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  1. Article ; Online: Sporadic Case of Heterozygous X-Linked Alport Syndrome.

    Zuckerman, Jonathan E / Srivastava, Rachana

    Glomerular diseases

    2023  Volume 3, Issue 1, Page(s) 126–131

    Abstract: Alport syndrome is a genetically and phenotypically heterogeneous disorder that can be transmitted in an X-linked, autosomal recessive, or autosomal dominant fashion and can affect glomerular, cochlear, and ocular basement membranes. The disorder results ...

    Abstract Alport syndrome is a genetically and phenotypically heterogeneous disorder that can be transmitted in an X-linked, autosomal recessive, or autosomal dominant fashion and can affect glomerular, cochlear, and ocular basement membranes. The disorder results from mutations in the collagen IV genes
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000530994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exacerbation of Minimal Change Disease Following mRNA COVID-19 Vaccination.

    Pirzadeh, Afshin / Emami, Sina / Zuckerman, Jonathan E / Nobakht, Niloofar

    The American journal of case reports

    2023  Volume 24, Page(s) e941621

    Abstract: BACKGROUND Minimal change disease is a common cause of nephrotic syndrome in adults. There are few reported cases of vaccine-related podocytopathy with nephrotic-range proteinuria in the setting of a minimal change disease history. There have been rare ... ...

    Abstract BACKGROUND Minimal change disease is a common cause of nephrotic syndrome in adults. There are few reported cases of vaccine-related podocytopathy with nephrotic-range proteinuria in the setting of a minimal change disease history. There have been rare reports of acute renal damage following vaccination to prevent COVID-19 and some cases of exacerbation of ongoing nephropathy. This report is a 33-year-old man with a 22-year history of nephrotic syndrome due to minimal change disease which exacerbated following a third dose of an mRNA SARS-CoV-2 vaccine for COVID-19. CASE REPORT We report a case of nephrotic syndrome after the third dose of the BNT162b2 mRNA COVID-19 vaccine. The patient presented with mild edema in the bilateral lower extremities and sacrum. Laboratory investigations confirmed nephrotic-range proteinuria and hypoalbuminemia. A kidney sonogram demonstrated mild renal parenchymal disease and a small non-obstructing right renal calculus. Renal biopsy revealed diffuse podocyte foot process effacement, punctuate IgG podocyte cytoplasmic staining, and minimal global glomerulosclerosis, consistent with a diagnosis of a diffuse podocytopathy with a minimal change disease phenotype. The patient was started on oral prednisone treatment, which led to remission of his symptoms and normalization of lab test results with normal BUN and Cr and resolution of proteinuria. Treatment was tapered off over the course of 28 weeks. CONCLUSIONS We presents a case of longstanding minimal change disease that showed exacerbation following a third dose of an mRNA vaccine for SARS-CoV-2. Although this may be a rare association, this case supports that patients with chronic glomerulonephritis need to be monitored.
    MeSH term(s) Adult ; Humans ; Male ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19/complications ; COVID-19 Vaccines/adverse effects ; Kidney Diseases/complications ; Nephrosis, Lipoid/diagnosis ; Nephrosis, Lipoid/etiology ; Nephrotic Syndrome/complications ; Proteinuria ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances BNT162 Vaccine ; COVID-19 Vaccines
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.941621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complement and Renal Thrombotic Microangiopathy Associated With Hypertension and Scleroderma.

    Zuckerman, Jonathan E / Chang, Anthony

    Advances in chronic kidney disease

    2020  Volume 27, Issue 2, Page(s) 149–154

    Abstract: Thrombotic microangiopathy is characterized by the presence of thrombocytopenia and microangiopathic hemolytic anemia and can occur in up to 50% of patients with hypertensive emergency and 10-15% with scleroderma. This review discusses the emerging role ... ...

    Abstract Thrombotic microangiopathy is characterized by the presence of thrombocytopenia and microangiopathic hemolytic anemia and can occur in up to 50% of patients with hypertensive emergency and 10-15% with scleroderma. This review discusses the emerging role of complement in these 2 clinical entities. Specifically, we evaluate the evidence linking complement dysregulation with the manifestation of thrombotic microangiopathy and its clinical course in these settings. We also explore the rationale for complement blockade in these complex clinical scenarios that often have poor outcomes.
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2019.11.002
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    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Large Multinucleated Variant Endothelial Cells in Allograft Kidney Microvasculature: A Biopsy Series.

    Zuckerman, Jonathan E / Brealey, John / Yabu, Julie M / Chang, Anthony

    Kidney medicine

    2022  Volume 4, Issue 3, Page(s) 100411

    Abstract: There are few published studies examining cytomorphologic alterations in endothelial cells in human tissue. One fascinating but largely unexplored endothelial morphologic variant is large multinucleated variant endothelial cells (MVECs). To our knowledge, ...

    Abstract There are few published studies examining cytomorphologic alterations in endothelial cells in human tissue. One fascinating but largely unexplored endothelial morphologic variant is large multinucleated variant endothelial cells (MVECs). To our knowledge, there are no published reports of MVECs identified in the kidney. Here, we present a case series of 4 kidney biopsies from allograft kidneys whose microvasculature contained MVECs. Electron microscopy confirmed the endothelial identity in all cases. A broad immunohistochemical panel used in 1 case was also confirmatory of an endothelial cell origin. All cases occurred in the setting of chronic, active, antibody-mediated rejection, and alternative etiologies, such as viral infections, were excluded. Two patients were positive for concurrent donor-specific antibodies, and 3 of the 4 cases occurred in second kidney allografts. We speculate that MVECs are a rare or often overlooked finding often confused for megakaryocytes and may be associated with chronic endothelial cell injury in the setting of chronic antibody-mediated rejection.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Case Reports
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2022.100411
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  5. Article ; Online: Osmotic Tubulopathy and Acute Thrombotic Microangiopathy in a Kidney Transplant Recipient With a Breakthrough SARS-CoV-2 Infection.

    Fahim, Peter / Nicolaysen, Anthony / Yabu, Julie M / Zuckerman, Jonathan E

    Kidney medicine

    2022  Volume 4, Issue 7, Page(s) 100492

    Abstract: Acute kidney injury is a known complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for which many different pathophysiological processes have been reported. Here, we present a case of a 45-year-old kidney transplant ... ...

    Abstract Acute kidney injury is a known complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for which many different pathophysiological processes have been reported. Here, we present a case of a 45-year-old kidney transplant recipient with a breakthrough SARS-CoV-2 infection complicated by an episode of acute kidney injury 26 months after transplant. She had minimal respiratory symptoms, pancytopenia, mild hematuria, and proteinuria. A kidney biopsy revealed acute thrombotic microangiopathy (TMA) as well as an osmotic tubulopathy. The TMA was favored to be secondary to the SARS-CoV-2 infection because other etiologies for TMA, such as acute calcineurin inhibitor toxicity and acute antibody-mediated rejection, were excluded. The osmotic tubulopathy was favored to be secondary to remdesivir therapy, specifically related to the sulfobutylether-β-cyclodextrin solubilizing carrier agent used in its formulation. The patient's kidney function improved after resolution of the SARS-CoV-2 infection. This case illustrates a unique occurrence of kidney injury secondary to SARS-CoV-2 infection and anti-COVID-19 therapy.
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Case Reports
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2022.100492
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  6. Article: Severe Polyneuropathy in Hereditary Transthyretin Amyloidosis Caused by H90D Variant.

    Pierce, Joshua / Han, Karam / Vinters, Harry V / Zuckerman, Jonathan E / Halabi, Anasheh

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2023  Volume 51, Issue 2, Page(s) 336–338

    MeSH term(s) Humans ; Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnostic imaging ; Amyloid Neuropathies, Familial/genetics ; Polyneuropathies/complications ; Prealbumin/genetics
    Chemical Substances Prealbumin
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2023.4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Lactobacillus

    Moosavi, Mitchell / Zuckerman, Jonathan E

    Case reports in pathology

    2019  Volume 2019, Page(s) 6198380

    Abstract: Kidney injury is a well-known sequelae of infectious endocarditis. Various types of kidney injury can be seen, including endocarditis-associated glomerulonephritis, and may affect nearly half of the patients with infectious endocarditis. ...

    Abstract Kidney injury is a well-known sequelae of infectious endocarditis. Various types of kidney injury can be seen, including endocarditis-associated glomerulonephritis, and may affect nearly half of the patients with infectious endocarditis.
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2019/6198380
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  8. Article ; Online: The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Renal Infection?

    Lau, Wei Ling / Zuckerman, Jonathan E / Gupta, Ajay / Kalantar-Zadeh, Kamyar

    Nephron

    2021  Volume 145, Issue 3, Page(s) 275–279

    Abstract: Context: Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. Subject of Review: A growing number of conflicting kidney biopsy and autopsy reports highlight this ... ...

    Abstract Context: Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. Subject of Review: A growing number of conflicting kidney biopsy and autopsy reports highlight this controversial issue. Second Opinion: Based on the collective evidence, therapies that improve hemodynamic stability and oxygenation, or dampen complement activation, are likely to ameliorate acute kidney injury in COVID-19. At this time, whether inhibition of viral infection and replication directly modulates kidney damage is inconclusive.
    MeSH term(s) Acute Kidney Injury/etiology ; Autopsy ; Biopsy ; COVID-19/complications ; COVID-19/therapy ; COVID-19/virology ; Humans ; Kidney/pathology ; Kidney/virology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Kidney Diseases/virology ; Nephritis, Interstitial/etiology
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000513789
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Non-HLA Antibodies to G Protein-coupled Receptors in Pediatric Kidney Transplant Recipients: Short- and Long-term Clinical Outcomes.

    Pearl, Meghan H / Chen, Lucia / Zuckerman, Jonathan E / Weng, Patricia L / Chambers, Eileen T / Zhang, Qiuheng / Reed, Elaine F

    Transplantation

    2023  Volume 108, Issue 1, Page(s) 276–283

    Abstract: Background: Angiotensin II type 1 receptor antibodies (AT1R-Abs) and endothelin-type A receptor antibodies (ETAR-Abs) are G protein-coupled receptor activating autoantibodies associated with antibody-mediated rejection, vascular pathology, increased ... ...

    Abstract Background: Angiotensin II type 1 receptor antibodies (AT1R-Abs) and endothelin-type A receptor antibodies (ETAR-Abs) are G protein-coupled receptor activating autoantibodies associated with antibody-mediated rejection, vascular pathology, increased cytokines, allograft dysfunction, and allograft loss in pediatric kidney transplant recipients in the first 2 y posttransplantation. The impact of AT1R-Ab and ETAR-Ab positivity on longer-term 5-y transplant outcomes is unknown.
    Methods: One hundred pediatric kidney transplant recipients were tested for ETAR-Ab and AT1R-Ab on serially collected blood samples in the first 2 y posttransplant. Biopsies were collected per protocol and 6, 12, and 24 mo posttransplant and at any time during the 5-y follow-up period for clinical indication. Clinical outcomes, including renal dysfunction, rejection, HLA donor-specific antibodies, and allograft loss, were assessed through 5 y posttransplantation.
    Results: AT1R-Ab or ETAR-Ab were positive in 59% of patients. AT1R-Ab or ETAR-Ab positivity was associated with greater declines in estimated glomerular filtration rate, and de novo AT1R-Ab or ETAR-Ab was associated with allograft loss in the first 2 y posttransplant. There was no association between antibody positivity and rejection, antibody-mediated rejection, or allograft loss in the first 5 y posttransplant. In a model controlled for age, sex, immunosuppression, and HLA mismatch, AT1R-Ab or ETAR-Ab positivity was significantly associated with the development of HLA donor-specific antibodies at 5 y posttransplant (odds ratio 2.87, P  = 0.034).
    Conclusions: Our findings suggest temporally distinct clinical complications associated with AT1R-Ab or ETAR-Ab positivity in pediatric patients; these injury patterns are of significant interest for developing effective treatment strategies.
    MeSH term(s) Humans ; Child ; Kidney Transplantation/adverse effects ; HLA Antigens ; Transplantation, Homologous ; Autoantibodies ; Treatment Outcome ; Receptor, Angiotensin, Type 1 ; Graft Rejection
    Chemical Substances HLA Antigens ; Autoantibodies ; Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004753
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 509: Show issues

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  10. Article: Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall.

    Zuckerman, Jonathan E / Moatamed, Neda A

    Rare tumors

    2017  Volume 9, Issue 3, Page(s) 6861

    Abstract: Sertoli-Leydig cells tumors are rare ovarian neoplasms that can be managed with conservative resection given their generally excellent prognosis. Here we report a case of Sertoli-Leydig cell tumor mistakenly diagnosed as an invasive mucinous ... ...

    Abstract Sertoli-Leydig cells tumors are rare ovarian neoplasms that can be managed with conservative resection given their generally excellent prognosis. Here we report a case of Sertoli-Leydig cell tumor mistakenly diagnosed as an invasive mucinous adenocarcinoma at time of intraoperative consultation because of its blue-mucinous appearance in the frozen section material. The patient subsequently underwent an extensive staging procedure revealing unilateral, ovarian confined disease. The mucinous features seen on frozen section were lost on the slides prepared from formalin fixed tissues. Immunohistochemical work up confirmed the diagnosis of a pure Sertoli-Leydig cell tumor. No heterologous elements were identified in this tumor. This case illustrates a hitherto unrecognized frozen section pitfall in evaluation of ovarian neoplasms. To the best of our knowledge, this is the first well documented case of pure Sertoli-Leydig cells tumor which resembled a well differentiated mucinous adenocarcinoma during frozen section.
    Language English
    Publishing date 2017-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514363-3
    ISSN 2036-3613 ; 2036-3605
    ISSN (online) 2036-3613
    ISSN 2036-3605
    DOI 10.4081/rt.2017.6861
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