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  1. Article ; Online: SARS-CoV-2 and COVID-19 for the ophthalmologist.

    Brandão-de-Resende, Camilo / Diniz-Filho, Alberto / de Almeida Brito, Fabiano / Vasconcelos-Santos, Daniel Vitor

    Clinical & experimental ophthalmology

    2020  Volume 49, Issue 1, Page(s) 70–80

    Abstract: The COVID-19 pandemic has had an unprecedented impact on ophthalmology. This review compiles general aspects of the novel coronavirus and COVID-19, further dissects the most recent data on the role of the eye regarding disease transmission and ... ...

    Abstract The COVID-19 pandemic has had an unprecedented impact on ophthalmology. This review compiles general aspects of the novel coronavirus and COVID-19, further dissects the most recent data on the role of the eye regarding disease transmission and manifestations, and summarizes preventive measures in the particular context of eye care.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/virology ; Education, Medical, Continuing ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/epidemiology ; Eye Infections, Viral/therapy ; Eye Infections, Viral/virology ; Humans ; Ophthalmologists ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/therapy ; Respiratory Tract Infections/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-09
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.13877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1064: Show issues Location:
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  2. Article: SARS-CoV-2 and COVID-19 for the ophthalmologist

    Brandão-de-Resende, Camilo / Diniz-Filho, Alberto / de Almeida Brito, Fabiano / Vasconcelos-Santos, Daniel Vitor

    Abstract: The COVID-19 pandemic has had an unprecedented impact on ophthalmology. This review compiles general aspects of the novel coronavirus and COVID-19, further dissects the most recent data on the role of the eye regarding disease transmission and ... ...

    Abstract The COVID-19 pandemic has had an unprecedented impact on ophthalmology. This review compiles general aspects of the novel coronavirus and COVID-19, further dissects the most recent data on the role of the eye regarding disease transmission and manifestations, and summarizes preventive measures in the particular context of eye care.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #901003
    Database COVID19

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  3. Article ; Online: VI Brazilian consensus guidelines for detection of anti-cell autoantibodies on HEp-2 cells.

    Cruvinel, Wilson de Melo / Andrade, Luis Eduardo Coelho / Dellavance, Alessandra / Ximenes, Antônio Carlos / Bichara, Carlos David Araújo / Mangueira, Cristóvão Luis Pitangueira / Bonfá, Eloísa / de Almeida Brito, Fabiano / Mariz, Henrique Ataíde / Dos Anjos, Lisiane Maria Enriconi / Pasoto, Sandra Gofinet / Valim, Valeria / Dos Santos, Wilton Ferreira Silva / Gomes, Clayson Moura / Neves, Roberpaulo Anacleto / Francescantonio, Paulo Luiz Carvalho

    Advances in rheumatology (London, England)

    2022  Volume 62, Issue 1, Page(s) 34

    Abstract: Background: The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were ... ...

    Abstract Background: The VI Brazilian Consensus on Autoantibodies against HEp-2 cells for determination of autoantibodies against cellular constituents on HEp-2 cells was held on September, 2019, in Fortaleza (CE, Brazil). The guidelines in this edition were formulated by the group of Brazilian experts discussing the classification of complex patterns, the classification of the nuclear discrete dots (few and multiple), the identification of the discrete fine speckled pattern (AC-4a) and improvements on the ANA report.
    Mainbody: Sixteen Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of Brazil participated in the meeting. Four main topics were discussed: (1) How to classify patterns with fluorescence in more than one cell compartment considering three relevant categoris: composite patterns, mixed patterns and multiple patterns; (2) The splitting of the discrete nuclear dots pattern into the multiple discrete nuclear dots (AC-6) and few discrete nuclear dots (AC-7) patterns, respectively; (3) Inclusion of a novel nuclear pattern characterized by discrete fine speckled pattern highly associated with antibodies to SS-A/Ro60, classified as AC-4a. In addition, adjustments on the Brazilian Consensus nomenclature were implemented aiming to harmonize the designation of some patterns with the International Consensus on ANA Patterns (ICAP). Furthermore, the designations of the PCNA-like pattern (AC-13), CENP-F-like pattern (AC-14) and Topo I-like pattern (AC-29) were adjusted in accordance to ICAP. Finally, there was a recommendation for adjustment in the test report in order to address the status of nuclear envelope staining. For all topics, the aim was to establish specific guidelines for laboratories and clinicians. All recommendations were based on consensus among participants. All recommendations from the V Consensus were maintained and there was relevant progress in the BCA/HEp-2 guidelines and further harmonization with ICAP.
    Conclusion: The VI BCA/HEp-2 edition was successful in establishing important recommendations regarding the classification of complex patterns, in supporting the identification of a novel pattern within the AC-4 group and in the harmonization process with the ICAP terminology.
    MeSH term(s) Antibodies, Antinuclear ; Autoantibodies ; Brazil ; Consensus ; Humans
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article
    ISSN 2523-3106
    ISSN (online) 2523-3106
    DOI 10.1186/s42358-022-00266-z
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  4. Article ; Online: Correction to: V Brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells.

    de Melo Cruvinel, Wilson / Andrade, Luis Eduardo Coelho / von Mühlen, Carlos Alberto / Dellavance, Alessandra / Ximenes, Antônio Carlos / Bichara, Carlos David / Bueno, Cleonice / Mangueira, Cristóvão Luis Pitangueira / Bonfá, Eloísa / de Almeida Brito, Fabiano / Flumian, Fernanda Bull / da Silva, Glaucielen Gomes / Rêgo, Jozelia / Dos Anjos, Lisiane Maria Ericoni / Slhessarenko, Natasha / Pasoto, Sandra Gofinet / Neves, Suzane Pretti Figueiredo / Valim, Valéria / Dos Santos, Wilton Silva /
    Francescantonio, Paulo Luiz Carvalho

    Advances in rheumatology (London, England)

    2020  Volume 60, Issue 1, Page(s) 6

    Abstract: After publication of the original article [1], we were notified that there is a mistake in Fig. 2. ...

    Abstract After publication of the original article [1], we were notified that there is a mistake in Fig. 2.
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article ; Published Erratum
    ISSN 2523-3106
    ISSN (online) 2523-3106
    DOI 10.1186/s42358-019-0103-7
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  5. Article ; Online: Diagnostic Evaluation of ELISA and Chemiluminescent Assays as Alternative Screening Tests to Indirect Immunofluorescence for the Detection of Antibodies to Cellular Antigens.

    de Almeida Brito, Fabiano / Maria Elói Santos, Silvana / Aparecida Ferreira, Gilda / Pedrosa, William / Gradisse, Janaina / Cristina Costa, Lara / Pretti Figueiredo Neves, Suzane

    American journal of clinical pathology

    2016  Volume 145, Issue 3, Page(s) 323–331

    Abstract: Objectives: Detection of antinuclear antibodies (ANAs) plays an important role in the diagnosis of systemic autoimmune rheumatic disease (SARD). Our goal was to evaluate the diagnostic accuracy of three commercially available enzyme-linked immunosorbent ...

    Abstract Objectives: Detection of antinuclear antibodies (ANAs) plays an important role in the diagnosis of systemic autoimmune rheumatic disease (SARD). Our goal was to evaluate the diagnostic accuracy of three commercially available enzyme-linked immunosorbent assay (ELISA) kits and one chemiluminescent assay for ANA detection, using the clinical diagnostic as the reference standard.
    Methods: We evaluated serum samples from 143 patients with an established diagnosis of SARD (group 1), 166 patients with infectious diseases and other rheumatic diseases for which the ANA test is not useful in diagnosis (group 2), and 89 outpatients with suspicion of SARD (group 3).
    Results: The sensitivity for ANA HEp-2, calculated in group 1, was 87.4% and varied between 62.9% and 90.0% for other tests. The specificity for ANA HEp-2, calculated in group 2, was 72.3% and varied between 45.2% and 90.4% for other tests. In group 3, the negative predictive value for ANA Hep-2 was 92.5% and varied between 89.3% and 100% for other tests.
    Conclusions: Some ELISA kits have comparable or superior diagnostic sensitivity to ANA HEp-2 and could be used as an alternative method for ANA screening, therefore allowing the immediate report of the results with fewer false negatives than ANA HEp-2. Owing to the lower specificity, ELISA-positive samples should be submitted to ANA HEp-2 for confirmation of results.
    MeSH term(s) Adult ; Aged ; Antibodies, Antinuclear/analysis ; Autoimmune Diseases/diagnosis ; Enzyme-Linked Immunosorbent Assay/methods ; False Negative Reactions ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Luminescent Measurements/methods ; Male ; Middle Aged ; Rheumatic Diseases/diagnosis ; Sensitivity and Specificity ; Young Adult
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqv083
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    Ud II Zs.91: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: V Brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells.

    Cruvinel, Wilson de Melo / Andrade, Luis Eduardo Coelho / von Mühlen, Carlos Alberto / Dellavance, Alessandra / Ximenes, Antônio Carlos / Bichara, Carlos David / Bueno, Cleonice / Mangueira, Cristóvão Luis Pitangueira / Bonfá, Eloísa / de Almeida Brito, Fabiano / Flumian, Fernanda Bull / da Silva, Glaucielen Gomes / Rêgo, Jozelia / Dos Anjos, Lisiane Maria Ericoni / Slhessarenko, Natasha / Pasoto, Sandra Gofinet / Neves, Suzane Pretti Figueiredo / Valim, Valéria / Dos Santos, Wilton Silva /
    Francescantonio, Paulo Luiz Carvalho

    Advances in rheumatology (London, England)

    2019  Volume 59, Issue 1, Page(s) 28

    Abstract: Background: The V Brazilian Consensus for determination of autoantibodies against cellular constituents on HEp-2 cells, held in Brasilia (DF, Brazil) on August 27, 2016, discussed the harmonization between the Brazilian Consensus on ANA (BCA) guidelines ...

    Abstract Background: The V Brazilian Consensus for determination of autoantibodies against cellular constituents on HEp-2 cells, held in Brasilia (DF, Brazil) on August 27, 2016, discussed the harmonization between the Brazilian Consensus on ANA (BCA) guidelines and the International Consensus on ANA Patterns (ICAP) recommendations ( www.anapatterns.org ). Initial guidelines were formulated by the group of Brazilian experts with the purpose of guiding and enabling Brazilian clinical laboratories to adopt recommendations and to provide a common standard for national and international consensuses.
    Mainbody: Twenty Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of the country participated in the meeting. Three main topics were discussed, namely the harmonization between the BCA guidelines and latest recommendations of the ICAP initiative, the adjustment of the terminology and report on HEp-2 patterns, and a reassessment of quality assurance parameters. For the three topics, our aim was to establish specific guidelines. All recommendations were based on consensus among participants. There was concrete progress in the adjustment of the BCA guidelines to match the ICAP guidelines. To a certain extent, this derives from the fact that ICAP recommendations were largely based on the algorithm and recommendations of the IV Brazilian ANA Consensus, as consistently recognized in the ICAP publications and presentations. However, although there is great overlap between the two Consensuses, there are some point divergences. These specific items were individually and extensively discussed, and it was acknowledged that in several points ICAP improved recommendations previously issued by the Brazilian ANA Consensus and these changes were readily implemented. Regarding some specific topics, the BCA panel of experts felt that the previously issued recommendations remained relevant and possibly will require further discussion with ICAP. The term anti-cell antibodies was adopted as the recommended designation, recognizing that the assay addresses antibodies against antigens in the nucleus and in other cell compartments. However, the acronym ANA HEp-2 was maintained due to historical and regulatory reasons. It was also signalized that the latest trend in ICAP is to adopt the term Indirect Immunofluorescent Assay on HEp-2 cell substrate (HEp-2 IIFA). In addition, the quality assurance strategies previously presented were ratified and emphasized.
    Conclusion: The V BCA edition was successful in establishing an overall harmonization with the ICAP recommendations for interpretation of the HEp-2 IIFA test, pinpointing the perspectives in filling the remaining gaps between both initiatives.
    MeSH term(s) Algorithms ; Antibodies, Antinuclear/analysis ; Autoantigens/immunology ; Cell Line ; Consensus ; Epithelial Cells/immunology ; Humans ; Quality Control ; Terminology as Topic
    Chemical Substances Antibodies, Antinuclear ; Autoantigens
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Consensus Development Conference ; Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
    ISSN 2523-3106
    ISSN (online) 2523-3106
    DOI 10.1186/s42358-019-0069-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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