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  1. AU="de Jongste, Johan C"
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  1. Article ; Online: Childhood asthma: pathogenesis and phenotypes.

    Pijnenburg, Mariëlle W / Frey, Urs / De Jongste, Johan C / Saglani, Sejal

    The European respiratory journal

    2022  Volume 59, Issue 6

    Abstract: In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory response to early life exposures or events. Interactions between infections, atopy, genetic susceptibility and environmental exposures (such as farmyard ... ...

    Abstract In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory response to early life exposures or events. Interactions between infections, atopy, genetic susceptibility and environmental exposures (such as farmyard environment, air pollution and tobacco smoke exposure) influence the development of wheezing illness and the risk of progression to asthma. The immune system, lung function and the microbiome in gut and airways develop in parallel, and dysbiosis of the microbiome may be a critical factor in asthma development. Increased infant weight gain and preterm birth are other risk factors for development of asthma and reduced lung function. The complex interplay between these factors explains the heterogeneity of asthma in children. Subgroups of patients can be identified as phenotypes, based on clinical parameters, or endotypes, based on a specific pathophysiological mechanism. Paediatric asthma phenotypes and endotypes may ultimately help to improve diagnosis of asthma, prediction of asthma development and treatment of individual children, based on clinical, temporal, developmental or inflammatory characteristics. Unbiased, data-driven clustering, using a multidimensional or systems biology approach may be needed to better define phenotypes. The present knowledge on inflammatory phenotypes of childhood asthma has now been successfully applied in the treatment with biologicals of children with severe therapy-resistant asthma, and it is to be expected that more personalised treatment options may become available.
    MeSH term(s) Asthma ; Child ; Female ; Humans ; Hypersensitivity, Immediate ; Infant, Newborn ; Phenotype ; Premature Birth ; Respiratory Sounds/etiology
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00731-2021
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  2. Article ; Online: Cardio-metabolic risk factors during childhood in relation to lung function and asthma.

    Mensink-Bout, Sara M / Santos, Susana / de Jongste, Johan C / Jaddoe, Vincent W V / Duijts, Liesbeth

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2021  Volume 32, Issue 5, Page(s) 945–952

    Abstract: Background: Cardio-metabolic risk factors might have an adverse effect on respiratory outcomes, but associations in children are unknown. We aimed to study the longitudinal associations of cardio-metabolic risk factors with lung function and asthma at ... ...

    Abstract Background: Cardio-metabolic risk factors might have an adverse effect on respiratory outcomes, but associations in children are unknown. We aimed to study the longitudinal associations of cardio-metabolic risk factors with lung function and asthma at school age. We also examined whether any association was explained by child's body mass index (BMI).
    Methods: In a population-based cohort study among 4988 children, cardio-metabolic risk factors were measured at 6 and 10 years and included blood pressure, cholesterol, triglycerides, insulin, and C-reactive protein (CRP) concentrations. At age 10 years, lung function was measured by spirometry and current physician-diagnosed asthma was assessed by questionnaire.
    Results: After adjustment for confounders, child's BMI, and multiple testing, we observed that a higher diastolic blood pressure at the age of 6 years was associated with a higher forced vital capacity (FVC) at the age of 10 years (Z-score difference (95% CI): 0.05 (0.01, 0.08), per SDS increase in diastolic blood pressure). Also, child's CRP concentrations above the 75th percentile at both ages 6 and 10 years were related to a lower FVC as compared to CRP concentrations below the 75th percentile at both ages (Z-score difference (95% CI) -0.21 (-0.36, -0.06)). No consistent associations of other cardio-metabolic risk factors with respiratory outcomes were observed.
    Conclusion: Blood pressure and CRP, but not lipids and insulin, were associated with lower lung function but not with asthma. The underlying mechanisms and long-term effects of these associations require further investigation.
    MeSH term(s) Asthma/epidemiology ; Body Mass Index ; Child ; Cohort Studies ; Humans ; Lung ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13509
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  3. Article ; Online: Associations of physical condition with lung function and asthma in adolescents from the general population.

    Mensink-Bout, Sara M / Jahangir, Marc R / de Jongste, Johan C / Raat, Hein / Jaddoe, Vincent W V / Duijts, Liesbeth

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 6

    Abstract: Background: The relation of physical condition with respiratory outcomes in adolescents is unclear. We examined the hypothesis that adolescents with a lower physical condition represented by a lower cardiorespiratory fitness and physical activity, and a ...

    Abstract Background: The relation of physical condition with respiratory outcomes in adolescents is unclear. We examined the hypothesis that adolescents with a lower physical condition represented by a lower cardiorespiratory fitness and physical activity, and a higher screen time have a lower lung function and higher risk of asthma.
    Methods: In a population-based prospective cohort study on 4854 children aged 13 years, we assessed cardiorespiratory fitness by using the peak work rate measured by the steep ramp test. Information on physical activity and screen time was obtained by self-reported questionnaires. Lung function was measured by spirometry and current asthma was assessed by a parental-reported questionnaire.
    Results: Taking sociodemographic, lifestyle, and growth-related confounders and multiple hypothesis testing into account, a 1 SD lower cardiorespiratory fitness was associated with a lower FEV
    Conclusion: Adolescents with a lower cardiorespiratory fitness had a lower lung function and a higher risk of asthma. Those with a higher screen time had a lower FVC. Further studies are needed to explore the effect of improvements in physical condition on long-term respiratory outcomes.
    MeSH term(s) Adolescent ; Asthma/epidemiology ; Child ; Humans ; Lung ; Prospective Studies ; Respiratory Function Tests ; Spirometry
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13811
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  4. Article ; Online: Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation.

    Monasso, Giulietta S / Jaddoe, Vincent W V / de Jongste, Johan C / Duijts, Liesbeth / Felix, Janine F

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2020  Volume 22, Issue 10, Page(s) 1917–1922

    Abstract: Introduction: Fetal changes in DNA methylation may underlie associations of maternal smoking during pregnancy with adverse outcomes in children. We examined critical periods and doses of maternal smoking during pregnancy in relation to newborn DNA ... ...

    Abstract Introduction: Fetal changes in DNA methylation may underlie associations of maternal smoking during pregnancy with adverse outcomes in children. We examined critical periods and doses of maternal smoking during pregnancy in relation to newborn DNA methylation, and associations of paternal smoking with newborn DNA methylation.
    Aims and methods: This study was embedded in the Generation R Study, a population-based prospective cohort study from early pregnancy onwards. We assessed parental smoking during pregnancy using questionnaires. We analyzed associations of prenatal smoke exposure with newborn DNA methylation at 5915 known maternal smoking-related cytosine-phosphate-guanine sites (CpGs) in 1261 newborns using linear regression. Associations with false discovery rate-corrected p-values < .05 were taken forward.
    Results: Sustained maternal smoking was associated with newborn DNA methylation at 1391 CpGs, compared with never smoking. Neither quitting smoking early in pregnancy nor former smoking was associated with DNA methylation, compared with never smoking. Among sustained smokers, smoking ≥5, compared with <5, cigarettes/d was associated with DNA methylation at seven CpGs. Paternal smoking was not associated with DNA methylation, independent of maternal smoking status.
    Conclusions: Our results suggest that CpGs associated with sustained maternal smoking are not associated with maternal smoking earlier in pregnancy or with paternal smoking. Some of these CpGs show dose-response relationships with sustained maternal smoking. The third trimester may comprise a critical period for associations of smoking with newborn DNA methylation, or sustained smoking may reflect higher cumulative doses. Alternatively, maternal smoking limited to early pregnancy and paternal smoking may be associated with DNA methylation at specific other CpGs not studied here.
    Implications: Our results suggest that quitting maternal smoking before the third trimester of pregnancy, and possibly lowering smoking dose, may prevent differential DNA methylation in the newborns at CpGs associated with sustained smoking. If the relevance of DNA methylation for clinical outcomes is established, these results may help in counseling parents-to-be about quitting smoking.
    MeSH term(s) DNA Methylation ; Female ; Humans ; Infant, Newborn ; Maternal Exposure ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prospective Studies ; Smoking ; Time Factors
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntaa069
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  5. Article ; Online: C

    van Meel, Evelien R / Attanasi, Marina / Jaddoe, Vincent W V / Reiss, Irwin K M / Moll, Henriëtte A / de Jongste, Johan C / Duijts, Liesbeth

    The European respiratory journal

    2020  Volume 56, Issue 1

    Abstract: Introduction: Chlamydia trachomatis: Results: The prevalence of : Conclusions: C. ... ...

    Abstract Introduction: Chlamydia trachomatis
    Results: The prevalence of
    Conclusions: C. trachomatis
    MeSH term(s) Asthma/epidemiology ; Child ; Chlamydia trachomatis ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Morbidity ; Pregnancy ; Prospective Studies
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01829-2019
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  6. Article ; Online: Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age.

    Mensink-Bout, Sara M / Voortman, Trudy / Dervishaj, Marsela / Reiss, Irwin K M / De Jongste, Johan C / Jaddoe, Vincent W V / Duijts, Liesbeth

    Nutrients

    2020  Volume 12, Issue 10

    Abstract: Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during ... ...

    Abstract Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child's respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A 'high n-6 polyunsaturated fatty acid (PUFA)', a 'monounsaturated and saturated fatty acid', and a 'high n-3 PUFA' pattern. At the age of 10 years, a child's lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher 'high n-6 PUFA' pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child's asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
    MeSH term(s) Adult ; Asthma/etiology ; Child ; Fatty Acids/blood ; Fatty Acids, Unsaturated/blood ; Female ; Forced Expiratory Volume ; Humans ; Hypersensitivity/etiology ; Male ; Maternal Nutritional Physiological Phenomena/physiology ; Maternal-Fetal Exchange/physiology ; Pregnancy/blood ; Prenatal Exposure Delayed Effects ; Prospective Studies ; Vital Capacity ; Young Adult
    Chemical Substances Fatty Acids ; Fatty Acids, Unsaturated
    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12103057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sociodemographic factors, current asthma and lung function in an urban child population.

    Yang-Huang, Junwen / van Grieken, Amy / van Meel, Evelien R / He, Huan / de Jongste, Johan C / Duijts, Liesbeth / Raat, Hein

    European journal of clinical investigation

    2020  Volume 50, Issue 10, Page(s) e13277

    Abstract: Background: We aimed to assess which sociodemographic factors are associated with current asthma and indicators of lung function in 10-year-old children.: Methods: We analysed data of 5237 children (Mean age: 9.7, SD: 0.3) from the Generation R Study ...

    Abstract Background: We aimed to assess which sociodemographic factors are associated with current asthma and indicators of lung function in 10-year-old children.
    Methods: We analysed data of 5237 children (Mean age: 9.7, SD: 0.3) from the Generation R Study (2012-2016), a population-based cohort study in the Netherlands. Indicators of sociodemographic factors included parental educational level, net household income, financial difficulties, parental employment status and child ethnic background. Current asthma (yes/no) was defined as ever doctor-diagnosed-asthma combined with wheezing symptoms or asthma-medication use in the past 12 months. Lung function was measured by spirometry and included forced expiratory volume in 1 second (FEV
    Results: After adjustment for all sociodemographic factors, an independent association was observed between ethnic background with current asthma and lung function. Compared with children with a Dutch background, children with a nonwestern ethnic background had a higher odds of having current asthma (OR: 1.61, 95% CI: 1.02, 2.53), lower FVC z-score (-0.25, 95% CI: -0.35, -0.14), higher FEV
    Conclusions: Among 10-year-old children, ethnic background was associated with current asthma and lung function after adjusting for a wide range of sociodemographic factors. No associations were found between socioeconomic status indicators and current asthma. Explanations for these associations such as language barriers, suboptimal care or pathophysiological differences require further investigation.
    MeSH term(s) Asthma/epidemiology ; Asthma/ethnology ; Asthma/physiopathology ; Child ; Educational Status ; Employment ; Ethnic Groups ; Female ; Forced Expiratory Flow Rates ; Forced Expiratory Volume ; Humans ; Income ; Male ; Netherlands/epidemiology ; Parents ; Socioeconomic Factors ; Urban Population ; Vital Capacity
    Language English
    Publishing date 2020-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13277
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  8. Article ; Online: Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

    van Meel, Evelien R / Jaddoe, Vincent W V / Looman, Kirsten I M / de Jongste, Johan C / Moll, Henriëtte A / Duijts, Liesbeth

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2020  Volume 31, Issue 7, Page(s) 774–782

    Abstract: Background: Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae ... ...

    Abstract Background: Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health.
    Objective: To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice versa, and of early-life airway bacterial carriage with wheezing, lung function, and asthma in later childhood.
    Methods: We collected upper airway swabs for bacterial culturing for S aureus, H influenzae, M catarrhalis, and H influenzae at six timepoints between the ages of 6 weeks and 6 years among 945 children participating in a population-based prospective cohort study. Information on respiratory tract infections and wheezing until age 6 years, and asthma at age 10 years was obtained by questionnaires. Lung function at age 10 years was measured by spirometry. We tested possible bidirectional associations between airway bacterial carriage and respiratory tract infections by cross-lagged models, and associations of repeatedly measured airway bacterial carriage with wheezing, lung function, and asthma by generalized estimating equations models and regression models.
    Results: Cross-lagged modeling showed that early-life airway bacterial carriage was not consistently associated with upper and lower respiratory tract infections or vice versa. Nasopharyngeal carriage with any bacteria in infancy was associated with an increased risk of wheezing (OR [95% CI]: 1.66 [1.31, 2.10]). Airway bacterial carriage was not consistently associated with school-age lung function or asthma.
    Conclusion: Nasopharyngeal carriage with any bacteria is associated with wheezing, but not respiratory tract infections, asthma, or lung function.
    MeSH term(s) Asthma/epidemiology ; Bacteria/isolation & purification ; Carrier State/microbiology ; Child ; Child, Preschool ; Cohort Studies ; Female ; Haemophilus influenzae/isolation & purification ; Humans ; Infant ; Male ; Moraxella catarrhalis/isolation & purification ; Nasal Cavity/microbiology ; Nasopharynx/microbiology ; Prospective Studies ; Respiratory Function Tests/methods ; Respiratory Sounds/etiology ; Respiratory Tract Infections/epidemiology ; Spirometry/methods ; Staphylococcus aureus/isolation & purification ; Streptococcus pneumoniae/isolation & purification ; Surveys and Questionnaires
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13310
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  9. Article: Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age

    Mensink-Bout, Sara M / Voortman, Trudy / Dervishaj, Marsela / Reiss, Irwin K. M / De Jongste, Johan C / Jaddoe, Vincent W. V / Duijts, Liesbeth

    Nutrients. 2020 Oct. 07, v. 12, no. 10

    2020  

    Abstract: Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during ... ...

    Abstract Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
    Keywords age ; asthma ; blood ; breathing ; flow ; immune response ; lung function ; nutrients ; omega-3 fatty acids ; omega-6 fatty acids ; pregnancy ; principal component analysis ; questionnaires ; school children ; skin prick tests ; volume
    Language English
    Dates of publication 2020-1007
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12103057
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: To wheeze or not to wheeze: prospective FENO-typing in early infancy.

    de Jongste, Johan C

    American journal of respiratory and critical care medicine

    2006  Volume 174, Issue 12, Page(s) 1281–1282

    MeSH term(s) Asthma/diagnosis ; Breath Tests ; Humans ; Infant, Newborn ; Nitric Oxide/analysis ; Respiratory Sounds/diagnosis
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2006-12-15
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 1073-449X ; 0003-0805
    ISSN (online) 1535-4970
    ISSN 1073-449X ; 0003-0805
    DOI 10.1164/rccm.200609-1393ED
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