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  1. Article ; Online: In vitro

    Farfour, Eric / d'Epenoux, Louise Ruffier / Muggeo, Anaëlle / Alauzet, Corentine / Crémet, Lise / Moussalih, Sophie / Roux, Antoine / de Verdière, Sylvie C / Bosphore, Amélie / Corvec, Stéphane / Guillard, Thomas / Vasse, Marc

    Future microbiology

    2023  Volume 18, Page(s) 117–126

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Meropenem/pharmacology ; Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacteria ; Stenotrophomonas maltophilia ; Burkholderia cepacia complex ; Microbial Sensitivity Tests
    Chemical Substances Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents ; vaborbactam (1C75676F8V) ; delafloxacin (6315412YVF)
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2021-0278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales.

    Jousset, Agnès B / Bernabeu, Sandrine / Emeraud, Cécile / Bonnin, Rémy A / Lomont, Alexandra / Zahar, Jean Ralph / Merens, Audrey / Isnard, Christophe / Soismier, Nathalie / Farfour, Eric / Fihman, Vincent / Yin, Nicolas / Barraud, Olivier / Jacquier, Hervé / Ranc, Anne-Gaëlle / Laurent, Frédéric / Corvec, Stéphane / d'Epenoux, Louise Ruffier / Bille, Emmanuelle /
    Degand, Nicolas / Plouzeau, Chloé / Guillard, Thomas / Cattoir, Vincent / Mizrahi, Asaf / Grillon, Antoine / Janvier, Frédéric / Brun, Cécile Le / Amara, Marlène / Bastide, Mathilda / Lemonnier, Alban / Dortet, Laurent

    Journal of global antimicrobial resistance

    2023  Volume 32, Page(s) 78–84

    Abstract: Objectives: Ceftolozane-tazobactam (C/T) proved its efficacy for the treatment of infections caused by non-carbapenemase producing Pseudomonas aeruginosa and Enterobacterales. Here, we aimed to provide susceptibility data on a large series of ... ...

    Abstract Objectives: Ceftolozane-tazobactam (C/T) proved its efficacy for the treatment of infections caused by non-carbapenemase producing Pseudomonas aeruginosa and Enterobacterales. Here, we aimed to provide susceptibility data on a large series of Enterobacterales since the revision of EUCAST categorization breakpoints in 2020.
    Methods: First, C/T susceptibility was determined on characterized Enterobacterales resistant to third generation cephalosporins (3GCs) (extended spectrum β-lactamase [ESBL] production or different levels of AmpC overexpression) (n = 213) and carbapenem-resistant Enterobacterales (CRE) (n = 259), including 170 carbapenemase producers (CPE). Then, 1632 consecutive clinical Enterobacterales responsible for infection were prospectively collected in 23 French hospitals. C/T susceptibility was determined by E-test® (biomérieux) and broth microdilution (BMD) (Sensititre™, Thermo Scientific) to perform method comparison.
    Results: Within the collection isolates, 88% of 3GC resistant strains were susceptible to C/T, with important variation depending on the resistance mechanism: 93% vs. 13% susceptibility for CTX-M and SHV-ESBL producers, respectively. Only 20% of the CRE were susceptible to C/T. Among CPE, 80% of OXA-48-like producers were susceptible to C/T, whereas all metallo-β-lactamase producers were resistant. The prospective study revealed that 95.6% of clinical isolates were susceptible to C/T. Method comparison performed on these 1632 clinical isolates demonstrated 99% of categorization agreement between MIC to C/T determined by E-test® in comparison with the BMD (reference) and only 74% of essential agreement.
    Conclusion: Overall, C/T showed good activity against wild-type Enterobacterales, AmpC producers, and ESBL-producing Escherichia coli but is less active against ESBL-producing Klebsiella pneumoniae, and CRE. E-test® led to an underestimation of the MICs in comparison to the BMD reference.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Prospective Studies ; Enterobacteriaceae/genetics ; Pseudomonas aeruginosa ; Pseudomonas Infections/drug therapy ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Tazobactam/pharmacology ; Tazobactam/therapeutic use ; Escherichia coli ; beta-Lactamases/genetics
    Chemical Substances ceftolozane (37A4IES95Q) ; Anti-Bacterial Agents ; Cephalosporins ; ceftolozane, tazobactam drug combination ; Tazobactam (SE10G96M8W) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-01-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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