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Article: Establishment and application of a TaqMan-based multiplex real-time PCR for simultaneous detection of three porcine diarrhea viruses.

Ren, Jing / Zu, Congcong / Li, Yang / Li, Meng / Gu, Jinyuan / Chen, Fengling / Li, Xiaowen

2024 Volume 15, Page(s) 1380849

Abstract: Introduction: Porcine viral diarrhea is a common clinical disease, which results in high mortality and economic losses in the pig industry. Porcine epidemic diarrhea virus (PEDV), porcine rotavirus (PoRV), and porcine deltacoronavirus (PDCoV) are ... ...

Abstract	Introduction: Porcine viral diarrhea is a common clinical disease, which results in high mortality and economic losses in the pig industry. Porcine epidemic diarrhea virus (PEDV), porcine rotavirus (PoRV), and porcine deltacoronavirus (PDCoV) are important diarrhea viruses in pig herds. The similarities of their clinical symptoms and pathological changes make it difficult to distinguish these three viruses clinically. Therefore, there is a need for a highly sensitive and specific method to simultaneously detect and differentiate these viruses. Methods: A multiplex real-time PCR assay using TaqMan probes was developed to simultaneously detect PEDV, PoRV, and PDCoV. To assess the efficacy of the established assay, 30 clinical samples with diarrhea symptoms were used to compare the results obtained from the multiplex real-time PCR assay with those obtained from commercial singleplex real-time PCR kit. Importantly, a total of 4,800 diarrhea samples were tested and analyzed to validate the utility of the assay. Results: This multiplex real-time PCR assay showed high sensitivity, specificity, and excellent repeatability with a detection limit of 1 × 10 Discussion: The multiplex real-time PCR method established in this study is a valuable diagnostic tool for simultaneously differentiating PEDV, PoRV, and PDCoV. This method is expected to significantly contribute to prevent and control the spread of infectious diseases, as well as aid in conducting epidemiological investigations.
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1380849
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Article ; Online: CAR-T cells for cancer immunotherapy-the barriers ahead and the paths through.

Zhang, Qiqi / Zu, Cheng / Hu, Yongxian / Huang, He

International reviews of immunology

2022 Volume 41, Issue 6, Page(s) 567–581

Abstract: This review discusses the major concerns and changes emerged during the rapidly extended clinical application of chimeric antigen receptor (CAR) T therapy based on our experience and understanding. In the past decades, the CAR-T cells have been ... ...

Abstract	This review discusses the major concerns and changes emerged during the rapidly extended clinical application of chimeric antigen receptor (CAR) T therapy based on our experience and understanding. In the past decades, the CAR-T cells have been questioned, sequentially, about their capability of inducing initial remission, their safety profile, their ability to sustain long-term persistence and response, and their potential to be industrialized. Significant advances, novel targeting strategies, innovative molecular structure, fine tuning of both CAR-T and host immune system, combination with other therapies, streamlined manufacturing, and etc., have been made to overcome these challenges. Although not perfectly resolved, rational pathways have been proposed to pass through the barriers. Here, we present the recent achievements on these pathways, and look into the possible future directions.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen/genetics ; Receptors, Antigen, T-Cell ; Immunotherapy, Adoptive ; Immunotherapy ; T-Lymphocytes ; Neoplasms
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	632825-8
ISSN	1563-5244 ; 1545-5858 ; 0883-0185
ISSN (online)	1563-5244 ; 1545-5858
ISSN	0883-0185
DOI	10.1080/08830185.2022.2080820
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Article: Clinical features of hemophagocytic syndrome following BCMA CAR-T cell therapy in patients with relapsed/refractory multiple myeloma.

Zu, Cheng / Wang, Kexin / Zhang, Qiqi / Hu, Yongxian / Huang, He

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2022 Volume 51, Issue 2, Page(s) 160–166

Abstract: Objective: To analyze the clinical features of hemophagocytic syndrome (HLH) following B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapy in patients with relapsed/refractory multiple myeloma.: Methods: Ninety-nine ... ...

Abstract	Objective: To analyze the clinical features of hemophagocytic syndrome (HLH) following B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapy in patients with relapsed/refractory multiple myeloma. Methods: Ninety-nine patients with relapsed/refractory multiple myeloma (including 3 cases of plasma cell leukemia) undergoing BCMA CAR-T cell therapy (monocentric phaseⅠclinical trial, ChiCTR1800017404) in the First Affiliated Hospital, Zhejiang University School of Medicine from July 2018 to December 2021 were enrolled in the study. The baseline features, laboratory findings, treatment, and clinical response of these patients were analyzed. Results: CAR-T cell associated HLH (carHLH) occurred in 20 patients (20.20%), and the median onset time was 7(0-19) d after cytokine release syndrome (CRS). Patients with carHLH were maily male patients, and manifested as high percentage of abnormal plasma cells, higher incidence of severe CRS (grade 3-4), and robust expansion of CAR-T cells in the peripheral blood (all Conclusions: The incidence of carHLH is relatively high in BCMA CAR-T cell treated patients, which is closely related to pretreatment tumor cell percentage in bone marrow, expansion of CAR-T cells and the secretion of cytokines. Medication based on tocilizumab and steroids can achieve considerable therapeutic effects in patient with carHLH.
MeSH term(s)	B-Cell Maturation Antigen/therapeutic use ; Cell- and Tissue-Based Therapy ; Cytokines ; Fibrinogen/therapeutic use ; Humans ; Interferons/therapeutic use ; Interleukin-10/therapeutic use ; Lymphohistiocytosis, Hemophagocytic/etiology ; Lymphohistiocytosis, Hemophagocytic/therapy ; Male ; Multiple Myeloma/therapy ; Receptors, Chimeric Antigen/therapeutic use
Chemical Substances	B-Cell Maturation Antigen ; Cytokines ; Receptors, Chimeric Antigen ; Interleukin-10 (130068-27-8) ; Fibrinogen (9001-32-5) ; Interferons (9008-11-1)
Language	English
Publishing date	2022-09-21
Publishing country	China
Document type	Journal Article
ISSN	1008-9292
ISSN	1008-9292
DOI	10.3724/zdxbyxb-2022-0039
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Article ; Online: Facial Expression Recognition with Contrastive Learning and Uncertainty-Guided Relabeling.

Yang, Yujie / Hu, Lin / Zu, Chen / Zhou, Qizheng / Wu, Xi / Zhou, Jiliu / Wang, Yan

International journal of neural systems

2023 Volume 33, Issue 6, Page(s) 2350032

Abstract: Facial expression recognition (FER) plays a vital role in the field of human-computer interaction. To achieve automatic FER, various approaches based on deep learning (DL) have been presented. However, most of them lack for the extraction of ... ...

Abstract	Facial expression recognition (FER) plays a vital role in the field of human-computer interaction. To achieve automatic FER, various approaches based on deep learning (DL) have been presented. However, most of them lack for the extraction of discriminative expression semantic information and suffer from the problem of annotation ambiguity. In this paper, we propose an elaborately designed end-to-end recognition network with contrastive learning and uncertainty-guided relabeling, to recognize facial expressions efficiently and accurately, as well as to alleviate the impact of annotation ambiguity. Specifically, a supervised contrastive loss (SCL) is introduced to promote inter-class separability and intra-class compactness, thus helping the network extract fine-grained discriminative expression features. As for the annotation ambiguity problem, we present an uncertainty estimation-based relabeling module (UERM) to estimate the uncertainty of each sample and relabel the unreliable ones. In addition, to deal with the padding erosion problem, we embed an amending representation module (ARM) into the recognition network. Experimental results on three public benchmarks demonstrate that our proposed method facilitates the recognition performance remarkably with 90.91% on RAF-DB, 88.59% on FERPlus and 61.00% on AffectNet, outperforming current state-of-the-art (SOTA) FER methods. Code will be available at http//github.com/xiaohu-run/fer_supCon.
MeSH term(s)	Humans ; Facial Recognition ; Uncertainty ; Facial Expression
Language	English
Publishing date	2023-05-16
Publishing country	Singapore
Document type	Journal Article
ISSN	1793-6462
ISSN (online)	1793-6462
DOI	10.1142/S0129065723500326
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Article ; Online: Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis.

Zu, Chao / Li, Jingyuan / He, Xijing / Ji, Le / Li, Xia

Experimental biology and medicine (Maywood, N.J.)

2022 Volume 247, Issue 11, Page(s) 931–944

Abstract: RNAs are closely associated with human diseases; however, immune-related genes (IRGs) and their potential regulatory networks in relation to spinal cord injury (SCI) are still poorly understood. Here, we investigated the key IRGs as well as the competing ...

Abstract	RNAs are closely associated with human diseases; however, immune-related genes (IRGs) and their potential regulatory networks in relation to spinal cord injury (SCI) are still poorly understood. Here, we investigated the key IRGs as well as the competing endogenous RNA (ceRNA) mechanisms that are associated with SCI pathogenesis based on microarray datasets and the use of a rat SCI model. Specifically, four independent SCI microarray datasets from Gene Expression Omnibus (GEO) database were analyzed and, thereafter, differentially expressed IRGs were annotated via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Furthermore, based on the GEO datasets, differentially expressed RNAs (DERNAs), including DEcircRNAs, DEmiRNAs, and DEmRNAs were identified and interactions between them were also predicted using online databases, and to construct a circular RNA (circRNA) mediated ceRNA network, candidate RNAs were also identified. Furthermore, the support vector machine (SVM) and least absolute shrinkage and selection operator (LASSO) methods were used for the identification of critical DERNAs, while differential gene expression was validated using the GSE20907 dataset. Our results were as follows. In the SCI microarray datasets, 32, 58, and 74 DEIRGs, DEcircRNAs, and DEmiRNAs were identified, respectively. In addition, GO and KEGG analyses showed that the DEIRGs were primarily enriched in neutrophil-mediated immunity and nuclear factor-kappa B (NF-κB) and hypoxia-inducible factor-1 (HIF-1) signaling pathways, and based on LASSO and SVM screening,
MeSH term(s)	Animals ; Gene Ontology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Messenger/genetics ; Rats ; Spinal Cord Injuries/genetics
Chemical Substances	MicroRNAs ; RNA, Circular ; RNA, Messenger
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702221082929
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Article: Cardiovascular Health Index Scores and Pregnancy-Induced Hypertension: An Association Study.

Cui, Kai / Huo, Hongqiu / He, Honghong / Liu, Chunlu / Zu, Changhao / Wu, Yuntao / Zhao, Haiyan

Alternative therapies in health and medicine

2023 Volume 29, Issue 5, Page(s) 141–145

Abstract: Objective: This cohort study investigated the association between cardiovascular health index scores and pregnancy-induced hypertension (PIH).: Methods: A total of 1466 first-time pregnant women who delivered a single child between 2006 and 2016 were ...

Abstract	Objective: This cohort study investigated the association between cardiovascular health index scores and pregnancy-induced hypertension (PIH). Methods: A total of 1466 first-time pregnant women who delivered a single child between 2006 and 2016 were included in the study. All participants underwent a physical examination before delivery, and seven cardiovascular health indexes were collected and scored. Three groups were created based on the tri-sectional quantiles of the total score to observe whether PIH occurred among the groups. A dichotomous logistic regression analysis was carried out to investigate the relationship between cardiovascular health index scores and the occurrence of PIH. Results: During the observation of 1150 subjects, 103 cases of PIH were identified, resulting in an incidence rate of 8.96%. The study found that the incidence of PIH in the three groups was 17.5% in the first group, 6.7% in the second, and 5.8% in the third group. These rates showed a sequential decrease with statistically significant differences (P < .001). The multifactorial regression analysis revealed that after adjusting for various factors, there was a significant inverse relationship between cardiovascular health index scores and the risk of PIH. Specifically, for every one-point increase in the seven cardiovascular health index scores, the risk of PIH decreased by 29% (OR = 0.71, 95% CI 0.59-0.86). Conclusions: The study found an inverse correlation between cardiovascular health index scores and PIH, with higher scores associated with lower incidences of PIH. Each cardiovascular health indicator helps to lower the risk of PIH, and optimum cardiovascular health behaviors and variables are protective factors against PIH.
MeSH term(s)	Child ; Pregnancy ; Female ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Cohort Studies ; Risk Factors ; Hypertension
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Influences of tobacco straw return with lime on microbial community structure of tobacco-planting soil and tobacco leaf quality.

Jiang, Chaoqiang / Zu, Chaolong / Riaz, Muhammad / Li, Chen / Zhu, Qifa / Xia, Hao / Dong, Qing / Shen, Jia

Environmental science and pollution research international

2024 Volume 31, Issue 21, Page(s) 30959–30971

Abstract: Soil amendment is an important strategy for improving soil quality and crop yield. From 2014 to 2019, we conducted a study to investigate the effects of tobacco straw return with lime on soil nutrients, soil microbial community structure, tobacco leaf ... ...

Abstract	Soil amendment is an important strategy for improving soil quality and crop yield. From 2014 to 2019, we conducted a study to investigate the effects of tobacco straw return with lime on soil nutrients, soil microbial community structure, tobacco leaf yield, and quality in southern Anhui, China. A field experiment was conducted with four treatments: straw removed (CK), straw return (St), straw return with dolomite (St + D), and straw return with lime (St + L). Results showed that after 5 years of application, the St + L significantly increased the soil pH by 16.9%, and the contents of soil alkaline nitrogen (N) and available potassium (K) by 17.2% and 23.0%, respectively, compared with the CK. Moreover, the St + L significantly increased tobacco leaf yield (24.0%) and the appearance (9.1%) and sensory (5.9%) quality of flue-cured tobacco leaves. The addition of soil conditioners (straw, dolomite, and lime) increased both the total reads and effective sequences of soil microorganisms. Bacterial diversity was more sensitive to changes in the external environment compared to soil fungi. The application of soil amendments (lime and straw) promoted the growth of beneficial microorganisms in the soil. Additionally, bacterial species had greater competition and limited availability of resources for survival compared to fungi. The results showed that soil microorganisms were significantly influenced by the presence of AK, AN, and pH contents. These findings can provide an effective method for improving the quality of flue-cured tobacco leaves and guiding the amelioration of acidic soil in regions where tobacco-rice rotation is practiced.
MeSH term(s)	Nicotiana ; Soil Microbiology ; Soil/chemistry ; Plant Leaves ; Calcium Compounds/pharmacology ; Calcium Compounds/chemistry ; Oxides ; Microbiota/drug effects ; Agriculture/methods ; China
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-33241-w
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Article: Investigation of fragmentation pathways of protonated 2‐methoxypyrimidine derivatives

Zu, Chengli / Wang, Nick X. / Brown, Christopher J. / Yang, Qiang / Gilbert, Jeffrey R.

Journal of mass spectrometry. 2022 Sept., v. 57, no. 9

2022

Abstract: Several representative pyrimidine derivatives were selected to undergo electrospray ionization (ESI) followed by collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. Two competitive pathways were found to govern the formation ... ...

Abstract	Several representative pyrimidine derivatives were selected to undergo electrospray ionization (ESI) followed by collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. Two competitive pathways were found to govern the formation of major fragment ions from protonated species of these molecules. The pathways were largely affected by the 2‐O‐methyl group but not significantly influenced by the substitution on C‐5 site of the pyrimidine ring. These findings were supported by both deuterium labeling CID MS/MS experiments and theoretical calculations. The deuterium labeled pyrimidine ion molecules were generated in‐source in ESI from the fully deuterated hydrazinyl pyrimidines, which were readily obtained through hydrogen/deuterium (H/D) exchange when dissolved in deuterium oxide (D₂O).
Keywords	deuterium ; deuterium oxide ; dissociation ; electrospray ionization mass spectrometry ; pyrimidines ; tandem mass spectrometry
Language	English
Dates of publication	2022-09
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	LETTER
ZDB-ID	1221763-3
ISSN	1096-9888 ; 1076-5174
ISSN (online)	1096-9888
ISSN	1076-5174
DOI	10.1002/jms.4883
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of vicinal diols using a diagnostic ion derived from the electron ionization of orthoester functional groups.

Samame, Renzo Alexander / Zu, Chengli / Knueppel, Daniel

Rapid communications in mass spectrometry : RCM

2020 Volume 34, Issue 17, Page(s) e8842

Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Letter
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.8842
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Article ; Online: Merging Photoredox Catalysis with Transition Metal Catalysis: Direct C4-H Sulfamidation of 1-Naphthylamine Derivatives.

Pei, Mengxue / Zu, Conghui / Liu, Zhen / Yang, Fan / Wu, Yangjie

The Journal of organic chemistry

2021 Volume 86, Issue 17, Page(s) 11324–11332

Abstract: A mild and efficient protocol for the copper(I)-catalyzed C4-H sulfamidation of 1-naphthylamine derivatives with diphenylsulfonimide (NHSI) was explored at room temperature, affording the desire produces in moderate to good yields. The control ... ...

Abstract	A mild and efficient protocol for the copper(I)-catalyzed C4-H sulfamidation of 1-naphthylamine derivatives with diphenylsulfonimide (NHSI) was explored at room temperature, affording the desire produces in moderate to good yields. The control experiments indicated that this visible-light-promoted reaction might proceed via a single-electron-transfer process. In addition, preliminary DFT studies for the intermediates in the catalytic cycle were also explored, indicating that the C4 site in the naphthyl ring is the most likely electrophilic reactive site and providing some exact basis for the plausible mechanism.
MeSH term(s)	1-Naphthylamine ; Catalysis ; Copper ; Light ; Molecular Structure
Chemical Substances	Copper (789U1901C5) ; 1-Naphthylamine (9753I242R5)
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c00635
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