LIVIVO - Search results -

Search results

Result 1 - 10 of total 294

Search options

Article ; Online: The mystery of autoantibodies solved?

de Groot, Philip G

2024 Volume 143, Issue 12, Page(s) 1065–1066

MeSH term(s)	Autoantibodies ; Antibodies, Antiphospholipid ; Thromboplastin
Chemical Substances	Autoantibodies ; Antibodies, Antiphospholipid ; Thromboplastin (9035-58-9)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023023637
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Viewpoint: The value of non-criteria antiphospholipid antibodies.

de Laat, Bas / Gehlen, Rachel / de Groot, Philip G

Rheumatology (Oxford, England)

2024 Volume 63, Issue SI, Page(s) SI64–SI71

Abstract: In 2006, at a meeting in Sydney, Australia, consensus was reached by an international group of specialists to establish a number of serological criteria that identify patients with a history of thrombosis or pregnancy complications as having ... ...

Abstract	In 2006, at a meeting in Sydney, Australia, consensus was reached by an international group of specialists to establish a number of serological criteria that identify patients with a history of thrombosis or pregnancy complications as having antiphospholipid syndrome (APS). These criteria were originally formulated for research purposes and to compare clinical trials in different centres. However, these same criteria are now generally used and accepted for the diagnosis and treatment of patients. The practice of using these criteria for direct patient care requires that these criteria are based on sound scientific evidence. Indeed, for all the autoantibodies that are officially included in the serological criteria, it has been shown that they induce thrombosis and fetal loss when infused into mice. There are also a number of additional autoantibodies that have been identified in these patients but for these antibodies there was not enough evidence to meet the official APS criteria in 2006. Seventeen years have now passed since the consensus meeting, therefore, this review examines whether additional studies performed with these 'non-criteria' autoantibodies have provided sufficient results to suggest the inclusion of these autoantibodies in the official serological criteria of APS.
MeSH term(s)	Pregnancy ; Female ; Humans ; Animals ; Mice ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome ; Autoantibodies ; Thrombosis ; Prenatal Care ; Prothrombin
Chemical Substances	Antibodies, Antiphospholipid ; Autoantibodies ; Prothrombin (9001-26-7)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead632
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The antiphospholipid syndrome finally fathomed?

de Groot, Philip G

Blood

2018 Volume 131, Issue 19, Page(s) 2091–2092

MeSH term(s)	Adaptor Proteins, Signal Transducing ; Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/immunology ; Apoptosis Regulatory Proteins ; Endothelium ; Humans ; Thrombosis ; Tumor Suppressor Proteins
Chemical Substances	Adaptor Proteins, Signal Transducing ; Antibodies, Antiphospholipid ; Apoptosis Regulatory Proteins ; DAB2 protein, human ; Tumor Suppressor Proteins
Language	English
Publishing date	2018-05-09
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2018-03-837880
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Platelets as pivot in the antiphospholipid syndrome.

de Groot, Philip G

Blood

2014 Volume 124, Issue 4, Page(s) 475–476

MeSH term(s)	Animals ; Antibodies, Antiphospholipid/blood ; Antiphospholipid Syndrome/immunology ; Blood Platelets/immunology ; Disease Models, Animal ; Endothelium/immunology ; Humans ; Thrombosis/immunology ; beta 2-Glycoprotein I/metabolism
Chemical Substances	Antibodies, Antiphospholipid ; beta 2-Glycoprotein I
Language	English
Publishing date	2014-07-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2014-06-576983
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Serotonin, key to thrombocytopenia in dengue?

de Mast, Quirijn / de Groot, Philip G

Blood

2019 Volume 133, Issue 21, Page(s) 2249–2250

MeSH term(s)	Dengue ; Dengue Virus ; Humans ; Leukopenia ; Serotonin ; Thrombocytopenia
Chemical Substances	Serotonin (333DO1RDJY)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2019-03-900852
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A thrombin-driven neural net diagnoses the antiphospholipid syndrome without the need for interruption of anticoagulation.

de Laat-Kremers, Romy M W / Wahl, Denis / Zuily, Stéphane / Ninivaggi, Marisa / Regnault, Véronique / Musial, Jacek / de Groot, Philip G / Devreese, Katrien M J / de Laat, Bas

Blood advances

2024 Volume 8, Issue 4, Page(s) 936–946

Abstract: Abstract: Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated with thrombosis. APS is currently diagnosed based on clinical and ... ...

Abstract	Abstract: Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated with thrombosis. APS is currently diagnosed based on clinical and laboratory criteria, the latter defined as anti-cardiolipin, anti-β2-glycoprotein I antibodies, or lupus anticoagulant (LA). APS testing is often performed after a thrombotic episode and subsequent administration of anticoagulation, which might hamper the interpretation of clotting assays used for LA testing. We set out to develop an artificial neural network (NN) that can diagnose APS in patients who underwent vitamin K antagonist (VKA) treatment, based on TG test results. Five NNs were trained to diagnose APS in 48 VKA-treated patients with APS and 64 VKA-treated controls, using TG and thrombin dynamics parameters as inputs. The 2 best-performing NNs were selected (accuracy, 96%; sensitivity, 96%-98%; and specificity, 95%-97%) and further validated in an independent cohort of VKA-anticoagulated patients with APS (n = 33) and controls (n = 62). Independent clinical validation favored 1 of the 2 selected NNs, with a sensitivity of 88% and a specificity of 94% for the diagnosis of APS. In conclusion, the combined use of TG and NN methodology allowed for us to develop an NN that diagnoses APS with an accuracy of 92% in individuals with VKA anticoagulation (n = 95). After further clinical validation, the NN could serve as a screening and diagnostic tool for patients with thrombosis, especially because there is no need to interrupt anticoagulant therapy.
MeSH term(s)	Humans ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Thrombin/pharmacology ; Anticoagulants/adverse effects ; Blood Coagulation ; Lupus Coagulation Inhibitor ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/etiology
Chemical Substances	Thrombin (EC 3.4.21.5) ; Anticoagulants ; Lupus Coagulation Inhibitor
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011938
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I.

Kim, Seung Joong / Schneidman-Duhovny, Dina / de Groot, Philip G / Urbanus, Rolf T / Carter, Lester / de Laat-Kremers, Romy / Weiss, Thomas M / Chan, Man K / Sali, Andrej / Rand, Jacob H / de Laat, Bas

Thrombosis research

2024 Volume 237, Page(s) 145–147

MeSH term(s)	Humans ; Thrombosis/metabolism ; beta 2-Glycoprotein I/immunology ; beta 2-Glycoprotein I/chemistry ; beta 2-Glycoprotein I/metabolism ; Epitopes/immunology ; Protein Domains
Chemical Substances	beta 2-Glycoprotein I ; Epitopes
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2024.03.025
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 863: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome.

Yin, Dongmei / de Groot, Philip G / Ninivaggi, Marisa / Devreese, Katrien M J / de Laat, Bas

Thrombosis and haemostasis

2021 Volume 121, Issue 9, Page(s) 1220–1227

Abstract: Background: Patients positive for all three types of antiphospholipid antibodies (aPLs; triple positivity) have been identified for having a high risk for thrombotic events. However, the clinical significance of isolated lupus anticoagulant (LAC) ... ...

Abstract	Background: Patients positive for all three types of antiphospholipid antibodies (aPLs; triple positivity) have been identified for having a high risk for thrombotic events. However, the clinical significance of isolated lupus anticoagulant (LAC) positivity is debated. Objectives: To investigate the clinical relevance of isolated LAC. Methods: A total of 456 patients were enrolled in this study; 66 antiphospholipid syndrome patients and 390 control patients. The control group consisted of autoimmune patients ( Results: In total, 70 patients were positive for LAC, of which 44 were negative for both anti-β2GPI and anti-CL antibodies. We found that isolated LAC proved to be strongly associated with vascular thrombosis (odds ratio [OR]: 7.3; 95% confidence interval [CI]: 3.3-16.1), even better than triple-positive samples (OR: 4.3; 95% CI: 1.6-12.2). The titers of the anti-PS/PT IgG and IgM were significantly higher in triple-positivity samples compared with samples with isolated LAC positivity. The majority of single LAC positives were anti-PS/PT-negative. We observed that LAC positivity was weaker in isolated LAC-positive patients compared with LAC activity in triple-positive patients. Conclusion: Isolated LAC was highly associated with thrombosis. The presence of anti-PS/PT antibodies could not explain LAC positivity in isolated LAC. Isolated LAC showed a weaker LAC activity compared with triple-positive patients.
MeSH term(s)	Adult ; Antibodies, Anticardiolipin/blood ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Immunoglobulin M/blood ; Lupus Coagulation Inhibitor/blood ; Male ; Middle Aged ; Predictive Value of Tests ; Thrombosis/blood ; Thrombosis/diagnosis ; Thrombosis/etiology
Chemical Substances	Antibodies, Anticardiolipin ; Biomarkers ; Immunoglobulin M ; Lupus Coagulation Inhibitor ; anti-beta 2 glycoprotein I autoantibody
Language	English
Publishing date	2021-03-03
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-1344-4271
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

Details ▾

Article ; Online: Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability.

Zou, Jinmi / Swieringa, Frauke / de Laat, Bas / de Groot, Philip G / Roest, Mark / Heemskerk, Johan W M

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and requires an activation step for binding to fibrinogen, fibrin or von ... ...

Abstract	Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and requires an activation step for binding to fibrinogen, fibrin or von Willebrand factor (VWF). A current model assumes that the process of integrin activation relies on actomyosin force-dependent molecular changes from a bent-closed and extended-closed to an extended-open conformation. In this paper we review the pathways that point to a functional reversibility of platelet αIIbβ3 activation and transient aggregation. Furthermore, we refer to mouse models indicating that genetic defects that lead to reversible platelet aggregation can also cause instable thrombus formation. We discuss the platelet agonists and signaling pathways that lead to a transient binding of ligands to integrin αIIbβ3. Our analysis points to the (autocrine) ADP P2Y
MeSH term(s)	Mice ; Animals ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; von Willebrand Factor/metabolism ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Aggregation Inhibitors/metabolism ; Actomyosin/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Platelet Activation ; Platelet Aggregation ; Blood Platelets/metabolism ; Thrombosis/metabolism ; Fibrinogen/metabolism ; Protein Kinase C/metabolism ; Adenosine Diphosphate/metabolism ; Fibrin/metabolism ; Phosphatidylinositols/metabolism
Chemical Substances	Platelet Glycoprotein GPIIb-IIIa Complex ; von Willebrand Factor ; Platelet Aggregation Inhibitors ; Actomyosin (9013-26-7) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Fibrinogen (9001-32-5) ; Protein Kinase C (EC 2.7.11.13) ; Adenosine Diphosphate (61D2G4IYVH) ; Fibrin (9001-31-4) ; Phosphatidylinositols
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012512
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Platelet Activation via Glycoprotein VI Initiates Thrombin Generation: A Potential Role for Platelet-Derived Factor IX?

Li, Li / Roest, Mark / Meijers, Joost C M / de Laat, Bas / Urbanus, Rolf T / de Groot, Philip G / Huskens, Dana

Thrombosis and haemostasis

2022 Volume 122, Issue 9, Page(s) 1502–1512

Abstract: Collagen triggers coagulation via activation of factor (F) XII. In a platelet-rich environment, collagen can also trigger coagulation independently of FXII. We studied a novel mechanism of coagulation initiation via collagen-dependent platelet activation ...

Abstract	Collagen triggers coagulation via activation of factor (F) XII. In a platelet-rich environment, collagen can also trigger coagulation independently of FXII. We studied a novel mechanism of coagulation initiation via collagen-dependent platelet activation using thrombin generation (TG) in platelet-rich plasma. Collagen-induced coagulation is minimally affected by active-site inactivated FVIIa, anti-FVII antibodies, or FXIIa inhibition (corn trypsin inhibitor). Activation of platelets via specific glycoprotein (GP) VI agonists initiates TG, FX activation, and fibrin formation. To determine the platelet-derived trigger of coagulation, we systematically reconstituted factor-deficient plasmas with washed platelets. TG triggered by GPVI-activated platelets was significantly affected in FIX- and FVIII-deficient plasma but not in FVII- and FXII-deficient plasma. In a purified system composed of FX and FVIII, we observed that absence of FIX was compensated by GPVI-activated platelets, which could be inhibited by an anti-FIX antibody, suggesting FIXa activity from activated platelets. Furthermore, with the addition of FVIII in FIX-deficient plasma, TG induced by GPVI-activated platelets was restored, and was inhibited by the anti-FIX antibody. In conclusion, GPVI-activated platelets initiate TG, probably via platelet-derived FIXa activity.
MeSH term(s)	Blood Coagulation Factors ; Blood Platelets ; Collagen ; Factor IX ; Glycoproteins ; Humans ; Platelet Activation ; Platelet Membrane Glycoproteins ; Thrombin
Chemical Substances	Blood Coagulation Factors ; Glycoproteins ; Platelet Membrane Glycoproteins ; platelet membrane glycoprotein VI ; Factor IX (9001-28-9) ; Collagen (9007-34-5) ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2022-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0042-1744379
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito