Article: The oldest unvaccinated Covid-19 survivors in South America.
2022 Volume 19, Issue 1, Page(s) 57
Abstract: Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, ... ...
| Abstract | Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity. |
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| Language | English |
| Publishing date | 2022-11-16 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2168941-6 |
| ISSN | 1742-4933 |
| ISSN | 1742-4933 |
| DOI | 10.1186/s12979-022-00310-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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