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  1. Article ; Online: Racial inequalities in multimorbidity: baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

    Oliveira, Fernanda Esthefane Garrides / Griep, Rosane Harter / Chor, Dora / Giatti, Luana / Machado, Luciana A C / Barreto, Sandhi Maria / da Costa Pereira, Alexandre / Fonseca, Maria de Jesus Mendes da / Bastos, Leonardo Soares

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1319

    Abstract: Background: Evidence of multimorbidity has come mainly from high-income regions, while disparities among racial groups have been less explored. This study examined racial differences in multimorbidity in the multiracial cohort of the Longitudinal Study ... ...

    Abstract Background: Evidence of multimorbidity has come mainly from high-income regions, while disparities among racial groups have been less explored. This study examined racial differences in multimorbidity in the multiracial cohort of the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto), ELSA-Brasil.
    Methods: The study examined baseline (2008-2010) data for 14 099 ELSA-Brasil participants who self-reported being white, mixed-race, or black. A list of 16 morbidities was used to evaluate multimorbidity, operationalised by simple count into ≥ 2, ≥ 3, ≥ 4, ≥ 5 and ≥ 6 morbidities, in addition to evaluating the number of coexisting conditions. Prevalence ratios (PR) were estimated from logistic models and a quantile model was used to examine racial differences graphically in the distribution quantiles for the number of morbidities.
    Results: Overall prevalence of multimorbidity (≥ 2 morbidities) was 70% and, after controlling for age and sex, was greater among mixed-race and black participants - by 6% (PR: 1.06; 95% CI: 1.03-1.08) and 9% (PR: 1.09; 95% CI: 1.06-1.12), respectively - than among white participants. As the cutoff value for defining multimorbidity was raised, so the strength of the association increased, especially among blacks: if set at ≥ 6 morbidities, the prevalence was 27% greater for those of mixed-race (PR: 1.27; 95% CI: 1.07-1.50) and 47% greater for blacks (PR: 1.47; 95% CI: 1.22-1.76) than for whites. The disparities were smaller in the lower morbidity distribution quantiles and larger in the upper quantiles, indicating a heavier burden of disease, particularly on blacks.
    Conclusions: Multimorbidity was common among adults and older adults in a Brazilian cohort, but important racial inequalities were found. Raising the cutoff point for defining multimorbidity revealed stronger associations between race/skin colour and multimorbidity, indicating a higher prevalence of multimorbidity among mixed-race and black individuals than among whites and that the former groups coexisted more often with more complex health situations (with more coexisting morbidities). Interventions to prevent and manage the condition of multimorbidity that consider the social determinants of health and historically discriminated populations in low- and middle-income regions are necessary.
    MeSH term(s) Aged ; Brazil/epidemiology ; Humans ; Longitudinal Studies ; Multimorbidity ; Prevalence ; Racial Groups
    Language English
    Publishing date 2022-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-13715-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Body adiposity index in assessing the risk of type 2 diabetes mellitus development: the Baependi Heart Study.

    de Oliveira, Camila Maciel / Pavani, Jessica / Krieger, José Eduardo / de Oliveira Alvim, Rafael / Mourão-Junior, Carlos Alberto / da Costa Pereira, Alexandre

    Diabetology & metabolic syndrome

    2019  Volume 11, Page(s) 76

    Abstract: Background: The association between diabetes and obesity is very well established. Faced with this, several anthropometric indices of adiposity are often involved in studies on diabetes. Our main goal in this paper is to evaluate the association between ...

    Abstract Background: The association between diabetes and obesity is very well established. Faced with this, several anthropometric indices of adiposity are often involved in studies on diabetes. Our main goal in this paper is to evaluate the association between body adiposity index (BAI) and type 2 diabetes mellitus (T2DM) in a sample of the Brazilian population after 5-year follow-up.
    Methods: The data used come from the Baependi Heart Study cohort, which consists of two periods: cycle 1 (2005-2006) and cycle 2 (2010-2013). Individuals of both sexes (n = 1121) were selected by excluding participants with type 2 diabetes mellitus at baseline or those that were lost to follow-up.
    Results: The diabetic subjects showed higher systolic blood pressure, BAI, body mass index, waist circumference and fasting glucose levels. In addition, using mixed-effects logistic regression, we found that the elevation of a single unit of BAI represented an increase of 8.4% in the risk of a patient developing T2DM (OR = 1.084 [95% CI 1.045-1.124]).
    Conclusions: Obesity is recognised as one of the most important risk factors for T2DM and BAI has proven to be a useful tool in estimating the risk of a patient developing T2DM in a Brazilian population.
    Language English
    Publishing date 2019-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-019-0467-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genetic associations of bradykinin type 2 receptor, alpha-adrenoceptors and endothelial nitric oxide synthase with blood pressure and left ventricular mass in outpatients without overt heart disease.

    Nunes, Rafael Amorim Belo / Lima, Larissa Barbosa / Tanaka, Nelson Ithiro / da Costa Pereira, Alexandre / Krieger, José Eduardo / Mansur, Alfredo José

    International journal of cardiology. Heart & vasculature

    2018  Volume 21, Page(s) 45–49

    Abstract: Background: Physiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function. Genetic variants of these pathways may impact blood pressure ...

    Abstract Background: Physiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function. Genetic variants of these pathways may impact blood pressure and left ventricular (LV) mass in different populations. To evaluate associations of genetic polymorphisms of bradykinin B2 receptor (BDKRB2), alpha-adrenergic receptors (ADRA) and endothelial nitric oxide synthase (eNOS) on the modulation of the blood pressure and the left ventricular mass.
    Methods: We enrolled 758 individuals without overt heart disease. Blood pressure was estimated by auscultatory method during the clinical examination. Left ventricular (LV) mass was assessed by echocardiography. Genotypes for ADRA1A rs1048101, ADRA2A rs553668, ADRA2B rs28365031, eNOS rs2070744, eNOS rs1799983, and BDKRB2 rs5810761 polymorphisms were assessed by high-resolution melting analysis.
    Results: BDKRB2 polymorphism rs5810761 was associated with blood pressure. Carriers of DD genotype had higher levels of SBP and DBP than carrier of II genotype (
    Conclusions: In a cohort of individuals without overt heart disease, the BDKRB2 rs5810761 polymorphism (DD genotype carriers) were associated higher systolic and diastolic blood pressures, and the eNOS rs1799983 polymorphism (T allele carriers) were associated with lower diastolic blood pressure. The eNOS rs2070744 polymorphism (C allele carriers) was associated with higher left ventricular mass. These data suggest that eNOS and bradykinin receptor genetic variants may be potential markers of common cardiovascular phenotypes.
    Language English
    Publishing date 2018-10-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2018.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erosive Tooth Wear and Dietary Patterns: A Clinical Study.

    Pedrão, Alice Moreira Neves / Andrews Portes, Leslie / Padilha Gomes, Everton / Figueira Teixeira, Fernanda Cristina / da Costa Pereira, Alexandre / de Oliveira, Natalia Cristina

    Oral health & preventive dentistry

    2018  Volume 16, Issue 2, Page(s) 145–151

    Abstract: Purpose: Evidence exists which suggests that a vegetarian diet is a predisposing factor to erosive tooth wear. The aim of this study was to assess the influence of dietary pattern (vegetarian, lacto-ovo vegetarian and omnivore) on erosive tooth wear.: ...

    Abstract Purpose: Evidence exists which suggests that a vegetarian diet is a predisposing factor to erosive tooth wear. The aim of this study was to assess the influence of dietary pattern (vegetarian, lacto-ovo vegetarian and omnivore) on erosive tooth wear.
    Materials and methods: Two hundred seven subjects (29 vegetarians, 96 lacto-ovo vegetarians and 82 omnivores) underwent an oral assessment and were asked to answer questionnaires about diet and oral care.
    Results: Individuals who followed vegetarian and lacto-ovo vegetarian diets had statistically significantly more erosive tooth wear than did omnivores (p = 0.004). Conversely, omnivores presented more tooth loss than did lacto-ovo vegetarians (p = 0.027). Being a vegetarian or a lacto-ovo vegetarian entailed an increased risk (4 times and 2.5 times, respectively) of presenting erosive tooth wear than being omnivorous.
    Conclusion: Vegetarian and lacto-ovo vegetarian dietary patterns seem to favour the loss of dental structure by erosion. Vegetarian patients should thus be informed about preventive measures and treated accordingly.
    MeSH term(s) Adult ; Aged ; Brazil/epidemiology ; Cross-Sectional Studies ; Diet/adverse effects ; Diet Surveys ; Diet, Vegetarian/adverse effects ; Female ; Habits ; Humans ; Male ; Meat ; Middle Aged ; Oral Hygiene ; Tooth Wear/epidemiology ; Tooth Wear/etiology
    Language English
    Publishing date 2018-05-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2136786-3
    ISSN 1757-9996 ; 1602-1622
    ISSN (online) 1757-9996
    ISSN 1602-1622
    DOI 10.3290/j.ohpd.a40321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: In silico analysis of upstream variants in Brazilian patients with Familial Hypercholesterolemia

    Nayara Góes de Araújo, Jéssica / Fernandes de Oliveira, Victor / Bassani Borges, Jéssica / Dagli-Hernandez, Carolina / da Silva Rodrigues Marçal, Elisangela / Caroline Costa de Freitas, Renata / Medeiros Bastos, Gisele / Marques Gonçalves, Rodrigo / Arpad Faludi, André / Elim Jannes, Cinthia / da Costa Pereira, Alexandre / Dominguez Crespo Hirata, Rosario / Hiroyuki Hirata, Mario / Ducati Luchessi, André / Nogueira Silbiger, Vivian

    Gene. 2022 Sept. 19,

    2022  

    Abstract: Familial hypercholesterolemia (FH) is a prevalent autosomal genetic disease associated with increased risk of early cardiovascular events and death due to chronic exposure to very high levels of low-density lipoprotein cholesterol (LDL-c). Pathogenic ... ...

    Abstract Familial hypercholesterolemia (FH) is a prevalent autosomal genetic disease associated with increased risk of early cardiovascular events and death due to chronic exposure to very high levels of low-density lipoprotein cholesterol (LDL-c). Pathogenic variants in the coding regions of LDLR, APOB and PCSK9 account for most FH cases, and variants in non-coding regions maybe involved in FH as well. Variants in the upstream region of LDLR, APOB and PCSK9 were screened by targeted next-generation sequencing and their effects were explored using in silico tools. Twenty-five patients without pathogenic variants in FH-related genes were selected. 3 kb upstream regions of LDLR, APOB and PCSK9 were sequenced using the AmpliSeq (Illumina) and Miseq Reagent Nano Kit v2 (Illumina). Sequencing data were analyzed using variant discovery and functional annotation tools. Potentially regulatory variants were selected by integrating data from public databases, published data and context-dependent regulatory prediction score. Thirty-four single nucleotide variants (SNVs) in upstream regions were identified (6 in LDLR, 15 in APOB, and 13 in PCSK9). Five SNVs were prioritized as potentially regulatory variants (rs934197, rs9282606, rs36218923, rs538300761, g.55038486A>G). APOB rs934197 was previously associated with increased rate of transcription, which in silico analysis suggests that could be due to reducing binding affinity of a transcriptional repressor. Our findings highlight the importance of variant screening outside of coding regions of all relevant genes. Further functional studies are necessary to confirm that prioritized variants could impact gene regulation and contribute to the FH phenotype.
    Keywords chronic exposure ; computer simulation ; death ; genes ; genetic disorders ; hypercholesterolemia ; low density lipoprotein cholesterol ; phenotype ; prediction ; repressor proteins ; risk
    Language English
    Dates of publication 2022-0919
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2022.146908
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: The Baependi Heart Study.

    de Oliveira, Camila Maciel / Pavani, Jessica / Liu, Chunyu / de Oliveira Alvim, Rafael / Balcells, Mercedes / Mourão-Junior, Carlos Alberto / Krieger, José Eduardo / da Costa Pereira, Alexandre

    Preventive medicine reports

    2020  Volume 20, Page(s) 101172

    Abstract: Considering that the incidence of type 2 diabetes mellitus (T2DM) has been increasing especially in developing countries and becoming a global public health problem, this study aims to evaluate the association between triglyceride glucose index (TyG) - ... ...

    Abstract Considering that the incidence of type 2 diabetes mellitus (T2DM) has been increasing especially in developing countries and becoming a global public health problem, this study aims to evaluate the association between triglyceride glucose index (TyG) - which is a mathematical product of the fasting blood glucose and triglyceride levels - and incident T2DM in an adult sample in the Baependi Heart Study (BHS). The data were from the BHS cohort consisting of two periods: cycle 1 (2005-2006; n = 1712; 119 families) and cycle 2 (2010-2013; n = 3017; 127 families). A total of 1121 individuals (both sexes, 18-100 years) were selected if they were assessed in both cycles and not diagnosed with T2DM at baseline (cycle 1). Our findings showed that a participant's risk of developing T2DM increased almost 10 times for a one-unit increase in the TyG (odds ratio OR = 10.17, 95% CI, 7.51-13.93). The association when stratified by age was OR = 28.13 [95% CI, 14.03-56.41] for young adults, meaning that the risk of developing T2DM increased more than 28 times for a one-unit increase in the TyG. For the other groups, young middle-aged adults, old middle-aged adults, and seniors, we found OR = 4.84 [95% CI, 2.91-8.06], OR = 28.73 [95% CI, 10.63-77.65, and OR = 9.88 [95% CI, 3.16-30.90], respectively. A higher TyG implies a significant increase in the risk of developing T2DM, which could be an important screening tool to target early lifestyle intervention in Brazil.
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2020.101172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Kefir metabolites in a fly model for Alzheimer's disease.

    Batista, Letícia Leandro / Malta, Serena Mares / Guerra Silva, Heitor Cappato / Borges, Luiza Diniz Ferreira / Rocha, Lays Oliveira / da Silva, Jéssica Regina / Rodrigues, Tamiris Sabrina / Venturini, Gabriela / Padilha, Kallyandra / da Costa Pereira, Alexandre / Espindola, Foued Salmen / Ueira-Vieira, Carlos

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11262

    Abstract: Alzheimer's Disease (AD) is the most common cause of dementia among elderly individuals worldwide, leading to a strong motor-cognitive decline and consequent emotional distress and codependence. It is traditionally characterized by amyloidogenic pathway ... ...

    Abstract Alzheimer's Disease (AD) is the most common cause of dementia among elderly individuals worldwide, leading to a strong motor-cognitive decline and consequent emotional distress and codependence. It is traditionally characterized by amyloidogenic pathway formation of senile plaques, and recent studies indicate that dysbiosis is also an important factor in AD's pathology. To overcome dysbiosis, probiotics-as kefir-have shown to be a great therapeutic alternative for Alzheimer's disease. In this present work, we explored kefir as a probiotic and a metabolite source as a modulator of microbiome and amyloidogenic pathway, using a Drosophila melanogaster model for AD (AD-like flies). Kefir microbiota composition was determined through 16S rRNA sequencing, and the metabolome of each fraction (hexane, dichloromethane, ethyl acetate, and n-butanol) was investigated. After treatment, flies had their survival, climbing ability, and vacuolar lesions accessed. Kefir and fraction treated flies improved their climbing ability survival rate and neurodegeneration index. In conclusion, we show that kefir in natura, as well as its fractions may be promising therapeutic source against AD, modulating amyloidogenic related pathways.
    MeSH term(s) Alzheimer Disease/metabolism ; Animals ; Behavior, Animal/physiology ; Disease Models, Animal ; Drosophila melanogaster ; Kefir ; Metabolome ; Microbiota ; Probiotics ; Survival Rate
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90749-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical Features, Genetic Findings, and Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: Data From a Brazilian Cohort.

    Olivetti, Natália Quintella Sangiorgi / Sacilotto, Luciana / Wulkan, Fanny / D'Arezzo Pessente, Gabrielle / Lombardi Peres de Carvalho, Mariana / Moleta, Danilo / Tessariol Hachul, Denise / Veronese, Pedro / Hardy, Carina / Pisani, Cristiano / Wu, Tan Chen / Vieira, Marcelo Luiz Campos / de França, Lucas Arraes / de Souza Freitas, Matheus / Rochitte, Carlos Eduardo / Bueno, Sávia Christina / Bastos Lovisi, Vitor / Krieger, José Eduardo / Scanavacca, Maurício /
    da Costa Pereira, Alexandre / da Costa Darrieux, Francisco

    Circulation. Arrhythmia and electrophysiology

    2023  Volume 16, Issue 2, Page(s) e011391

    Abstract: Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disease, causes ventricular tachycardia, sudden cardiac death, and heart failure (HF). We investigated ARVC clinical features, genetic findings, natural history, and ... ...

    Abstract Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disease, causes ventricular tachycardia, sudden cardiac death, and heart failure (HF). We investigated ARVC clinical features, genetic findings, natural history, and the occurrence of life-threatening arrhythmic events (LTAEs), HF death, or heart transplantation (HF-death/HTx) to identify risk factors.
    Methods: The clinical course of 111 consecutive patients with definite ARVC, predictors of LTAE, HF-death/HTx, and combined events were analyzed in the entire cohort and in a subgroup of 40 patients without sustained ventricular arrhythmia before diagnosis.
    Results: The 5-year cumulative probability of LTAE was 30% and HF-death/HTx was 10%. Predictors of HF-death/HTx were reduced right ventricle ejection fraction (HR: 0.93;
    Conclusions: Our study demonstrated the characteristics of a specific cohort with a high prevalence of arrhythmic burden at presentation, male predominance, younger age and HF severe outcomes. Our main results suggest that the presence and extension of low QRS voltage can be a risk predictor for HF-death/HTx in ARVC patients, regardless of the arrhythmic risk. This study can contribute to the global ARVC risk stratification, adding new insights to the international current scientific knowledge.
    MeSH term(s) Humans ; Male ; Female ; Arrhythmogenic Right Ventricular Dysplasia ; Brazil ; Arrhythmias, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Risk Factors ; Ventricular Fibrillation ; Heart Failure/complications ; Electrocardiography ; Risk Assessment/methods
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.122.011391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nutritional aspects of Noonan syndrome and Noonan-related disorders.

    da Silva, Fernanda Marchetto / Jorge, Alexander Augusto / Malaquias, Alexandra / da Costa Pereira, Alexandre / Yamamoto, Guilherme Lopes / Kim, Chong Ae / Bertola, Debora

    American journal of medical genetics. Part A

    2016  Volume 170, Issue 6, Page(s) 1525–1531

    Abstract: Rasopathies are a group of rare disorders characterized by neurocardiofaciocutaneous involvement, and caused by mutations in several genes of the RAS/MAPK pathway. In the present study, we characterized growth parameters, body composition, and ... ...

    Abstract Rasopathies are a group of rare disorders characterized by neurocardiofaciocutaneous involvement, and caused by mutations in several genes of the RAS/MAPK pathway. In the present study, we characterized growth parameters, body composition, and nutritional aspects of children and adults (n = 62) affected by these disorders, mainly Noonan syndrome, using an indirect method-anthropometry-and a 24-hr recall questionnaire. The growth parameters in our cohort showed short stature, especially in individuals with RAF1 and SHOC2 mutations, lower obesity rates compared to the control population, and BMI scores highest in individuals with BRAF mutations and lowest in individuals with SHOC2. Body composition showed a compromise in the upper arm muscle circumference, with a statistically significant difference in the z-score of triceps skinfold (P = 0.0204) and upper arm fat area (P = 0.0388) between BRAF and SHOC2 groups and in the z-score of triceps skinfold between RAF1 and SHOC2 (P = 0.0218). The pattern of macronutrient consumption was similar to the control population. Our study is the first to address body composition in RASopathy individuals and the data indicate a compromise not only in adipose tissue, but also in muscle mass. Studies using different techniques, such as dual-energy X-ray absorptiometry or imaging studies, which give a more precise delineation of fat and non-fat mass, are required to confirm our results, ultimately causing an impact on management strategies. © 2016 Wiley Periodicals, Inc.
    MeSH term(s) Adult ; Anthropometry ; Body Composition ; Child ; Cross-Sectional Studies ; Feeding Behavior ; Female ; Genetic Association Studies ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Mutation ; Noonan Syndrome/diagnosis ; Noonan Syndrome/genetics ; Nutritional Status ; Phenotype ; Proto-Oncogene Proteins c-raf/genetics
    Chemical Substances Intracellular Signaling Peptides and Proteins ; SHOC2 protein, human ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1)
    Language English
    Publishing date 2016-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.37639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition.

    Franco-de-Moraes, Ana Carolina / de Almeida-Pititto, Bianca / da Rocha Fernandes, Gabriel / Gomes, Everton Padilha / da Costa Pereira, Alexandre / Ferreira, Sandra Roberta G

    Diabetology & metabolic syndrome

    2017  Volume 9, Page(s) 62

    Abstract: Aims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile.: Methods: A ...

    Abstract Aims: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile.
    Methods: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene. Samples were clustered into operational taxonomic units at 97% similarity using GreenGenes 13.5 database. Clinical, biochemical, and circulating inflammatory markers were compared by ANOVA or Kruskal-Wallis test.
    Results: The sample (54.2% women, mean age 49.5 years) was composed of 66 strict vegetarians, 102 lacto-ovo-vegetarians and 100 omnivores. Considering the entire sample, the greatest abundant phyla were
    Conclusions: There are differences in gut microbiota composition of individuals with distinct dietary habits, who differ according to their inflammatory and metabolic profiles. Based on the findings relative to bacteria abundances and on their recognized actions in the metabolism, we suggest that exposure to animal foods may favor an intestinal environment which could trigger systemic inflammation and insulin resistance-dependent metabolic disorders.
    Language English
    Publishing date 2017-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-017-0261-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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