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  1. AU="de Cesare, Niccolò"
  2. AU="Agrawal, Rohit Vijay"
  3. AU="Nakae, Mami"
  4. AU="Blake, Christine E"
  5. AU=Pareek Anil
  6. AU="Shokrollahi, Mitra"
  7. AU="Charles?Luce"
  8. AU="Denadai, Rafael"
  9. AU="Ambrosino, Teresa"
  10. AU=Antipova Tatiana
  11. AU="Moens, Pierre D J"
  12. AU="Abdel-Megied, Ahmed M."
  13. AU="Jain, Aseem"
  14. AU="Marcos, Jose F"
  15. AU="Furr-Stimming, Erin"
  16. AU="Schüle, Birgit"
  17. AU="Travieso-González, Alejandro"
  18. AU=Turilli Emily Samuela
  19. AU="Rueckert, Erroll H"
  20. AU=Keestra-Gounder A. Marijke
  21. AU="María José Endara"
  22. AU="Li, Lin-Zi"
  23. AU="Shirvanian, Moein"
  24. AU="Capaldo, Bianca D"
  25. AU="Matose, Takunda"
  26. AU=Plouffe Brian D.
  27. AU=Kuter David J
  28. AU="Moore, I D"
  29. AU="Schreibing, Felix"
  30. AU=Kang Keunsoo
  31. AU="de Pedro-Múñez, Álvaro"

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  1. Artikel ; Online: Numerical modelling of abdominal wall mechanics: The role of muscular contraction and intra-abdominal pressure.

    Todros, Silvia / de Cesare, Niccolò / Concheri, Gianmaria / Natali, Arturo N / Pavan, Piero G

    Journal of the mechanical behavior of biomedical materials

    2019  Band 103, Seite(n) 103578

    Abstract: The biomechanics of the abdominal wall depends on muscular activation, tissue mechanical behavior and Intra-Abdominal Pressure (IAP). In this work, a numerical model of a human abdomen is presented, based on abdominal wall geometry from medical images. ... ...

    Abstract The biomechanics of the abdominal wall depends on muscular activation, tissue mechanical behavior and Intra-Abdominal Pressure (IAP). In this work, a numerical model of a human abdomen is presented, based on abdominal wall geometry from medical images. Specific constitutive formulations describe tissues mechanical behavior. Connective tissues are modelled as hyperelastic fiber-reinforced materials, while muscular tissues are described by means of a three-element Hill's model. The abdominal cavity is represented by a volume region interacting with the abdominal wall. Numerical analyses are developed by applying a muscular contraction, inducing a volume reduction of the abdominal cavity and a simultaneous IAP increase. Numerical results of abdomen displacement at IAP corresponding to an abdominal crunch are compared with experimental results acquired via 3D laser scanning on a healthy subject. Numerical and experimental results are mutually consistent and show that muscular activation induces a raising in the region adjacent to linea alba along the posterior-anterior direction and a lowering along lateral-medial direction of the abdominal wall sides. The numerical model developed in this work allows a coherent representation of the abdominal wall mechanics.
    Mesh-Begriff(e) Abdominal Muscles ; Abdominal Wall ; Biomechanical Phenomena ; Humans ; Muscle Contraction ; Pressure
    Sprache Englisch
    Erscheinungsdatum 2019-11-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2019.103578
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  2. Artikel ; Online: Development of detailed finite element models for in silico analyses of brain impact dynamics.

    Pavan, Piero G / Nasim, Mohammed / Brasco, Veronica / Spadoni, Silvia / Paoloni, Francesco / d'Avella, Domenico / Khosroshahi, Siamak Farajzadeh / de Cesare, Niccolò / Gupta, Karan / Galvanetto, Ugo

    Computer methods and programs in biomedicine

    2022  Band 227, Seite(n) 107225

    Abstract: Background and objective: In the last few decades, several studies have been performed to investigate traumatic brain injuries (TBIs) and to understand the biomechanical response of brain tissues, by using experimental and computational approaches. As ... ...

    Abstract Background and objective: In the last few decades, several studies have been performed to investigate traumatic brain injuries (TBIs) and to understand the biomechanical response of brain tissues, by using experimental and computational approaches. As part of computational approaches, human head finite element (FE) models show to be important tools in the analysis of TBIs, making it possible to estimate local mechanical effects on brain tissue for different accident scenarios. The present study aims to contribute to the computational approach by means of the development of three advanced FE head models for accurately describing the head tissue dynamics, the first step to predict TBIs.
    Methods: We have developed three detailed FE models of human heads from magnetic resonance images of three volunteers: an adult female (32 yrs), an adult male (35 yrs), and a young male (16 yrs). These models have been validated against experimental data of post mortem human subjects (PMHS) tests available in the literature. Brain tissue displacements relative to the skull, hydrostatic intracranial pressure, and head acceleration have been used as the parameters to compare the model response with the experimental response for validation. The software CORAplus (CORrelation and Analysis) has been adopted to evaluate the bio-fidelity level of FE models.
    Results: Numerical results from the three models agree with experimental data. FE models presented in this study show a good bio-fidelity for hydrostatic pressure (CORA score of 0.776) and a fair bio-fidelity brain tissue displacements relative to the skull (CORA score of 0.443 and 0.535). The comparison among numerical simulations carried out with the three models shows negligible differences in the mechanical state of brain tissue due to the different morphometry of the heads, when the same acceleration history is considered.
    Conclusions: The three FE models, thanks to their accurate description of anatomical morphology and to their bio-fidelity, can be useful tools to investigate brain mechanics due to different impact scenarios. Therefore, they can be used for different purposes, such as the investigation of the correlation between head acceleration and tissue damage, or the effectiveness of helmet designs. This work does not address the issue to define injury thresholds for the proposed models.
    Mesh-Begriff(e) Adult ; Male ; Female ; Humans ; Finite Element Analysis ; Head ; Brain/physiology ; Head Protective Devices ; Skull ; Brain Injuries, Traumatic/diagnostic imaging ; Biomechanical Phenomena ; Models, Biological
    Sprache Englisch
    Erscheinungsdatum 2022-11-03
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.107225
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  3. Artikel ; Online: 3D surface imaging of abdominal wall muscular contraction.

    Todros, Silvia / de Cesare, Niccolò / Pianigiani, Silvia / Concheri, Gianmaria / Savio, Gianpaolo / Natali, Arturo N / Pavan, Piero G

    Computer methods and programs in biomedicine

    2019  Band 175, Seite(n) 103–109

    Abstract: Background and objective: The biomechanical analysis of the abdominal wall should take into account muscle activation and related phenomena, such as intra-abdominal pressure variation and abdomen surface deformation. The geometry of abdominal surface ... ...

    Abstract Background and objective: The biomechanical analysis of the abdominal wall should take into account muscle activation and related phenomena, such as intra-abdominal pressure variation and abdomen surface deformation. The geometry of abdominal surface and its deformation during contraction have not been extensively characterized, while represent a key issue to be investigated.
    Methods: In this work, the antero-lateral abdominal wall surface of ten healthy volunteers in supine position is acquired via laser scanning in relaxed conditions and during abdominal muscles contraction, repeating each acquisition six times. The average relaxed and contracted abdominal surfaces are compared for each subject and displacements measured.
    Results: Muscular activation induces raising in the region adjacent to linea alba along the posterior-anterior direction and a simultaneous lowering along lateral-medial direction of the abdominal wall sides. Displacements reach a maximum value of 12.5 mm for the involved subjects. The coefficient of variation associated to the abdomen surface measurements in the same configuration (relaxed or contracted) is below 0.75%. Non-parametric Mann-Whitney U test highlights that the differences between relaxed and contracted abdominal wall surfaces are significant (p < 0.01).
    Conclusions: Laser scanning is an accurate and reliable method to evaluate surface changes on the abdominal wall during muscular contraction. The results of this experimental activity can be useful to validate numerical models aimed at describing abdominal wall biomechanics.
    Mesh-Begriff(e) Abdominal Muscles/diagnostic imaging ; Abdominal Wall/diagnostic imaging ; Adult ; Biomechanical Phenomena ; Female ; Healthy Volunteers ; Humans ; Imaging, Three-Dimensional/methods ; Male ; Middle Aged ; Muscle Contraction ; Reproducibility of Results ; Surface Properties
    Sprache Englisch
    Erscheinungsdatum 2019-04-12
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2019.04.013
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  4. Artikel ; Online: Computational Models for the Mechanical Investigation of Stomach Tissues and Structure.

    Fontanella, Chiara Giulia / Salmaso, Claudia / Toniolo, Ilaria / de Cesare, Niccolò / Rubini, Alessandro / De Benedictis, Giulia Maria / Carniel, Emanuele Luigi

    Annals of biomedical engineering

    2019  Band 47, Heft 5, Seite(n) 1237–1249

    Abstract: Bariatric surgery is performed on obese people aiming at reducing the capacity of the stomach and/or the absorbing capability of the gastrointestinal tract. A more reliable and effective approach to bariatric surgery may integrate different expertise, in ...

    Abstract Bariatric surgery is performed on obese people aiming at reducing the capacity of the stomach and/or the absorbing capability of the gastrointestinal tract. A more reliable and effective approach to bariatric surgery may integrate different expertise, in the areas of surgery, physiology and biomechanics, availing of a strong cooperation between clinicians and engineers. This work aimed at developing a computational model of the stomach, as a computational tool for the physio-mechanical investigation of stomach functionality and the planning of bariatric procedures. In this sense, coupled experimental and numerical activities were developed. Experimental investigations on pig and piglet stomachs aimed at providing information about stomach geometrical configuration and structural behavior. The computational model was defined starting from the analysis of data from histo-morphometric investigations and mechanical tests. A fiber-reinforced visco-hyperelastic constitutive model was developed to interpret the mechanical response of stomach tissues; constitutive parameters were identified considering mechanical tests at both tissue and structure levels. Computational analyses were performed to investigate the pressure-volume behavior of the stomach. The developed model satisfactorily interpreted results from experimental activities, suggesting its reliability. Furthermore, the model was exploited to investigate stress and strain fields within gastric tissues, as the stimuli for mechanoreceptors that interact with the central nervous system leading to the feeling of satiety. In this respect, the developed computational model may be employed to evaluate the influence of bariatric intervention on the stimulation of mechanoreceptors, and the following meal induced satiety.
    Mesh-Begriff(e) Animals ; Computer Simulation ; Models, Biological ; Stomach/anatomy & histology ; Stomach/physiology ; Swine
    Sprache Englisch
    Erscheinungsdatum 2019-02-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-019-02229-w
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  5. Artikel: Muscle in Variable Gravity: "I Do Not Know Where I Am, But I Know What to Do".

    Monti, Elena / Waldvogel, Janice / Ritzmann, Ramona / Freyler, Kathrin / Albracht, Kirsten / Helm, Michael / De Cesare, Niccolò / Pavan, Piero / Reggiani, Carlo / Gollhofer, Albert / Narici, Marco Vincenzo

    Frontiers in physiology

    2021  Band 12, Seite(n) 714655

    Abstract: Purpose: ...

    Abstract Purpose:
    Sprache Englisch
    Erscheinungsdatum 2021-08-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.714655
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  6. Artikel ; Online: Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model.

    Trevisan, Caterina / Maghin, Edoardo / Dedja, Arben / Caccin, Paola / de Cesare, Niccolò / Franzin, Chiara / Boso, Daniele / Pesce, Paola / Caicci, Federico / Boldrin, Francesco / Urbani, Luca / De Coppi, Paolo / Pozzobon, Michela / Pavan, Piero / Piccoli, Martina

    Acta biomaterialia

    2019  Band 89, Seite(n) 115–125

    Abstract: Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal organs into the thoracic cavity and impeding lung development and function. Large diaphragmatic defects require ... ...

    Abstract Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal organs into the thoracic cavity and impeding lung development and function. Large diaphragmatic defects require correction with prosthetic patches to close the malformation. This treatment leads to a consequent generation of unwelcomed mechanical stress in the repaired diaphragm and hernia recurrences, thereby resulting in high morbidity and significant mortality rates. We proposed a specific diaphragm-derived extracellular matrix (ECM) as a scaffold for the treatment of CDH. To address this strategy, we developed a new surgical CDH mouse model to test the ability of our tissue-specific patch to regenerate damaged diaphragms. Implantation of decellularized diaphragmatic ECM-derived patches demonstrated absence of rejection or hernia recurrence, in contrast to the performance of a commercially available synthetic material. Diaphragm-derived ECM was able to promote the generation of new blood vessels, boost long-term muscle regeneration, and recover host diaphragmatic function. In addition, using a GFP + Schwann cell mouse model, we identified re-innervation of implanted patches. These results demonstrated for the first time that implantation of a tissue-specific biologic scaffold is able to promote a regenerating diaphragm muscle and overcome issues commonly related to the standard use of prosthetic materials. STATEMENT OF SIGNIFICANCE: Large diaphragmatic hernia in paediatric patients require application of artificial patches to close the congenital defect. The use of a muscle-specific decellularized scaffold in substitution of currently used synthetic materials allows new blood vessel growth and nerve regeneration inside the patch, supporting new muscle tissue formation. Furthermore, the presence of a tissue-specific scaffold guaranteed long-term muscle regeneration, improving diaphragm performance to almost complete functional recovery. We believe that diaphragm-derived scaffold will be key player in future pre-clinical studies on large animal models.
    Mesh-Begriff(e) Allografts ; Animals ; Extracellular Matrix/transplantation ; Female ; Hernia, Diaphragmatic/metabolism ; Hernia, Diaphragmatic/pathology ; Hernia, Diaphragmatic/surgery ; Male ; Mice ; Mice, Inbred BALB C ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiology ; Regeneration ; Tissue Scaffolds
    Sprache Englisch
    Erscheinungsdatum 2019-03-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2019.03.007
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