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  1. Book: Internationales Steuerrecht

    Zweifel, Martin

    (Kommentar zum schweizerischen Steuerrecht ; [...])

    2015  

    Author's details Hrsg.: Martin Zweifel
    Series title Kommentar zum schweizerischen Steuerrecht
    [...]
    Keywords Double taxation ; Income tax/Foreign income ; International business enterprises/Taxation/Law and legislation ; Internationales Steuerrecht ; Schweiz
    Language German
    Size XLIII, 2003 S.
    Publisher Helbing Lichtenhahn
    Publishing place Basel
    Document type Book
    ISBN 3719023001 ; 9783719023003
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: Granulocyte Colony-stimulating Factor Producing Oropharyngeal Squamous Cell Carcinoma.

    Schurmann, Gregory / Zweifel, Martin / Giger, Roland / Rau, Tilman T / Vinzens, Sarah / Dettmer, Matthias S / Kurian, Yojena

    In vivo (Athens, Greece)

    2021  Volume 35, Issue 3, Page(s) 1785–1790

    Abstract: Case report: We report on the case of a 47-year old woman with granulocyte colony-stimulating factor (G-CSF)-producing relapsed oropharyngeal squamous cell cancer. Palliative immunotherapy with nivolumab was started. Absolute neutrophilic count ... ...

    Abstract Case report: We report on the case of a 47-year old woman with granulocyte colony-stimulating factor (G-CSF)-producing relapsed oropharyngeal squamous cell cancer. Palliative immunotherapy with nivolumab was started. Absolute neutrophilic count increased during the course of immunotherapy and correlated with tumour progression. Under chemotherapy with weekly paclitaxel, dramatic tumour regression and decreasing absolute neutrophilic count were noted. G-CSF concentration in serum increased from 4.77 to 9.61 pg/ml during the final phase of tumour progression. Immunohistochemical staining of the initial biopsies showed that some of the tumour cells as well as infiltrating cells stained positively for G-CSF, and some of the tumour cells even stained positively for the G-CSF receptor.
    Conclusion: Leukaemoid reaction in malignant disease with increased neutrophilic granulocytes has been shown to correlate with dismal prognosis in other tumours. The role of G-CSF in progression and prognosis of head and neck squamous cell carcinomas is still unclear but in patients with these tumours there seems also to be a correlation between elevated G-CSF and poor prognosis. Further systematic evaluation of G-CSF secretion in this tumour entity should clarify the role and potential treatment possibilities for these tumours.
    MeSH term(s) Female ; Granulocyte Colony-Stimulating Factor ; Head and Neck Neoplasms ; Humans ; Leukocyte Count ; Middle Aged ; Prognosis ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2021-04-28
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
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  3. Book: Bundesgesetz über die direkte Bundessteuer (DBG)

    Zweifel, Martin / Zweifel-Athanas

    Art. 1 - 82

    (Kommentar zum schweizerischen Steuerrecht ; / Hrsg. Martin Zweifel ... ; I/2a)

    2008  

    Series title Kommentar zum schweizerischen Steuerrecht
    / Hrsg. Martin Zweifel ... ; I/2a
    Language German
    Size XXXVI, 1272 S
    Edition 2. Aufl
    Publisher Helbing & Lichtenhahn
    Publishing place Basel u.a.
    Document type Book
    Note Literaturverz. S. XXXI - XXXVI
    ISBN 9783719025090 ; 3719025098
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Bundesgesetz über die direkte Bundessteuer (DBG)

    Zweifel, Martin / Zweifel-Athanas

    Art. 83 - 222

    (Kommentar zum schweizerischen Steuerrecht ; / Hrsg. Martin Zweifel ... ; 1,2,B)

    2008  

    Series title Kommentar zum schweizerischen Steuerrecht
    / Hrsg. Martin Zweifel ... ; 1,2,B
    Language German
    Size XXXV, 1164 S
    Edition 2. Aufl.
    Publisher Helbing Lichtenhahn
    Publishing place Basel u.a.
    Document type Book
    Note Literaturverz. S. XXXI - XXXV
    ISBN 9783719025090 ; 3719025098
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy.

    Scherz, Amina / Feller, Katrin / Berezowska, Sabina / Genitsch, Vera / Zweifel, Martin

    Anticancer research

    2017  Volume 37, Issue 6, Page(s) 3111–3115

    Abstract: We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Magnetic ... ...

    Abstract We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Magnetic resonance imaging of the brain showed a 14×8.4 mm enhancing lesion of the pituitary stalk and histopathology of the neurosurgical biopsy confirmed pituitary germinoma. The patient was treated with 3 cycles of chemotherapy, consisting of 150 mg/m
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/analysis ; Biopsy ; Bleomycin/administration & dosage ; Cisplatin/administration & dosage ; Drug Administration Schedule ; Etoposide/administration & dosage ; Germinoma/chemistry ; Germinoma/diagnostic imaging ; Germinoma/drug therapy ; Germinoma/pathology ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Male ; Methotrexate/administration & dosage ; Pituitary Neoplasms/chemistry ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/drug therapy ; Pituitary Neoplasms/pathology ; Remission Induction ; Time Factors ; Treatment Outcome ; Vincristine/administration & dosage
    Chemical Substances Biomarkers, Tumor ; Bleomycin (11056-06-7) ; Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Cisplatin (Q20Q21Q62J) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2017
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.11668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Biologicals in the upfront treatment of ovarian cancer: focus on bevacizumab and poly (adp-ribose) polymerase inhibitors.

    Roux, Rene / Zweifel, Martin / Rustin, Gordon J S

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2014  , Page(s) 340–344

    Abstract: Biologicals have made a major impact in the management of several cancers, but have hitherto had a negligible impact in ovarian cancer. Fortunately, ovarian cancer has been much more sensitive to cytotoxic chemotherapy than many cancers, so treatments ... ...

    Abstract Biologicals have made a major impact in the management of several cancers, but have hitherto had a negligible impact in ovarian cancer. Fortunately, ovarian cancer has been much more sensitive to cytotoxic chemotherapy than many cancers, so treatments were still available. However, improvements are required as more than 80% of patients who present with advanced ovarian cancer eventually will die as a result of their disease. The antiangiogenic antibody bevacizumab and the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib have recently been shown to improve progression-free survival of patients with ovarian cancer with better hazard ratios in certain groups than have been seen previously.
    Language English
    Publishing date 2014-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.14694/EdBook_AM.2012.32.340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perfusion MRI in the early clinical development of antivascular drugs: decorations or decision making tools?

    Zweifel, Martin / Padhani, Anwar R

    European journal of nuclear medicine and molecular imaging

    2010  Volume 37 Suppl 1, Page(s) S164–82

    Abstract: Introduction: Classically, the first step in the clinical development of drugs in oncology involves assessments of dose limiting toxicity (DLT) and maximum tolerated dose (MTD). New paradigms are needed for antiangiogenic drugs and vascular disrupting ... ...

    Abstract Introduction: Classically, the first step in the clinical development of drugs in oncology involves assessments of dose limiting toxicity (DLT) and maximum tolerated dose (MTD). New paradigms are needed for antiangiogenic drugs and vascular disrupting agents (VDAs) as they are active at doses well below the MTD and as single agents their use might not translate into anti-tumour efficacy. MRI is able to assess the antivascular effects of antivascular drugs via changes in functional kinetic parameters; however, the usefulness of MRI in decision making has been questioned by many.
    Objectives: Our aim is to review the experience of using dynamic contrast-enhanced MRI (DCE-MRI) in early clinical development of vascular directed anticancer therapies over the last decade. Thirty-nine phase I and II studies including data on more than 700 patients have been published as abstracts and/or papers, documenting DCE-MRI changes after the administration of antiangiogenic drugs and VDAs.
    Discussion: Perfusion MRI is helpful in assessing whether mechanistic goals are achieved, in assisting dose selection for phase II studies, in selecting subpopulations enriched for response and in predicting patient benefit. Imaging tools are increasingly available. Future challenges for imaging include correlation with clinical measures of efficacy and determining relationships with blood and serum biomarkers.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Animals ; Blood Vessels/drug effects ; Blood Vessels/physiopathology ; Contrast Media ; Decision Making ; Drug Discovery/methods ; Humans ; Magnetic Resonance Angiography/methods ; Neoplasms/blood supply ; Neoplasms/diagnosis ; Neoplasms/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Contrast Media
    Language English
    Publishing date 2010-05-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-010-1451-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Do Not Give Up.

    Roux, René Lynnette / Hall, Marcia Rosalind / Rustin, Gordon John Sampson / Zweifel, Martin

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2015  Volume 27, Issue 6, Page(s) 1060–1062

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Cancer Survivors ; Carcinoma, Endometrioid/drug therapy ; Carcinoma, Endometrioid/pathology ; Carcinoma, Endometrioid/surgery ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Drug Resistance, Neoplasm ; Female ; Humans ; Life Expectancy ; Middle Aged ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Platinum Compounds/administration & dosage ; Recurrence ; Time Factors
    Chemical Substances Antineoplastic Agents ; Platinum Compounds
    Language English
    Publishing date 2015-11-12
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1097/IGC.0000000000000584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Granulocyte Colony-stimulating Factor Producing Anaplastic Carcinoma of the Pancreas: Case Report and Review of the Literature.

    Vinzens, Sarah / Zindel, Joel / Zweifel, Martin / Rau, Tilman / Gloor, Beat / Wochner, Annette

    Anticancer research

    2017  Volume 37, Issue 1, Page(s) 223–228

    Abstract: We report on the case of a 67-year-old man with granulocyte colony-stimulating factor (G-CSF) producing anaplastic carcinoma of the pancreas. Preoperative routine tests revealed an elevated white blood cell (WBC) count of 25.2 G/l, consisting almost ... ...

    Abstract We report on the case of a 67-year-old man with granulocyte colony-stimulating factor (G-CSF) producing anaplastic carcinoma of the pancreas. Preoperative routine tests revealed an elevated white blood cell (WBC) count of 25.2 G/l, consisting almost exclusively of neutrophilic granulocytes (23.31 G/l) with a predominance of segmented neutrophils (78% of all neutrophilic granulocytes), and elevated levels of C-reactive protein at 87 mg/l. Upon surgery, local tumour infiltration was more extensive than expected from preoperative imaging. However, no peritoneal dissemination was found and curative resection was attempted. Only seven days after the operation, signs of relapse were seen upon computed tomograpy. Histology revealed an undifferentiated anaplastic carcinoma, on the basis of a poorly differentiated ductal adenocarcinoma. Immunohistochemistry demonstrated G-CSF and G-CSF-Receptor expression in some CD68-positive syncytial macrophages. Granulocyte colony-stimulating factor (G-CSF) in serum was elevated at 5.6 pg/ml, which further raised to 43 pg/ml one week after FOLFIRINOX chemotherapy (oxaliplatin, irinotecan, 5-fluorouracil), while WBC decreased from 103.3 G/l to 59.3 G/l. Granulocyte macrophage-colony stimulating factor (GM-CSF) in serum was normal (<0.5 pg/ml). The patient died on postoperative day 34.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Carcinoma/blood ; Carcinoma/diagnostic imaging ; Carcinoma/drug therapy ; Carcinoma/metabolism ; Female ; Fluorouracil/therapeutic use ; Granulocyte Colony-Stimulating Factor/blood ; Granulocyte Colony-Stimulating Factor/metabolism ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Organoplatinum Compounds/therapeutic use ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Receptors, Granulocyte Colony-Stimulating Factor/metabolism ; Tomography Scanners, X-Ray Computed
    Chemical Substances Organoplatinum Compounds ; Receptors, Granulocyte Colony-Stimulating Factor ; oxaliplatin (04ZR38536J) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; irinotecan (7673326042) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2017
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.11310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Kommentar zum schweizerischen Steuerrecht

    Zweifel, Martin

    1997  

    Author's details Hrsg. Martin Zweifel
    Keywords Steuerrecht ; Schweiz
    Language German
    Dates of publication 1997-9999
    Publisher Helbing & Lichtenhahn
    Publishing place Basel u.a.
    Document type Book
    Note Literaturangaben ; Später ohne Bandzählung
    ISBN 3719017206 ; 9783719017200
    Database Former special subject collection: coastal and deep sea fishing

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