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  1. Article ; Online: Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome.

    Song, Li / Zhao, Yingjie / Wang, Gang / Zou, Wenlu / Sai, Lintao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1538

    Abstract: Patients with severe fever with thrombocytopenia syndrome (SFTS) had been confirmed to have immune dysfunction and were prone to invasive pulmonary aspergillosis (IPA), which was directly related to the increased mortality. The aim of this study was to ... ...

    Abstract Patients with severe fever with thrombocytopenia syndrome (SFTS) had been confirmed to have immune dysfunction and were prone to invasive pulmonary aspergillosis (IPA), which was directly related to the increased mortality. The aim of this study was to investigate the predictors for IPA in SFTS patients, and the results were expected to be helpful for early identification of IPA and initiation of anti-fungal therapy. The study was performed to review laboratory confirmed SFTS patients in two tertiary hospitals in Shandong province (Qilu Hospital of Shandong University and Shandong Public Health Clinical Center) from April 2021 to August 2022. The enrolled patients were further divided into IPA group and non-IPA group. Demographic characteristics, clinical manifestations and laboratory parameters between IPA group and non-IPA group patients were analyzed and compared to identify the independent predictors for IPA by univariate analysis and multivariable logistic regression analysis. Sensitivity and specificity of independent predictors were evaluated by receiver operating characteristic (ROC) curve analysis. In total, 67 SFTS patients were enrolled with an average age of 64.7 (± 8.4) years old. The incidence of IPA was 32.8% (22/67). Mortality of patients in IPA group was 27.3% (6/22), which was significantly higher than that in non-IPA group. Results of univariate analysis showed that uncontrolled diabetes, central nervous system symptoms, platelet < 40 × 10
    MeSH term(s) Humans ; Middle Aged ; Invasive Pulmonary Aspergillosis/complications ; Invasive Pulmonary Aspergillosis/diagnosis ; Severe Fever with Thrombocytopenia Syndrome ; CD8-Positive T-Lymphocytes ; Risk Factors ; Blood Platelets ; Phlebovirus
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28851-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects.

    Zou, Wenlu / Lu, Jie / Hao, Yan

    Journal of inflammation research

    2021  Volume 14, Page(s) 3077–3088

    Abstract: Under physiological conditions, immune checkpoint molecules downregulate the activation and effector function of myocardial antigen-reactive T cells through an immunosuppressive pathway, thus enabling myocardial T cells to maintain immune homeostasis ... ...

    Abstract Under physiological conditions, immune checkpoint molecules downregulate the activation and effector function of myocardial antigen-reactive T cells through an immunosuppressive pathway, thus enabling myocardial T cells to maintain immune homeostasis under the action of central and peripheral tolerance mechanisms. The PD-1/PD-L1 signalling pathway is particularly important for limiting the ability of T cells to attack the heart. Immune checkpoint inhibitors (ICIs) specifically block this PD-1/PD-L1-mediated restriction of T cell activation and other immunosuppressive pathways by targeting immune checkpoints. In recent years, with the wide use of ICIs in cancer treatment, even though the incidence of immunomyocarditis is low, it has attracted increasing attention because of its complex clinical symptoms, rapid progression of disease and high mortality rates. The pathogenesis, genetic susceptibility factors and predictive biomarkers of immunomyocarditis still need to be understood, and multidisciplinary cooperation in the clinical treatment of this complication is necessary.
    Language English
    Publishing date 2021-07-08
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S311616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The presence of foci of

    Xu, Nannan / Liu, Hui / Qu, Chunmei / Wen, Sai / Zou, Wenlu / Chang, Caiyun / Wang, Gang

    Infectious medicine

    2023  Volume 2, Issue 4, Page(s) 334–337

    Abstract: China is not considered as an endemic area ... ...

    Abstract China is not considered as an endemic area of
    Language English
    Publishing date 2023-09-17
    Publishing country China
    Document type Case Reports
    ISSN 2772-431X
    ISSN (online) 2772-431X
    DOI 10.1016/j.imj.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polyethylene glycol combined with linaclotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial.

    Zhang, Menghan / Zou, Wenlu / Xu, Changqin / Jia, Ruzhen / Liu, Keke / Xu, Qianqian / Xu, Hongwei

    European journal of gastroenterology & hepatology

    2021  Volume 33, Issue 1S Suppl 1, Page(s) e625–e633

    Abstract: Background and aim: Bowel preparation is an important determinant of the quality of colonoscopy. The traditional split-dose regimen of 4 L polyethylene glycol (PEG) solutions for bowel preparation is effective but poorly tolerated. The aim of this was ... ...

    Abstract Background and aim: Bowel preparation is an important determinant of the quality of colonoscopy. The traditional split-dose regimen of 4 L polyethylene glycol (PEG) solutions for bowel preparation is effective but poorly tolerated. The aim of this was to study the efficacy and tolerability of using linaclotide as an adjunctive agent with low-volume PEG for bowel preparation.
    Methods: This was an endoscopist-blinded, randomized, controlled trial of 432 patients randomly assigned to three groups: 2 L PEG, 4 L PEG and 2 L PEG + 290 µg linaclotide (2 L PEG + L group). The primary outcome measure was efficacy of bowel preparation according to the Boston Bowel Preparation Scale (BBPS), with secondary outcomes of patients' tolerance, defecating frequency, complications, sleeping quality, cecal intubation rate, preparation-to-colonoscopy interval, withdrawal time, cecal intubation time, and adenoma and polyp detection rates.
    Results: The percentage of adequate bowel preparation in the 2 L PEG + L group was higher than that of the 2 L PEG group (87.9% vs. 77.0%; P = 0.017), but not the 4 L PEG group (87.9% vs. 91.4%; P = 0.339). In terms of the mean (SD) BBPS score for the total and segmental colons, the bowel cleansing efficacy of 2 L PEG + L was superior to that of 2 L PEG and similar to that of 4 L PEG. Patient's tolerance (including complications, willingness to repeat and sleeping quality) were compatible between the 2 L and 2 L + L group, and the 4 L group was the worst among these three groups.
    Conclusion: Two liters of PEG combined with 290 µg linaclotide was an effective and well-tolerated bowel preparation regimen.
    MeSH term(s) Cathartics/adverse effects ; Cecum ; Colonoscopy ; Humans ; Peptides ; Polyethylene Glycols/adverse effects
    Chemical Substances Cathartics ; Peptides ; Polyethylene Glycols (3WJQ0SDW1A) ; linaclotide (N0TXR0XR5X)
    Language English
    Publishing date 2021-05-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000002184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Endoscopic resection of benign esophageal schwannoma: Three case reports and review of literature.

    Li, Bin / Wang, Xue / Zou, Wen-Lu / Yu, Shu-Xia / Chen, Yong / Xu, Hong-Wei

    World journal of clinical cases

    2018  Volume 8, Issue 22, Page(s) 5690–5700

    Abstract: Background: Esophageal schwannomas are uncommon esophageal submucosal benign tumors and are usually treated with surgery.: Case summary: Here, we report three cases of middle/lower thoracic esophageal schwannoma treated successfully with endoscopic ... ...

    Abstract Background: Esophageal schwannomas are uncommon esophageal submucosal benign tumors and are usually treated with surgery.
    Case summary: Here, we report three cases of middle/lower thoracic esophageal schwannoma treated successfully with endoscopic resection. These lesions were misdiagnosed as leiomyoma on preoperative imaging. During the endoscopic resection of such tumors, there is a risk of esophageal perforation due to their deep location. If possible, submucosal tunneling endoscopic resection should be used.
    Conclusion: For larger schwannomas, endoscopy combined with thoracoscopy can be considered for en bloc resection. We performed a mini literature review in order to present the current status of diagnosis and treatment for esophageal schwannoma.
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i22.5690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increased CD105 expression is associated with disease progression in phyllodes tumors - A report of a borderline phyllodes tumor with lung metastases and a study of 54 phyllodes tumors.

    Wang, Kangyu / Li, Qianhua / Shi, Ranran / Yang, Dandan / Zou, Wenlu / Mu, Kun

    Annals of diagnostic pathology

    2017  Volume 32, Page(s) 4–9

    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Disease Progression ; Endoglin/metabolism ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Middle Aged ; Neoplasm Metastasis/pathology ; Phyllodes Tumor/diagnosis ; Phyllodes Tumor/metabolism ; Phyllodes Tumor/secondary
    Chemical Substances ENG protein, human ; Endoglin
    Language English
    Publishing date 2017-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2017.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5463: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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