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Article ; Online: Trend analysis of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in the post-COVID-19 era: an extra challenge for healthcare institutions.

de Carvalho Hessel Dias, V M / Tuon, F / de Jesus Capelo, P / Telles, J P / Fortaleza, C M C B / Pellegrino Baena, C

The Journal of hospital infection

2021  Volume 120, Page(s) 43–47

Abstract: The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December ... ...

Abstract The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumannii (CRAB) per 1000 patient-days increased in 2020 and this finding had a strong positive correlation with the incidence density of COVID-19 by the Spearman test. Polymyxin consumption also increased in 2020 but without significant correlation with CRAB or COVID-19 incidence density, presumably due to empirical and untargeted prescribing as a consequence of concern about CRAB infections. These findings are a warning to infection control programmes and antimicrobial stewardship.
MeSH term(s) Acinetobacter baumannii ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; COVID-19 ; Carbapenems ; Delivery of Health Care ; Drug Resistance, Bacterial ; Gram-Negative Bacteria ; Humans ; Microbial Sensitivity Tests ; SARS-CoV-2
Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Carbapenems
Language English
Publishing date 2021-11-19
Publishing country England
Document type Journal Article
ZDB-ID 779366-2
ISSN 1532-2939 ; 0195-6701
ISSN (online) 1532-2939
ISSN 0195-6701
DOI 10.1016/j.jhin.2021.11.011
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Zs.A 1586: Show issues Location:
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