Article ; Online: DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016.
2018 Volume 8, Issue 1, Page(s) 17160
Abstract: In Brazil, DENV-1 introduced in the 80's, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was ... ...
| Abstract | In Brazil, DENV-1 introduced in the 80's, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was not fully characterized. In this study, we performed the continuous molecular surveillance after the reemergence period (2012 to 2016), covering the 30 years of circulation of DENV-1 in Brazil. Phylogenetic analysis allowed confirmation of the continued presence of genotype V, as well as three distinct co-circulating lineages. The molecular characterization of the E gene presented two new amino acid substitutions previously unidentified in the country. Phylogeographic analysis has shown that a large flow of migrations has occurred between Brazil and Argentina in the last 10 years. |
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| MeSH term(s) | Brazil/epidemiology ; Dengue/epidemiology ; Dengue/virology ; Dengue Virus/classification ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Epidemiological Monitoring ; Genotype ; Humans ; Molecular Epidemiology ; Phylogeny ; Sequence Analysis, DNA ; Serogroup ; Spatio-Temporal Analysis ; Viral Envelope Proteins/genetics |
| Chemical Substances | Viral Envelope Proteins |
| Language | English |
| Publishing date | 2018-11-21 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-018-35622-x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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