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Article: Biosynthesis of amidated pectins with ultra-high viscosity and low gelation restriction through ultra-low temperature enzymatic method

Zheng, Chenmin / Zou, Yuping / Huang, Yufan / Shen, Bihua / Fei, Peng / Zhang, Guoguang

Food hydrocolloids. 2023 Jan., v. 134

2023

Abstract: In traditional industry, amidated pectin was usually prepared by adding ammonia gas under the alkaline condition or ethanol system which degrades the galacturonic acid chain of pectin and weakens the advantage of amidated pectin in gel. In this study, ... ...

Abstract	In traditional industry, amidated pectin was usually prepared by adding ammonia gas under the alkaline condition or ethanol system which degrades the galacturonic acid chain of pectin and weakens the advantage of amidated pectin in gel. In this study, amidated pectin with ultra-high viscosity and low gelation restriction were prepared by grafting with the neutral aliphatic amino acids through enzymatic method at ultra-low temperature to extend the application of the pectin in food, daily use chemical, medicine and other fields. The amino acid grafting ratio of alanine amidated pectin (V-PE), valine amidated pectin (A-PE) and leucine amidated pectin (L-PE) were 14.12%, 24.36% and 18.94%, respectively. The results of dynamic viscosity showed that the dynamic viscosity of high methoxy pectin (HMP) increased from 186 to 39799 (V-PE), 20396 (A-PE) and 23781 mPa s (L-PE), respectively. Through ultra-low temperature enzymatic, the V-PE with the highest amino acid grafting ratio had the highest solution viscosity and gel hardness. Furthermore, the hydrogel has better thermal stability, which can maintain the three-dimensional network structure of the gel at higher temperatures without collapse. Amidated pectin with ultra-high viscosity and low gelation restriction can provide valuable information in applications such as food and medicine.
Keywords	alanine ; ammonia ; biosynthesis ; enzymatic treatment ; ethanol ; galacturonic acid ; gelation ; hardness ; hydrocolloids ; hydrogels ; industry ; leucine ; medicine ; pectins ; temperature ; thermal stability ; valine ; viscosity
Language	English
Dates of publication	2023-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	742742-6
ISSN	1873-7137 ; 0268-005X
ISSN (online)	1873-7137
ISSN	0268-005X
DOI	10.1016/j.foodhyd.2022.108037
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Utilization of the antagonistic yeast, Wickerhamomyces anomalus, combined with UV-C to manage postharvest rot of potato tubers caused by Alternaria tenuissima.

Leng, Jinsong / Dai, Yuan / Qiu, Dongxiao / Zou, Yuping / Wu, Xuehong

International journal of food microbiology

2022 Volume 377, Page(s) 109782

Abstract: Postharvest rot of potato tubers caused by fungal pathogens is the main cause of significant economic losses, while also raising potential food safety issues. Integrated disease management, utilizing bio-safe and eco-friendly methods, represents a ... ...

Abstract	Postharvest rot of potato tubers caused by fungal pathogens is the main cause of significant economic losses, while also raising potential food safety issues. Integrated disease management, utilizing bio-safe and eco-friendly methods, represents a sustainable strategy for reducing postharvest losses in crops, including potato. In the current study, the application of the antagonistic yeast, Wickerhamomyces anomalus, combined with a UV-C treatment was evaluated for the management of postharvest Alternaria rot of potato tubers, caused by Alternaria tenuissima. Both W. anomalus and UV-C as individual treatments reduced the size of A. tenuissima infections on potato tubers, relative to the control, while the combined treatment of W. anomalus and UV-C exhibited the highest level of inhibition. W. anomalus or UV-C alone, and especially when used in combination, induced the expression of defense-related genes, including polyphenol oxidase, peroxidase, and β-1,3-glucanase, and also increased the level of flavonoids and lignin in potato tubers. Our findings indicate that the mechanism of action by which UV-C enhances the biocontrol effect of W. anomalus against postharvest Alternaria rot includes the activation of defense-related response in potato tubers. The integration of biocontrol agents and physical treatments (e.g., UV-C) represents an effective, eco-friendly hurdle technology for managing postharvest rot in potato.
MeSH term(s)	Alternaria/physiology ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Saccharomycetales ; Solanum tuberosum/microbiology ; Yeasts/physiology
Language	English
Publishing date	2022-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2022.109782
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Article ; Online: Preparation of amidated pectins through enzymatic method: Structures, hydrogel properties and its application potential in fat substitutes

Zheng, Chenmin / Huang, Wensi / Zou, Yuping / Huang, Wanping / Zhang, Guoguang / Fei, Peng

Food Research International. 2022 Oct., v. 160 p.111719-

2022

Abstract: In this paper, α-alanine and β-alanine were used as modifiers to prepare α-alanine amidated pectin (α-AP) and β-alanine amidated pectin (β-AP) through enzymatic method. The effects of alanine and its isomer on the amidation degree and physicochemical ... ...

Abstract	In this paper, α-alanine and β-alanine were used as modifiers to prepare α-alanine amidated pectin (α-AP) and β-alanine amidated pectin (β-AP) through enzymatic method. The effects of alanine and its isomer on the amidation degree and physicochemical properties of pectin were studied. Fourier transform infrared spectrum, proton nuclear magnetic resonance analysis, X-ray photoelectron spectrum and elemental analysis indicated that the amino groups from α-C and β-C could be aminated with the carboxyl group of pectin to form the corresponding aminated pectin. The alanine grafting ratio of α-AP and β-AP were 21.99% and 18.92%, respectively. The results showed that the dynamic viscosity of β-AP was significantly higher than that of α-AP due to the influence of amino acid side chain. However, due to the higher alanine grafting ratio of α-AP, the strength of hydrogel prepared by α-AP was higher than that of β-AP, and it also has the highest elastic modulus and swelling capacity. In addition, pectin, as a carbohydrate-based fat substitute, has been widely used in the field of food to simulate the smooth and delicate taste of fat. Compared with High methoxy pectin (HMP) and β-AP, α-AP had better colloid stability and smaller hydrogel particles in the composite system. The results provide references for the application of amidated pectin in low-fat food.
Keywords	Fourier transform infrared spectroscopy ; X-radiation ; alanine ; enzymatic treatment ; food research ; hydrogels ; isomers ; low fat foods ; modulus of elasticity ; nuclear magnetic resonance spectroscopy ; pectins ; taste ; viscosity ; Pectin ; Hydrogel ; Isomer ; Enzymatic Method ; Amidation
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111719
Database	NAL-Catalogue (AGRICOLA)

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Article: Utilization of the antagonistic yeast, Wickerhamomyces anomalus, combined with UV-C to manage postharvest rot of potato tubers caused by Alternaria tenuissima

Leng, Jinsong / Dai, Yuan / Qiu, Dongxiao / Zou, Yuping / Wu, Xuehong

International journal of food microbiology. 2022 Sept. 16, v. 377

2022

Abstract	Postharvest rot of potato tubers caused by fungal pathogens is the main cause of significant economic losses, while also raising potential food safety issues. Integrated disease management, utilizing bio-safe and eco-friendly methods, represents a sustainable strategy for reducing postharvest losses in crops, including potato. In the current study, the application of the antagonistic yeast, Wickerhamomyces anomalus, combined with a UV-C treatment was evaluated for the management of postharvest Alternaria rot of potato tubers, caused by Alternaria tenuissima. Both W. anomalus and UV-C as individual treatments reduced the size of A. tenuissima infections on potato tubers, relative to the control, while the combined treatment of W. anomalus and UV-C exhibited the highest level of inhibition. W. anomalus or UV-C alone, and especially when used in combination, induced the expression of defense-related genes, including polyphenol oxidase, peroxidase, and β-1,3-glucanase, and also increased the level of flavonoids and lignin in potato tubers. Our findings indicate that the mechanism of action by which UV-C enhances the biocontrol effect of W. anomalus against postharvest Alternaria rot includes the activation of defense-related response in potato tubers. The integration of biocontrol agents and physical treatments (e.g., UV-C) represents an effective, eco-friendly hurdle technology for managing postharvest rot in potato.
Keywords	Alternaria tenuissima ; Wickerhamomyces anomalus ; biological control ; catechol oxidase ; disease control ; flavonoids ; food microbiology ; food safety ; fungal antagonists ; fungi ; lignin ; mechanism of action ; peroxidase ; postharvest diseases ; potatoes
Language	English
Dates of publication	2022-0916
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2022.109782
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Article: Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application

Zheng, Chenmin / Huang, Wanping / Zou, Yuping / Huang, Wensi / Fei, Peng / Zhang, Guoguang

International journal of biological macromolecules. 2022 Sept. 01, v. 216

2022

Abstract: In this study, pectin was modified with phenylalanine by ultra-low temperature enzymatic method to improve its gel properties. The grafting ratio of phenylalanine amidated pectin was studied under different reaction conditions. The highest value (29.21 %) ...

Abstract	In this study, pectin was modified with phenylalanine by ultra-low temperature enzymatic method to improve its gel properties. The grafting ratio of phenylalanine amidated pectin was studied under different reaction conditions. The highest value (29.21 %) was reached a reaction temperature of −5 °C and time of 12 h. Further analysis indicated that phenylalanine and high methoxyl pectin combined at the solid-liquid two phase interface under the catalysis of papain to form phenylalanine amidated pectin. Moreover, the physicochemical properties of pectin hydrogel and its feasibility as a sustained-release drug carrier were discussed. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and there is no need to add a lot of soluble solids and divalent cations. Besides, the phenylalanine amidated pectin hydrogel as a sustained release carrier of drugs showed more sustained and complete drug release.
Keywords	catalytic activity ; drug carriers ; drugs ; enzymatic treatment ; hydrogels ; papain ; pectins ; phenylalanine ; temperature
Language	English
Dates of publication	2022-0901
Size	p. 263-271.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.174
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Article ; Online: Associations of Urinary Phytoestrogen Concentrations with Nonalcoholic Fatty Liver Disease among Adults.

Xiong, Guang / Huang, Changbo / Zou, Yuping / Tao, Ziyin / Zou, Jun / Huang, Jiean

Journal of healthcare engineering

2022 Volume 2022, Page(s) 4912961

Abstract: Phytoestrogens can alleviate some pathological processes related to nonalcoholic fatty liver disease (NAFLD). However, there are limited and contradictory studies on the relationships between phytoestrogens (especially single phytoestrogen) and NAFLD. ... ...

Abstract	Phytoestrogens can alleviate some pathological processes related to nonalcoholic fatty liver disease (NAFLD). However, there are limited and contradictory studies on the relationships between phytoestrogens (especially single phytoestrogen) and NAFLD. The purpose of this study was to explore the relationships between urinary phytoestrogen concentrations and NAFLD in American adults. This cross-sectional study used the data of the National Health and Nutrition Examination Survey from 1999 to 2010, and 2294 adults were finally enrolled in this study. The concentrations of phytoestrogens were measured in urine samples, and urinary phytoestrogens were divided into tertiles according to the concentration distributions. The diagnosis of NAFLD was determined by the United States fatty liver index. The main analysis used a multivariate logistic regression model. The fully adjusted models included gender, age, race, education, marriage, poverty, body mass index, waist circumference, smoking, diabetes, hypertension, total cholesterol, high-density lipoprotein cholesterol, triglycerides, and other five phytoestrogens. In the fully adjusted model, the urinary enterolactone (ENL) concentration was negatively correlated with NAFLD (OR of Tertile 3 : 0.48, 95% CI 0.25-0.94). When stratified by age and gender, the urinary ENL concentration was negatively correlated with NAFLD in males aged 40-59 years (OR of Tertile 3 : 0.08, 95% CI 0.01-0.82), while the urinary equol concentration was positively correlated with NAFLD in such population (OR of Tertile 3 : 4.27, 95% CI 1.02-17.85). In addition, a negative correlation between enterodiol (END) concentration and NAFLD was observed in males aged 60 years or over (OR of Tertile 2 : 0.18, 95% CI 0.05-0.69). Collectively, in middle-aged males, urinary ENL may be associated with a lower risk of NAFLD, while urinary equol may be related to a higher risk. In addition, urinary END has a possible relationship with a reduced risk of NAFLD in elder males. Definitely, clinical randomized controlled trials are needed to further verify the conclusions.
MeSH term(s)	Adult ; Aged ; Cholesterol, HDL ; Cross-Sectional Studies ; Equol ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Nutrition Surveys ; Phytoestrogens/urine ; United States/epidemiology
Chemical Substances	Cholesterol, HDL ; Phytoestrogens ; Equol (531-95-3)
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/4912961
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Article ; Online: Preparation of amidated pectins through enzymatic method: Structures, hydrogel properties and its application potential in fat substitutes.

Zheng, Chenmin / Huang, Wensi / Zou, Yuping / Huang, Wanping / Zhang, Guoguang / Fei, Peng

Food research international (Ottawa, Ont.)

2022 Volume 160, Page(s) 111719

Abstract	In this paper, α-alanine and β-alanine were used as modifiers to prepare α-alanine amidated pectin (α-AP) and β-alanine amidated pectin (β-AP) through enzymatic method. The effects of alanine and its isomer on the amidation degree and physicochemical properties of pectin were studied. Fourier transform infrared spectrum, proton nuclear magnetic resonance analysis, X-ray photoelectron spectrum and elemental analysis indicated that the amino groups from α-C and β-C could be aminated with the carboxyl group of pectin to form the corresponding aminated pectin. The alanine grafting ratio of α-AP and β-AP were 21.99% and 18.92%, respectively. The results showed that the dynamic viscosity of β-AP was significantly higher than that of α-AP due to the influence of amino acid side chain. However, due to the higher alanine grafting ratio of α-AP, the strength of hydrogel prepared by α-AP was higher than that of β-AP, and it also has the highest elastic modulus and swelling capacity. In addition, pectin, as a carbohydrate-based fat substitute, has been widely used in the field of food to simulate the smooth and delicate taste of fat. Compared with High methoxy pectin (HMP) and β-AP, α-AP had better colloid stability and smaller hydrogel particles in the composite system. The results provide references for the application of amidated pectin in low-fat food.
MeSH term(s)	Alanine ; Fat Substitutes ; Hydrogels ; Pectins/chemistry ; beta-Alanine
Chemical Substances	Fat Substitutes ; Hydrogels ; beta-Alanine (11P2JDE17B) ; Pectins (89NA02M4RX) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-07-22
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111719
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Article ; Online: Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application.

Zheng, Chenmin / Huang, Wanping / Zou, Yuping / Huang, Wensi / Fei, Peng / Zhang, Guoguang

International journal of biological macromolecules

2022 Volume 216, Page(s) 263–271

Abstract	In this study, pectin was modified with phenylalanine by ultra-low temperature enzymatic method to improve its gel properties. The grafting ratio of phenylalanine amidated pectin was studied under different reaction conditions. The highest value (29.21 %) was reached a reaction temperature of -5 °C and time of 12 h. Further analysis indicated that phenylalanine and high methoxyl pectin combined at the solid-liquid two phase interface under the catalysis of papain to form phenylalanine amidated pectin. Moreover, the physicochemical properties of pectin hydrogel and its feasibility as a sustained-release drug carrier were discussed. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and there is no need to add a lot of soluble solids and divalent cations. Besides, the phenylalanine amidated pectin hydrogel as a sustained release carrier of drugs showed more sustained and complete drug release.
MeSH term(s)	Delayed-Action Preparations ; Drug Liberation ; Hydrogels/chemistry ; Pectins/chemistry ; Phenylalanine ; Temperature
Chemical Substances	Delayed-Action Preparations ; Hydrogels ; Phenylalanine (47E5O17Y3R) ; Pectins (89NA02M4RX)
Language	English
Publishing date	2022-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.174
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Article: Chronic hypotony management using endoscopy-assisted vitrectomy after severe ocular trauma or vitrectomy.

Yu, Yong-Zhen / Zou, Xiu-Lan / Chen, Xuan-Ge / Zhang, Chu / Yu, Yang-Yang / Zhang, Meng-Yi / Zou, Yu-Ping

International journal of ophthalmology

2023 Volume 16, Issue 6, Page(s) 947–954

Abstract: Aim: To report outcomes of endoscopy-assisted vitrectomy (EAV) in patients with chronic hypotony following severe ocular trauma or vitrectomy.: Methods: This was a retrospective, noncomparative case series. Ciliary bodies were evaluated using ... ...

Abstract	Aim: To report outcomes of endoscopy-assisted vitrectomy (EAV) in patients with chronic hypotony following severe ocular trauma or vitrectomy. Methods: This was a retrospective, noncomparative case series. Ciliary bodies were evaluated using ultrasound biomicroscopy pre-operatively and direct visualisation intraoperatively. All selected individuals (seven patients/seven eyes) underwent EAV. Removal of ciliary membrane and traction, gas/silicone oil tamponade (GT/SOT), and scleral buckling (SB) were performed in selected eyes. Outcome measurements mainly included intraocular pressure (IOP) and best-corrected visual acuity (BCVA). Results: Seven eyes from 7 male aphakic patients with a mean age of 45 (range, 20-68)y were included in this study; the average follow-up time was 12 (9-15)mo. GT was performed in 2 eyes; membrane peeling (MP) and SOT in 2 eyes; and MP, SOT, and SB in 3 eyes. The mean pre- and post-operative IOP were 4.5 (range, 4.0±0.11 to 4.8±0.2) mm Hg and 9.9 (range, 5.6±0.17 to 12.1±0.2) mm Hg at 52wk (12mo), respectively. BCVA improved in six eyes; one eye still showed light perception, and no bulbi phthisis was observed. Conclusion: Endoscopy offers improved judgment and recognition and has an improved prognosis for chronic hypotony. Therefore, endoscopy can be an effective and promising operative technique for chronic traumatic hypotony management.
Language	English
Publishing date	2023-06-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2023.06.18
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Article ; Online: Gender-specific lncRNA-miRNA-mRNA regulatory network to reveal potential genes for primary open-angle glaucoma.

Chen, Jingxia / Zhang, Chu / Peng, Jinyan / Tang, Cuicui / Zhang, Chunli / Zhang, Mengyi / Zou, Xiulan / Zou, Yuping

Experimental eye research

2023 Volume 236, Page(s) 109668

Abstract: Background: Investigation of biomarkers may facilitate understanding the mechanisms of primary open-angle glaucoma (POAG) and developing therapeutic targets. This study aimed to identify potential genes based on competing endogenous RNA (ceRNA) network ... ...

Abstract	Background: Investigation of biomarkers may facilitate understanding the mechanisms of primary open-angle glaucoma (POAG) and developing therapeutic targets. This study aimed to identify potential genes based on competing endogenous RNA (ceRNA) network for POAG. Methods: Based on long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and messenger RNAs (mRNAs) from the Gene Expression Omnibus (GEO) database, we identified differential expressed lncRNAs (DELs), differential expressed miRNAs (DEMis) and differential expressed mRNAs (DEMs) and then constructed a ceRNA network. Through weighted gene co-expression network analysis (WGCNA), we identified gender-specific genes for gender-associated ceRNA network construction, followed by the protein-protein interaction (PPI) network and functional enrichment analysis to screen hub genes and reveal their functions. The expression levels of hub genes were measured in steroid-induced ocular hypertension (SIOH) mice. Results: A total of 175 DELs, 727 DEMs and 45 DEMis were screened between control and POAG samples. Seven modules were identified through WGCNA and one module was associated with gender of POAG patients. We discovered 41 gender-specific genes for gender-associated ceRNA construction and then identified 8 genes (NAV3, C1QB, RXRB, P2RY4, ADAM15, VAV3, ZNF207 and TOP1), which were enriched in cell cycle-related pathways and immune-related pathways. C1QB, RXRB, Top1 and ZNF207 were highly interacted with other proteins. The expression levels of NAV3 and C1QB were downregulated in SIOH, while the levels of RXRB, P2RY4, ADAM15, VAV3, ZNF207 and TOP1 were upregulated in SIOH. Conclusion: This study identifies hub genes associated with the pathogenesis of gender-specific POAG and provides potential biomarkers for POAG.
MeSH term(s)	Humans ; Mice ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; Glaucoma, Open-Angle/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Gene Regulatory Networks ; Biomarkers, Tumor/genetics ; Membrane Proteins/genetics ; ADAM Proteins/genetics ; Microtubule-Associated Proteins/genetics
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger ; Biomarkers, Tumor ; ADAM15 protein, human (EC 3.4.24.-) ; Membrane Proteins ; ADAM Proteins (EC 3.4.24.-) ; ZNF207 protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2023.109668
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