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  1. Article ; Online: Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic

    de Oliveira Carvalho, Helison / Sauma, Ana Laura Ribeiro / do Nascimento, Aline Lopes / de Lima Teixeira, Abrahão Victor Tavares / Gonçalves, Danna Emanuelle Santos / Gomes, Lauana / da Costa Furtado, Gabriel / da Silva, Heitor Ribeiro / de Souza, Gisele Custódio / Pereira, Arlindo César Matias / Carvalho, José Carlos Tavares

    Inflammopharmacology

    2023  Volume 31, Issue 2, Page(s) 877–886

    Abstract: Bixa orellana L. is a plant popularly known as "ucurum", "annatto", and "achiote". It is native to South America, and its seeds are an abundant source of geranylgeraniol and tocotrienols. Nanoencapsulation is a valuable technique that can decrease the ... ...

    Abstract Bixa orellana L. is a plant popularly known as "ucurum", "annatto", and "achiote". It is native to South America, and its seeds are an abundant source of geranylgeraniol and tocotrienols. Nanoencapsulation is a valuable technique that can decrease the drug needed to achieve an effect, decreasing potential toxicity, side effects and potentiate the anti-inflammatory effect. This study aimed to evaluate the acute toxicity of an intramuscular application of a nanodispersion containing a standardized extract from the seeds of Bixa orellana (NBO) in Wistar rats. The chemical evaluation showed δ-tocotrienol at 0.725 ± 0.062 mg/mL (72.6 ± 0.9%). The stability study showed the nanoparticles had an average size from 53.15 ± 0.64 to 59.9 ± 3.63 nm, with a polydispersity index ranging from 0.574 ± 0.032 to 0.574 ± 0.32, Zeta potential from 18.26 ± 0.59 to 19.66 ± 1.45 mV. After testing the intramuscular application of NBO with doses from 1 to 5 mg/kg in animals, it was observed that the acute treatment did not elicit any toxic effects within this range. The dose of 10 mg/kg, although not affecting hematological and biochemical parameters (CPK, LDH, myoglobin, AST, ALT, TC, TG, glucose levels, creatinine, and urea), could induce some muscle tissue changes, including leukocyte infiltration, morphological chances, and potentially necrosis. In conclusion, the results showed that the treatments devoided toxicity between 1 and 5 mg/kg.
    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Bixaceae ; Tocotrienols/pharmacology ; Tocotrienols/therapeutic use ; Anti-Inflammatory Agents/toxicity ; Seeds ; Plant Extracts/toxicity ; Plant Extracts/therapeutic use
    Chemical Substances Tocotrienols ; Anti-Inflammatory Agents ; Plant Extracts
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01162-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3274: Show issues Location:
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  2. Article: Acute and Reproductive Toxicity Evaluation of Ormona

    da Rocha, Clarice Flexa / Flexa, Camila de Nazaré Nunes / de Souza, Gisele Custodio / Pereira, Arlindo César Matias / Carvalho, Helison de Oliveira / do Nascimento, Aline Lopes / de Jesus Vasconcelos, Natasha Juliana Perdigão / da Silva, Heitor Ribeiro / Carvalho, José Carlos Tavares

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 11

    Abstract: The zebrafish is a popular organism to test the toxicity of compounds. Here, we evaluate the acute and reproductive toxicity of Ormona ... ...

    Abstract The zebrafish is a popular organism to test the toxicity of compounds. Here, we evaluate the acute and reproductive toxicity of Ormona SI
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15111434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential of the Compounds from

    Batista, Mateus Alves / de Lima Teixeira Dos Santos, Abrahão Victor Tavares / do Nascimento, Aline Lopes / Moreira, Luiz Fernando / Souza, Indira Ramos Senna / da Silva, Heitor Ribeiro / Pereira, Arlindo César Matias / da Silva Hage-Melim, Lorane Izabel / Carvalho, José Carlos Tavares

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These compounds have beneficial effects against hyperlipidemia and chronic diseases, where oxidative stress and inflammation are present, but the exact mechanism of ... ...

    Abstract Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These compounds have beneficial effects against hyperlipidemia and chronic diseases, where oxidative stress and inflammation are present, but the exact mechanism of action of such activities is still a subject of research. This study aimed to evaluate possible mechanisms of action that could be underlying the activities of these molecules. For this, in silico approaches such as ligand topology (PASS and SEA servers) and molecular docking with the software GOLD were used. Additionally, we screened some pharmacokinetic and toxicological parameters using the servers PreADMET, SwissADME, and ProTox-II. The results corroborate the antidyslipidemia and anti-inflammatory activities of geranylgeraniol and tocotrienols. Notably, some new mechanisms of action were predicted to be potentially underlying the activities of these compounds, including inhibition of squalene monooxygenase, lanosterol synthase, and phospholipase A
    MeSH term(s) Bixaceae ; Carotenoids ; Diterpenes ; Dyslipidemias ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Tocotrienols/pharmacology
    Chemical Substances Diterpenes ; Plant Extracts ; Tocotrienols ; Carotenoids (36-88-4) ; annatto (6PQP1V1B6O) ; geranylgeraniol (AIA02AJA3A)
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  4. Article ; Online: Co-Treatment of Purified Annatto Oil (

    Pereira, Arlindo César Matias / de Oliveira Carvalho, Helison / Gonçalves, Danna Emanuelle Santos / Picanço, Karyny Roberta Tavares / de Lima Teixeira Dos Santos, Abrahão Victor Tavares / da Silva, Heitor Ribeiro / Braga, Francinaldo Sarges / Bezerra, Roberto Messias / de Sousa Nunes, Alessandro / Nazima, Maira Tiyomi Sacata Tongo / Cerqueira, Júlia Gomes / Taglialegna, Talisson / Teixeira, Janayra Maris / Carvalho, José Carlos Tavares

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 16

    Abstract: This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, ... ...

    Abstract This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic
    MeSH term(s) Animals ; Bixaceae/chemistry ; Body Weight/drug effects ; Carotenoids/chemistry ; Drinking Behavior/drug effects ; Feeding Behavior/drug effects ; Femur/drug effects ; Femur/ultrastructure ; Lipids/blood ; Male ; Orchiectomy ; Osteoporosis/blood ; Osteoporosis/etiology ; Plant Extracts/chemistry ; Plant Oils/pharmacology ; Protective Agents/pharmacology ; Rats, Wistar ; Testosterone/pharmacology ; Rats
    Chemical Substances Lipids ; Plant Extracts ; Plant Oils ; Protective Agents ; Carotenoids (36-88-4) ; Testosterone (3XMK78S47O) ; annatto (6PQP1V1B6O)
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  5. Article: Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio)

    dos Santos Sampaio, Tafnis Ingret / de Melo, Nayara Costa / de Freitas Paiva, Bianca Thais / da Silva Aleluia, Gerley Anatê / da Silva Neto, Fernando Luiz Pinheiro / da Silva, Heitor Ribeiro / Keita, Hady / Cruz, Rodrigo Alves Soares / Sánchez-Ortiz, Brenda Lorena / Pineda-Peña, Elizabeth Arlen / Balderas, José Luis / Navarrete, Andres / Carvalho, José Carlos Tavares

    Journal of ethnopharmacology. 2018 Oct. 05, v. 224

    2018  

    Abstract: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it ... ...

    Abstract Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species.the hydroethanolic extract from S. mombin leaves (HELSm) was evaluated by oral administration (25 mg/kg) and by immersion (25 mg/l) in scototaxis test in zebrafish (Danio rerio). For this study, caffeine (100 mg/kg) and buspirone (25 mg/kg) were used as standard drugs. The antidepressant action of the HELSm was evaluated assessed in the novel tank diving test (NTDT). In this study, a group with 1% ethanol, one with unpredictable chronic mild stress (UCMS), and another with developmental, social isolation (DSI) were used as induction groups for depression-like behavior and fluoxetine (20 mg/kg) as a drug pattern.by the HPLC-UV fingerprint analysis, the HELSm presented several derivatives of polyphenolic compounds and flavonoids and identified ellagic acid and isoquercitrin, and by the gas-chromatographic, the majority of the identified compounds were fatty acids, esters, and alcohols. By immersion, the LC50 was 49.86 mg/l and by oral via the LD50 in 48 h, was 4.515 g/kg in zebrafish. For all spatiotemporal and behavioral variables (time spent, white compartment, latency, toggle, erratic swimming, freezing duration, thigmotaxis, and risk assessment), the treatment with HELSm produced a similar effect to buspirone and was significant when compared to the caffeine and control group (p < 0.01, Tukey-Kramer test). For all spatiotemporal and behavioral variables evaluated (time spent at the top of the apparatus, crossed quadrants, erratic swimming, and duration of freezing), treatment with HELSm produced a change in the depression-like behavior in the groups tested, with a similar effect to fluoxetine, both with a significant difference when compared to the control groups (p < 0.01).Our results suggest that the acute administration of the HELSm in the scototaxis and NTDT tests in a zebrafish model (Danio rerio) produced anxiolytic and antidepressant effects, devoid of hypnotic and sedative actions by immersion, and this action was improved when administered by oral via. Possibly, the presence of isoquercitrin in the leaves of Spondias mombin participates in the anxiolytic and antidepressant effects.
    Keywords Danio rerio ; Spondias mombin ; antidepressants ; caffeine ; ellagic acid ; esters ; ethanol ; fatty acids ; freezing ; gas chromatography ; high performance liquid chromatography ; isoquercitrin ; leaves ; lethal concentration 50 ; lethal dose 50 ; models ; oral administration ; polyphenols ; risk assessment ; sedatives ; swimming ; thigmotaxis ; traditional medicine ; tranquilizers ; tropics ; Africa ; Asia ; Brazil
    Language English
    Dates of publication 2018-1005
    Size p. 563-578.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.05.037
    Database NAL-Catalogue (AGRICOLA)

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    Z 90/710: Show issues

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  6. Article ; Online: Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio).

    Dos Santos Sampaio, Tafnis Ingret / de Melo, Nayara Costa / de Freitas Paiva, Bianca Thais / da Silva Aleluia, Gerley Anatê / da Silva Neto, Fernando Luiz Pinheiro / da Silva, Heitor Ribeiro / Keita, Hady / Cruz, Rodrigo Alves Soares / Sánchez-Ortiz, Brenda Lorena / Pineda-Peña, Elizabeth Arlen / Balderas, José Luis / Navarrete, Andres / Carvalho, José Carlos Tavares

    Journal of ethnopharmacology

    2018  Volume 224, Page(s) 563–578

    Abstract: Ethnobotanical relevance: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric ...

    Abstract Ethnobotanical relevance: Spondias mombin L. is a plant dispersed throughout the tropical regions of South America, Africa, and Asia, being found mainly in the North and Northeast of Brazil, where the leaves are used in preparations for neuropsychiatric disorders. Therefore, it is of great importance to carry out studies in different pharmacological models that can prove the traditional use of this plant species.
    Materials and methods: the hydroethanolic extract from S. mombin leaves (HELSm) was evaluated by oral administration (25 mg/kg) and by immersion (25 mg/l) in scototaxis test in zebrafish (Danio rerio). For this study, caffeine (100 mg/kg) and buspirone (25 mg/kg) were used as standard drugs. The antidepressant action of the HELSm was evaluated assessed in the novel tank diving test (NTDT). In this study, a group with 1% ethanol, one with unpredictable chronic mild stress (UCMS), and another with developmental, social isolation (DSI) were used as induction groups for depression-like behavior and fluoxetine (20 mg/kg) as a drug pattern.
    Results: by the HPLC-UV fingerprint analysis, the HELSm presented several derivatives of polyphenolic compounds and flavonoids and identified ellagic acid and isoquercitrin, and by the gas-chromatographic, the majority of the identified compounds were fatty acids, esters, and alcohols. By immersion, the LC
    Conclusions: Our results suggest that the acute administration of the HELSm in the scototaxis and NTDT tests in a zebrafish model (Danio rerio) produced anxiolytic and antidepressant effects, devoid of hypnotic and sedative actions by immersion, and this action was improved when administered by oral via. Possibly, the presence of isoquercitrin in the leaves of Spondias mombin participates in the anxiolytic and antidepressant effects.
    MeSH term(s) Anacardiaceae ; Animals ; Anti-Anxiety Agents/pharmacology ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Female ; Male ; Plant Extracts/pharmacology ; Plant Leaves ; Social Isolation ; Stress, Psychological/drug therapy ; Zebrafish/physiology
    Chemical Substances Anti-Anxiety Agents ; Antidepressive Agents ; Plant Extracts
    Language English
    Publishing date 2018-05-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.05.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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