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  1. Article ; Online: Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry-based plasma metabolomics study of hepatoprotective effect of cuscutae semen on CCl

    Xu, Shu-Ya / Zhang, Ying / Han, Ting / Li, Xiang-Ri / Li, Li-Hong / Zuo, Li-Jie

    Biomedical chromatography : BMC

    2022  Volume 36, Issue 12, Page(s) e5489

    Abstract: Hepatic disorders are a serious health problem threatening human beings. Cuscutae semen (CS), a widely used Chinese medicine, is a tonic to nourish the liver and kidney. Our research aimed to assess the hepatoprotective effect of CS on ... ...

    Abstract Hepatic disorders are a serious health problem threatening human beings. Cuscutae semen (CS), a widely used Chinese medicine, is a tonic to nourish the liver and kidney. Our research aimed to assess the hepatoprotective effect of CS on CCl
    MeSH term(s) Humans ; Rats ; Mice ; Animals ; Carbon Tetrachloride/toxicity ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury, Chronic/metabolism ; Metabolomics/methods ; Mass Spectrometry/methods ; Chromatography, Liquid ; Liver/metabolism ; Chromatography, High Pressure Liquid ; Biomarkers
    Chemical Substances cuscutae semen ; Carbon Tetrachloride (CL2T97X0V0) ; Biomarkers
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.5489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: [Identification of 3-demethylchuangxinmycin from Actinoplanes tsinanensis CPCC 200056].

    Zuo, Li-jie / Zhao, Wei / Jiang, Zhi-bo / Jiang, Bing-ya / Li, Shu-fen / Liu, Hong-yu / Yu, Li-yan / Hong, Bin / Hu, Xin-xin / You, Xue-fu / Wu, Lin-zhuan

    Yao xue xue bao = Acta pharmaceutica Sinica

    2016  Volume 51, Issue 1, Page(s) 105–109

    Abstract: Chuangxinmycin (CM) from Actinoplanes tsinanensis was an antibiotic discovered by Chinese scientists about 40 years ago. It contains a new heterocyclic system of indole fused with dihydrothiopyran, whose biosynthetic mechanism remains unclear. CM is used ...

    Abstract Chuangxinmycin (CM) from Actinoplanes tsinanensis was an antibiotic discovered by Chinese scientists about 40 years ago. It contains a new heterocyclic system of indole fused with dihydrothiopyran, whose biosynthetic mechanism remains unclear. CM is used as an oral medicine in the treatment of bacterial infections in China. The simple structure makes CM as an attractive candidate of structure modification for improvement of antibacterial activity. Recently, we analyzed the secondary metabolites of Actinoplanes tsinanensis CPCC 200056, a CM producing strain, as a natural CM analogue. We discovered the first natural CM analogue 3-demethylchuangxinmycin (DCM) as a new natural product. Compared to CM, DCM exhibited a much weaker activity in the inhibition of the bacterial strains tested. The finding provides valuable information for the structure-activity relationship in the biosynthesis of CM.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; China ; Indoles/chemistry ; Indoles/isolation & purification ; Micromonosporaceae/chemistry ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Indoles ; chuangxinmycin (63339-68-4)
    Language Chinese
    Publishing date 2016-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 788758-9
    ISSN 0513-4870
    ISSN 0513-4870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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