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  1. Book ; Thesis: Serumkinetik und Funktion des Lipopolysaccharid (LPS)-bindenden Proteins (LBP) in der humanen Sepsis und bei traumainduzierter inflammatorischer Aktivität

    Zweigner, Janine

    2003  

    Author's details von Janine Zweigner
    Language German
    Size 123 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2003
    HBZ-ID HT013730704
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 1392 order for loan Magazin

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  2. Article: Hygieneprobleme in der Radiologie und ihre Prävention

    Zweigner, Janine / Meißner, Arne

    Krankenhaushygiene up2date

    2023  Volume 18, Issue 04, Page(s) 349–367

    Keywords Infektionsprävention ; Kontamination ; interventionelle Radiologie ; Erreger ; Hygiene ; Ausbruch
    Language German
    Publishing date 2023-11-27
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2242136-1
    ISSN 1862-5800 ; 1862-5797
    ISSN (online) 1862-5800
    ISSN 1862-5797
    DOI 10.1055/a-1193-4061
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    Zs.A 6477: Show issues Location:
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  3. Book ; Online: Management von COVID-19 Verdachtsfällen im Krankenhaus

    Kochanek, Matthias / Zweigner, Janine / Klein, Florian / Meißner, Arne Matthias Kurt / Kolibay, Felix / Fätkenheuer, Gerd / Deppe, Antje-Christin / Jung, Norma / Rybniker, Jan

    2020  

    Abstract: Im aufgeführten Algorithmus wird das interhospitale Management von COVID-19 Verdachtsfälle beschrieben. Es dient der Identifikation, Abklärung und Isolation bzw. Kohortierung von entsprechenden Fällen im Krankenhaus inklusive der Quarantäne-Bedingungen ... ...

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Matthias Kochanek, Janine Zweigner, Florian Klein, Arne Meissner, Felix Kolibay, Gerd Fätkenheuer, Antje Deppe, Norma Jung, Jan Rybniker ; Universitätsklinikum Köln, Klinik I für Innere Medizin
    Abstract Im aufgeführten Algorithmus wird das interhospitale Management von COVID-19 Verdachtsfälle beschrieben. Es dient der Identifikation, Abklärung und Isolation bzw. Kohortierung von entsprechenden Fällen im Krankenhaus inklusive der Quarantäne-Bedingungen und Vorraussetzung für die Beendigung der Quarantäne. Der Algorithmus wurde in Kooperation der Krankenhaushygiene, Intensivmedizin, Infektiologie und Virologie erstellt.
    Keywords COVID-19
    Subject Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
    Subject code 610
    Language German
    Size 1 Online-Ressource (1 Seite), Diagramme
    Publisher Universitätsklinikum Köln, Klinik I für Innere Medizin
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020459100
    DOI 10.4126/FRL01-006421043
    Database Repository for Life Sciences

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  4. Article ; Online: Usefulness of screening for Candida auris colonisation in international patients admitted to a large university hospital.

    Heindel, Judith / Zweigner, Janine / Fuchs, Frieder / Hamprecht, Axel

    Mycoses

    2022  

    Abstract: Introduction: Candida auris is an emerging pathogen in health care-associated infections. In contrast to many other countries with rising numbers of C. auris, only seven cases have been reported in Germany from 2015 to 2017, mostly from patients who ... ...

    Abstract Introduction: Candida auris is an emerging pathogen in health care-associated infections. In contrast to many other countries with rising numbers of C. auris, only seven cases have been reported in Germany from 2015 to 2017, mostly from patients who received prior medical treatment abroad. We therefore established a mandatory screening for C. auris colonisation at our tertiary care centre for all patients who were admitted as international patients or previously hospitalised in a foreign country within the past 6 months.
    Methods: Colonisation of patients was assessed using a previously established screening protocol for multidrug resistant bacteria. Since 2017, all screening samples were additionally analysed for C. auris using CHROMagar Candida (CHROMagar, Paris, France). Yeast isolates were identified using matrix-assisted laser ionisation time-of-flight (MALDI TOF), except for C. albicans (identified by the typical green colour on chromogenic agar). Data were analysed retrospectively.
    Results: Our study cohort included 655 patients and an overall number of 1399 samples. Fifty-three patients were colonised with Candida species (C. albicans, n = 37; C. glabrata, n = 14; others n = 9). No case of C. auris was detected. Candida spp. were mainly detected from respiratory samples (5.4% positive) and gastrointestinal specimen (5.2%). Laboratory costs were 14,689 € and analyses resulted in 98.7 h of additional technician's work.
    Conclusion: No colonisation with C. auris was detected among patients with previous hospitalisation abroad. Universal C. auris screening of patients with any contact to foreign health care does not seem to be cost-effective in our setting and more targeted screening strategies have to be developed.
    Language English
    Publishing date 2022-09-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13533
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  5. Article ; Online: Lack of monkeypox virus (MPXV) transmission despite occupational exposure of a large number of health care workers.

    Wetsch, Wolfgang A / Heger, Eva / Drinhaus, Hendrik / Böttiger, Bernd W / Overbeek, Remco / Lehmann, Clara / Fätkenheuer, Gerd / Jung, Norma / Fischer, Julia / Kneifel, Jens / Zweigner, Janine / Klein, Florian / Wieland, Ulrike

    Journal of medical virology

    2024  Volume 96, Issue 1, Page(s) e29353

    MeSH term(s) Humans ; Monkeypox virus/genetics ; Mpox (monkeypox)/epidemiology ; DNA, Viral ; Health Personnel ; Occupational Exposure
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29353
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  6. Article ; Online: Molds and More: Rare Fungal Infections in Preterm Infants <24 Weeks of Gestation.

    Mehler, Katrin / Cornely, Oliver / Seifert, Harald / Zweigner, Janine / Janssen, Saskia / Oberthuer, André

    The Pediatric infectious disease journal

    2021  Volume 41, Issue 4, Page(s) 352–357

    Abstract: Background: Extreme immature infants are at an increased risk of fungal infection due to immaturity of the skin barrier and the immune system. Besides Candida infections, in particular, Aspergillus may cause life-threatening diseases in preterm infants. ...

    Abstract Background: Extreme immature infants are at an increased risk of fungal infection due to immaturity of the skin barrier and the immune system. Besides Candida infections, in particular, Aspergillus may cause life-threatening diseases in preterm infants. Frequently, Aspergillus primarily affects the skin and may cause extensive damage.
    Methods: We searched our hospital database for fungal infections other than Candida in preterm infants treated between 2015 and 2020 at our level III neonatal intensive care unit of the University Hospital of Cologne.
    Results: In total, 13 preterm infants were identified. Of these, 11 had cutaneous Aspergillosis, one infant had severe enterocolitis caused by Aspergillus and Rhizopus and one had invasive intraabdominal Trichosporon mucoides infection. All infants were born <24 weeks of gestation, were delivered due to premature labor or chorioamnionitis, and had received prenatal steroids and/or hydrocortisone. Voriconazole and liposomal Amphotericin B were first-line treatments and the length of treatment varied between 3 and 148 days. Two infants died associated with severe infection. Liver toxicity was observed in six infants treated with Voriconazole. Therapeutic drug management for Voriconazole was performed in four infants. Target levels were not achieved by the doses that are recommended.
    Conclusions: Rare fungal infections, predominantly cutaneous Aspergillosis affects the most immature preterm infants and may cause severe disease. Treatment with Voriconazole has a high rate of liver toxicity and target levels are difficult to achieve in extremely immature infants.
    MeSH term(s) Antifungal Agents/therapeutic use ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Female ; Fungi ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Premature, Diseases/drug therapy ; Infant, Premature, Diseases/epidemiology ; Mycoses/drug therapy ; Mycoses/epidemiology ; Pregnancy ; Voriconazole/therapeutic use
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003407
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  7. Article: Rate of antibiotic prescriptions in German outpatient care - are the guidelines followed or are they still exceeded?

    Zweigner, Janine / Meyer, Elisabeth / Gastmeier, Petra / Schwab, Frank

    GMS hygiene and infection control

    2018  Volume 13, Page(s) Doc04

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2018-03-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2717852-3
    ISSN 2196-5226
    ISSN 2196-5226
    DOI 10.3205/dgkh000310
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  8. Article ; Online: Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections.

    Dewald, Felix / Detmer, Susanne / Pirkl, Martin / Hellmich, Martin / Heger, Eva / Herrmann, Maximilian / Lehmann, Clara / Zweigner, Janine / Klein, Florian

    The Journal of infectious diseases

    2022  Volume 226, Issue 10, Page(s) 1721–1725

    Abstract: To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were ... ...

    Abstract To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Viral Load ; Serologic Tests ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac290
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  9. Article: Multiresistente gramnegative Erreger in der Pädiatrie

    Zweigner, Janine / Simon, Arne

    Pädiatrie up2date

    2017  Volume 12, Issue 02, Page(s) 123–137

    Keywords multiresistente gramnegative Erreger ; Antibiotikaresistenz ; Infektionsprävention ; 3MRGN ; 4MRGN
    Language German
    Publishing date 2017-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2256194-8
    ISSN 1862-9393 ; 1611-6445
    ISSN (online) 1862-9393
    ISSN 1611-6445
    DOI 10.1055/s-0043-101269
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    Zs.A 6448: Show issues Location:
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  10. Article ; Online: Rate of antibiotic prescriptions in German outpatient care – are the guidelines followed or are they still exceeded?

    Zweigner, Janine / Meyer, Elisabeth / Gastmeier, Petra / Schwab, Frank

    GMS Hygiene and Infection Control, Vol 13, p Doc

    2018  Volume 04

    Abstract: Aim: The consequences of antibiotic overuse are substantial. We combined and analyzed the infection diagnoses and antibiotic prescribing practices of physicians in outpatient settings. Recommendations for targeting policy efforts to focused areas are ... ...

    Abstract Aim: The consequences of antibiotic overuse are substantial. We combined and analyzed the infection diagnoses and antibiotic prescribing practices of physicians in outpatient settings. Recommendations for targeting policy efforts to focused areas are given. Methods: Antibiotic prescriptions and infections diagnosed were provided by a German statutory health insurance provider over a 12-month period. Antibiotic use was expressed as prescriptions per 100 patients.Results: 2,594,000 patient-physician contacts within twelve months were analyzed. A median of 6.5 antibiotics was prescribed to 100 patients. Antibiotic use in private practice showed large variations between and within medical specialties (the upper quarter of physicians who prescribed above the 75 percentile of all prescriptions, at a rate of approximately 43%), by season (antibiotic prescription was 50% higher in winter than in summer) and a considerable proportion of the antibiotics prescribed did not conform with the recommendations of national guidelines. Fluoroquinolones, predominantly ciprofloxacin, were among the top three antibiotics prescribed by all physicians (except pediatricians), although national guidelines do not recommend these agents for uncomplicated respiratory or urinary tract infections. Respiratory tract infections headed the list for the prescription of antibiotics.Conclusions: Antibiotics were still not prescribed appropriately in respect to indication and selection (often unnecessary and/or too broad). We recommend focusing on I) high/over-prescribers, because improved and appropriate antibiotic prescription by this group would result in an over-proportionally lower antibiotic prescription rate, II) respiratory tract infections, because they represent the vast majority of infections treated in primary care and III) intelligent implementation strategies of guidelines.
    Keywords outpatient setting ; antibiotic prescribing ; general practitioner ; over-prescribers ; infection ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Microbiology ; QR1-502
    Subject code 610
    Language German
    Publishing date 2018-03-01T00:00:00Z
    Publisher German Medical Science GMS Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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