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  1. Article ; Online: SCD and MTHFD2 inhibitors for high-risk acute myeloid leukaemia patients, as suggested by ELN2017-pathway association.

    Kim, Han Sun / Kim, Doyeon / Kim, Jiwoo / Park, Sunghyouk / de Guzman, Arvie Camille V

    Clinical and translational medicine

    2023  Volume 13, Issue 7, Page(s) e1311

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/drug therapy
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson's Disease-like Symptoms in

    de Guzman, Arvie Camille V / Razzak, Md Abdur / Cho, Joong Hee / Kim, Ji Yi / Choi, Shin Sik

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: Parkinson's disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. ...

    Abstract Parkinson's disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to improving its aqueous solubility and bioavailability. The curcumin-loaded HSA nanoparticles were acquired in the particle size and at the zeta potential of 200 nm and -10 mV, respectively. The curcumin-loaded human serum albumin nanoparticles ameliorated Parkinson's disease features in the
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12050758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.

    Phan, Hong-Duc / Nguyen, Tin Tin Manh / Lee, Sujin / Seo, Munjun / An, Yong Jin / de Guzman, Arvie Camille V

    Metabolomics : Official journal of the Metabolomic Society

    2023  Volume 19, Issue 6, Page(s) 58

    Abstract: Background and aims: SKN-1, a C. elegans transcription factor analogous to the mammalian NF-E2-related factor (Nrf2), has been known to promote oxidative stress resistance aiding nematodes' longevity. Although SKN-1's functions suggest its implication ... ...

    Abstract Background and aims: SKN-1, a C. elegans transcription factor analogous to the mammalian NF-E2-related factor (Nrf2), has been known to promote oxidative stress resistance aiding nematodes' longevity. Although SKN-1's functions suggest its implication in lifespan modulation through cellular metabolism, the actual mechanism of how metabolic rearrangements contribute to SKN-1's lifespan modulation has yet to be well characterized. Therefore, we performed the metabolomic profiling of the short-lived skn-1-knockdown C. elegans.
    Methods: We analyzed the metabolic profile of the skn-1-knockdown worms with nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-tandem mass spectrometry (LC-MS/MS) and obtained distinctive metabolomic profiles compared to WT worms. We further extended our study with gene expression analysis to examine the expression level of genes encoding all metabolic enzymes.
    Results: A significant increase in the phosphocholine and AMP/ATP ratio, potential biomarkers of aging, was observed, accompanied by a decrease in the transsulfuration metabolites, NADPH/NADP
    Conclusion: Our multi-omics results consistently revealed that the cytoprotective mechanisms, including cellular redox reactions and xenobiotic detoxification system, contribute to the roles of SKN-1/Nrf2 in the lifespan of worms.
    MeSH term(s) Animals ; Acetaminophen/metabolism ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Chromatography, Liquid ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Glutathione/metabolism ; Longevity/genetics ; Mammals/metabolism ; Metabolomics ; NADP/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Tandem Mass Spectrometry
    Chemical Substances Acetaminophen (362O9ITL9D) ; Caenorhabditis elegans Proteins ; DNA-Binding Proteins ; Glutathione (GAN16C9B8O) ; NADP (53-59-8) ; NF-E2-Related Factor 2 ; skn-1 protein, C elegans (148733-36-2)
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250617-2
    ISSN 1573-3890 ; 1573-3882
    ISSN (online) 1573-3890
    ISSN 1573-3882
    DOI 10.1007/s11306-023-02022-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6361: Show issues Location:
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  4. Article ; Online: High-Glucose Diet Attenuates the Dopaminergic Neuronal Function in

    de Guzman, Arvie Camille V / Kang, Seunghun / Kim, Eun Ji / Kim, Jin Ho / Jang, Nari / Cho, Joong Hee / Choi, Shin Sik

    ACS omega

    2022  Volume 7, Issue 36, Page(s) 32339–32348

    Abstract: Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective degeneration of neurons, primarily in the substantia nigra. Environmental or exogenous factors that cause Parkinson's disease have not been sufficiently elucidated. ... ...

    Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective degeneration of neurons, primarily in the substantia nigra. Environmental or exogenous factors that cause Parkinson's disease have not been sufficiently elucidated. Our study aims to investigate the causative effect of a high-glucose diet on Parkinson's disease-relevant dopaminergic neuronal system in
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03384
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  5. Article ; Online: Anti-Parkinson's Disease Function of Dioscin-Zein-Carboxymethyl Cellulose Nanocomplex in Caenorhabditis elegans.

    de Guzman, Arvie Camille V / Razzak, Md Abdur / Purevdulam, Batmagnai / Choi, Shin Sik

    Biotechnology journal

    2020  Volume 15, Issue 12, Page(s) e2000080

    Abstract: Nanosized dioscin-loaded zein-CMC (DZC) complex comprising dioscin (glycoside saponin), zein (corn protein), and carboxymethyl cellulose (CMC) is fabricated through anti-solvent coprecipitation. The optimized ratio of zein to CMC for the homogenous ... ...

    Abstract Nanosized dioscin-loaded zein-CMC (DZC) complex comprising dioscin (glycoside saponin), zein (corn protein), and carboxymethyl cellulose (CMC) is fabricated through anti-solvent coprecipitation. The optimized ratio of zein to CMC for the homogenous complexation is 5:1, and DZC maintains its stability in a wide range of pH (3.0-8.0) and ionic strength (0-50 mm NaCl). No biological toxicity of DZC is found in Caenorhabditis elegans with a normal lifespan and body size. Parkinson's disease (PD) is characterized by the loss of dopamine (DA) and dopaminergic neurons. In cat-2 mutant with defective biosynthesis of DA, DZC-fed animals show intact DA behaviors including basal slowing response (≈60%) and alcohol avoidance (≈80%). Such DA promotional effects are a result of the enhanced expression/activation of DA transporter, DAT-1 in DA neurons. Taken together, DZC has a potential for preventing PD as an oral-administered drugs and supplements.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Carboxymethylcellulose Sodium ; Diosgenin/analogs & derivatives ; Disease Models, Animal ; Parkinson Disease/drug therapy ; Zein
    Chemical Substances dioscin (3B95U4OLWV) ; Zein (9010-66-6) ; Diosgenin (K49P2K8WLX) ; Carboxymethylcellulose Sodium (K679OBS311)
    Language English
    Publishing date 2020-08-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2221885-3
    ISSN 1860-7314 ; 1860-6768
    ISSN (online) 1860-7314
    ISSN 1860-6768
    DOI 10.1002/biot.202000080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6349: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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