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  1. AU="Zugasti, Ana"
  2. AU="Zhou, Xunjian"
  3. AU="Montero-Vergara, Jetsy"
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  5. AU="Stabel, Judith R"
  6. AU=Badgley C E AU=Badgley C E
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  8. AU="Sethi, Ansh"
  9. AU="Tibbo, Meagan E"
  10. AU="Prechtl, Stefan"
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  12. AU="Annukka Pasanen"
  13. AU="Yi, Ling Ka"
  14. AU="Kong, Hyejin"
  15. AU="Bilio, João"
  16. AU=Hill Stephen J
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  27. AU="Moura-Alves, Márcio"
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  29. AU=Eichfelder Sebastian
  30. AU=Timins M E
  31. AU="Weber, Stephan"
  32. AU=Galuska David
  33. AU="Carrieri, Mariella"
  34. AU="Hafkamp, Frederique J"
  35. AU="Jessica M. Perkins"
  36. AU="Tariq, Syeda Sumayya"
  37. AU="Meehan, Rebecca"

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  1. Artikel ; Online: Nutritional and Morphofunctional Assessment of Post-ICU Patients with COVID-19 at Hospital Discharge: NutriEcoMuscle Study.

    Joaquín, Clara / Bretón, Irene / Ocón Bretón, María Julia / Burgos, Rosa / Bellido, Diego / Matía-Martín, Pilar / Martínez Olmos, Miguel Ángel / Zugasti, Ana / Riestra, María / Botella, Francisco / García Almeida, José M

    Nutrients

    2024  Band 16, Heft 6

    Abstract: This paper presents baseline results from the NutriEcoMuscle study, a multicenter observational study conducted in Spain which focused on changes in nutritional status, body composition, and functionality in post-intensive care unit (ICU) COVID-19 ... ...

    Abstract This paper presents baseline results from the NutriEcoMuscle study, a multicenter observational study conducted in Spain which focused on changes in nutritional status, body composition, and functionality in post-intensive care unit (ICU) COVID-19 patients following a nutritional intervention. Assessments at hospital discharge included Subjective Global Assessment (SGA), Global Leadership Initiative on Malnutrition (GLIM) criteria, the Barthel index, handgrip strength (HGS) and the Timed Up-and-Go test, bioelectrical impedance analysis (BIA), and nutritional ultrasound (US). The study involved 96 patients (71.9% male, mean age 58.8 years, mean BMI 28.8 kg/m
    Mesh-Begriff(e) Humans ; Male ; Middle Aged ; Female ; Nutrition Assessment ; Patient Discharge ; Hand Strength ; COVID-19/complications ; Nutritional Status ; Malnutrition/epidemiology ; Intensive Care Units ; Hospitals
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland Switzerland
    Dokumenttyp Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16060886
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  2. Artikel ; Online: RECALSEEN 2021. Resources and quality in the Endocrinology and Nutrition units of the National Health System of Spain.

    Santamaria, Javier / Bretón, Irene / Fernández, Alberto / Hanzu, Felicia / Luque, Raúl / Pinés, Pedro / Tejera, Cristina / Zugasti, Ana / Del Prado, Náyade / Elola, Javier / Escalada, Javier

    Endocrinologia, diabetes y nutricion

    2023  Band 70, Heft 7, Seite(n) 459–467

    Abstract: Objectives: RECALSEEN project aims to analyze the structure, activity, and outcomes of the departments of endocrinology and nutrition (S-U_EyN) of the Spanish National Health System (SNHS). Based on the results obtained, the challenges for the specialty ...

    Abstract Objectives: RECALSEEN project aims to analyze the structure, activity, and outcomes of the departments of endocrinology and nutrition (S-U_EyN) of the Spanish National Health System (SNHS). Based on the results obtained, the challenges for the specialty are analyzed and proposals for improvement policies are made. In this paper 2021 survey data and activity data from the 2007-2019 from the Minimum Basic Data Set (MBDS) are presented.
    Material and methods: Cross-sectional descriptive study of the S-U_EyN of acute general hospitals of the NHS in 2020. Data were obtained through: 1. an "ad hoc" survey answered by the S-U_EyN' consultants; and 2. analysing the acute general hospital discharges from S-U_EyN and discharges with endocrine-metabolic comorbidities registered in the minimum basis data set (MBDS) of the SNHS.
    Results: 112 responses from S-U_EyN were obtained from a total of 154 general acute hospitals of the NHS (73%). The 2021 S-U_EyN sample includes 24 more centers than in 2017. 54% of the S-U_EyN were endocrinology departments. The median number of endocrinologists per S-U_EyN was 7. The estimated rate of endocrinologists was 2.5 per 100,000 inhabitants. S-U_EyN showed a high level of collaboration with primary care teams and other hospital units. Use of telemedicine by S-U_EyN experienced a high increase in 2020. Notable differences in resources and activity have been found between hospitals and Autonomous Communities. There was a wide margin for improvement in quality management.
    Conclusions: RECALSEEN is a useful project for the analysis of S-U_EyN. The remarkable variability found in the indicators of structure, activity and management probably indicates a wide margin for improvement.
    Mesh-Begriff(e) Humans ; Spain ; Cross-Sectional Studies ; Endocrinology ; Hospitals, General ; Hospital Units
    Sprache Englisch
    Erscheinungsdatum 2023-07-27
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2023.03.022
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  3. Artikel ; Online: Recommendations for the diagnosis and treatment of hypoglycaemia after bariatric surgery.

    Vilarrasa, Nuria / Bretón, Irene / Ballesteros-Pomar, María / Lecube, Albert / Goday, Albert / Pellitero, Silvia / Sánchez, Raquel / Zugasti, Ana / Ciudin, Andrea / de Hollanda, Ana / Rubio, Miguel Angel

    Endocrinologia, diabetes y nutricion

    2022  Band 69, Heft 9, Seite(n) 723–731

    Abstract: Postprandial hyperinsulinaemic hypoglycaemia is a common complication of bariatric surgery. Although in general its evolution is mild and self-limited, it can lead to neuroglycopaenia and compromise the patient's safety and quality of life. The aim of ... ...

    Abstract Postprandial hyperinsulinaemic hypoglycaemia is a common complication of bariatric surgery. Although in general its evolution is mild and self-limited, it can lead to neuroglycopaenia and compromise the patient's safety and quality of life. The aim of this document is to offer some recommendations to facilitate the clinical care of these complex patients, reviewing the aetiopathogenesis, its diagnosis and treatment that, sequentially, will include dietary and pharmacological measures and surgery in refractory cases. In the absence of high-quality studies, the diagnostic and therapeutic approach proposed is based on the consensus of experts of the Grupo de Obesidad de la Sociedad Española de Endocrinología y Nutrición [Obesity Group of the Spanish Society of Endocrinology and Nutrition], GOSEEN. Those undergoing bariatric surgery should be informed of the possibility of developing this complication.
    Sprache Englisch
    Erscheinungsdatum 2022-11-21
    Erscheinungsland Spain
    Dokumenttyp Journal Article ; Review
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2021.09.005
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  4. Artikel ; Online: Malnutrition management of hospitalized patients with diabetes/hyperglycemia and COVID-19 infection.

    Burgos, Rosa / García-Almeida, José Manuel / Matía-Martín, Pilar / Palma, Samara / Sanz-Paris, Alejandro / Zugasti, Ana / Alfaro, José Joaquín / Fullana, Ana Artero / Continente, Alfonso Calañas / Chicetru, María Jesús / Malpartida, Katherine García / Faes, Ángela González / Sánchez, Víctor González / López, María Lainez / Ortega, Antonio Jesús Martínez / Roldán, Juana Oliva / Moreno, Clara Serrano / Llanos, Pablo Suárez

    Reviews in endocrine & metabolic disorders

    2022  Band 23, Heft 2, Seite(n) 205–213

    Abstract: Diabetes mellitus and/or hyperglycemia are highly prevalent medical conditions in patients hospitalized for coronavirus disease 2019 (COVID-19) and are associated with adverse outcomes. In addition, COVID-19 itself can provoke fluctuating and high ... ...

    Abstract Diabetes mellitus and/or hyperglycemia are highly prevalent medical conditions in patients hospitalized for coronavirus disease 2019 (COVID-19) and are associated with adverse outcomes. In addition, COVID-19 itself can provoke fluctuating and high glucose levels that can be difficult to manage upon hospitalization. Hospitalized patients with COVID-19 are at high risk of malnutrition due to an increase in nutritional requirements and a severe acute inflammatory response. The management of patients with diabetes/hyperglycemia and COVID-19 is challenging and requires a specific nutritional approach, the purpose of which is to fulfill the nutritional requirements while maintaining an optimal glycemic control. In this study, an expert group of nutritional endocrinologists carried out a qualitative literature review and provided recommendations based on evidence and guidelines, when available, or on their own experience. The optimal care based on these recommendations was compared with the routine bedside care as reported by a panel of physicians (mainly, endocrinologists, geriatricians, and internists) treating patients with diabetes/hyperglycemia and COVID-19 in their daily practice. Early screening and diagnosis, a diabetes-specific therapeutic approach, and a close malnutrition monitoring are essential to improve the clinical outcomes of these patients. In conclusion, the proposed recommendations are intended to provide a useful guide on the clinical management of malnutrition in patients with COVID-19 and diabetes/hyperglycemia, in order to improve their outcomes and accelerate their recovery. The comparison of the recommended optimal care with routine clinical practice could aid to identify gaps in knowledge, implementation difficulties, and areas for improvement in the management of malnutrition in this population.
    Mesh-Begriff(e) COVID-19/complications ; COVID-19/therapy ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Humans ; Hyperglycemia/complications ; Hyperglycemia/therapy ; Malnutrition/therapy ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-03-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-022-09714-z
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  5. Artikel ; Online: Efficacy of different 8 h time-restricted eating schedules on visceral adipose tissue and cardiometabolic health: A study protocol.

    Dote-Montero, Manuel / Merchan-Ramirez, Elisa / Oses, Maddi / Echarte, Jon / Clavero-Jimeno, Antonio / Alcantara, Jma / Camacho-Cardenosa, Alba / Cupeiro, Rocío / Rodríguez-Miranda, María de Las Nieves / López-Vázquez, Alejandro / Amaro-Gahete, Francisco J / González Cejudo, María Trinidad / Martin-Olmedo, Juan J / Molina-Fernandez, Marcos / García Pérez, Patricia Virginia / Contreras-Bolívar, Victoria / Muñoz-Garach, Araceli / Andreo-López, María C / Carneiro-Barrera, Almudena /
    Miranda-Ferrúa, Emiliano / Zugasti, Ana / Petrina, Estrella / Álvarez de Eulate, Natalia / Goñi, Elena / Ribelles, María Jesús / Brugos, Cristina Armendáriz / Izquierdo, Claudia / Fernández-Puggioni, Victoria / Galbete, Arkaitz / Villanueva, Arantxa / Medrano, María / Alfaro-Magallanes, Víctor Manuel / Muñoz-Torres, Manuel / Martín-Rodríguez, José L / Idoate, Fernando / Cabeza, Rafael / Ruiz, Jonatan R / Labayen, Idoia

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Band 34, Heft 1, Seite(n) 177–187

    Abstract: Background and aims: To investigate the efficacy and feasibility of three different 8 h time-restricted eating (TRE) schedules (i.e., early, late, and self-selected) compared to each other and to a usual-care (UC) intervention on visceral adipose tissue ...

    Abstract Background and aims: To investigate the efficacy and feasibility of three different 8 h time-restricted eating (TRE) schedules (i.e., early, late, and self-selected) compared to each other and to a usual-care (UC) intervention on visceral adipose tissue (VAT) and cardiometabolic health in men and women.
    Methods and results: Anticipated 208 adults (50% women) aged 30-60 years, with overweight/obesity (25 ≤ BMI<40 kg/m
    Conclusion: This study will determine whether the timing of the eating window during TRE impacts its efficacy on VAT, body composition and cardiometabolic risk factors and provide insights about its feasibility.
    Mesh-Begriff(e) Adult ; Male ; Humans ; Female ; Intra-Abdominal Fat ; Body Composition ; Cardiometabolic Risk Factors ; Educational Status ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Fasting ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-09-21
    Erscheinungsland Netherlands
    Dokumenttyp Clinical Trial Protocol ; Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.09.014
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  6. Artikel: Encefalopatía de Hashimoto en un paciente de 20 años.

    Bacarizo, Paloma / Zugasti, Ana / Salmerón de Diego, Juan / Caretti, Eugenia

    Medicina clinica

    2005  Band 125, Heft 2, Seite(n) 78–79

    Titelübersetzung Hashimoto's encephalopathy in a 20 years old patient.
    Mesh-Begriff(e) Adult ; Antibodies/immunology ; Diagnosis, Differential ; Female ; Humans ; Thyroid Gland/immunology ; Thyroid Gland/physiopathology ; Thyroiditis, Autoimmune/diagnosis ; Thyroiditis, Autoimmune/immunology ; Thyroiditis, Autoimmune/physiopathology
    Chemische Substanzen Antibodies
    Sprache Spanisch
    Erscheinungsdatum 2005-06-13
    Erscheinungsland Spain
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1157/13076469
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  7. Artikel: Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial

    Olveira, Gabriel / Abuín, Jose / López, Rafael / Herranz, Sandra / García-Almeida, Jose M / García-Malpartida, Katherine / Ferrer, Mercedes / Cancer, Emilia / Luengo-Pérez, Luis M / Álvarez, Julia / Aragón, Carmen / Ocón, María J / García-Manzanares, Álvaro / Bretón, Irene / Serrano-Aguayo, Pilar / Pérez-Ferre, Natalia / López-Gómez, Juan J / Olivares, Josefina / Arraiza, Carmen /
    Tejera, Cristina / Martín, Jorge D / García, Sara / Abad, Ángel L / Alhambra, María R / Zugasti, Ana / Parra, Juan / Torrejón, Sara / Tapia, María J

    Clinical nutrition. 2019 Feb. 20,

    2019  

    Abstract: There is no established insulin regimen in T2DM patients receiving parenteral nutrition.To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN.Prospective, open-label, multicenter, ... ...

    Abstract There is no established insulin regimen in T2DM patients receiving parenteral nutrition.To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN.Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Patients were randomized on one of these two regimens: 100% of RI on TPN or 50% of Regular insulin added to TPN bag and 50% subcutaneous GI. Data were analyzed according to intention-to-treat principle.81 patients were on RI and 80 on GI. No differences were observed in neither average total daily dose of insulin, programmed or correction, nor in capillary mean blood glucose during TPN infusion (165.3 ± 35.4 in RI vs 172.5 ± 43.6 mg/dL in GI; p = 0.25). Mean capillary glucose was significantly lower in the GI group within two days after TPN interruption (160.3 ± 45.1 in RI vs 141.7 ± 43.8 mg/dL in GI; p = 0.024). The percentage of capillary glucose above 180 mg/dL was similar in both groups. The rate of capillary glucose ≤70 mg/dL, the number of hypoglycemic episodes per 100 days of TPN, and the percentage of patients with non-severe hypoglycemia were significantly higher on GI group. No severe hypoglycemia was detected. No differences were observed in length of stay, infectious complications, or hospital mortality.Effectiveness of both regimens was similar. GI group achieved better metabolic control after TPN interruption but non-severe hypoglycemia rate was higher in the GI group.This trial is registered at clinicaltrials.gov as NCT02706119.
    Schlagwörter adults ; blood glucose ; data analysis ; glucose ; hospitals ; hypoglycemia ; insulin ; noninsulin-dependent diabetes mellitus ; patients ; randomized clinical trials ; total parenteral nutrition
    Sprache Englisch
    Erscheinungsverlauf 2019-0220
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.02.036
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: RISK FACTORS FOR HYPOGLYCEMIA IN INPATIENTS WITH TOTAL PARENTERAL NUTRITION AND TYPE 2 DIABETES: A POST HOC ANALYSIS OF THE INSUPAR STUDY.

    Olveira, Gabriel / Abuín, Jose / López, Rafael / Herranz, Sandra / García-Almeida, Jose M / García-Malpartida, Katherine / Ferrer, Mercedes / Cancer, Emilia / Luengo-Pérez, Luis M / Álvarez, Julia / Aragón, Carmen / Ocón, María J / García-Manzanares, Álvaro / Bretón, Irene / Serrano-Aguayo, Pilar / Pérez-Ferre, Natalia / López-Gómez, Juan J / Olivares, Josefina / Arraiza, Carmen /
    Tejera, Cristina / Martín, Jorge D / Urioste-Fondo, Ana / Abad, Ángel L / Alhambra, María R / Zugasti, Ana / Parra, Juan / Torrejón, Sara / Tapia, María J

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2020  Band 26, Heft 6, Seite(n) 604–611

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Blood Glucose ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemia ; Hypoglycemic Agents ; Inpatients ; Insulin ; Insulin Glargine ; Parenteral Nutrition, Total ; Prospective Studies ; Risk Factors
    Chemische Substanzen Blood Glucose ; Hypoglycemic Agents ; Insulin ; Insulin Glargine (2ZM8CX04RZ)
    Sprache Englisch
    Erscheinungsdatum 2020-03-11
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/EP-2019-0482
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Treatment with nandrolone decanoate and megestrol acetate in HIV-infected men.

    Cuerda, Cristina / Zugasti, Ana / Bretón, Irene / Camblor, Miguel / Miralles, Pilar / García, Pilar

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2005  Band 20, Heft 1, Seite(n) 93–97

    Abstract: Background: Malnutrition, especially loss of lean body mass, is a frequent complication of people living with HIV that may increase their mortality and morbidity.: Methods: Nine HIV-infected men with unexplained loss of >10% of their usual weight ... ...

    Abstract Background: Malnutrition, especially loss of lean body mass, is a frequent complication of people living with HIV that may increase their mortality and morbidity.
    Methods: Nine HIV-infected men with unexplained loss of >10% of their usual weight were selected. They received megestrol acetate (MA) (400 mg/day by mouth) and nandrolone decanoate (ND) (100 mg/15 days intermuscular injection) over 16 weeks. Anthropometric evaluations, bioelectrical impedance, grip strength dynamometry, hematologic, biochemical, immunological and hormonal analysis before, during, and after the treatment were performed. Quality of life was evaluated by the Karnofsky index.
    Results: In the 7 men that finished the treatment, there were significant increases in weight (11.9 +/- 9.1 kg, p < .05), 4-site skinfold measurements (p < .05), midarm circumference (p < .005), and fat-free mass (FFM) (5.1 +/- 4.1 kg, p < .05). The increase in fat mass was not statistically significant (6.9 +/- 6.4 kg, NS). Muscle strength increased significantly (p < .005). The Karnofsky index values increased from 59% to 73% (p < .05). One patient developed mild hyperglycemia and another one had an increase in aspartate transaminase and gamma-glutamyl transpeptidase that reversed after the treatment. Four patients developed asymptomatic adrenal suppression. Testosterone serum levels decreased significantly during the study (p < .05), and 4 patients had serum values below the normal range at week 16. One patient developed gynecomastia.
    Conclusions: The combined treatment with MA and ND led to a significant increase in body weight and FFM. Muscle strength and quality of life improved during the study. The treatment was well tolerated with mild side effects.
    Mesh-Begriff(e) Adult ; Anabolic Agents/adverse effects ; Anabolic Agents/therapeutic use ; Anthropometry ; Appetite Stimulants/adverse effects ; Appetite Stimulants/therapeutic use ; Drug Therapy, Combination ; HIV Infections/complications ; HIV Wasting Syndrome/drug therapy ; Humans ; Male ; Megestrol Acetate/adverse effects ; Megestrol Acetate/therapeutic use ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/growth & development ; Muscle, Skeletal/metabolism ; Nandrolone/adverse effects ; Nandrolone/analogs & derivatives ; Nandrolone/therapeutic use ; Quality of Life ; Safety ; Testosterone/blood ; Treatment Outcome ; Weight Gain/drug effects
    Chemische Substanzen Anabolic Agents ; Appetite Stimulants ; Testosterone (3XMK78S47O) ; Nandrolone (6PG9VR430D) ; nandrolone decanoate (H45187T098) ; Megestrol Acetate (TJ2M0FR8ES)
    Sprache Englisch
    Erscheinungsdatum 2005-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1177/011542650502000193
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial.

    Olveira, Gabriel / Abuín, Jose / López, Rafael / Herranz, Sandra / García-Almeida, Jose M / García-Malpartida, Katherine / Ferrer, Mercedes / Cancer, Emilia / Luengo-Pérez, Luis M / Álvarez, Julia / Aragón, Carmen / Ocón, María J / García-Manzanares, Álvaro / Bretón, Irene / Serrano-Aguayo, Pilar / Pérez-Ferre, Natalia / López-Gómez, Juan J / Olivares, Josefina / Arraiza, Carmen /
    Tejera, Cristina / Martín, Jorge D / García, Sara / Abad, Ángel L / Alhambra, María R / Zugasti, Ana / Parra, Juan / Torrejón, Sara / Tapia, María J

    Clinical nutrition (Edinburgh, Scotland)

    2019  Band 39, Heft 2, Seite(n) 388–394

    Abstract: Background: There is no established insulin regimen in T2DM patients receiving parenteral nutrition.: Aims: To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN.: Design: ... ...

    Abstract Background: There is no established insulin regimen in T2DM patients receiving parenteral nutrition.
    Aims: To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN.
    Design: Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Patients were randomized on one of these two regimens: 100% of RI on TPN or 50% of Regular insulin added to TPN bag and 50% subcutaneous GI. Data were analyzed according to intention-to-treat principle.
    Results: 81 patients were on RI and 80 on GI. No differences were observed in neither average total daily dose of insulin, programmed or correction, nor in capillary mean blood glucose during TPN infusion (165.3 ± 35.4 in RI vs 172.5 ± 43.6 mg/dL in GI; p = 0.25). Mean capillary glucose was significantly lower in the GI group within two days after TPN interruption (160.3 ± 45.1 in RI vs 141.7 ± 43.8 mg/dL in GI; p = 0.024). The percentage of capillary glucose above 180 mg/dL was similar in both groups. The rate of capillary glucose ≤70 mg/dL, the number of hypoglycemic episodes per 100 days of TPN, and the percentage of patients with non-severe hypoglycemia were significantly higher on GI group. No severe hypoglycemia was detected. No differences were observed in length of stay, infectious complications, or hospital mortality.
    Conclusion: Effectiveness of both regimens was similar. GI group achieved better metabolic control after TPN interruption but non-severe hypoglycemia rate was higher in the GI group.
    Clinical trial registry: This trial is registered at clinicaltrials.gov as NCT02706119.
    Mesh-Begriff(e) Aged ; Combined Modality Therapy ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Injections, Subcutaneous ; Insulin/therapeutic use ; Insulin Glargine/administration & dosage ; Insulin Glargine/therapeutic use ; Male ; Parenteral Nutrition, Total/methods ; Prospective Studies ; Spain ; Treatment Outcome
    Chemische Substanzen Hypoglycemic Agents ; Insulin ; Insulin Glargine (2ZM8CX04RZ)
    Sprache Englisch
    Erscheinungsdatum 2019-03-20
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.02.036
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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