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  1. Article: Occupational Risk for Coronary Artery Disease in Shift Workers - A Systematic Review.

    D'Ettorre, Gabriele / Piscitelli, Prisco / Pellicani, Vincenza / Tornese, Roberta / Ceccarelli, Giancarlo / D'Ettorre, Gabriella / La Torre, Giuseppe

    La Medicina del lavoro

    2024  Volume 115, Issue 2, Page(s) e2024015

    Abstract: Background: Coronary artery disease (CAD) prevention in shift workers (SWs) poses a significant challenge worldwide, as CAD remains a major cause of mortality and disability. In the past, SWs were found at higher risk of CAD than non-s SWs. Nevertheless, ...

    Abstract Background: Coronary artery disease (CAD) prevention in shift workers (SWs) poses a significant challenge worldwide, as CAD remains a major cause of mortality and disability. In the past, SWs were found at higher risk of CAD than non-s SWs. Nevertheless, the pathogenic mechanism between shift work and CAD to date is unclear. This systematic review aims to enhance understanding of the risk of CAD occurrence in SWs.
    Methods: A systematic literature review was conducted from January 2013 to December 2023. MEDLINE/Pubmed databases were used initially, and additional relevant studies were searched from references. Shift work was defined as any schedule outside traditional shifts, including the night shift.
    Results: Fifteen pertinent papers were categorized into risk assessment or risk management. Findings demonstrated an increased risk of CAD among SWs compared to non-SWs, with an increased CAD risk observed for both shift work and night shift work.
    Discussion: Duration-response associations indicate that greater shift exposure is linked to higher CAD risk. SWs incur an increased risk of CAD through the atherosclerotic process. As shift work duration increases as the risk of atherosclerosis is higher, workers demonstrate a higher prevalence and severity of coronary artery plaques.
    Conclusions: The evidence-based results underscore the increased risk of CAD in SWs and are sufficient for proposing guidelines aimed at reducing the risk of CAD in SWs and at managing people with CAD in return to work characterized by disrupted circadian rhythms.
    MeSH term(s) Humans ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/etiology ; Shift Work Schedule/adverse effects ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Risk Factors ; Risk Assessment ; Work Schedule Tolerance
    Language English
    Publishing date 2024-04-24
    Publishing country Italy
    Document type Systematic Review ; Journal Article
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v115i2.15532
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  2. Article ; Online: Dysbiosis in SARS-CoV-2-Infected Patients.

    Marazzato, Massimiliano / Ceccarelli, Giancarlo / d'Ettorre, Gabriella

    Gastroenterology

    2020  Volume 160, Issue 6, Page(s) 2195

    MeSH term(s) COVID-19 ; Dysbiosis ; Hospitalization ; Humans ; Mycobiome ; Patient Discharge ; SARS-CoV-2
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.12.056
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  3. Article ; Online: Time to Effective Therapy Is an Important Determinant of Survival in Bloodstream Infections Caused by Vancomycin-Resistant

    Russo, Alessandro / Picciarella, Alice / Russo, Roberta / d'Ettorre, Gabriella / Ceccarelli, Giancarlo

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: Enterococcal bloodstream infections (EBSI) caused by vancomycin-resistant enterococci (VRE) are associated with a significant rate of unfavorable outcomes. No definitive data have been reported about the association between delayed antibiotic therapy and ...

    Abstract Enterococcal bloodstream infections (EBSI) caused by vancomycin-resistant enterococci (VRE) are associated with a significant rate of unfavorable outcomes. No definitive data have been reported about the association between delayed antibiotic therapy and mortality. In this prospective observational study in three large hospitals in Italy (from August 2016 to April 2021), all consecutive hospitalized patients with a confirmed diagnosis of hospital-acquired monomicrobial BSI caused by VRE—with no evidence of endocarditis—were analyzed. Cox regression analysis showed that risk factors independently associated with 30-day mortality were age (HR 2.98, CI95% 1.44−6.81, p = 0.002), chronic kidney disease (HR 5.21, CI95% 1.48−22.23, p = 0.001), oncologic disease (HR 2.81, CI95% 1.45−19.8, p = 0.005), and intensive care unit admission (HR 3.71, CI95% 2.23−7.99, p < 0.001). Conversely, early effective therapy was associated with survival (HR 0.32, CI95% 0.38−0.76, p < 0.001). The administration of early effective antibiotic therapy within 48 h from blood culture collection was associated with 30-day mortality rates lower than 33%. Time from blood culture collection to appropriate therapy was an independent predictor of 30-day mortality in patients with EBSI caused by VRE. Based on these data, clinicians should start effective antibiotic therapy as soon as possible, preferably within the first 48 h from blood culture collection. Treatment strategies allowing the early delivery of in vitro active antibiotics are urgently needed, especially in critically ill patients at risk of VRE bacteremia.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Retrospective Studies ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Vancomycin Resistance ; Vancomycin-Resistant Enterococci
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911925
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  4. Article ; Online: SARS-CoV-2 pandemic, influenza, and influenza-like illness epidemics: Allies or enemies?

    Ceccarelli, Giancarlo / d'Ettorre, Gabriele / Russo, Alessandro / Fabris, Silvia / Ciccozzi, Massimo / d'Ettorre, Gabriella

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28148

    MeSH term(s) Humans ; SARS-CoV-2 ; Influenza, Human/epidemiology ; Pandemics ; COVID-19/epidemiology ; Virus Diseases ; Epidemics
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28148
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  5. Article ; Online: Comment on: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study.

    Ciccullo, Arturo / Baldin, Gianmaria / Sterrantino, Gaetana / Madeddu, Giordano / D'ettorre, Gabriella / Mussini, Cristina / Di Giambenedetto, Simona

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 7, Page(s) 1808–1809

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Oxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/adverse effects ; Pyridones/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad151
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    Zs.MO 124: Show issues

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  6. Article ; Online: Early recognition of a superinfection: This is the problem in the critically ill COVID-19 patients.

    Alessandri, Francesco / d'Ettorre, Gabriella / Ciccozzi, Massimo / Migliara, Giuseppe / Baccolini, Valentina / Pugliese, Francesco / Ceccarelli, Giancarlo

    Journal of medical virology

    2023  Volume 96, Issue 1, Page(s) e29345

    MeSH term(s) Humans ; COVID-19/diagnosis ; Critical Illness ; Superinfection/diagnosis ; SARS-CoV-2
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29345
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  7. Article: The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy).

    Fracella, Matteo / Oliveto, Giuseppe / Roberto, Piergiorgio / Cinti, Lilia / Gentile, Massimo / Coratti, Eleonora / D'Ettorre, Gabriella / Cavallari, Eugenio Nelson / Romano, Francesco / Santinelli, Letizia / Maddaloni, Luca / Frasca, Federica / Scagnolari, Carolina / Antonelli, Guido / Pierangeli, Alessandra

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal infections in ... ...

    Abstract Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal infections in groups at different risk for anal cancer has not been well described in Italy. This retrospective study reports the results of HPV DNA testing and complete genotyping performed on anal swabs from 691 female and male patients attending proctology clinics in Rome during 2012-2021; one-third had repeated testing. Cumulative HPV positivity in 1212 anal swabs was approximately 60%, was not age related, and showed an increasing trend over the study period. HPV rates differed significantly by sex and HIV status: HIV-negative women had the lowest (43.6%) and HIV-positive men the highest (83.5%) HPV prevalence. HIV-positive men had more oncogenic HPV genotypes detected, more multiple infections, and the highest frequency of persistent infections. Two-thirds of all infections were vaccine-preventable. This study found that anal HPV infection rates are still elevated and even increasing in groups at low and high risk of developing anal cancer. Prevention programs need to be improved to reduce rates of anal infection in young women and men.
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020163
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  8. Article: Lesson learned from the 2017 measles outbreak in Italy: report from an emergency department.

    Spagnolello, Ornella / Russo, Alessandro / Borrazzo, Cristian / d'Ettorre, Gabriella / Ceccarelli, Giancarlo

    Le infezioni in medicina

    2021  Volume 29, Issue 2, Page(s) 252–258

    Abstract: Measles is a preventable disease still responsible for a number of outbreaks worldwide. Although most adults with measles recover uneventfully, measles-related complications may occur. However, as to whether every complicated case requires hospital ... ...

    Abstract Measles is a preventable disease still responsible for a number of outbreaks worldwide. Although most adults with measles recover uneventfully, measles-related complications may occur. However, as to whether every complicated case requires hospital management is still a point of debate. In this study we described the rate, clinical features and severity of measles complications in patients admitted to the ED of a tertiary-care teaching hospital during the outbreak that took place in 2017. Some insights into the impact on the health care system are reported as well. A retrospective cohort study was performed. Medical records of adults discharged from January to December 2017 with diagnosis of "measles" were collected and analyzed. Out of 58,579 of ED admissions, 162 measles cases were enrolled. Acute measles infection was laboratory confirmed in 71.6% and deemed as possible/probable in 24.0% of cases. Three percent of patients were immunocompromised while 1.2% of cases occurred in pregnant women. Of all complications reported (37%), hepatitis was the most frequent (29%) followed by pneumonia (10.4%), keratitis (3.8%), thrombocytopenia (3.8%) and otitis media (0.6%). No significant clinical and laboratory difference emerged between complicated and non-complicated cases besides antibiotic prescription (80.0% vs 66.3%; p=0.039). The course of the disease was mild, and no life-threatening measles-related complications or critical care support were reported. One out of three measles cases may experience at least one measles-related complication. However, the course of the disease seems to be rather benign in young adults, and the widespread use of the ED and hospitalization observed seem an inappropriate approach to the issue.
    MeSH term(s) Disease Outbreaks ; Emergency Service, Hospital ; Hospitalization ; Humans ; Italy/epidemiology ; Measles/epidemiology ; Measles/prevention & control ; Vaccination
    Language English
    Publishing date 2021-06-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
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  9. Article ; Online: Early antibiotic treatment in emergency department: the critical balance.

    Russo, Alessandro / Venditti, Mario / Ceccarelli, Giancarlo / Mastroianni, Claudio Maria / d'Ettorre, Gabriella

    Internal and emergency medicine

    2021  Volume 16, Issue 7, Page(s) 1743–1745

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Emergency Service, Hospital ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-06
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02779-9
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  10. Article ; Online: Procalcitonin in daily clinical practice: an evergreen tool also during a pandemic.

    Russo, Alessandro / Venditti, Mario / Ceccarelli, Giancarlo / Mastroianni, Claudio Maria / d'Ettorre, Gabriella

    Internal and emergency medicine

    2021  Volume 16, Issue 3, Page(s) 541–543

    MeSH term(s) Biomarkers ; Humans ; Pandemics ; Procalcitonin ; Protein Precursors
    Chemical Substances Biomarkers ; Procalcitonin ; Protein Precursors
    Language English
    Publishing date 2021-02-12
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02659-2
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