Article ; Online: Evaluation of clinical and microbiological factors related to mortality in patients with Gram-negative bacterial infections treated with ceftazidime-avibactam: A prospective multicentric cohort study.
Journal of global antimicrobial resistance
2024 Volume 36, Page(s) 393–398
Abstract: Objectives: This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime-avibactam for carbapenem-resistant Gram-negative bacterial infections.: Methods: This multicentric ... ...
| Abstract | Objectives: This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime-avibactam for carbapenem-resistant Gram-negative bacterial infections. Methods: This multicentric prospective cohort study included hospitalized adult patients with a microbiologically confirmed infection treated with ceftazidime-avibactam for ≥48 hours. The clinical and microbiological risk factors for 30-day mortality were evaluated using a Cox regression model. Results: Of the 193 patients evaluated from the five tertiary hospitals, 127 were included in the study. Thirty-five patients (27.6%) died within 30 days. Infections with AmpC beta-lactamase-carrying bacteria were independently related to 30-day mortality (adjusted hazard ratio [aHR] 2.49, 95% confidence interval [CI] 1.28-4.84, P < 0.01) after adjusting for time from infection to antimicrobial prescription (P = 0.04). Further, these bacterial infections were also related to higher in-hospital mortality (aHR 2.17, 95% CI 1.24-3.78, P < 0.01). Only one patient developed resistance to ceftazidime-avibactam during treatment. Conclusions: Treatment with ceftazidime-avibactam had worse clinical outcomes in patients with infections with bacteria with chromosomally encoded AmpC beta-lactamase. However, these findings should be confirmed in future studies. |
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| MeSH term(s) | Adult ; Humans ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds ; beta-Lactamase Inhibitors/adverse effects ; Ceftazidime/adverse effects ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacterial Infections/drug therapy ; Prospective Studies |
| Chemical Substances | Anti-Bacterial Agents ; avibactam, ceftazidime drug combination ; Azabicyclo Compounds ; beta-Lactamase Inhibitors ; Ceftazidime (9M416Z9QNR) ; Drug Combinations |
| Language | English |
| Publishing date | 2024-02-09 |
| Publishing country | Netherlands |
| Document type | Multicenter Study ; Journal Article |
| ZDB-ID | 2710046-7 |
| ISSN | 2213-7173 ; 2213-7173 |
| ISSN (online) | 2213-7173 |
| ISSN | 2213-7173 |
| DOI | 10.1016/j.jgar.2024.02.001 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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