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Article ; Online: Combining b2500 diffusion-weighted imaging with BI-RADS improves the specificity of breast MRI.

Saccenti, Laetitia / Mellon, Constance de Margerie / Scholer, Margaux / Jolibois, Zoe / Stemmer, Alto / Weiland, Elisabeth / de Bazelaire, Cedric

Diagnostic and interventional imaging

2023 Volume 104, Issue 9, Page(s) 410–418

Abstract: Purpose: The purpose of this study was to evaluate the diagnostic performance of visual assessment of diffusion-weighted images (DWI) obtained with a b value of 2500 s/mm: Materials and methods: This single-institution retrospective study included ... ...

Abstract	Purpose: The purpose of this study was to evaluate the diagnostic performance of visual assessment of diffusion-weighted images (DWI) obtained with a b value of 2500 s/mm Materials and methods: This single-institution retrospective study included participants who underwent clinically indicated breast MRI and breast biopsy from May 2017 to February 2020. The examination included a conventional MRI protocol including DWI obtained with a b value of 50 s/mm Results: A total of 260 patients with 212 malignant and 100 benign breast lesions were included. There were 259 women and one man with a median age of 53 years (Q1, Q3: 48, 66 years). b Conclusion: Visual assessment of b
MeSH term(s)	Female ; Humans ; Middle Aged ; Retrospective Studies ; Contrast Media ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/methods ; Breast Neoplasms/diagnostic imaging ; Sensitivity and Specificity
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-05-18
Publishing country	France
Document type	Journal Article
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2023.05.001
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Article ; Online: A massive open online course to teach undergraduate medical students in oncology: keys of success

Hamdan, Diaddin / Pamoukdjian, Frédéric / Lehmann-Che, Jaqueline / de Bazelaire, Cédric / Vercellino, Laetitia / Calvani, Julien / Battistella, Maxime / Bertheau, Philippe / Falgarone, Géraldine / Bousquet, Guilhem

Heliyon. 2022 Nov., v. 8, no. 11 p.e11306-

2022

Abstract: Massive Open Online Courses (MOOCs) are gaining popularity in education while classroom lectures are being deserted, especially after COVID-19 pandemic. Their added value in teaching undergraduate medical students remains to be confirmed. This study ... ...

Abstract	Massive Open Online Courses (MOOCs) are gaining popularity in education while classroom lectures are being deserted, especially after COVID-19 pandemic. Their added value in teaching undergraduate medical students remains to be confirmed. This study evaluated a MOOC devoted to undergraduate medical students in a blended oncology-teaching university program. It was the first to target undergraduate medical students in oncology at its beginning. Students were asked to participate in a survey before and after MOOC to explore interactions between their characteristics and final grades, 65% of the participating students belonged to the rich class. 70% of the students completed the MOOC. Grades distributions were similar before and after MOOC implementation, so MOOC doesn't alter overall results. In addition, there was a positive effect of the MOOC on median grades on the immediate test. The univariate and multivariate analysis showed that socioeconomic status and student's willingness to participate interacted significantly with final results. Particularly, students' motivation and satisfaction were associated with better results; Almost 70% of students asked for blended learning. E-learning is reliable to teach oncology to undergraduate medical students. The success is directly linked to students’ willingness to participate, and can be improved using blended methods including tutorials.
Keywords	COVID-19 infection ; electronic learning ; motivation ; multivariate analysis ; online courses ; socioeconomic status ; surveys ; university programs ; MOOC ; Oncology ; Medical undergraduates ; Student perception ; Success factors
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e11306
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nonpalpable breast lesions: impact of a second-opinion review at a breast unit on BI-RADS classification.

de Margerie-Mellon, Constance / Debry, Jean-Baptiste / Dupont, Axelle / Cuvier, Caroline / Giacchetti, Sylvie / Teixeira, Luis / Espié, Marc / de Bazelaire, Cédric

European radiology

2021 Volume 31, Issue 8, Page(s) 5913–5923

Abstract: Objective: To compare BI-RADS classification, management, and outcome of nonpalpable breast lesions assessed both by community practices and by a multidisciplinary tumor board (MTB) at a breast unit.: Methods: All nonpalpable lesions that were first ... ...

Abstract	Objective: To compare BI-RADS classification, management, and outcome of nonpalpable breast lesions assessed both by community practices and by a multidisciplinary tumor board (MTB) at a breast unit. Methods: All nonpalpable lesions that were first assigned a BI-RADS score by community practices and then reassessed by an MTB at a single breast unit from 2009 to 2017 were retrospectively reviewed. Inter-review agreement was assessed with Cohen's kappa statistic. Changes in biopsy recommendation were calculated. The percentage of additional tumor lesions detected by the MTB was obtained. The sensitivity, AUC, and cancer rates for BI-RADS category 3, 4, and 5 lesions were computed for both reviews. Results: A total of 1909 nonpalpable lesions in 1732 patients were included. For BI-RADS scores in the whole cohort, a fair agreement was found (κ = 0.40 [0.36-0.45]) between the two reviews. Agreement was higher when considering only mammography combined with ultrasound (κ = 0.53 [0.44-0.62]), masses (κ = 0.50 [0.44-0.56]), and architectural distortion (κ = 0.44 [0.11-0.78]). Changes in biopsy recommendation occurred in 589 cases (31%). Ninety of 345 additional biopsies revealed high-risk or malignant lesions. Overall, the MTB identified 27% additional high-risk and malignant lesions compared to community practices. The BI-RADS classification AUCs for detecting malignant lesions were 0.66 (0.63-0.69) for community practices and 0.76 (0.75-0.78) for the MTB (p < 0.001). Conclusion: Agreement between community practices and MTB reviews for BI-RADS classification in nonpalpable lesions is only fair. MTB review improves diagnostic performances of breast imaging and patient management. Key points: • The inter-review agreement for BI-RADS classification between community practices and the multidisciplinary board was only fair (κ = 0.40). • Disagreements resulted in changes of biopsy recommendation in 31% of the lesions. • The multidisciplinary board identified 27% additional high-risk and malignant lesions compared to community practices.
MeSH term(s)	Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Mammography ; Observer Variation ; Retrospective Studies ; Ultrasonography, Mammary
Language	English
Publishing date	2021-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-07664-1
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Article: A massive open online course to teach undergraduate medical students in oncology: keys of success.

Heliyon

2022 Volume 8, Issue 11, Page(s) e11306

Abstract	Massive Open Online Courses (MOOCs) are gaining popularity in education while classroom lectures are being deserted, especially after COVID-19 pandemic. Their added value in teaching undergraduate medical students remains to be confirmed. This study evaluated a MOOC devoted to undergraduate medical students in a blended oncology-teaching university program. It was the first to target undergraduate medical students in oncology at its beginning. Students were asked to participate in a survey before and after MOOC to explore interactions between their characteristics and final grades, 65% of the participating students belonged to the rich class. 70% of the students completed the MOOC. Grades distributions were similar before and after MOOC implementation, so MOOC doesn't alter overall results. In addition, there was a positive effect of the MOOC on median grades on the immediate test. The univariate and multivariate analysis showed that socioeconomic status and student's willingness to participate interacted significantly with final results. Particularly, students' motivation and satisfaction were associated with better results; Almost 70% of students asked for blended learning. E-learning is reliable to teach oncology to undergraduate medical students. The success is directly linked to students' willingness to participate, and can be improved using blended methods including tutorials.
Language	English
Publishing date	2022-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e11306
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Article: Safety Profile of Ambulatory Prostatic Artery Embolization after a Significant Learning Curve: Update on Adverse Events.

Amouyal, Gregory / Tournier, Louis / De Margerie-Mellon, Constance / Pachev, Atanas / Assouline, Jessica / Bouda, Damien / De Bazelaire, Cédric / Marques, Florent / Le Strat, Solenne / Desgrandchamps, François / De Kerviler, Eric

Journal of personalized medicine

2022 Volume 12, Issue 8

Abstract: Background: to report the safety of outpatient prostatic artery embolization (PAE) after a significant learning curve.: Methods: a retrospective bi-institutional study was conducted between June 2018 and April 2022 on 311 consecutive patients, with a ...

Abstract	Background: to report the safety of outpatient prostatic artery embolization (PAE) after a significant learning curve. Methods: a retrospective bi-institutional study was conducted between June 2018 and April 2022 on 311 consecutive patients, with a mean age of 69 years ± 9.8 (47-102), treated by outpatient PAE. Indications included lower urinary tract symptoms, acute urinary retention, and hematuria. When needed, 3D-imaging and/or coil protection of extra-prostatic supplies were performed to avoid non-target embolization. Adverse events were monitored at 1-, 6-, and 12-month follow-ups. Results: bilateral PAE was achieved in 305/311 (98.1%). Mean dose area product/fluoroscopy times were 16,408.3 ± 12,078.9 (2959-81,608) μGy.m Conclusion: outpatient PAE performed after achieving a significant learning curve may lead to a decreased and low rate of adverse events. Experience in arterial anatomy and coil protection may play a role in safety, but the necessity of the latter in some patterns may need confirmation by additional studies in randomized designs.
Language	English
Publishing date	2022-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12081261
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Article: Feasibility of Outpatient Transradial Prostatic Artery Embolization and Safety of a Shortened Deflation Protocol for Hemostasis.

Amouyal, Gregory / Tournier, Louis / de Margerie-Mellon, Constance / Bouda, Damien / Pachev, Atanas / Assouline, Jessica / de Bazelaire, Cédric / Marques, Florent / Le Strat, Solenne / Desgrandchamps, François / De Kerviler, Eric

Journal of personalized medicine

2022 Volume 12, Issue 7

Abstract: Background: to evaluate the safety and feasibility of a shorter time to hemostasis applied to outpatient transradial (TR) Prostatic Artery Embolization (PAE).: Methods: a retrospective bi-institutional study was conducted between July 2018 and April ... ...

Abstract	Background: to evaluate the safety and feasibility of a shorter time to hemostasis applied to outpatient transradial (TR) Prostatic Artery Embolization (PAE). Methods: a retrospective bi-institutional study was conducted between July 2018 and April 2022 on 300 patients treated by outpatient TR PAE. Indications included lower urinary tract symptoms, acute urinary retention, and hematuria. Mean patient height was 176 ± 6.3 (158-192) cm. The primary endpoint was safety of a 45 min deflation protocol for hemostasis. The secondary endpoint was the feasibility of PAE using TR access. Results: technical success was 98.7% (296/300). There was one failure due to patient height. Mean DAP/fluoroscopy times were 16,225 ± 12,126.3 (2959-81,608) μGy·m Conclusion: the safety of TR PAE using a 45 min time to hemostasis was confirmed, and TR PAE is feasible in most cases. Radial artery occlusion was still observed and may be favored by smoking.
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12071138
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Article ; Online: Coaxial versus Noncoaxial Techniques in Percutaneous Core Needle Biopsy of Renal Parenchyma.

Prud'homme, Clara / de Margerie-Mellon, Constance / de Bazelaire, Cédric / de Kerviler, Eric

Cardiovascular and interventional radiology

2017 Volume 40, Issue 5, Page(s) 799–800

Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Letter
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-017-1609-1
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Article ; Online: Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin.

Varma, Gopal / Duhamel, Guillaume / de Bazelaire, Cedric / Alsop, David C

Magnetic resonance in medicine

2014 Volume 73, Issue 2, Page(s) 614–622

Abstract: Purpose: To characterize a new approach to magnetization transfer (MT) imaging with improved specificity for myelinated tissues relative to conventional MT.: Methods: Magnetization transfer preparation sequences were implemented with all ... ...

Abstract	Purpose: To characterize a new approach to magnetization transfer (MT) imaging with improved specificity for myelinated tissues relative to conventional MT. Methods: Magnetization transfer preparation sequences were implemented with all radiofrequency power centered on a single frequency and also with power evenly divided between positive and negative frequencies. Dual frequency saturation was achieved both with short, alternating frequency pulses and with sinusoidal modulation of continuous irradiation. Images following preparation were acquired with a single shot fast spin echo sequence. Single and dual frequency preparation should achieve similar saturation of molecules except for those with inhomogenously broadened lines. Inhomogenous MT (IHMT) images were generated by subtraction of dual from single frequency prepared images. IHMT imaging was performed with different power and frequency in the brains of normal volunteers. Results: The IHMT method demonstrated a greater white/gray matter ratio than conventional MT and virtual elimination of signal in scalp and other unmyelinated tissues. IHMT exceeded 5% of the fully relaxed magnetization in white matter. A broad frequency spectrum and signs of axonal angular dependence at high frequency were observed that are consistent with dipolar broadening. Conclusion: IHMT shows promise for myelin-specific imaging. Further study of physical mechanisms and diagnostic sensitivity are merited.
MeSH term(s)	Adult ; Biomarkers ; Brain/cytology ; Brain/metabolism ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Myelin Sheath/metabolism ; Nerve Fibers, Myelinated/metabolism ; Proton Magnetic Resonance Spectroscopy/methods ; Reproducibility of Results ; Sensitivity and Specificity
Chemical Substances	Biomarkers
Language	English
Publishing date	2014-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.25174
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Zs.A 1959: Show issues

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Article ; Online: Diagnostic strategy for trigger identification in severe reactive hemophagocytic lymphohistiocytosis: A diagnostic accuracy study.

Tudesq, Jean-Jacques / Valade, Sandrine / Galicier, Lionel / Zafrani, Lara / Boutboul, David / de Bazelaire, Cédric / Munoz-Bongrand, Nicolas / Canet, Emmanuel / Ardisson, Fanny / Lemiale, Virginie / Darmon, Michael / Azoulay, Elie / Mariotte, Eric

Hematological oncology

2020 Volume 39, Issue 1, Page(s) 114–122

Abstract: Reactive hemophagocytic lymphohistiocytosis (rHLH) management requires early recognition, trigger identification, and adequate treatment in order to reduce mortality. We assessed the diagnostic yield of tissue biopsies to identify trigger in severe rHLH. ...

Abstract	Reactive hemophagocytic lymphohistiocytosis (rHLH) management requires early recognition, trigger identification, and adequate treatment in order to reduce mortality. We assessed the diagnostic yield of tissue biopsies to identify trigger in severe rHLH. We included all consecutive patients presenting an rHLH diagnosis (HLH-2004 criteria) admitted to the intensive care unit (ICU) of a tertiary hospital. This retrospective diagnostic accuracy study was conducted according to the Standards for Reporting Diagnostic Accuracy Statement. Among the 134 included patients (median age 47 years [IQR 47-56]), an underlying immunodeficiency was previously known in 61.2%. rHLH trigger was identified in 127 patients (94.8%) (hematological disorder 75%, infection 16%, systemic disease 4%). Diagnostic yield of tissue biopsies was as follows: lymph node 75% (95% confidence interval [CI], 61-85), skin 50% (95% CI, 27-73), bone marrow 44% (95% CI, 34-55), liver 30% (95% CI, 15-49). Splenectomy (yield 77%; 95% CI, 46-95) was reserved to cases of diagnostic deadlock. Procedural severe adverse events included two cases of reversible hemorrhagic shock. Seventy-eight percent of patients received etoposide regarding to the rHLH severity, and 68% could receive trigger-specific treatment in the ICU. A comprehensive diagnostic workup led to an rHLH trigger identification in 95% of patients, allowing prompt initiation of appropriate therapy. Prospective studies to validate a standardized diagnostic approach are warranted.
MeSH term(s)	Adult ; Etoposide/administration & dosage ; Female ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/metabolism ; Lymphohistiocytosis, Hemophagocytic/pathology ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Etoposide (6PLQ3CP4P3)
Language	English
Publishing date	2020-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.2819
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Article: Negative Relationship between Post-Treatment Stromal Tumor-Infiltrating Lymphocyte (TIL) and Survival in Triple-Negative Breast Cancer Patients Treated with Dose-Dense Dose-Intense NeoAdjuvant Chemotherapy.

Cancers

2022 Volume 14, Issue 5

Abstract: Background: Patients with triple-negative breast cancers (TNBC) have a poor prognosis unless a pathological complete response (pCR) is achieved after neoadjuvant chemotherapy (NAC). Few studies have analyzed changes in TIL levels following dose-dense ... ...

Abstract	Background: Patients with triple-negative breast cancers (TNBC) have a poor prognosis unless a pathological complete response (pCR) is achieved after neoadjuvant chemotherapy (NAC). Few studies have analyzed changes in TIL levels following dose-dense dose-intense (dd-di) NAC. Patients and methods: From 2009 to 2018, 117 patients with TNBC received dd-di NAC at our institution. We aimed to identify factors associated with pre- and post-NAC TIL levels, and oncological outcomes relapse-free survival (RFS), and overall survival (OS). Results: Median pre-NAC and post-NAC TIL levels were 15% and 3%, respectively. Change in TIL levels with treatment was significantly correlated with metabolic response (SUV) and pCR. High post-NAC TIL levels were associated with a weak metabolic response after two cycles of NAC, with the presence of residual disease and nodal involvement at NAC completion. In multivariate analyses, high post-NAC TIL levels independently predicted poor RFS and poor OS (HR = 1.4 per 10% increment, 95%CI (1.1; 1.9) p = 0.014 and HR = 1.8 per 10% increment 95%CI (1.3−2.3), p < 0.0001, respectively). Conclusion: Our results suggest that TNBC patients with TIL enrichment after NAC are at higher risk of relapse. These patients are potential candidates for adjuvant treatment, such as immunotherapy, in clinical trials.
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14051331
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