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  1. Article: Gold-coated plant virus as computed tomography imaging contrast agent.

    Aljabali, Alaa A A / Zoubi, Mazhar S Al / Al-Batanyeh, Khalid M / Al-Radaideh, Ali / Obeid, Mohammad A / Al Sharabi, Abeer / Alshaer, Walhan / AbuFares, Bayan / Al-Zanati, Tasnim / Tambuwala, Murtaza M / Akbar, Naveed / Evans, David J

    Beilstein journal of nanotechnology

    2019  Volume 10, Page(s) 1983–1993

    Abstract: Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for ... ...

    Abstract Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types.
    Language English
    Publishing date 2019-10-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.10.195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

    Bakshi, Hamid A / Zoubi, Mazhar S Al / Faruck, Hakkim L / Aljabali, Alaa A A / Rabi, Firas A / Hafiz, Amin A / Al-Batanyeh, Khalid M / Al-Trad, Bahaa / Ansari, Prawej / Nasef, Mohamed M / Charbe, Nitin B / Satija, Saurabh / Mehta, Meenu / Mishra, Vijay / Gupta, Gaurav / Abobaker, Salem / Negi, Poonam / Azzouz, Ibrahim M / Dardouri, Ashref Ali K /
    Dureja, Harish / Prasher, Parteek / Chellappan, Dinesh K / Dua, Kamal / Webba da Silva, Mateus / Tanani, Mohamed El / McCarron, Paul A / Tambuwala, Murtaza M

    Nutrients. 2020 June 26, v. 12, no. 6

    2020  

    Abstract: Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic ... ...

    Abstract Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
    Keywords administrative management ; antineoplastic agents ; apoptosis ; body weight ; carotenoids ; caspases ; cell cycle ; cell viability ; cyclin-dependent kinase ; cytosol ; drug therapy ; liver ; microarray technology ; mitochondria ; pancreatic neoplasms ; prognosis ; saffron ; surgery ; toxicity
    Language English
    Dates of publication 2020-0626
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061901
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α.

    Aljabali, Alaa A A / Bakshi, Hamid A / Hakkim, Faruck L / Haggag, Yusuf A / Al-Batanyeh, Khalid M / Zoubi, Mazhar S Al / Al-Trad, Bahaa / Nasef, Mohamed M / Satija, Saurabh / Mehta, Meenu / Pabreja, Kavita / Mishra, Vijay / Khan, Mohammed / Abobaker, Salem / Azzouz, Ibrahim M / Dureja, Harish / Pabari, Ritesh M / Dardouri, Ashref Ali K / Kesharwani, Prashant /
    Gupta, Gaurav / Dhar Shukla, Shakti / Prasher, Parteek / Charbe, Nitin B / Negi, Poonam / Kapoor, Deepak N / Chellappan, Dinesh Kumar / Webba da Silva, Mateus / Thompson, Paul / Dua, Kamal / McCarron, Paul / Tambuwala, Murtaza M

    Cancers

    2020  Volume 12, Issue 12

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2020-11-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

    Bakshi, Hamid A / Zoubi, Mazhar S Al / Hakkim, Faruck L / Aljabali, Alaa A A / Rabi, Firas A / Hafiz, Amin A / Al-Batanyeh, Khalid M / Al-Trad, Bahaa / Ansari, Prawej / Nasef, Mohamed M / Charbe, Nitin B / Satija, Saurabh / Mehta, Meenu / Mishra, Vijay / Gupta, Gaurav / Abobaker, Salem / Negi, Poonam / Azzouz, Ibrahim M / Dardouri, Ashref Ali K /
    Dureja, Harish / Prasher, Parteek / Chellappan, Dinesh K / Dua, Kamal / Webba da Silva, Mateus / El Tanani, Mohamed / McCarron, Paul A / Tambuwala, Murtaza M

    Nutrients

    2020  Volume 12, Issue 6

    Abstract: Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic ... ...

    Abstract Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic ; Apoptosis/drug effects ; Carotenoids/therapeutic use ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Crocus/chemistry ; Cytochromes c/metabolism ; Female ; Humans ; Lipid Peroxidation/drug effects ; Liver Diseases/etiology ; Liver Diseases/prevention & control ; Mice ; Mice, Nude ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/radiotherapy ; Radiation Injuries/prevention & control ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcriptome ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents, Phytogenic ; Cell Cycle Proteins ; Carotenoids (36-88-4) ; crocin (877GWI46C2) ; Cytochromes c (9007-43-6)
    Language English
    Publishing date 2020-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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