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  1. Article ; Online: HTLV-1 persistent infection and ATLL oncogenesis.

    Zuo, Xiaorui / Zhou, Ruoning / Yang, Sikai / Ma, Guangyong

    Journal of medical virology

    2023  Volume 95, Issue 1, Page(s) e28424

    Abstract: Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus; whereas HTLV-1 mainly persists in the infected host cell as a provirus, it also causes a malignancy called adult T-cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV-1 ... ...

    Abstract Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus; whereas HTLV-1 mainly persists in the infected host cell as a provirus, it also causes a malignancy called adult T-cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV-1 replication is in most cases silent in vivo and viral de novo infection rarely occurs; HTLV-1 rather relies on clonal proliferation of infected T cells for viral propagation as it multiplies the number of the provirus copies. It is mechanistically elusive how leukemic clones emerge during the course of HTLV-1 infection in vivo and eventually cause the onset of ATLL. This review summarizes our current understanding of HTLV-1 persistence and oncogenesis, with the incorporation of recent cutting-edge discoveries obtained by high-throughput sequencing.
    MeSH term(s) Adult ; Humans ; Leukemia-Lymphoma, Adult T-Cell ; Human T-lymphotropic virus 1/genetics ; Persistent Infection ; T-Lymphocytes ; Carcinogenesis ; Proviruses/genetics ; Cell Transformation, Neoplastic
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.

    Ma, Guangyong / Yasunaga, Jun-Ichirou / Shimura, Kazuya / Takemoto, Keiko / Watanabe, Miho / Amano, Masayuki / Nakata, Hirotomo / Liu, Benquan / Zuo, Xiaorui / Matsuoka, Masao

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 17

    Abstract: Human retroviruses, including human T cell leukemia virus type 1 (HTLV-1) and HIV type 1 (HIV-1), encode an antisense gene in the negative strand of the provirus. Besides coding for proteins, the messenger RNAs (mRNAs) of retroviral antisense genes have ... ...

    Abstract Human retroviruses, including human T cell leukemia virus type 1 (HTLV-1) and HIV type 1 (HIV-1), encode an antisense gene in the negative strand of the provirus. Besides coding for proteins, the messenger RNAs (mRNAs) of retroviral antisense genes have also been found to regulate transcription directly. Thus, it has been proposed that retroviruses likely localize their antisense mRNAs to the nucleus in order to regulate nuclear events; however, this opposes the coding function of retroviral antisense mRNAs that requires a cytoplasmic localization for protein translation. Here, we provide direct evidence that retroviral antisense mRNAs are localized predominantly in the nuclei of infected cells. The retroviral 3' LTR induces inefficient polyadenylation and nuclear retention of antisense mRNA. We further reveal that retroviral antisense RNAs retained in the nucleus associate with chromatin and have transcriptional regulatory function. While HTLV-1 antisense mRNA is recruited to the promoter of C-C chemokine receptor type 4 (
    MeSH term(s) Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Cell Line ; Cell Nucleus/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Viral/genetics ; HIV-1/genetics ; Human Immunodeficiency Virus Proteins/genetics ; Human Immunodeficiency Virus Proteins/metabolism ; Human T-lymphotropic virus 1/genetics ; Humans ; Primary Cell Culture ; Promoter Regions, Genetic/genetics ; Proviruses/genetics ; RNA, Antisense/genetics ; RNA, Antisense/metabolism ; RNA, Messenger/metabolism ; RNA, Viral/genetics ; Retroviridae Proteins/genetics ; Retroviridae Proteins/metabolism ; Terminal Repeat Sequences/genetics ; Transcription, Genetic/genetics ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Viral Proteins/metabolism ; Virus Latency/genetics ; Virus Replication/genetics
    Chemical Substances ASP protein, HIV-1 ; Basic-Leucine Zipper Transcription Factors ; HBZ protein, human T-cell leukemia virus type I ; Human Immunodeficiency Virus Proteins ; RNA, Antisense ; RNA, Messenger ; RNA, Viral ; Retroviridae Proteins ; Viral Envelope Proteins ; Viral Proteins
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2014783118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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