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  1. Article: Subsets of Cytokines and Chemokines from DENV-4-Infected Patients Could Regulate the Endothelial Integrity of Cultured Microvascular Endothelial Cells.

    Cipitelli, Marcio da Costa / Paiva, Iury Amancio / Badolato-Corrêa, Jéssica / Marinho, Cíntia Ferreira / Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / de Azeredo, Elzinandes Leal / de Souza, Luiz José / da Cunha, Rivaldo Venâncio / de-Oliveira-Pinto, Luzia Maria

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11050509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hematological and biochemical findings in patients with dengue fever: a current issue.

    da Cunha, Rivaldo Venâncio / de Oliveira, Eveny Cristine Luna

    Revista brasileira de hematologia e hemoterapia

    2012  Volume 34, Issue 2, Page(s) 78–79

    Language English
    Publishing date 2012-09-20
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20120026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease.

    Torrentes-Carvalho, Amanda / Sánchez-Arcila, Juan Camilo / Azamor, Tamiris / Barbosa, Luciana Santos / Hottz, Eugênio Damaceno / Gandini, Mariana / Bozza, Fernando Augusto / da Cunha, Rivaldo Venâncio / de Oliveira Pinto, Luzia Maria / Damasco, Paulo Vieira / de Azeredo, Elzinandes Leal

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 6351

    Abstract: Dengue virus (DENV) co-circulation in Brazil represents a challenge for treatment and vaccine development. Despite public health impact, the occurrence of coinfections with other viruses is a common event. Increased T cell activation and altered ... ...

    Abstract Dengue virus (DENV) co-circulation in Brazil represents a challenge for treatment and vaccine development. Despite public health impact, the occurrence of coinfections with other viruses is a common event. Increased T cell activation and altered inflammatory response are found during DENV coinfection with Human Immunodeficiency Virus (HIV) impacting HIV-pathogenesis. Even with Antiretroviral therapy (ART), HIV- treated patients had chronic immune activation and lymphocyte apoptosis. However, apoptotic mechanisms have not been investigated during coinfection with DENV. Our attention was attracted to apoptotic cell markers expressions in PBMCs from DENV and DENV/HIV coinfected patients. We found CD4/CD8 ratio inversion in most coinfected patients. CD4 T and CD8 T-cell subsets from DENV and DENV/HIV groups expressed low levels of anti-apoptotic protein Bcl-2. Furthermore, CD8 CD95 double positive cells frequency expressing low levels of Bcl-2 were significantly higher in these patients. Additionally, the density of Bcl-2 on classical monocytes (CD14
    MeSH term(s) Acute Disease/epidemiology ; Adult ; Aged ; Apoptosis/genetics ; Brazil/epidemiology ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes/immunology ; Coinfection/blood ; Coinfection/immunology ; Coinfection/virology ; Dengue/blood ; Dengue/immunology ; Dengue/pathology ; Dengue/virology ; Dengue Virus/pathogenicity ; Female ; HIV/pathogenicity ; HIV Infections/blood ; HIV Infections/immunology ; HIV Infections/pathology ; HIV Infections/virology ; Humans ; Leukocytes, Mononuclear/virology ; Lymphocyte Activation/genetics ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/pathology ; Young Adult
    Chemical Substances BCL2 protein, human ; Proto-Oncogene Proteins c-bcl-2
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-62776-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus.

    Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / Dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / Dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

    Viruses

    2021  Volume 13, Issue 9

    Abstract: The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile ...

    Abstract The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (
    MeSH term(s) Adult ; Biomarkers/blood ; Blood Coagulation Factors/classification ; Blood Coagulation Factors/immunology ; Brazil ; Chemokines/blood ; Chemokines/classification ; Chemokines/immunology ; Cytokines/blood ; Cytokines/classification ; Cytokines/immunology ; Dengue/blood ; Dengue/immunology ; Dengue Virus/immunology ; Female ; Humans ; Inflammation ; Male ; Middle Aged ; Severity of Illness Index
    Chemical Substances Biomarkers ; Blood Coagulation Factors ; Chemokines ; Cytokines
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seroepidemiology of SARS-CoV-2 on a partially vaccinated island in Brazil: Determinants of infection and vaccine response.

    Cerbino-Neto, José / Peres, Igor Tona / Varela, Margareth Catoia / Brandão, Luciana Gomes Pedro / de Matos, Juliana Arruda / Pinto, Luiz Felipe / da Costa, Marcellus Dias / Garcia, Márcio Henrique de Oliveira / Soranz, Daniel / Maia, Maria de Lourdes de Sousa / Krieger, Marco Aurélio / da Cunha, Rivaldo Venâncio / Camacho, Luiz Antonio Bastos / Ranzani, Otavio / Hamacher, Silvio / Bozza, Fernando Augusto / Penna, Gerson Oliveira

    Frontiers in public health

    2022  Volume 10, Page(s) 1017337

    Abstract: Background: A vaccination campaign targeted adults in response to the pandemic in the City of Rio de Janeiro.: Objective: We aimed to evaluate the seroprevalence of SARS-CoV-2 antibodies and identify factors associated with seropositivity on ... ...

    Abstract Background: A vaccination campaign targeted adults in response to the pandemic in the City of Rio de Janeiro.
    Objective: We aimed to evaluate the seroprevalence of SARS-CoV-2 antibodies and identify factors associated with seropositivity on vaccinated and unvaccinated residents.
    Methods: We performed a seroepidemiologic survey in all residents of Paquetá Island, a neighborhood of Rio de Janeiro city, during the COVID-19 vaccine roll-out. Serological tests were performed from June 16 to June 19, 2021, and adjusted seropositivity rates were estimated by age and epidemiological variables. Logistic regression models were used to estimate adjusted ORs for risk factors to SARS-CoV-2 seropositivity in non-vaccinated individuals, and potential determinants of the magnitude of antibody responses in the seropositive population.
    Results: We included in the study 3,016 residents of Paquetá (83.5% of the island population). The crude seroprevalence of COVID-19 antibodies in our sample was 53.6% (95% CI = 51.0, 56.3). The risk factors for SARS-CoV-2 seropositivity in non-vaccinated individuals were history of confirmed previous COVID-19 infection (OR = 4.74; 95% CI = 3.3, 7.0), being a household contact of a case (OR = 1.93; 95% CI = 1.5, 2.6) and in-person learning (OR = 2.01; 95% CI = 1.4, 3.0). Potential determinants of the magnitude of antibody responses among the seropositive were hybrid immunity, the type of vaccine received, and time since the last vaccine dose. Being vaccinated with Pfizer or AstraZeneca (Beta = 2.2; 95% CI = 1.8, 2.6) determined higher antibody titers than those observed with CoronaVac (Beta = 1.2; 95% CI = 0.9, 1.5).
    Conclusions: Our study highlights the impact of vaccination on COVID-19 collective immunity even in a highly affected population, showing the difference in antibody titers achieved with different vaccines and how they wane with time, reinforcing how these factors should be considered when estimating effectiveness of a vaccination program at any given time. We also found that hybrid immunity was superior to both infection-induced and vaccine-induced immunity alone, and online learning protected students from COVID-19 exposure.
    MeSH term(s) Adult ; Humans ; SARS-CoV-2 ; Seroepidemiologic Studies ; Brazil/epidemiology ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1017337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retrospective Genomic Surveillance of Chikungunya Transmission in Minas Gerais State, Southeast Brazil.

    Fritsch, Hegger / Giovanetti, Marta / Xavier, Joilson / Adelino, Talita Emile Ribeiro / Fonseca, Vagner / de Jesus, Jaqueline Góes / de Jesus, Ronaldo / Freitas, Carla / Peterka, Cassio Roberto Leonel / Campelo de Albuquerque, Carlos Frederico / Bispo de Filippis, Ana Maria / da Cunha, Rivaldo Venâncio / Silva, Erniria Carvalhais / Alcantara, Luiz Carlos Junior / Iani, Felipe Campos de Melo

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0128522

    Abstract: Brazil accounted for a total number of 1,276,194 reported cases of chikungunya fever between 2014 and 2022. Additionally, since 2015, the country has experienced an increasing death toll, in which the Northeast and Southeast regions appear to report the ... ...

    Abstract Brazil accounted for a total number of 1,276,194 reported cases of chikungunya fever between 2014 and 2022. Additionally, since 2015, the country has experienced an increasing death toll, in which the Northeast and Southeast regions appear to report the worst scenarios. Although the CHIKV transmission dynamics have been studied in many parts of the country since its introduction in 2014, little is still known about chikungunya virus (CHIKV) transmission and genetic diversity in the state of Minas Gerais, located in southeast Brazil. Moreover, no studies have been published characterizing CHIKV genomic surveillance in this state. Thus, to retrospectively explore the CHIKV epidemic in Minas Gerais, we generated 40 genomes from clinical samples using Nanopore sequencing. Phylogenetic analysis indicated that multiple introductions of CHIKV occurred, likely from the northeastern Brazilian states, with the most recent common ancestral strain dating to early March 2016, which is in agreement with local epidemiological reports. Additionally, epidemiological data reveals a decline in the number of reported cases from 2017 to 2021, indicating that population immunity or changes in vector activity may have contributed to the decreasing waves of CHIKV infection. Together, our results shed light on the dispersion dynamics of CHIKV and show that infections decreased from March 2017 to January 2021 despite multiple introductions into Minas Gerais State. In conclusion, our study highlights the importance of combining genomic and epidemiological data in order to assist public health laboratories in monitoring and understanding the patterns and diversity of mosquito-borne viral epidemics.
    MeSH term(s) Animals ; Humans ; Chikungunya Fever/epidemiology ; Brazil/epidemiology ; Retrospective Studies ; Phylogeny ; Chikungunya virus/genetics ; Zika Virus ; Genomics ; Zika Virus Infection
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01285-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil.

    Giovanetti, Marta / Pereira, Luiz Augusto / Adelino, Talita Émile Ribeiro / Fonseca, Vagner / Xavier, Joilson / de Araújo Fabri, Allison / Slavov, Svetoslav Nanev / da Silva Lemos, Poliana / de Almeida Marques, William / Kashima, Simone / Lourenço, José / de Oliveira, Tulio / Campelo de Albuquerque, Carlos Frederico / Freitas, Carla / Peterka, Cassio Roberto Leonel / da Cunha, Rivaldo Venancio / Mendonça, Ana Flávia / Lemes da Silva, Vinícius / Alcantara, Luiz Carlos Junior

    Microbiology spectrum

    2022  Volume 10, Issue 2, Page(s) e0015522

    Abstract: Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission dynamics have been intensively studied in many parts of the country, although much is still unknown about its circulation in the midwestern states. Here, using nanopore ...

    Abstract Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission dynamics have been intensively studied in many parts of the country, although much is still unknown about its circulation in the midwestern states. Here, using nanopore technology, we obtained 23 novel partial and near-complete ZIKV genomes from the state of Goiás, located in the Midwest of Brazil. Genomic, phylogenetic, and epidemiological approaches were used to retrospectively explore the spatiotemporal evolution of the ZIKV-Asian genotype in this region. As a likely consequence of a gradual accumulation of herd immunity, epidemiological data revealed a decline in the number of reported cases over 2018 to 2021. Phylogenetic reconstructions revealed that multiple independent introductions of the Asian lineage have occurred in Goiás over time and revealed a complex transmission dynamic between epidemic seasons. Together, our results highlight the utility of genomic, epidemiological, and evolutionary methods to understand mosquito-borne epidemics.
    MeSH term(s) Animals ; Brazil/epidemiology ; Phylogeny ; Retrospective Studies ; Zika Virus/genetics ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00155-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus

    Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

    Viruses. 2021 Sept. 08, v. 13, no. 9

    2021  

    Abstract: The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile ...

    Abstract The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (p < 0.001), IL-6 (p = 0.005), IL-10 (p < 0.001), IL-18 (p = 0.001), CXCL8/IL-8 (p < 0.001), CCL2/MCP-1 (p < 0.001), CXCL10/IP-10 (p = 0.001), fibrinogen (p = 0.037), D-dimer (p = 0.01) and TFPI (p = 0.042) and lower levels of TF (p = 0.042) compared to healthy controls. A principal component analysis (PCA) distinguished between two profiles of mediators of inflammation and coagulation: protective (TNF-α, IL-1β and CXCL8/IL-8) and pathological (IL-6, TF and TFPI). Lastly, multivariate logistic regression analysis identified high aspartate aminotransferase-to-platelet ratio index (APRI) as independent risk factors associated with severity (adjusted OR: 1.33; 95% CI 1.03–1.71; p = 0.027), the area under the receiver operating characteristics curve (AUC) was 0.775 (95% CI 0.681–0.869) and an optimal cutoff value was 1.4 (sensitivity: 76%; specificity: 79%), so it could be a useful marker for the triage of patients attending primary care centers.
    Keywords Dengue virus ; aspartic acid ; biomarkers ; coagulation ; dengue ; fibrinogen ; inflammation ; interleukin-10 ; interleukin-18 ; interleukin-6 ; principal component analysis ; regression analysis ; Brazil ; Latin America
    Language English
    Dates of publication 2021-0908
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091789
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Clinical, Virological, and Immunological Profiles of DENV, ZIKV, and/or CHIKV-Infected Brazilian Patients.

    Sánchez-Arcila, Juan Camilo / Badolato-Correa, Jessica / de Souza, Thiara Manuele Alves / Paiva, Iury Amâncio / Barbosa, Luciana Santos / Nunes, Priscila Conrado Guerra / Lima, Monique da Rocha Queiroz / Dos Santos, Flavia Barrento / Damasco, Paulo Vieira / da Cunha, Rivaldo Venancio / Azeredo, Elzinandes Leal de / de Oliveira-Pinto, Luzia Maria

    Intervirology

    2020  Volume 63, Issue 1-6, Page(s) 33–45

    Abstract: Background: Arboviruses co-circulating within a population that are transmitted by the same vector have the potential to cause coinfections. Coinfections with dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) have been occurring in ... ...

    Abstract Background: Arboviruses co-circulating within a population that are transmitted by the same vector have the potential to cause coinfections. Coinfections with dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) have been occurring in Brazil, but it is not well-understood how human responses vary during mono- or coinfections and whether they play different roles in pathogenesis.
    Methods: We investigated the clinical, virological, and immunological status during patients' acute infections, focusing on the CCL/CXC chemokines, proinflammatory, as well as anti-inflammatory cytokines levels quantified by ELISAs. Viral load was determined by qRT-PCR in serum samples from 116 acute DENV, ZIKV, CHIKV, DENV/ZIKV, and CHIKV/ZIKV-infected adult patients from Brazil.
    Results: Most of the acute patients displayed fever, headache, prostration, and myalgia, regardless of the type of arbovirus infection. Zika viral load was higher in CHIKV/ZIKV coinfected patients compared with ZIKV or DENV/ZIKV infections. All infected individuals presented increased concentrations of C-X-C motif chemokine ligand 10/interferon protein-10 (CXCL10/IP-10), C-C motif chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1), and tumor necrosis factor alpha (TNF-α) compared to healthy donors. Interestingly, the ZIKV group separated from CHIKV/ZIKV due to higher levels of interleukin-10 (IL-10) and lower levels of TNF-α. While DENV/ZIKV differentiated from CHIKV due to their higher levels of CCL2/MCP-1, in CHIKV- and CHIKV/ZIKV-infected patients, levels of CXC10/IP-10, CCL2/MCP-1, and migration inhibitory factor (MIF) were associated with CHIKV viral load. By contrast, in DENV/ZIKV- and CHIKV/ZIKV-infected patients, levels of CXCL10/IP-10, CCL2/MCP-1, and TNF-α showed a significant inverse correlation with ZIKV viral load.
    Conclusions: From all the circulating mediators measured, we detected differences of IL-10, TNF-α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.
    MeSH term(s) Adult ; Brazil ; Chemokines, CC/blood ; Chemokines, CXC/blood ; Chikungunya Fever/immunology ; Chikungunya Fever/virology ; Chikungunya virus/physiology ; Coinfection ; Cytokines/blood ; Dengue/immunology ; Dengue Virus/physiology ; Female ; Humans ; Male ; Middle Aged ; Viral Load ; Young Adult ; Zika Virus/physiology ; Zika Virus Infection/immunology ; Zika Virus Infection/virology
    Chemical Substances Chemokines, CC ; Chemokines, CXC ; Cytokines
    Language English
    Publishing date 2020-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 184545-7
    ISSN 1423-0100 ; 0300-5526
    ISSN (online) 1423-0100
    ISSN 0300-5526
    DOI 10.1159/000510223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures.

    Demarchi, Luiz Henrique Ferraz / Bandeira, Larissa Melo / Taira, Deborah Ledesma / Zardin, Marina Castilhos Souza Umaki / Ibanhes, Mary Luizia / Esposito, Ana Olivia Pascoto / De Arruda, Larissa Domingues Castilho / Gonçalves, Crhistinne Cavalheiro Maymone / Weis-Torres, Sabrina Moreira Dos Santos / Cesar, Gabriela Alves / Da Cunha, Rivaldo Venâncio / Tanaka, Tayana Serpa Ortiz / Puga, Marco Antonio Moreira / De Rezende, Grazielli Rocha / Lopes, Roberta Barbosa / Uehara, Silvia Naomi de Oliveira / Pinho, João Renato Rebello / Carrilho, Flair Jose / Gomes-Gouvêa, Michele Soares /
    Motta-Castro, Ana Rita Coimbra

    Viruses

    2022  Volume 14, Issue 5

    Abstract: This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with ... ...

    Abstract This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (
    MeSH term(s) Brazil/epidemiology ; Cross-Sectional Studies ; Emigrants and Immigrants ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Humans ; Japan/epidemiology
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14051085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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