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Article ; Online: Spatiotemporal dynamics and epidemiological impact of SARS-CoV-2 XBB lineage dissemination in Brazil in 2023.

Arantes, Ighor / Gomes, Marcelo / Ito, Kimihito / Sarafim, Sharbilla / Gräf, Tiago / Miyajima, Fabio / Khouri, Ricardo / de Carvalho, Felipe Cotrim / de Almeida, Walquiria Aparecida Ferreira / Siqueira, Marilda Mendonça / Resende, Paola Cristina / Naveca, Felipe Gomes / Bello, Gonzalo

Microbiology spectrum

2024 Volume 12, Issue 3, Page(s) e0383123

Abstract: The SARS-CoV-2 XBB is a group of highly immune-evasive lineages of the Omicron variant of concern that emerged by recombining BA.2-descendent lineages and spread worldwide during 2023. In this study, we combine SARS-CoV-2 genomic data (: Importance: ... ...

Abstract	The SARS-CoV-2 XBB is a group of highly immune-evasive lineages of the Omicron variant of concern that emerged by recombining BA.2-descendent lineages and spread worldwide during 2023. In this study, we combine SARS-CoV-2 genomic data ( Importance: Brazil was one the most affected countries by the SARS-CoV-2 pandemic, with more than 700,000 deaths by mid-2023. This study reconstructs the dissemination of the virus in the country in the first half of 2023, a period characterized by the dissemination of descendants of XBB.1, a recombinant of Omicron BA.2 lineages evolved in late 2022. The analysis supports that XBB dissemination was marked by the continuous emergence of indigenous lineages bearing similar mutations in key sites of their Spike protein, a process followed by continuous increments in transmissibility, and without repercussions in the incidence of severe cases. Thus, the results suggest that the epidemiological impact of the spread of a SARS-CoV-2 variant is influenced by an intricate interplay of factors that extend beyond the virus's transmissibility alone. The study also underlines the need for SARS-CoV-2 genomic surveillance that allows the monitoring of its ever-shifting composition.
MeSH term(s)	Humans ; Brazil/epidemiology ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03831-23
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Article ; Online: Clinical and epidemiological aspects of severe acute respiratory infection: before and during the first year of the COVID-19 pandemic in Brazil.

de Carvalho, Felipe Cotrim / da Silva, Erica Tatiane / de Almeida, Walquiria Aparecida Ferreira / Maroneze, Matheus Almeida / Schwartz, Jaqueline de Araujo / Jardim, João Pedro Vieira / Peixoto, Henry Maia

Transactions of the Royal Society of Tropical Medicine and Hygiene

2023 Volume 117, Issue 3, Page(s) 161–173

Abstract: Background: Widespread respiratory infections with high morbidity rates caused by respiratory viruses represent a significant global public health problem. Our objective was to describe cases and deaths from severe acute respiratory infection (SARI) in ... ...

Abstract	Background: Widespread respiratory infections with high morbidity rates caused by respiratory viruses represent a significant global public health problem. Our objective was to describe cases and deaths from severe acute respiratory infection (SARI) in Brazil over the past 8 y as well as changes in the distribution and risk of illness and death from SARI before and in the first year of the coronavirus disease 2019 (COVID-19) pandemic (FYP). Methods: We performed a descriptive epidemiological study of hospitalized SARI cases and deaths between 2013 and 2020 in Brazil, separated into pre-pandemic (2013 to 2019) and FYP (2020). We estimate the increase in SARI cases and deaths in the FYP as well as the mortality and infection risks attributable to the FYP (MRAP and IRAP, respectively). Results: In 2020, an excess of 425 054 cases and 109 682 deaths was observed, with a significant increase in the risk of falling ill and dying from SARI, with an IRAP of 200.06 and an MRAP of 51.68 cases per 100 000 inhabitants. The increase in SARI cases and deaths was particularly prominent among patients with COVID-19, the elderly, males, those self-identifying as mixed race and patients with heart disease and diabetes. We conclude that an important increase in morbidity and mortality due to SARI was observed in the FYP. More vulnerable groups and those living in the Southeast, North and Center-West regions of the country suffered the most.
MeSH term(s)	Male ; Humans ; Infant ; Aged ; COVID-19 ; Influenza, Human/epidemiology ; Pandemics ; Brazil ; Respiratory Tract Infections/epidemiology ; Hospitalization
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trac074
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Article ; Online: Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study.

Sartor, Ivaine Tais Sauthier / de David, Caroline Nespolo / Telo, Gabriela Heiden / Zavaglia, Gabriela Oliveira / Fernandes, Ingrid Rodrigues / Kern, Luciane Beatriz / Polese-Bonatto, Márcia / Azevedo, Thaís Raupp / Santos, Amanda Paz / de Almeida, Walquiria Aparecida Ferreira / Porto, Victor Bertollo Gomes / Varela, Fernanda Hammes / Scotta, Marcelo Comerlato / Rosa, Regis Goulart / Stein, Renato T

Archives of endocrinology and metabolism

2022 Volume 66, Issue 4, Page(s) 512–521

Abstract: Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil.: Methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public ... ...

Abstract	Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.
MeSH term(s)	Adult ; Brazil/epidemiology ; COVID-19/epidemiology ; Female ; Hospitalization ; Humans ; Male ; Obesity/epidemiology ; Outpatients ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-09-21
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-3997000000486
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Article ; Online: Children Have Similar Reverse Transcription Polymerase Chain Reaction Cycle Threshold for Severe Acute Respiratory Syndrome Coronavirus 2 in Comparison With Adults.

Polese-Bonatto, Márcia / Sartor, Ivaine Tais Sauthier / Varela, Fernanda Hammes / Giannini, Gabriela Luchiari Tumioto / Azevedo, Thaís Raupp / Kern, Luciane Beatriz / Fernandes, Ingrid Rodrigues / Zavaglia, Gabriela Oliveira / de David, Caroline Nespolo / Santos, Amanda Paz / de Almeida, Walquiria Aparecida Ferreira / Porto, Victor Bertollo Gomes / Scotta, Marcelo Comerlato / Stein, Renato T

The Pediatric infectious disease journal

2021 Volume 40, Issue 11, Page(s) e413–e417

Abstract: Background: The viral dynamics and the role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (RT-PCR) cycle ... ...

Abstract	Background: The viral dynamics and the role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values among children with confirmed SARS-CoV-2 compared with that of adult subjects. Methods: Patients (from 2 months to ≤18 years of age and adults) with signs and symptoms of acute SARS-CoV-2 infection for less than 7 days were prospectively enrolled in the study from May to November 2020. All participants performed RT-PCR assay for SARS-CoV-2 detection; Ct values of ORF1ab, N and S gene targets and the average of all the 3 probes were used as surrogates of viral load. Results: There were 21 infants (2 months to <2 years), 40 children (≥2 to <12 years), 22 adolescents (≥12 to <18 years) and 293 adults of 376 participants with confirmed SARS-CoV-2 infections. RT-PCR Ct values from all participants less than 18 years of age, as well as from all childhood subgroups, were not significantly different from adults, comparing ORF1ab, N, S and all the gene targets together (P = 0.453). Conclusions: Ct values for children were comparable with that of adults. Although viral load is not the only determinant of SARS-CoV-2 transmission, children may play a role in the spread of coronavirus disease 2019 in the community.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Brazil ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing ; Child ; Cross-Sectional Studies ; Humans ; Infant ; RNA, Viral ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/standards ; SARS-CoV-2/genetics ; Viral Load
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003300
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Article ; Online: Absence of detection of RSV and influenza during the COVID-19 pandemic in a Brazilian cohort: Likely role of lower transmission in the community.

Varela, Fernanda Hammes / Scotta, Marcelo Comerlato / Polese-Bonatto, Márcia / Sartor, Ivaine Tais Sauthier / Ferreira, Charles Francisco / Fernandes, Ingrid Rodrigues / Zavaglia, Gabriela Oliveira / de Almeida, Walquiria Aparecida Ferreira / Arakaki-Sanchez, Denise / Pinto, Leonardo Araújo / Nader Bastos, Gisele Alsina / Nasi, Luiz Antônio / Falavigna, Maicon / Pitrez, Paulo Márcio / Stein, Renato T

Journal of global health

2021 Volume 11, Page(s) 5007

Abstract: Background: Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing SARS-CoV-2 ... ...

Abstract	Background: Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing SARS-CoV-2 spread could impact transmission of other respiratory viruses as well. The aim of this study is to report the detection of RSV and influenza during the period of social distancing due to COVID-19 pandemic in a heavily affected community. Methods: Prospective study with pediatric and adult populations seeking care for COVID-19-like symptoms during the fall and winter of 2020 at two hospitals in Southern Brazil. RT-PCR tests for SARS-CoV-2, influenza A (Flu A), influenza B (Flu B) and respiratory syncytial virus (RSV) was performed for all participants. Results: 1435 suspected COVID-19 participants (1137 adults, and 298 children). were included between May and August. Median age was 37.7 years (IQR = 29.6-47.7), and 4.92 years (IQR = 1.96-9.53), for the adult and child cohorts, respectively. SARS-CoV-2 was positive in 469 (32.7%) while influenza and RSV were not detected at all. Conclusions: Measures to reduce SARS-CoV-2 transmission likely exerted a huge impact in the spread of alternate respiratory pathogens. These findings contribute to the knowledge about the dynamics of virus spread. Further, it may be considered for guiding therapeutic choices for these other viruses.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; Child ; Child, Preschool ; Female ; Hospitals ; Humans ; Infant ; Influenza A virus/isolation & purification ; Influenza B virus/isolation & purification ; Influenza, Human/diagnosis ; Influenza, Human/transmission ; Male ; Middle Aged ; Physical Distancing ; Prospective Studies ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/transmission ; Respiratory Syncytial Viruses/isolation & purification ; SARS-CoV-2/isolation & purification ; Seasons ; Young Adult
Language	English
Publishing date	2021-03-01
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.11.05007
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Article ; Online: Low prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasons.

Sousa, Thiago das Chagas / Martins, Jessica Santa Cruz Carvalho / Miranda, Milene Dias / Garcia, Cristiana Couto / Resende, Paola Cristina / Santos, Cliomar A / Debur, Maria do Carmo / Rodrigues, Rodrigo Ribeiro / Cavalcanti, Andrea Cony / Gregianini, Tatiana Schäffer / Iani, Felipe Campos de Melo / Pereira, Felicidade Mota / Fernandes, Sandra Bianchini / Ferreira, Jessylene de Almeida / Santos, Katia Correa de Oliveira / Motta, Fernando / Brown, David / de Almeida, Walquiria Aparecida Ferreira / Siqueira, Marilda Mendonça /

Matos, Aline da Rocha

Frontiers in public health

2022 Volume 10, Page(s) 944277

Abstract: The influenza A virus (IAV) is of a major public health concern as it causes annual epidemics and has the potential to cause pandemics. At present, the neuraminidase inhibitors (NAIs) are the most widely used anti-influenza drugs, but, more recently, the ...

Abstract	The influenza A virus (IAV) is of a major public health concern as it causes annual epidemics and has the potential to cause pandemics. At present, the neuraminidase inhibitors (NAIs) are the most widely used anti-influenza drugs, but, more recently, the drug baloxavir marboxil (BXM), a polymerase inhibitor, has also been licensed in some countries. Mutations in the viral genes that encode the antiviral targets can lead to treatment resistance. Worldwide, a low prevalence of antiviral resistant strains has been reported. Despite that, this situation can change rapidly, and resistant strain surveillance is a priority. Thus, the aim of this was to evaluate Brazilian IAVs antiviral resistance from 2017 to 2019 through the identification of viral mutations associated with reduced inhibition of the drugs and by testing the susceptibility of IAV isolates to oseltamivir (OST), the most widely used NAI drug in the country. Initially, we analyzed 282 influenza A(H1N1)pdm09 and 455 A(H3N2) genetic sequences available on GISAID. The amino acid substitution (AAS) NA:S247N was detected in one A(H1N1)pdm09 strain. We also identified NA:I222V (
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Brazil/epidemiology ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Guanidines/pharmacology ; Guanidines/therapeutic use ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/metabolism ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/metabolism ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Neuraminidase/genetics ; Neuraminidase/metabolism ; Neuraminidase/therapeutic use ; Oseltamivir/pharmacology ; Oseltamivir/therapeutic use ; Prevalence ; Seasons
Chemical Substances	Antiviral Agents ; Enzyme Inhibitors ; Guanidines ; Oseltamivir (20O93L6F9H) ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.944277
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Article ; Online: SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies.

Lima, Karina / Fontoura, Julia C / de Souza, Priscila Oliveira / Fazolo, Tiago / Hilario, Gabriel / Zorzetto, Renata / Rodrigues Junior, Luiz C / Coimbra, Lais D / Borin, Alexandre / Bispo-Dos-Santos, Karina / Granja, Fabiana / Marques, Rafael Elias / Zavaglia, Gabriela Oliveira / Fernandes, Ingrid Rodrigues / Varela, Fernanda Hammes / Polese-Bonatto, Marcia / Tonini, Maiko Luís / Ikeda do Carmo, Greice Madeleine / de Almeida, Walquiria Aparecida Ferreira /

Borges, Thiago J / Nakaya, Helder I / Proenca-Modena, José Luiz / Callegari-Jacques, Sidia Maria / Scotta, Marcelo Comerlato / Stein, Renato T / Bonorino, Cristina

Frontiers in immunology

2022 Volume 13, Page(s) 1033364

Abstract: This is the third year of the SARS-CoV-2 pandemic, and yet most children remain unvaccinated. COVID-19 in children manifests as mostly mild or asymptomatic, however high viral titers and strong cellular and humoral responses are observed upon acute ... ...

Abstract	This is the third year of the SARS-CoV-2 pandemic, and yet most children remain unvaccinated. COVID-19 in children manifests as mostly mild or asymptomatic, however high viral titers and strong cellular and humoral responses are observed upon acute infection. It is still unclear how long these responses persist, and if they can protect from re-infection and/or disease severity. Here, we analyzed immune memory responses in a cohort of children and adults with COVID-19. Important differences between children and adults are evident in kinetics and profile of memory responses. Children develop early N-specific cytotoxic T cell responses, that rapidly expand and dominate their immune memory to the virus. Children's anti-N, but not anti-S, antibody titers increase over time. Neutralization titers correlate with N-specific antibodies and CD8
MeSH term(s)	Humans ; Adult ; Child ; SARS-CoV-2 ; Immunologic Memory ; COVID-19 ; CD8-Positive T-Lymphocytes ; Nucleocapsid ; Antibodies
Chemical Substances	Antibodies
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1033364
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Article ; Online: Severity of influenza illness by seasonal influenza vaccination status among hospitalised patients in four South American countries, 2013-19: a surveillance-based cohort study.

Regan, Annette K / Arriola, Carmen Sofia / Couto, Paula / Duca, Lindsey / Loayza, Sergio / Nogareda, Francisco / de Almeida, Walquiria Aparecida Ferreira / Antman, Julian / Araya, Soraya / Avendaño Vigueras, Marcela Alejandra / Battaglia Paredes, Silvia Carolina / Brstilo, Ivan Fedor / Bustos, Patricia / Fandiño, Maria Eugenia / Fasce, Rodrigo / Giovacchini, Carlos Maria / González Caro, Cecilia Isaura / von Horoch, Marta / Del Valle Juarez, Maria /

Katz, Nathalia / Olivares, Maria Fernanda / da Silva, Daiana Araújo / da Silva, Erica Tatiane / Sotomayor, Viviana / Vergara, Natalia / Azziz-Baumgartner, Eduardo / Ropero, Alba Maria

The Lancet. Infectious diseases

2022 Volume 23, Issue 2, Page(s) 222–232

Abstract: Background: Although several studies have reported attenuated influenza illness following influenza vaccination, results have been inconsistent and have focused predominantly on adults in the USA. This study aimed to evaluate the severity of influenza ... ...

Abstract	Background: Although several studies have reported attenuated influenza illness following influenza vaccination, results have been inconsistent and have focused predominantly on adults in the USA. This study aimed to evaluate the severity of influenza illness by vaccination status in a broad range of influenza vaccine target groups across multiple South American countries. Methods: We analysed data from four South American countries (Argentina, Brazil, Chile, and Paraguay) participating in REVELAC-i, a multicentre, test-negative design, vaccine effectiveness network including 41 sentinel hospitals. Individuals hospitalised at one of these centres with severe acute respiratory infection were tested for influenza by real-time RT-PCR, and were included in the analysis if they had complete information about their vaccination status and outcomes of their hospital stay. We used multivariable logistic regression weighted by inverse probability of vaccination and adjusted for antiviral use, duration of illness before admission, and calendar week, to calculate the adjusted odds ratios (aORs) of intensive care unit (ICU) admission and in-hospital death (and combinations of these outcomes) among influenza-positive patients by vaccination status for three target groups: young children (aged 6-24 months), adults (aged 18-64 years) with pre-existing health conditions, and older adults (aged ≥65 years). Survival curves were used to compare length of hospital stay by vaccination status in each target group. Findings: 2747 patients hospitalised with PCR-confirmed influenza virus infection between Jan 1, 2013, and Dec 8, 2019, were included in the study: 649 children (70 [10·8%] fully vaccinated, 193 [29·7%] partially vaccinated) of whom 87 (13·4%) were admitted to ICU and 12 (1·8%) died in hospital; 520 adults with pre-existing medical conditions (118 [22·7%] vaccinated), of whom 139 (26·7%) were admitted to ICU and 55 (10·6%) died in hospital; and 1578 older adults (609 [38·6%] vaccinated), of whom 271 (17·2%) were admitted to ICU and 220 (13·9%) died in hospital. We observed earlier discharge among partially vaccinated children (adjusted hazard ratio 1·14 [95% CI 1·01-1·29]), fully vaccinated children (1·24 [1·04-1·47]), and vaccinated adults with pre-existing medical conditions (1·78 [1·18-2·69]) compared with their unvaccinated counterparts, but not among vaccinated older adults (0·82 [0·65-1·04]). Compared with unvaccinated individuals, lower odds of ICU admission were found for partially vaccinated children (aOR 0·64 [95% CI 0·44-0·92]) and fully vaccinated children (0·52 [0·28-0·98]), but not for adults with pre-existing conditions (1·25 [0·93-1·67]) or older adults (0·88 [0·72-1·08]). Lower odds of in-hospital death (0·62 [0·50-0·78]) were found in vaccinated versus unvaccinated older adults, with or without ICU admission, but did not differ significantly in partially vaccinated (1·35 [0·57-3·20]) or fully vaccinated young children (0·88 [0·16-4·82]) or adults with pre-existing medical conditions (1·09 [0·73-1·63]) compared with the respective unvaccinated patient groups. Interpretation: Influenza vaccination was associated with illness attenuation among those hospitalised with influenza, although results differed by vaccine target group. These findings might suggest that attenuation of disease severity might be specific to certain target groups, seasons, or settings. Funding: US Centers for Disease Control and Prevention. Translations: For the Spanish and Portuguese translations of the abstract see Supplementary Materials section.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Aged ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza Vaccines ; Seasons ; Cohort Studies ; Hospital Mortality ; Hospitalization ; Vaccination ; Brazil/epidemiology
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(22)00493-5
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Article ; Online: Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction.

Sartor, Ivaine Tais Sauthier / Varela, Fernanda Hammes / Meireles, Mariana Rost / Kern, Luciane Beatriz / Azevedo, Thaís Raupp / Giannini, Gabriela Luchiari Tumioto / da Silva, Mariana Soares / Demoliner, Meriane / Gularte, Juliana Schons / de Almeida, Paula Rodrigues / Fleck, Juliane Deise / Zavaglia, Gabriela Oliveira / Fernandes, Ingrid Rodrigues / de David, Caroline Nespolo / Santos, Amanda Paz / de Almeida, Walquiria Aparecida Ferreira / Porto, Victor Bertollo Gomes / Scotta, Marcelo Comerlato / Vieira, Gustavo Fioravanti /

Spilki, Fernando Rosado / Stein, Renato T / Polese-Bonatto, Márcia

Diagnostic microbiology and infectious disease

2022 Volume 102, Issue 4, Page(s) 115636

Abstract: We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID- ... ...

Abstract	We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. All participants performed RT-PCR assay, and samples with S gene dropout and cycle threshold < 30 were submitted to high-throughput sequencing (HTS). 484 out of 1,557 participants tested positive for SARS-CoV-2. The S gene dropout was detected in 7.4% (36/484) and a peak was observed in August. The B.1.1.28, B.1.91 and B.1.1.33 lineages were circulating in early pandemic. The RBD novel mutation (Y380Q) was found in one sample occurring simultaneously with C379W and V395A, and the B.1.91 lineage in the spike protein. The Y380Q and C379W may interfere with the binding of neutralizing antibodies (CR3022, EY6A, H014, S304).
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Child ; Humans ; Infant ; Mutation ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; CR3022 ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115636
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Article: The Global Epidemiology of RSV in Community and Hospitalized Care: Findings From 15 Countries.

Staadegaard, Lisa / Caini, Saverio / Wangchuk, Sonam / Thapa, Binay / de Almeida, Walquiria Aparecida Ferreira / de Carvalho, Felipe Cotrim / Njouom, Richard / Fasce, Rodrigo A / Bustos, Patricia / Kyncl, Jan / Novakova, Ludmila / Caicedo, Alfredo Bruno / de Mora Coloma, Domenica Joseth / Meijer, Adam / Hooiveld, Mariëtte / Huang, Sue / Wood, Tim / Guiomar, Raquel / Rodrigues, Ana Paula /

Danilenko, Daria / Stolyarov, Kirill / Lee, Vernon Jian Ming / Ang, Li Wei / Cohen, Cheryl / Moyes, Jocelyn / Larrauri, Amparo / Delgado-Sanz, Concepción / Le, Mai Quynh / Hoang, Phuong Vu Mai / Demont, Clarisse / Bangert, Mathieu / van Summeren, Jojanneke / Dückers, Michel / Paget, John

Open forum infectious diseases

2021 Volume 8, Issue 7, Page(s) ofab159

Abstract: Background: Respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infections. To optimize control strategies, a better understanding of the global epidemiology of RSV is critical. To this end, we initiated the Global ... ...

Abstract	Background: Respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infections. To optimize control strategies, a better understanding of the global epidemiology of RSV is critical. To this end, we initiated the Global Epidemiology of RSV in Hospitalized and Community care study (GERi). Methods: Focal points from 44 countries were approached to join GERi and share detailed RSV surveillance data. Countries completed a questionnaire on the characteristics of their surveillance system. Results: Fifteen countries provided granular surveillance data and information on their surveillance system. A median (interquartile range) of 1641 (552-2415) RSV cases per season were reported from 2000 and 2020. The majority (55%) of RSV cases occurred in the <1-year-olds, with 8% of cases reported in those aged ≥65 years. Hospitalized cases were younger than those in community care. We found no age difference between RSV subtypes and no clear pattern of dominant subtypes. Conclusions: The high number of cases in the <1-year-olds indicates a need to focus prevention efforts in this group. The minimal differences between RSV subtypes and their co-circulation implies that prevention needs to target both subtypes. Importantly, there appears to be a lack of RSV surveillance data in the elderly.
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab159
Database	MEDical Literature Analysis and Retrieval System OnLINE

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