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  1. Article ; Online: Obatoclax reduces cell viability of acute myeloid leukemia cell lines independently of their sensitivity to venetoclax.

    Lima, Keli / Vicari, Hugo Passos / Carlos, Jorge Antonio Elias Godoy / da Silva, Jean Carlos Lipreri / Figueiredo-Pontes, Lorena Lobo de / Rego, Eduardo Magalhães / Machado-Neto, João Agostinho

    Hematology, transfusion and cell therapy

    2021  Volume 44, Issue 1, Page(s) 124–127

    Language English
    Publishing date 2021-03-13
    Publishing country Brazil
    Document type Letter
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2021.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthetic cyclopenta[b]indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells.

    Vicari, Hugo Passos / Lima, Keli / Gomes, Ralph da Costa / Fernandes, Daniara Cristina / da Silva, Jean Carlos Lipreri / Rodrigues Junior, Manoel Trindade / Barroso de Oliveira, Aline Silva / Dos Santos, Ricardo Nascimento / Andricopulo, Adriano Defini / Coelho, Fernando / Costa-Lotufo, Leticia Veras / Machado-Neto, João Agostinho

    European journal of pharmacology

    2021  Volume 894, Page(s) 173853

    Abstract: Acute promyelocytic leukemia (APL) is associated with PML-RARα oncogene, which is treated using all-trans retinoic acid (ATRA)-based chemotherapy. However, chemoresistance is observed in 20-30% of treated patients and represents a clinical challenge, ... ...

    Abstract Acute promyelocytic leukemia (APL) is associated with PML-RARα oncogene, which is treated using all-trans retinoic acid (ATRA)-based chemotherapy. However, chemoresistance is observed in 20-30% of treated patients and represents a clinical challenge, raising the importance of the development of new therapeutic options. In the present study, the effects of three synthetic cyclopenta[b]indoles on the leukemia phenotype were investigated using NB4 (ATRA-sensitive) and NB4-R2 (ATRA-resistant) cells. Among the tested synthetic cyclopenta[b]indoles, compound 2, which contains a heterocyclic nucleus, was the most active, presenting time-dependent cytotoxic activity in the μM range in APL cells, without cytotoxicity for normal leukocytes, and was selected for further characterization. Compound 2 significantly decreased clonogenicity, increased apoptosis, and caused cell cycle arrest at S and G
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclopentanes/chemistry ; DNA Damage/drug effects ; Drug Resistance, Neoplasm/drug effects ; Humans ; Indoles/chemistry ; Indoles/pharmacology ; Leukemia, Promyelocytic, Acute/drug therapy ; Microtubules/drug effects ; Microtubules/metabolism ; Mitosis/drug effects ; Models, Molecular ; Stathmin/biosynthesis ; Tumor Stem Cell Assay
    Chemical Substances Antineoplastic Agents ; Cyclopentanes ; Indoles ; STMN1 protein, human ; Stathmin
    Language English
    Publishing date 2021-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2021.173853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours.

    Dos Santos Passaia, Bárbara / Lima, Keli / Kremer, Jean Lucas / da Conceição, Barbara Brito / de Paula Mariani, Beatriz Marinho / da Silva, Jean Carlos Lipreri / Zerbini, Maria Claudia Nogueira / Fragoso, Maria Candida Barisson Villares / Machado-Neto, João Agostinho / Lotfi, Claudimara Ferini Pacicco

    Investigational new drugs

    2019  Volume 38, Issue 3, Page(s) 899–908

    Abstract: Adrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant ... ...

    Abstract Adrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant phenotype of cancer cells. Recently, it was reported that STMN1 is highly expressed in ACC patients, and STMN1 silencing reduces the clonogenicity and migration of ACC cell lines. However, the prognostic significance of STMN1 and its therapeutic potential remain undefined in ACC. In the present study, STMN1 mRNA levels were significantly higher (p < 0.05) in ACC patients, especially in an advanced stage, and correlated with BUB1B and PINK1 expression, the prognostic-related genes in ACC. In paediatric tumours, high STMN1 expression was observed in both adrenocortical carcinoma and adrenocortical adenoma patients. Among the adult malignant tumours, STMN1 level was an independent predictor of survival outcomes (overall survival: hazard ratio = 6.08, p = 0.002; disease-free survival: hazard ratio = 4.65, p < 0.0001). Paclitaxel, a microtubule-stabilizing drug, reduces the activation of STMN1 and significantly decreases cell migration and invasion in ACC cell lines and ACC cells from secondary cell culture (all p < 0.0001). In summary, STMN1 expression may be of great value to clinical and pathological findings in therapeutic trials and deserves future studies in ACC.
    MeSH term(s) Adrenal Cortex Neoplasms/drug therapy ; Adrenal Cortex Neoplasms/genetics ; Adrenal Cortex Neoplasms/mortality ; Adrenocortical Carcinoma/drug therapy ; Adrenocortical Carcinoma/genetics ; Adrenocortical Carcinoma/mortality ; Adrenocortical Carcinoma/pathology ; Adult ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Child, Preschool ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Paclitaxel/therapeutic use ; Prognosis ; RNA, Messenger/genetics ; Stathmin/genetics
    Chemical Substances Biomarkers, Tumor ; RNA, Messenger ; STMN1 protein, human ; Stathmin ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604895-x
    ISSN 1573-0646 ; 0167-6997
    ISSN (online) 1573-0646
    ISSN 0167-6997
    DOI 10.1007/s10637-019-00846-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1823: Show issues Location:
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