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  1. Article ; Online: Cytotoxic lesion of the corpus callosum as presenting neuroradiological manifestation of COVID-2019 infection.

    Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Boulouis, Grégoire

    Journal of neurology

    2020  Volume 268, Issue 5, Page(s) 1595–1597

    MeSH term(s) Brain Diseases ; COVID-19 ; Corpus Callosum/diagnostic imaging ; Diffusion Magnetic Resonance Imaging ; Humans ; Magnetic Resonance Imaging ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-10166-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cytotoxic lesion of the corpus callosum as presenting neuroradiological manifestation of COVID-2019 infection

    Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Boulouis, Grégoire

    J. neurol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #718419
    Database COVID19

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  3. Article ; Online: High predictive value of brain MRI imaging in primary mitochondrial respiratory chain deficiency.

    de Beaurepaire, Isaure / Grévent, David / Rio, Marlène / Desguerre, Isabelle / de Lonlay, Pascale / Levy, Raphaël / Dangouloff-Ros, Volodia / Bonnefont, Jean-Paul / Barcia, Giulia / Funalot, Benoit / Besmond, Claude / Metodiev, Metodi D / Ruzzenente, Benedetta / Assouline, Zahra / Munnich, Arnold / Rötig, Agnès / Boddaert, Nathalie

    Journal of medical genetics

    2018  Volume 55, Issue 6, Page(s) 378–383

    Abstract: Background: Because the mitochondrial respiratory chain (RC) is ubiquitous, its deficiency can theoretically give rise to any symptom in any organ or tissue at any age with any mode of inheritance, owing to the twofold genetic origin of respiratory ... ...

    Abstract Background: Because the mitochondrial respiratory chain (RC) is ubiquitous, its deficiency can theoretically give rise to any symptom in any organ or tissue at any age with any mode of inheritance, owing to the twofold genetic origin of respiratory enzyme machinery, that is, nuclear and mitochondrial. Not all respiratory enzyme deficiencies are primary and secondary or artefactual deficiency is frequently observed, leading to a number of misleading conclusions and inappropriate investigations in clinical practice. This study is aimed at investigating the potential role of brain MRI in distinguishing primary RC deficiency from phenocopies and other aetiologies.
    Methods: Starting from a large series of 189 patients (median age: 3.5 years (8 days-56 years), 58% males) showing signs of RC enzyme deficiency, for whom both brain MRIs and disease-causing mutations were available, we retrospectively studied the positive predictive value (PPV) and the positive likelihood ratio (LR+) of brain MRI imaging and its ability to discriminate between two groups: primary deficiency of the mitochondrial RC machinery and phenocopies.
    Results: Detection of (1) brainstem hyperintensity with basal ganglia involvement (P≤0.001) and (2) lactate peak with either brainstem or basal ganglia hyperintensity was highly suggestive of primary RC deficiency (P≤0.01). Fourteen items had a PPV>95% and LR+ was greater than 9 for seven signs. Biallelic
    Conclusion: Based on these results and owing to invasiveness of skeletal muscle biopsies and cost of high-throughput DNA sequencing, we suggest giving consideration to brain MRI imaging as a diagnostic marker and an informative investigation to be performed in patients showing signs of RC enzyme deficiency.
    MeSH term(s) Adolescent ; Adult ; Atrophy/diagnosis ; Atrophy/diagnostic imaging ; Atrophy/physiopathology ; Brain/diagnostic imaging ; Brain/pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mitochondrial Diseases/diagnosis ; Mitochondrial Diseases/diagnostic imaging ; Mitochondrial Diseases/pathology ; Predictive Value of Tests ; Young Adult
    Language English
    Publishing date 2018-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmedgenet-2017-105094
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  4. Article ; Online: Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study.

    Kremer, Stéphane / Lersy, François / Anheim, Mathieu / Merdji, Hamid / Schenck, Maleka / Oesterlé, Hélène / Bolognini, Federico / Messie, Julien / Khalil, Antoine / Gaudemer, Augustin / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Jager, Lavinia / Nesser, Patrick / Mba, Yannick Talla /
    Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Constans, Jean-Marc / Zorn, Pierre-Emmanuel / Mathieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean-Christophe / Caillard, Sophie / Collange, Olivier / Mertes, Paul Michel / Schneider, Francis / Fafi-Kremer, Samira / Ohana, Mickael / Meziani, Ferhat / Meyer, Nicolas / Helms, Julie / Cotton, François

    Neurology

    2020  Volume 95, Issue 13, Page(s) e1868–e1882

    Abstract: Objective: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations.: Methods: In this retrospective multicenter study (11 ... ...

    Abstract Objective: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations.
    Methods: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI.
    Results: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome (
    Conclusions: Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF.
    Clinicaltrialsgov identifier: NCT04368390.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Brain/diagnostic imaging ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/physiopathology ; COVID-19 ; Confusion/physiopathology ; Consciousness Disorders/physiopathology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Encephalitis/diagnostic imaging ; Encephalitis/physiopathology ; Female ; France ; Headache/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Meningitis/diagnostic imaging ; Meningitis/physiopathology ; Meningoencephalitis/diagnostic imaging ; Meningoencephalitis/physiopathology ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; Psychomotor Agitation/physiopathology ; Pyramidal Tracts/diagnostic imaging ; Pyramidal Tracts/physiopathology ; Respiratory Distress Syndrome/physiopathology ; Retrospective Studies ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/physiopathology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study

    Kremer, Stéphane / Lersy, François / Anheim, Mathieu / Merdji, Hamid / Schenck, Maleka / Oesterlé, Hélène / Bolognini, Federico / Messie, Julien / Khalil, Antoine / Gaudemer, Augustin / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Jager, Lavinia / Nesser, Patrick / Mba, Yannick Talla /
    Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Constans, Jean-Marc / Zorn, Pierre-Emmanuel / Mathieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean-Christophe / Caillard, Sophie

    Neurology

    Abstract: OBJECTIVE: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. METHODS: In this retrospective multicenter study (11 hospitals), ...

    Abstract OBJECTIVE: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. METHODS: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. RESULTS: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome (p = 0.006) and more frequently had corticospinal tract signs (p = 0.02). Patients with encephalitis were younger (p = 0.007), whereas agitation was more frequent for patients with leptomeningeal enhancement (p = 0.009). CONCLUSIONS: Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF. CLINICALTRIALSGOV IDENTIFIER: NCT04368390.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #653268
    Database COVID19

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  6. Article: Neurologic and neuroimaging findings in COVID-19 patients: A retrospective multicenter study

    Kremer, Stéphane / Lersy, François / Anheim, Mathieu / Merdji, Hamid / Schenck, Maleka / Oesterlé, Hélène / Bolognini, Federico / Messie, Julien / Henri-Feugeas, Marie-Cécile / Khalil, Antoine / Gaudemer, Augustin / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Jager, Lavinia / Nesser, Patrick /
    Mba, Yannick Talla / Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Constans, Jean Marc / Zorn, Pierre-Emmanuel / Mathieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean Christophe

    Neurology

    Abstract: OBJECTIVE: To describe neuroimaging findings and to report the epidemiological and clinical characteristics of COVID-19 patients with neurological manifestations. METHODS: In this retrospective multicenter study (10 Hospitals), we included 64 confirmed ... ...

    Abstract OBJECTIVE: To describe neuroimaging findings and to report the epidemiological and clinical characteristics of COVID-19 patients with neurological manifestations. METHODS: In this retrospective multicenter study (10 Hospitals), we included 64 confirmed COVID-19 patients with neurologic manifestations who underwent a brain MRI. RESULTS: The cohort included 43 men (67%), 21 women (33%), and the median age was 66 years (range: 20-92). 36 (56%) brain MRIs were considered abnormal, possibly related to SARS-CoV-2. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurological manifestation, following by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from the other patients with abnormal brain imaging since the former had less frequently acute respiratory distress syndrome (p=0·006) and more frequently corticospinal tract signs (p=0·02). Patients with encephalitis were younger (p=0·007), whereas agitation was more frequent for patients with leptomeningeal enhancement (p=0·009). CONCLUSIONS: COVID-19 patients may develop a wide range of neurological symptoms, which can be associated with severe and fatal complications, such as ischemic stroke or encephalitis. Concerning the meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology rather seems to involve an immune and/or inflammatory process given the presence of signs of inflammation in both cerebrospinal fluid and neuroimaging but the lack of virus in cerebrospinal fluid.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32680942
    Database COVID19

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  7. Article ; Online: Neurologic and neuroimaging findings in patients with COVID-19 ; A retrospective multicenter study

    Kremer, Stéphane / Lersy, François / Anheim, Mathieu / Merdji, Hamid / Schenck, Maleka / Oesterlé, Hélène / Bolognini, Federico / Messie, Julien / Khalil, Antoine / Gaudemer, Augustin / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Jager, Lavinia / Nesser, Patrick / Mba, Yannick Talla /
    Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Constans, Jean-Marc / Zorn, Pierre-Emmanuel / Mathieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean-Christophe / Caillard, Sophie / Collange, Olivier / Mertes, Paul Michel / Schneider, Francis / Fafi-Kremer, Samira / Ohana, Mickael / Meziani, Ferhat / Meyer, Nicolas / Helms, Julie / Cotton, François

    Neurology

    2020  Volume 95, Issue 13, Page(s) e1868–e1882

    Abstract: Objective To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. Methods In this retrospective multicenter study (11 hospitals), ... ...

    Abstract Objective To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. Methods In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. Results The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20–92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome ( p = 0.006) and more frequently had corticospinal tract signs ( p = 0.02). Patients with encephalitis were younger ( p = 0.007), whereas agitation was more frequent for patients with leptomeningeal enhancement ( p = 0.009). Conclusions Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF. ClinicalTrials.gov identifier NCT04368390.
    Keywords Clinical Neurology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000010112
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study.

    Kremer, Stéphane / Lersy, François / de Sèze, Jérome / Ferré, Jean-Christophe / Maamar, Adel / Carsin-Nicol, Béatrice / Collange, Olivier / Bonneville, Fabrice / Adam, Gilles / Martin-Blondel, Guillaume / Rafiq, Marie / Geeraerts, Thomas / Delamarre, Louis / Grand, Sylvie / Krainik, Alexandre / Caillard, Sophie / Constans, Jean Marc / Metanbou, Serge / Heintz, Adrien /
    Helms, Julie / Schenck, Maleka / Lefèbvre, Nicolas / Boutet, Claire / Fabre, Xavier / Forestier, Géraud / de Beaurepaire, Isaure / Bornet, Grégoire / Lacalm, Audrey / Oesterlé, Hélène / Bolognini, Federico / Messié, Julien / Hmeydia, Ghazi / Benzakoun, Joseph / Oppenheim, Catherine / Bapst, Blanche / Megdiche, Imen / Henry Feugeas, Marie-Cécile / Khalil, Antoine / Gaudemer, Augustin / Jager, Lavinia / Nesser, Patrick / Talla Mba, Yannick / Hemmert, Céline / Feuerstein, Philippe / Sebag, Nathan / Carré, Sophie / Alleg, Manel / Lecocq, Claire / Schmitt, Emmanuelle / Anxionnat, René / Zhu, François / Comby, Pierre-Olivier / Ricolfi, Frédéric / Thouant, Pierre / Desal, Hubert / Boulouis, Grégoire / Berge, Jérome / Kazémi, Apolline / Pyatigorskaya, Nadya / Lecler, Augustin / Saleme, Suzana / Edjlali-Goujon, Myriam / Kerleroux, Basile / Zorn, Pierre-Emmanuel / Matthieu, Muriel / Baloglu, Seyyid / Ardellier, François-Daniel / Willaume, Thibault / Brisset, Jean Christophe / Boulay, Clotilde / Mutschler, Véronique / Hansmann, Yves / Mertes, Paul-Michel / Schneider, Francis / Fafi-Kremer, Samira / Ohana, Mickael / Meziani, Ferhat / David, Jean-Stéphane / Meyer, Nicolas / Anheim, Mathieu / Cotton, François

    Radiology

    2020  Volume 297, Issue 2, Page(s) E242–E251

    Abstract: Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus ... ...

    Abstract Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection. Materials and Methods This was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (
    MeSH term(s) Adolescent ; Adult ; Aged ; Betacoronavirus ; Brain/diagnostic imaging ; Brain/pathology ; COVID-19 ; Child ; Cohort Studies ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/pathology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; Retrospective Studies ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020202222
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