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Article: Morphological diversity and altitudinal differentiation of

Lu, Wenzhu / Shao, Shimiao / Zu, Lingling / Luo, Xu / Duan, Yubao

2023 Volume 13, Issue 9, Page(s) e10473

Abstract: The morphological characteristics of birds are an important tool for studying their adaptation and evolution. The morphological evolution of a clade is not only constrained by the phylogenetic relationship, but also influenced by ecological factors and ... ...

Abstract	The morphological characteristics of birds are an important tool for studying their adaptation and evolution. The morphological evolution of a clade is not only constrained by the phylogenetic relationship, but also influenced by ecological factors and interspecific competition.
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10473
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Article ; Online: [The Expression of RTN1 in Lung Adenocarcinoma and  Its Effect on Immune Microenvironment].

Zhu, Shuai / Zu, Lingling / Xu, Song

Zhongguo fei ai za zhi = Chinese journal of lung cancer

2022 Volume 25, Issue 6, Page(s) 385–395

Abstract: Background: Reticulosome family gene 1 (RTN1) is a reticulosome-encoding gene associated with the endoplasmic reticulum. RTN1 plays a key role in membrane trafficking or neuroendocrine secretion of neuroendocrine cells, while RTN1 serves as a potential ... ...

Abstract	Background: Reticulosome family gene 1 (RTN1) is a reticulosome-encoding gene associated with the endoplasmic reticulum. RTN1 plays a key role in membrane trafficking or neuroendocrine secretion of neuroendocrine cells, while RTN1 serves as a potential diagnostic/therapeutic marker for neurological diseases and cancer. However, the expression of RTN1 and its effect on the immune microenvironment in patients with lung adenocarcinoma have not been reported. In this study, we aimed to investigate the expression of RTN1 in lung adenocarcinoma and its correlation with immune infiltration and survival in lung adenocarcinoma using public databases and bioinformatics network tools. Methods: Expression levels of RTN1 mRNA in tumor and normal tissues were analyzed using Tumor Immune Estimation Resource 2.0 (TIMER 2.0) and Gene Expression Profiling Interactive Analysis 2 (GEPIA 2). RTN1 protein expression was examined using the Human Protein Atlas. The clinical prognostic significance of RTN1 was analyzed using the GEPIA2 plotter database. To further confirm the potential function of RTN1, the data were analyzed using gene set enrichment analysis. In addition, We performed dimensionality-reduced clustering analysis at the single-cell sequencing level on two datasets from the Tumor Immune Single-cell Hub (TISCH) database to observe the cellular clustering of RTN1 in different types of immune cells. Using the TIMER online tool to analyze and predict the infiltration abundance of different types of immune cells in the immune microenvironment of lung adenocarcinoma patients in the TCGA cohort; TIMER and CIBERSORT were used to study the relationship between genes co-expressed with RTN1 and its associated tumor-infiltrating immune cells; finally, TIMER was used to analyze the relationship between RTN1 and immune correlations between immune checkpoints. Results: We found that RTN1 expression was decreased in patients with lung adenocarcinoma and was closely related to patient prognosis. RTN1 is involved in the process of phagosome formation, hematopoietic cell formation and cell adhesion, and plays an important role in T cell activation. Using cBioPortal and TCGA data to analyze, it is found that RTN1 is significantly associated with BTK, CD4, ECSF1R, MNDA, NCKAP1L and SNX20. High expression of the above genes may cause significant upregulation of CD4+ T cells, mast cells, monocytes, myeloid dendritic cells and M1 macrophages. The expression of RTN1 is closely related to the common immune checkpoints CD274, CTLA4, HAVCR2, LAG3, PDCD1, PDCD1LG2, TIGIT and SIGLEC15 immune checkpoints. Conclusions: RTN1 may act as a tumor suppressor gene and indicate better prognosis. Furthermore, RTN1 is associated with immune infiltration that may be involved in the immunotherapy response in LUAD. However, the related mechanism needs further research.
MeSH term(s)	Adenocarcinoma of Lung/pathology ; Biomarkers, Tumor/metabolism ; Gene Expression Profiling ; Humans ; Lung Neoplasms/pathology ; Mast Cells/metabolism ; Mast Cells/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Prognosis ; Sorting Nexins/genetics ; Sorting Nexins/metabolism ; Tumor Microenvironment/genetics
Chemical Substances	Biomarkers, Tumor ; Membrane Proteins ; Nerve Tissue Proteins ; RTN1 protein, human ; SNX20 protein, human ; Sorting Nexins ; NCKAP1L protein, human (144351-15-5)
Language	Chinese
Publishing date	2022-06-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2438672-8
ISSN	1999-6187 ; 1009-3419
ISSN (online)	1999-6187
ISSN	1009-3419
DOI	10.3779/j.issn.1009-3419.2022.105.02
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Article ; Online: Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer.

Zu, Lingling / He, Jinling / Zhou, Ning / Tang, Quanying / Liang, Maoli / Xu, Song

Cell death & disease

2023 Volume 14, Issue 12, Page(s) 798

Abstract: Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the transcriptomic landscape of NSCLC-cells with organ-specific metastatic potentials would advance our understanding of NSCLC ... ...

Abstract	Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the transcriptomic landscape of NSCLC-cells with organ-specific metastatic potentials would advance our understanding of NSCLC metastasis process. In this study, we established NSCLC bone-metastatic (BoM), brain-metastatic (BrM), and lymph-metastatic (LnM) cells by an in vivo spontaneous metastatic model. Subsequently, by analyzing the entire transcriptomic profiles of BoM, BrM, LnM, LuM, in comparison with their parental cell line L9981, we identified miR-660-5p as a key driver that is associated with NSCLC progression and distant metastasis, potentially through its targeting of LIMCH1, SMARCA5 and TPP2. In addition, a six-gene signature (ADRB2, DPYSL2, IL7R, LIMCH1, PIK3R1, and SOX2) was subsequently established to predict NSCLC metastasis based on differentially expressed genes, three of which (DPYSL2, PIK3R1, LIMCH1) along with the transcriptional factors RB1 and TP63, were ultimately validated by experiments. Taken together, aberrant gene signature and miRNA can serve as biomarkers for predicting NSCLC distant metastasis, and targeting them could potentially contribute to the development of novel therapeutic strategies.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Lung Neoplasms/pathology ; RNA, Messenger ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
Chemical Substances	MicroRNAs ; RNA, Messenger ; MIRN660 microRNA, human
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-06286-x
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Article: A Review of Biomarkers and Their Clinical Impact in Resected Early-Stage Non-Small-Cell Lung Cancer.

Cao, Weibo / Tang, Quanying / Zeng, Jingtong / Jin, Xin / Zu, Lingling / Xu, Song

Cancers

2023 Volume 15, Issue 18

Abstract: The postoperative survival of early-stage non-small-cell lung cancer (NSCLC) patients remains unsatisfactory. In this review, we examined the relevant literature to ascertain the prognostic effect of related indicators on early-stage NSCLC. The ... ...

Abstract	The postoperative survival of early-stage non-small-cell lung cancer (NSCLC) patients remains unsatisfactory. In this review, we examined the relevant literature to ascertain the prognostic effect of related indicators on early-stage NSCLC. The prognostic effects of the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), mesenchymal-epithelial transition (MET), C-ros oncogene 1 (ROS1), or tumour protein p53 (TP53) alterations in resected NSCLC remains debatable. Kirsten rat sarcoma viral oncogene homologue (KRAS) alterations indicate unfavourable outcomes in early-stage NSCLC. Meanwhile, adjuvant or neoadjuvant EGFR-targeted agents can substantially improve prognosis in early-stage NSCLC with EGFR alterations. Based on the summary of current studies, resected NSCLC patients with overexpression of programmed death-ligand 1 (PD-L1) had worsening survival. Conversely, PD-L1 or PD-1 inhibitors can substantially improve patient survival. Considering blood biomarkers, perioperative peripheral venous circulating tumour cells (CTCs) and pulmonary venous CTCs predicted unfavourable prognoses and led to distant metastases. Similarly, patients with detectable perioperative circulating tumour DNA (ctDNA) also had reduced survival. Moreover, patients with perioperatively elevated carcinoembryonic antigen (CEA) in the circulation predicted significantly worse survival outcomes. In the future, we will incorporate mutated genes, immune checkpoints, and blood-based biomarkers by applying artificial intelligence (AI) to construct prognostic models that predict patient survival accurately and guide individualised treatment.
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15184561
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Article ; Online: The role and underlying mechanisms of tumour-derived exosomes in lung cancer metastasis.

He, Jinling / Yang, Lingqi / Zhou, Ning / Zu, Lingling / Xu, Song

Current opinion in oncology

2022 Volume 35, Issue 1, Page(s) 46–53

Abstract: Purpose of review: Lung cancer is one of the most common malignant tumours worldwide. Metastasis is a serious influencing factor for poor treatment effect and shortened survival in lung cancer. But the complicated underlying molecular mechanisms of ... ...

Abstract	Purpose of review: Lung cancer is one of the most common malignant tumours worldwide. Metastasis is a serious influencing factor for poor treatment effect and shortened survival in lung cancer. But the complicated underlying molecular mechanisms of tumour metastasis remain unclear. In this review, we aim to further summarize and explore the underlying mechanisms of tumour-derived exosomes (TDEs) in lung cancer metastasis. Recent findings: TDEs are actively produced and released by tumour cells and carry messages from tumour cells to normal or abnormal cells residing at close or distant sites. Many studies have shown that TDEs promote lung cancer metastasis and development through multiple mechanisms, including epithelial-mesenchymal transition, immunosuppression and the formation of a premetastatic niche. TDEs regulate these mechanisms to promote metastasis by carrying DNA, proteins, miRNA, mRNA, lncRNA and ceRNA. Further exploring TDEs related to metastasis may be a promising treatment strategy and deserve further investigation. Summary: Overall, TDEs play a critical role in metastatic of lung cancer. Further studies are needed to explore the underlying mechanisms of TDEs in lung cancer metastasis.
MeSH term(s)	Humans ; Lung Neoplasms/genetics
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000913
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Article ; Online: The first complete mitochondrial genome of Blossom-headed Parakeet

Zhang, Jiansong / Zhao, Chenguang / Zu, Lingling / Duan, Yubao

Mitochondrial DNA. Part B, Resources

2020 Volume 5, Issue 3, Page(s) 3457–3459

Abstract: Blossom-headed ... ...

Abstract	Blossom-headed Parakeet
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2020.1825131
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Article ; Online: Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration.

Ji, Jiaqi / Yang, Shuping / Zu, Lingling / Li, Yongwen / Li, Ying

Thoracic cancer

2021 Volume 12, Issue 7, Page(s) 1041–1047

Abstract: Background: To reveal the function of deubiquitylating enzyme USP41 in lung adenocarcinoma.: Methods: The relationship between USP41 and lung cancer was determined by analyzing data from The Cancer Genome Atlas (TCGA). A549 and H1299 cell lines were ... ...

Abstract	Background: To reveal the function of deubiquitylating enzyme USP41 in lung adenocarcinoma. Methods: The relationship between USP41 and lung cancer was determined by analyzing data from The Cancer Genome Atlas (TCGA). A549 and H1299 cell lines were transfected with short hairpin RNA against USP41 (shUSP41 group) or negative control (shCon group). Western blotting was used to verify the transfection efficacy and marker expression. Cell proliferation and apoptosis were analyzed by EdU assay, MTT assay, and flow cytometry after USP41 knockdown. Transwell assay was used to determine the effect of USP41 downregulation on cell migration. Results: Analysis of lung cancer data from TCGA database indicated a higher level of USP41 expression in lung cancer tumor tissue compared with that in noncancerous tissue, and USP41 overexpression was correlated with poor overall survival of lung cancer patients (p < 0.01). The outcomes of the EdU, MTT, and flow cytometry assays indicated decreased cell proliferation and enhanced apoptosis in shUSP41-transfected cells. Transwell assay further demonstrated that USP41 knockdown increased the migration rate of A549 and H1299 cells. Conclusions: In our study, USP41 was overexpressed in lung cancer tissue and associated with poor prognosis of lung cancer. USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer.
MeSH term(s)	Cell Movement ; Cell Proliferation ; Deubiquitinating Enzymes/metabolism ; Female ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Ubiquitin-Specific Proteases/metabolism
Chemical Substances	Deubiquitinating Enzymes (EC 3.4.19.12) ; USP41 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2021-02-22
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.13843
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Article ; Online: Correction: Wilms' tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p.

Li, Xuebing / An, Wenzhe / Pan, Hongli / Fan, Yaguang / Huang, Hua / Wang, Yixuan / Shen, Wang / Zu, Lingling / Meng, Fanrong / Zhou, Xuexia

BMC cancer

2023 Volume 23, Issue 1, Page(s) 909

Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11399-9
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Article ; Online: Lobe-specific analysis of perioperative chemotherapy for non-small cell lung cancer patients.

Lei, Xi / Li, Tong / Mao, Fuling / Ren, Fan / Tang, Quanying / Cao, Weibo / Zu, Lingling / Xu, Song

Cancer medicine

2023 Volume 12, Issue 16, Page(s) 16896–16905

Abstract: Objectives: Perioperative cisplatin-based chemotherapy decreases the risk of death over surgery alone and is a standard of care. Here, we examined perioperative chemotherapy indications for stage IB-III non-small cell lung cancer (NSCLC) patients ... ...

Abstract	Objectives: Perioperative cisplatin-based chemotherapy decreases the risk of death over surgery alone and is a standard of care. Here, we examined perioperative chemotherapy indications for stage IB-III non-small cell lung cancer (NSCLC) patients according to lobe-specific analysis. Methods: Resectable NSCLC patients with stage IB-III who received perioperative chemotherapy with and without radiotherapy after lung resection were identified from the SEER database. Propensity score matching (PSM) analysis was performed to reduce the inherent bias of retrospective studies. The Kaplan-Meier method and log-rank tests were used to assess the differences in overall survival (OS). Results: The study enrolled 23,844 patients before PSM. The perioperative chemotherapy group had better OS than the nonperioperative chemotherapy group in stage IB-III NSCLC patients before and after PSM. However, subgroup analysis according to stage demonstrated that perioperative chemotherapy did not markedly benefit patients with stage IB. Furthermore, lobar subgroup analysis did not show survival advantages in primary tumors located in either the right middle lobe in stages II and III NSCLC or the right lower lobe in stage III NSCLC. Conclusions: Lobe-specific perioperative chemotherapy is recommended in NSCLC patients. For stage IB NSCLC, right middle lobe NSCLC from stage IB-III and right lower lobe NSCLC from stage III, perioperative chemotherapy might not confer survival benefits.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/surgery ; Lung Neoplasms/drug therapy ; Lung Neoplasms/surgery ; Retrospective Studies ; Chemotherapy, Adjuvant ; Cisplatin/therapeutic use ; Neoplasm Staging
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6319
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Article ; Online: Wilms' tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p.

Li, Xuebing / An, Wenzhe / Pan, Hongli / Fan, Yaguang / Huang, Hua / Wang, Yixuan / Shen, Wang / Zu, Lingling / Meng, Fanrong / Zhou, Xuexia

BMC cancer

2023 Volume 23, Issue 1, Page(s) 824

Abstract: Background: Wilms' tumour gene 1 (WT1) is clearly recognized as a tumour promoter in diversiform of human malignancies. Nevertheless, knowledge of its expression, functions and potential molecular mechanisms in non-small cell lung cancer (NSCLC) remains ...

Abstract	Background: Wilms' tumour gene 1 (WT1) is clearly recognized as a tumour promoter in diversiform of human malignancies. Nevertheless, knowledge of its expression, functions and potential molecular mechanisms in non-small cell lung cancer (NSCLC) remains elusive. Methods: Differential expression of WT1 mRNA and protein between NSCLC and normal tissues were assessed by analyzing RNA-seq data from Oncomine and protein data from Human Protein Atlas, respectively. Subsequently, prognosis significance and immune cell infiltration were analyzed by Kaplan-Meier plotter and CIBERSORT. 60 pairs of local NSCLC tissues were involved to validate WT1 expression by quantitative PCR (qPCR) and Western blot. Moreover, Cell Counting Kit-8 (CCK-8), colony formation, transwell, dual luciferase reporter assays and in vivo xenograft tumour growth experiments were conducted to explore the function and mechanism of WT1 in NSCLC. Results: Our solid data indicated that WT1 was increased in NSCLC tissues and cell lines in comparison with their matched controls. In particular, its upregulation correlated with worse prognosis and immune infiltration of the patients. Functional assays demonstrated that knockdown of WT1 inhibited NSCLC malignancy, including inhibiting cell proliferation, survival and invasion. Further exploration discovered that microRNA-498-5p (miR-498-5p) was the upstream suppressor of WT1 by directly targeting the 3' untranslated region (UTR) of WT1 mRNA. Moreover, expression of miR-498-5p was notably decreased and inversely correlated with WT1 in NSCLC tissues. Finally, we proved that miR-498-5p was a potent tumour suppressor in NSCLC by suppressing cell proliferation, survival and invasion, while WT1 restoration could in turn disrupt this suppression both in vitro and in vivo. Conclusion: The abnormal increase in WT1 contributes to the malignant properties of NSCLC cells, and miR-498-5p is a natural inhibitor of WT1. Our findings might facilitate the development of novel therapeutic strategies against NSCLC in the future.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Genes, Wilms Tumor ; Lung Neoplasms/genetics ; Carcinogens ; 3' Untranslated Regions ; MicroRNAs/genetics ; WT1 Proteins/genetics
Chemical Substances	Carcinogens ; 3' Untranslated Regions ; MicroRNAs ; WT1 protein, human ; WT1 Proteins ; MIRN498 microRNA, human
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11295-2
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