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  1. Article ; Online: Edentulism and Individual Factors of Active Aging Framework in Colombia.

    Gutiérrez, Bruno / Martínez, Adriana Gisella / Zuluaga, Iván Arroyave

    Annals of geriatric medicine and research

    2023  Volume 28, Issue 1, Page(s) 46–56

    Abstract: Background: While edentulism remains a serious public health problem for older adults in Colombia, few analyses have been conducted from the framework of active aging as a part of the positive discourse of aging. This study analyzed complete edentulism ... ...

    Abstract Background: While edentulism remains a serious public health problem for older adults in Colombia, few analyses have been conducted from the framework of active aging as a part of the positive discourse of aging. This study analyzed complete edentulism and its relationship with determinants including personal, behavioral, and health systems and social services.
    Methods: This study included a total of 19,004 older adults. We used univariate, bivariate, and multivariate logistic regression type scores to investigate the relationships between the variables. The personal determinants included basic (Barthel scale) and instrumental activities of daily living (Lawton scale), public transportation, functional limitations, self-perceived health, and health problems. The behavioral factors included alcohol and tobacco use, mini nutritional tests, and physical activity. The last determinant was the healthcare system, while social services access included dental services. The analysis also included sociodemographic variables.
    Results: The results revealed significant associations for the variables of the three determinants, including the risk of malnutrition (odds ratio [OR]=1.15), functional limitation (OR=1.15), moderate physical activity (OR=1.08), and access to dental services (OR=2.31). Sex, years of education, and race were also risk factors, among other variables. Personal determinants, behavior, and use and access to health services were related to edentulism in older adults.
    Conclusion: These findings support the need to include different analyses of edentulism from multicausality and to understand the oral cavity and the living conditions of aging adults.
    Language English
    Publishing date 2023-12-15
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3035056-6
    ISSN 2508-4909 ; 2508-4798
    ISSN (online) 2508-4909
    ISSN 2508-4798
    DOI 10.4235/agmr.23.0158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study.

    Chang, Aileen Y / Tritsch, Sarah R / Herrera Gomez, Carlos Andres / Encinales, Liliana / Cadena Bonfanti, Andres / Rosales, Wendy / Mendoza-Torres, Evelyn / Simmens, Samuel / Amdur, Richard L / Mores, Christopher N / Fierbaugh, Paige / Perez Hernandez, Carlos Alberto / Avendaño, Geraldine / Silvera, Paula Bruges / Crespo, Yerlenis Galvis / Jimenez, Alberto David Cabana / Martinez Zapata, Jennifer Carolina / Jimenez, Dennys / Osorio-Llanes, Estefanie /
    Castellar-Lopez, Jairo / Suchowiecki, Karol / Martins, Karen / Gregory, Melissa / Zuluaga, Ivan / Proctor, Abigale / Hernández, Alfonso Sucerquia / Sierra-Carrero, Leandro / Colpas, Maria Villanueva / Hernandez, Juan Carlos Perez / Quast, Andres Alberto Figueroa / De Barros, Joaquin Andres Calderon / Mejía, José Forero / Ruiz, Johan Penagos / Boyle, David / Firestein, Gary S / Simon, Gary L

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299521

    Abstract: Objective: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.: Methods: Participants with chikungunya arthritis were ... ...

    Abstract Objective: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.
    Methods: Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay. Peripheral blood T cell subsets were measured using flow cytometry.
    Results: Among participants with chikungunya arthritis (N = 158), IL-2 levels and frequency of regulatory T cells (Tregs) were low. Increased arthritis disease activity was associated with higher levels of inflammatory cytokines (IL-6, TNF and CRP) and immunoregulatory cytokine IL-10 (p<0.05). Increased arthritis flare activity was associated with higher Treg frequencies (p<0.05) without affecting T effector (Teff) frequencies, Treg/Teff ratios and Treg subsets. Finally, elevated levels of IL-2 were correlated with increased Treg frequency, percent Tregs out of CD4+ T cells, and Treg subsets expressing immunosuppressive markers, while also correlating with an increased percent Teff out of live lymphocytes (p<0.05).
    Conclusion: Chikungunya arthritis is characterized by increased inflammatory cytokines and deficient IL-2 and Treg responses. Greater levels of IL-2 were associated with improved Treg numbers and immunosuppressive markers. Future research may consider targeting these pathways for therapy.
    MeSH term(s) Humans ; Cytokines/metabolism ; Interleukin-10/metabolism ; Cross-Sectional Studies ; Interleukin-2/metabolism ; Interleukin-6/metabolism ; Chikungunya Fever/complications ; T-Lymphocytes, Regulatory/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Arthritis, Infectious ; Immunosuppressive Agents
    Chemical Substances Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Immunosuppressive Agents
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.

    Montealegre, Maria Camila / Correa, Adriana / Briceño, David F / Rosas, Natalia C / De La Cadena, Elsa / Ruiz, Sory J / Mojica, Maria F / Camargo, Ruben Dario / Zuluaga, Ivan / Marin, Adriana / Quinn, John P / Villegas, Maria Virginia

    Antimicrobial agents and chemotherapy

    2011  Volume 55, Issue 5, Page(s) 2428–2430

    Abstract: We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located ... ...

    Abstract We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further studies are needed to clarify its epidemiological and clinical impact.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Colombia ; Drug Resistance, Multiple, Bacterial/genetics ; Integrons/genetics ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Plasmids/chemistry ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2011-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01208-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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