Article ; Online: Metabolic syndrome improves cardiovascular dysfunction and survival during cecal ligation and puncture-induced mild sepsis in mice.
2021 Volume 286, Page(s) 120033
Abstract: Aims: Sepsis is a potentially fatal systemic inflammatory response and its underlying pathophysiology is still poorly understood. Studies suggest that obesity, a component of metabolic syndrome (MS), is associated with sepsis survival. Therefore, this ... ...
| Abstract | Aims: Sepsis is a potentially fatal systemic inflammatory response and its underlying pathophysiology is still poorly understood. Studies suggest that obesity, a component of metabolic syndrome (MS), is associated with sepsis survival. Therefore, this study focused on investigating the influence of MS on mortality and cardiovascular dysfunction induced by sublethal cecal ligation and puncture (SL-CLP). Main methods: Newborn Swiss mice received monosodium glutamate (MSG) (4 mg kg Key findings: MS improved the survival of septic mice, preventing impairment to hematological and cardiovascular parameters. In addition, MS attenuated plasmatic NO increase, which is a typical feature of sepsis. Significance: These findings provide new insights into the relationship between obesity and mild sepsis in mice, thus revealing an approach in favor of the "obesity paradox." |
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| MeSH term(s) | Animals ; Cardiovascular System/physiopathology ; Cecum/pathology ; Disease Models, Animal ; Ligation ; Metabolic Syndrome/physiopathology ; Mice ; Nitric Oxide/metabolism ; Punctures ; Sepsis/etiology ; Survival Analysis |
| Chemical Substances | Nitric Oxide (31C4KY9ESH) |
| Language | English |
| Publishing date | 2021-10-08 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 3378-9 |
| ISSN | 1879-0631 ; 0024-3205 |
| ISSN (online) | 1879-0631 |
| ISSN | 0024-3205 |
| DOI | 10.1016/j.lfs.2021.120033 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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