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  1. Article ; Online: Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores.

    Zou, Zongsen / Robinson, John I / Steinberg, Lindsey K / Henderson, Jeffrey P

    The Journal of biological chemistry

    2023  Volume 300, Issue 1, Page(s) 105554

    Abstract: Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and ... ...

    Abstract Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and its related products to be prominent components of the iron-responsive extracellular metabolome of a model UPEC strain. Using defined Ent biosynthesis and import mutants, we identify lower molecular weight dimeric exometabolites as products of incomplete siderophore catabolism, rather than prematurely released biosynthetic intermediates. In E. coli, iron acquisition from iron(III)-Ent complexes requires intracellular esterases that hydrolyze the siderophore. Although UPEC are equipped to consume the products of completely hydrolyzed Ent, we find that Ent and its derivatives may be incompletely hydrolyzed to yield products with retained siderophore activity. These results are consistent with catabolic inefficiency as means to obtain more than one iron ion per siderophore molecule. This is compatible with an evolved UPEC strategy to maximize the nutritional returns from metabolic investments in siderophore biosynthesis.
    MeSH term(s) Enterobactin/metabolism ; Ferric Compounds/metabolism ; Iron/metabolism ; Siderophores/metabolism ; Uropathogenic Escherichia coli/metabolism
    Chemical Substances Enterobactin (28384-96-5) ; Ferric Compounds ; Iron (E1UOL152H7) ; Siderophores
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Uropathogenic

    Zou, Zongsen / Robinson, John I / Steinberg, Lindsey K / Henderson, Jeffrey P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... ...

    Abstract Uropathogenic
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.25.550588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Reprogramming Short-Chain Fatty Acid Metabolism Mitigates Tissue Damage for Streptococcus pyogenes Necrotizing Skin Infection.

    Caparon, Michael / Xu, Wei / Bradstreet, Tara / Zou, Zongsen / Hickerson, Suzanne / Zhou, Yuan / He, Hongwu / Edelson, Brian

    Research square

    2023  

    Abstract: Disease Tolerance (DT) is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid ... ...

    Abstract Disease Tolerance (DT) is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid bacterium
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3689163/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: E. coli catheter-associated urinary tract infections are associated with distinctive virulence and biofilm gene determinants.

    Zou, Zongsen / Potter, Robert F / McCoy, William H / Wildenthal, John A / Katumba, George L / Mucha, Peter J / Dantas, Gautam / Henderson, Jeffrey P

    JCI insight

    2023  Volume 8, Issue 2

    Abstract: Urinary catheterization facilitates urinary tract colonization by E. coli and increases infection risk. Here, we aimed to identify strain-specific characteristics associated with the transition from colonization to infection in catheterized patients. In ... ...

    Abstract Urinary catheterization facilitates urinary tract colonization by E. coli and increases infection risk. Here, we aimed to identify strain-specific characteristics associated with the transition from colonization to infection in catheterized patients. In a single-site study population, we compared E. coli isolates from patients with catheter-associated asymptomatic bacteriuria (CAASB) to those with catheter-associated urinary tract infection (CAUTI). CAUTI isolates were dominated by a phylotype B2 subclade containing the multidrug-resistant ST131 lineage relative to CAASB isolates, which were phylogenetically more diverse. A distinctive combination of virulence-associated genes was present in the CAUTI-associated B2 subclade. Catheter-associated biofilm formation was widespread among isolates and did not distinguish CAUTI from CAASB strains. Preincubation with CAASB strains could inhibit catheter colonization by multiple ST131 CAUTI isolates. Comparative genomic analysis identified a group of variable genes associated with high catheter biofilm formation present in both CAUTI and CAASB strains. Among these, ferric citrate transport (Fec) system genes were experimentally associated with enhanced catheter biofilm formation using reporter and fecA deletion strains. These results are consistent with a variable role for catheter biofilm formation in promoting CAUTI by ST131-like strains or resisting CAUTI by lower-risk strains that engage in niche exclusion.
    MeSH term(s) Humans ; Bacteriuria/microbiology ; Biofilms ; Catheters/adverse effects ; Escherichia coli/genetics ; Escherichia coli Proteins ; Receptors, Cell Surface ; Urinary Tract Infections/microbiology ; Virulence
    Chemical Substances Escherichia coli Proteins ; FecA protein, E coli ; Receptors, Cell Surface
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.161461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat

    Zou, Zongsen / Obernuefemann, Chloe L P / Singh, Pardeep / Pinkner, Jerome S / Xu, Wei / Nye, Taylor M / Dodson, Karen W / Almqvist, Fredrik / Hultgren, Scott J / Caparon, Michael G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone scaffold that have antimicrobial activities against a broad-spectrum of Gram-positive pathogens. Here we examine the treatment efficacy of GmPcides using skin and soft ...

    Abstract We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone scaffold that have antimicrobial activities against a broad-spectrum of Gram-positive pathogens. Here we examine the treatment efficacy of GmPcides using skin and soft tissue infection (SSTI) and biofilm formation models by
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.02.573960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microbial co-occurrences on catheters from long-term catheterized patients.

    Nye, Taylor M / Zou, Zongsen / Obernuefemann, Chloe L P / Pinkner, Jerome S / Lowry, Erin / Kleinschmidt, Kent / Bergeron, Karla / Klim, Aleksandra / Dodson, Karen W / Flores-Mireles, Ana L / Walker, Jennifer N / Wong, Daniel Garrett / Desai, Alana / Caparon, Michael G / Hultgren, Scott J

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 61

    Abstract: Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are increasingly becoming antibiotic resistant. We analyze the microbial occurrences in catheter ... ...

    Abstract Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are increasingly becoming antibiotic resistant. We analyze the microbial occurrences in catheter and urine samples from 55 human long-term catheterized patients collected over one year. Although most of these patients were prescribed antibiotics over several collection periods, their catheter samples remain colonized by one or more bacterial species. Examination of a total of 366 catheter and urine samples identify 13 positive and 13 negative genus co-occurrences over 12 collection periods, representing associations that occur more or less frequently than expected by chance. We find that for many patients, the microbial species composition between collection periods is similar. In a subset of patients, we find that the most frequently sampled bacteria, Escherichia coli and Enterococcus faecalis, co-localize on catheter samples. Further, co-culture of paired isolates recovered from the same patients reveals that E. coli significantly augments E. faecalis growth in an artificial urine medium, where E. faecalis monoculture grows poorly. These findings suggest novel strategies to collapse polymicrobial CAUTI in long-term catheterized patients by targeting mechanisms that promote positive co-associations.
    MeSH term(s) Humans ; Escherichia coli ; Catheter-Related Infections/microbiology ; Catheters ; Urinary Tract Infections/microbiology ; Enterococcus faecalis ; Bacteria
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44095-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Numerical simulation and operation optimization of biological filter].

    Zou, Zong-Sen / Shi, Han-Chang / Chen, Xiang-Qiang / Xie, Xiao-Qing

    Huan jing ke xue= Huanjing kexue

    2014  Volume 35, Issue 12, Page(s) 4627–4635

    Abstract: BioWin software and two sensitivity analysis methods were used to simulate the Denitrification Biological Filter (DNBF) + Biological Aerated Filter (BAF) process in Yuandang Wastewater Treatment Plant. Based on the BioWin model of DNBF + BAF process, the ...

    Abstract BioWin software and two sensitivity analysis methods were used to simulate the Denitrification Biological Filter (DNBF) + Biological Aerated Filter (BAF) process in Yuandang Wastewater Treatment Plant. Based on the BioWin model of DNBF + BAF process, the operation data of September 2013 were used for sensitivity analysis and model calibration, and the operation data of October 2013 were used for model validation. The results indicated that the calibrated model could accurately simulate practical DNBF + BAF processes, and the most sensitive parameters were the parameters related to biofilm, OHOs and aeration. After the validation and calibration of model, it was used for process optimization with simulating operation results under different conditions. The results showed that, the best operation condition for discharge standard B was: reflux ratio = 50%, ceasing methanol addition, influent C/N = 4.43; while the best operation condition for discharge standard A was: reflux ratio = 50%, influent COD = 155 mg x L(-1) after methanol addition, influent C/N = 5.10.
    MeSH term(s) Biofilms ; Bioreactors ; Denitrification ; Filtration ; Models, Theoretical ; Waste Disposal, Fluid/methods ; Waste Water
    Chemical Substances Waste Water
    Language Chinese
    Publishing date 2014-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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