Article: Genomic surveillance: Circulating lineages and genomic variation of SARS-CoV-2 in early pandemic in Ceará state, Northeast Brazil
Virus research. 2022 Nov., v. 321
2022
Abstract: In the Northeast of Brazil, Ceará was the second state most impacted by COVID-19 in number of cases and death rate. Despite that, the early dynamics of the pandemic in Ceará was not yet well understood due the low genomic surveillance of SARS-CoV-2 in ... ...
| Abstract | In the Northeast of Brazil, Ceará was the second state most impacted by COVID-19 in number of cases and death rate. Despite that, the early dynamics of the pandemic in Ceará was not yet well understood due the low genomic surveillance of SARS-CoV-2 in 2020. In this study, we analyze the circulating lineages and the genomic variation of the virus in Ceará state. Thirty-four genomes were sequenced and combined with sequences available in GISAID database from March 2020 to June 2021 to compose the study dataset. The most prevalent lineages detected were B.1.1.33, in 2020, and P.1, in 2021. Other lineages were found, such as P.2, sublineages of P.1, B.1, B.1.1, B.1.1.28 and B.1.212. Analyzing the mutations, a total of 202 single-nucleotide polymorphisms (SNPs) were identified among the 34 genomes sequenced, of which 127 were missense, 74 synonymous, and one was a nonsense mutation. Among the missense mutations, C14408T, A23403G, T27299C, G28881A G28883C, and T29148C were the most prevalent within the dataset. Although SARS-CoV-2 sequencing data was limited in 2020, our results could provide insights to better understand the genetic diversity of the circulating lineages in Ceará. |
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| Keywords | COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; data collection ; databases ; genetic variation ; genome ; genomics ; monitoring ; mortality ; nonsense mutation ; pandemic ; research ; viruses ; Brazil |
| Language | English |
| Dates of publication | 2022-11 |
| Publishing place | Elsevier B.V. |
| Document type | Article |
| ZDB-ID | 605780-9 |
| ISSN | 1872-7492 ; 0168-1702 |
| ISSN (online) | 1872-7492 |
| ISSN | 0168-1702 |
| DOI | 10.1016/j.virusres.2022.198908 |
| Database | NAL-Catalogue (AGRICOLA) |
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