Article ; Online: Expression of Toll-like receptors 2 and 4 in the saliva of patients with systemic lupus erythematosus and chronic periodontitis.
2021 Volume 40, Issue 7, Page(s) 2727–2734
Abstract: Objective: The aim of this study was to investigate the expression of salivary Toll-like receptors (TRL) 2 and 4 in patients with systemic lupus erythematosus (SLE) and chronic periodontitis (CP).: Methods: A case-control study was conducted with 77 ... ...
| Abstract | Objective: The aim of this study was to investigate the expression of salivary Toll-like receptors (TRL) 2 and 4 in patients with systemic lupus erythematosus (SLE) and chronic periodontitis (CP). Methods: A case-control study was conducted with 77 participants (42 SLE and 35 non-SLE) stratified according to CP diagnosis criteria. Periodontal parameters consisted of clinical attachment level (CAL), probing depth (PD), the visible plaque index (VPI), and the gingival bleeding index (GBI). Salivary TRL 2 and 4 expressions were determined by quantitative real-time polymerase chain reaction (RT-PCR). Statistical analysis included Mann-Whitney U test, Kruskal-Wallis test, Spearman's correlation rank, and multiple linear regression. Results: Patients with isolated SLE or CP had higher TLR 2 and TLR 4 expression in their saliva samples (P < 0.05). The group with both SLE and CP had lower TLR 2 and 4 expressions (P < 0.05). TLR 2 and TLR 4 showed significant negative correlations with PD, CAL, and GBI in SLE patients, and a significant positive correlation with periodontal parameters in non-SLE patients. CP was independently associated with reduction of TLR2 and TLR4 expression, even after adjusting for clinical data and current drug use. Conclusion: Reduced TRL 2 and 4 expression in saliva was associated with the presence of CP in SLE patients. Key Points • Patients affected by isolated CP or SLE had higher TLR2 and TLR4 expression. • TLR under-expression may be associated with a worse periodontal status in SLE. • Abnormalities in TLRs expression may increase the susceptibility to periodontitis. |
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| MeSH term(s) | Case-Control Studies ; Chronic Periodontitis ; Humans ; Lupus Erythematosus, Systemic ; Saliva ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics |
| Chemical Substances | TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 |
| Language | English |
| Publishing date | 2021-02-11 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 604755-5 |
| ISSN | 1434-9949 ; 0770-3198 |
| ISSN (online) | 1434-9949 |
| ISSN | 0770-3198 |
| DOI | 10.1007/s10067-020-05560-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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