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  1. Article ; Online: Diacetylcurcumin: a novel strategy against

    Souza, Vanessa de / Polaquini, Carlos Roberto / de Moraes, Graciele Ribeiro / Oliveira Braga, Arthur Rodrigues / da Silva, Priscila Vieira / da Silva, Diego Romário / Ribeiro Lima, Francisco Ricardo / Regasini, Luís Octávio / Cássia Orlandi Sardi, Janaina de

    Future microbiology

    2024  

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2023-0235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans: a study in vitro.

    Graciani, Joice / Rosalen, Pedro Luiz / de Oliveira Chaves Dos Santos, Emmanuely / Rocha, Kellyth Andrade Pereira / Balen, Bruno Rafael Teixeira / Garcia, Mayara Aparecida Rocha / Lazarini, Josy Goldoni / da Silva, Diego Romario / Carvalho, Suzana Gonçalves / Regasini, Luís Octávio / Chorilli, Marlus / Orlandi Sardi, Janaina de Cássia

    Odontology

    2022  Volume 111, Issue 3, Page(s) 573–579

    Abstract: The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were ... ...

    Abstract The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C. albicans and E. faecalis strains with different aminochalcones (AM) were carried out, and the compound that presented the best activity against both pathogens was chosen. The formulation of an endodontic irrigant was elaborated, tested in mono and dual specie biofilms. Disks were sterilized and then incubated with E. faecalis, C. albicans and E. faecalis and C. albicans mixed for 72 h for biofilm maturation. After contamination, samples were divided in 4 experimental groups and 2 positive control group as follows: Group1: Irrigant; Group2: Irrigant + AM-38; Group3: Chlorhexidine 2% (positive control) and, Group 4: 1.0% sodium hypochlorite (positive control). The samples were analyzed by CFU/ml count. The sample was taken to sonicador to remove the cells and then plated. The toxicity was determined in vitro with human gingival fibroblast cells (HGF) and in vivo using the Galleria mellonella model. Formulation showed antimicrobial activity, with MIC on C. albicans 15.6 and E. faecalis 7.8 µg/ml. Treatment with formulation in concentration 156 µg/ml significantly reduced mono or dual species biofilm formation and viability (p < 0.05). The results were significant against C. albicans and E. faecalis and did not show toxicity in cells and G. mellonella. In general, the formulation showed effective antibiofilm activity, significantly reducing microorganisms, opening paths in search of new endodontic irrigants.
    MeSH term(s) Humans ; Candida albicans ; Enterococcus faecalis ; Chalcones/pharmacology ; Root Canal Irrigants/pharmacology ; Sodium Hypochlorite/pharmacology ; Biofilms ; Dental Pulp Cavity
    Chemical Substances Chalcones ; Root Canal Irrigants ; Sodium Hypochlorite (DY38VHM5OD)
    Language English
    Publishing date 2022-11-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2092085-4
    ISSN 1618-1255 ; 1618-1247
    ISSN (online) 1618-1255
    ISSN 1618-1247
    DOI 10.1007/s10266-022-00764-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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