortality in COVID-19 patients. A high combined score might indicate a poor outcome in COVID-19 patients with pneumonia.
MeSH term(s)	Humans ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; China/epidemiology ; Radiography
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-02992-0
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Article ; Online: [Oral health management for children].

Zou, Jing

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

2018 Volume 36, Issue 5, Page(s) 465–468

Abstract: Pediatric dentistry should focus not only on the treatment of various oral diseases during the entire growth and development of children but also on the early prevention, diagnosis, and intervention of various oral diseases in this process. Early ... ...

Abstract	Pediatric dentistry should focus not only on the treatment of various oral diseases during the entire growth and development of children but also on the early prevention, diagnosis, and intervention of various oral diseases in this process. Early identification and removal of risk factors or early intervention for common oral diseases is necessary to the implementation of oral health management for pregnant women, infants, preschool and school-age children, and adolescents with different general and oral physiological characteristics and common oral diseases. The treatment enables the growth and development of the teeth, as well as occlusion and facials along the normal trajectory, ultimately achieving the functional perfection and aesthetic coordination of the cranio-maxillary and occlusion.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Dental Caries ; Esthetics, Dental ; Female ; Humans ; Infant ; Oral Health ; Pediatric Dentistry ; Pregnancy ; Risk Factors
Language	Chinese
Publishing date	2018-11-21
Publishing country	China
Document type	Journal Article
ZDB-ID	1202342-5
ISSN	2618-0456 ; 1000-1182
ISSN (online)	2618-0456
ISSN	1000-1182
DOI	10.7518/hxkq.2018.05.001
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Zs.A 4073: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Past, Present, and Future Perspectives on Whey as a Promising Feedstock for Bioethanol Production by Yeast.

Zou, Jing / Chang, Xuedong

Journal of fungi (Basel, Switzerland)

2022 Volume 8, Issue 4

Abstract: Concerns about fossil fuel depletion and the environmental effects of greenhouse gas emissions have led to widespread fermentation-based production of bioethanol from corn starch or sugarcane. However, competition for arable land with food production has ...

Abstract	Concerns about fossil fuel depletion and the environmental effects of greenhouse gas emissions have led to widespread fermentation-based production of bioethanol from corn starch or sugarcane. However, competition for arable land with food production has led to the extensive investigation of lignocellulosic sources and waste products of the food industry as alternative sources of fermentable sugars. In particular, whey, a lactose-rich, inexpensive byproduct of dairy production, is available in stable, high quantities worldwide. This review summarizes strategies and specific factors essential for efficient lactose/whey fermentation to ethanol. In particular, we cover the most commonly used strains and approaches for developing high-performance strains that tolerate fermentation conditions. The relevant genes and regulatory systems controlling lactose utilization and sources of new genes are also discussed in detail. Moreover, this review covers the optimal conditions, various feedstocks that can be coupled with whey substrates, and enzyme supplements for increasing efficiency and yield. In addition to the historical advances in bioethanol production from whey, this review explores the future of yeast-based fermentation of lactose or whey products for beverage or fuel ethanol as a fertile research area for advanced, environmentally friendly uses of industrial waste products.
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof8040395
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