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  1. Book ; Online ; Thesis: Investigations into interferon response of novel bat cell cultures upon alphavirus infection

    Zweerink, Susanne

    2013  

    Author's details vorgelegt von Susanne Elisabeth Zweerink
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Special collection on veterinary medicine and general parasitology

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  2. Book ; Online ; Thesis: Investigations into interferon response of novel bat cell cultures upon alphavirus infection

    Zweerink, Susanne

    2013  

    Author's details vorgelegt von Susanne Elisabeth Zweerink
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  3. Book ; Online ; Thesis: Investigations into interferon response of novel bat cell cultures upon alphavirus infection

    Zweerink, Susanne

    2013  

    Author's details vorgelegt von Susanne Elisabeth Zweerink
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Thesis: Investigations into interferon response of novel bat cell cultures upon alphavirus infection

    Zweerink, Susanne

    2013  

    Author's details vorgelegt von Susanne Elisabeth Zweerink
    Language English
    Size vii, 121 S., Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Bonn, 2013
    Database Special collection on veterinary medicine and general parasitology

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    Inter-library loan at ZB MED

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  5. Article ; Online: Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival.

    Kütting, Fabian / Gebauer, Florian / Zweerink, Susanne / Krämer, Laurenz / Schramm, Christoph / Quaas, Alexander / Bruns, Christiane / Goeser, Tobias / Nierhoff, Dirk

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3584

    Abstract: Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of ... ...

    Abstract Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in the development of invasive capabilities of carcinoma. The oncofetal stem/progenitor cell marker NOPE is expressed in adult depolarized murine hepatocytes and in murine/human hepatocellular carcinoma. We analyzed NOPE expression in 363 patients with esophageal adenocarcinoma using an RNA Scope Assay on a tissue microarray and correlated results with clinical data. Median follow-up was 57.7 months with a 5-year survival rate of 26.6%. NOPE was detectable in 32 patients (8.8%). In pT1/2 stages, NOPE expression was associated with a significantly reduced median OS of 6.3 months (95% CI 1.2-19.4 months), the median OS is not reached in the NOPE-negative group (calculated mean OS 117.1 months) (P = 0.012). In advanced tumor stages, a NOPE dependent survival difference was not detected. This is the first report of NOPE expression demonstrating a prognostic value in esophageal cancer. Early stage, NOPE positive patients are at a high risk of tumor progression and may benefit from neoadjuvant treatment analogous to advanced stage cancer.
    MeSH term(s) Adenocarcinoma/pathology ; Adult ; Animals ; Carcinoma, Hepatocellular/pathology ; Esophageal Neoplasms/pathology ; Humans ; Immunoglobulins/metabolism ; Liver Neoplasms/pathology ; Mice ; Neoadjuvant Therapy ; Neoplasm Staging ; Nerve Tissue Proteins/metabolism ; Prognosis ; Retrospective Studies ; Survival Rate
    Chemical Substances Immunoglobulins ; Nerve Tissue Proteins ; Nope protein, mouse
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07580-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Repolarization Precedes Oval Cell-mediated Hepatocytic Regeneration in the CDE Diet Mouse Model.

    Zweerink, Susanne / Mueck, Vera / Kraemer, Laurenz P / Tischler, Eva / Schulte, Sigrid / Goeser, Tobias / Nierhoff, Dirk

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2022  Volume 70, Issue 5, Page(s) 377–389

    Abstract: The liver has a unique ability to recover from injury unlike any other organ. A poorly understood aspect of liver regeneration is the role of hepatocellular polarization. Neighbor of Punc E11 (Nope) is an oncofetal stem/progenitor cell marker, which is ... ...

    Abstract The liver has a unique ability to recover from injury unlike any other organ. A poorly understood aspect of liver regeneration is the role of hepatocellular polarization. Neighbor of Punc E11 (Nope) is an oncofetal stem/progenitor cell marker, which is expressed by depolarized adult hepatocytes after cholestatic liver injury and in hepatocellular carcinoma. Liver injury induced by a choline-deficient and ethionine-supplemented diet is reversible if followed by an additional dietary stop interval and enabled us to study the expression of Nope during the induction of chronic liver injury and during subsequent liver regeneration. We could show by quantitative RT-PCR, Western blotting, and immunohistochemistry that the expression of Nope is induced in depolarized adult hepatocytes during injury. However, after another 2 weeks of a normal diet, the polarization of hepatocytes was almost completely restored and the expression of Nope remained limited to bile ducts and oval cells. Using an inducible CK19-lineage tracing model, we could demonstrate that oval cell-mediated hepatocyte regeneration is rare and was preceded by repolarization of hepatocytes. In conclusion, polarization of hepatocytes is an important part of liver regeneration and precedes oval cell-mediated regeneration of the liver. This process can be visualized by a characteristic expression pattern of Nope.
    MeSH term(s) Animals ; Diet ; Disease Models, Animal ; Hepatocytes/pathology ; Immunoglobulins ; Liver/pathology ; Liver Neoplasms/metabolism ; Mice ; Nerve Tissue Proteins/metabolism ; Stem Cells/metabolism
    Chemical Substances Immunoglobulins ; Nerve Tissue Proteins ; Nope protein, mouse
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/00221554221084665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Book ; Online ; Thesis: Investigations into Interferon Response of Novel Bat Cell Cultures upon Alphavirus Infection

    Zweerink, Susanne [Verfasser]

    2013  

    Author's details Susanne Zweerink
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Activity-Based Protein Profiling with Natural Product-Derived Chemical Probes in Human Cell Lysates.

    Zweerink, Susanne / Pollmann, Tanja / Ninck, Sabrina / Kaschani, Farnusch / Kaiser, Markus

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1491, Page(s) 23–46

    Abstract: Bioreactive natural products represent versatile starting points for the development of structurally unique activity-based probes. In the present protocol, we describe the workflow for an activity-based protein profiling (ABPP) experiment with an alkyne- ... ...

    Abstract Bioreactive natural products represent versatile starting points for the development of structurally unique activity-based probes. In the present protocol, we describe the workflow for an activity-based protein profiling (ABPP) experiment with an alkyne-tagged natural product derivative. Our protocol includes experimental procedures for in vivo labeling, sample preparation and 2-step (click chemistry) visualization and sample preparation for mass spectrometry-based target identification.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6439-0_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family.

    Krahn, Daniel / Heilmann, Geronimo / Vogel, Felix C E / Papadopoulos, Chrisovalantis / Zweerink, Susanne / Kaschani, Farnusch / Meyer, Hemmo / Roesch, Alexander / Kaiser, Markus

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 39, Page(s) 8524–8531

    Abstract: Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of Ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural ... ...

    Abstract Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of Ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural similarities as well as differences to the argyrin NP family, a class of peptidic NPs with promising anticancer activities and diverse mode-of-action at the molecular level. By a combination of structure elucidation experiments, the first total synthesis of zelkovamycin and bioassays, the zelkovamycin configuration was determined and its previously proposed molecular structure was revised. The full structure assignment proves zelkovamycin as an additional member of the argyrins with however unique OXPHOS inhibitory properties. Zelkovamycin may therefore not only serve as a new starting point for chemical inhibitors of the OXPHOS system, but also guide customized argyrin NP isolation and biosynthesis studies.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Biological Products/chemistry ; Biological Products/pharmacology ; Molecular Structure
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Cationic Peptides ; Biological Products ; zelkovamycin
    Language English
    Publishing date 2020-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202001577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: First evaluation of Neighbor of Punc E11 (NOPE) as a novel marker in human hepatocellular carcinoma.

    Zweerink, Susanne / Mesghenna, Senait / Mueck, Vera / Schulte, Sigrid / Kuetting, Fabian / Quaas, Alexander / Goeser, Tobias / Nierhoff, Dirk

    Cancer biomarkers : section A of Disease markers

    2020  Volume 30, Issue 1, Page(s) 75–83

    Abstract: Background: Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide and the search for clinically useful biomarkers is ongoing. Neighbor of Punc E11 (NOPE) is an established biomarker of murine HCC that remains ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide and the search for clinically useful biomarkers is ongoing. Neighbor of Punc E11 (NOPE) is an established biomarker of murine HCC that remains undetectable in normal liver and at preneoplastic stages.
    Objective: The aim of our study was to evaluate the presence of NOPE in human HCC.
    Methods: Histologically confirmed HCC and corresponding non-tumor liver samples from 20 patients were analyzed for expression of NOPE using qRT-PCR and mRNA-in-situ technology in a conserved tissue context.
    Results: In our cohort, 30% of HCC samples were expressing NOPE which proved particularly useful in non-cirrhotic HCC samples with up to 155-fold higher expression than in adult liver. Using mRNA-in-situ technology, NOPE was clearly identified within epithelial tumor cells of NOPE positive human HCCs. In our analyzed cohort, the combination of AFP with NOPE did not reach more than 40% sensitivity while GPC-3 and NOPE were complementary to each other reaching a combined sensitivity of 85.7%.
    Conclusions: This is the first characterization of NOPE as a potential biomarker for human HCC. Our results underline the value of NOPE as a complementing biomarker for human HCC.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Female ; Humans ; Immunoglobulins/genetics ; Immunoglobulins/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism
    Chemical Substances Biomarkers, Tumor ; IGDCC4 protein, human ; Immunoglobulins ; Nerve Tissue Proteins
    Language English
    Publishing date 2020-10-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-190819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6127: Show issues Location:
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