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  1. Article: Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer.

    Coerts, Hannelore Iris / de Keizer, Bart / Verburg, Frederik Anton

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Thyroid cancer poses a significant challenge in clinical management, necessitating precise diagnostic tools and treatment strategies for optimal patient outcomes. This review explores the evolving field of radiotracers in the diagnosis and management of ... ...

    Abstract Thyroid cancer poses a significant challenge in clinical management, necessitating precise diagnostic tools and treatment strategies for optimal patient outcomes. This review explores the evolving field of radiotracers in the diagnosis and management of thyroid cancer, focusing on prostate-specific membrane antigen (PSMA)-based radiotracers, fibroblast activation protein inhibitor (FAPI)-based radiotracers, Arg-Gly-Asp (RGD)-based radiotracers, and
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071401
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  2. Article ; Online: Imaging in neuroblastoma.

    Littooij, Annemieke S / de Keizer, Bart

    Pediatric radiology

    2022  Volume 53, Issue 4, Page(s) 783–787

    Abstract: Neuroblastoma is the most common extracranial solid malignancy of childhood. The prognosis is highly variable ranging from spontaneous involution in infants to fatal outcome, despite aggressive treatment, in disseminated high-risk neuroblastoma. This ... ...

    Abstract Neuroblastoma is the most common extracranial solid malignancy of childhood. The prognosis is highly variable ranging from spontaneous involution in infants to fatal outcome, despite aggressive treatment, in disseminated high-risk neuroblastoma. This paper provides a comprehensive review of the crucial role of imaging during the extensive treatment course.
    MeSH term(s) Infant ; Humans ; Diagnostic Imaging ; Neuroblastoma/pathology ; Prognosis
    Language English
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-022-05489-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 927: Show issues Location:
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  3. Article ; Online: Comparison of different diagnostic approaches in the management of the clinically negative neck in early oral cancer patients.

    de Bree, Remco / de Keizer, Bart

    Cancer

    2021  Volume 127, Issue 12, Page(s) 1959–1962

    MeSH term(s) Humans ; Mouth Neoplasms/surgery ; Mouth Neoplasms/therapy ; Neck Dissection
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33443
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  4. Article ; Online: Recombinant or endogenous thyroid-stimulating hormone for radioactive iodine therapy in thyroid cancer: state of knowledge and current controversies.

    Coerts, Hannelore I / de Keizer, Bart / Marlowe, Robert J / Verburg, Frederik A

    European journal of endocrinology

    2023  Volume 188, Issue 2

    Abstract: For patients undergoing radioiodine therapy (RIT) of differentiated thyroid carcinoma (DTC), thyroid-stimulating hormone (TSH) stimulation prior to RIT can be achieved using thyroid hormone withdrawal (THW) or administration of recombinant human TSH ( ... ...

    Abstract For patients undergoing radioiodine therapy (RIT) of differentiated thyroid carcinoma (DTC), thyroid-stimulating hormone (TSH) stimulation prior to RIT can be achieved using thyroid hormone withdrawal (THW) or administration of recombinant human TSH (rhTSH). As THW can lead to nausea, headaches, vomiting, fatigue, and dizziness secondary to transient acute hypothyroidism, rhTSH could be a good alternative. Recombinant human TSH has been administered in patients in order to stimulate TSH for RIT since 2005. According to the Martinique criteria formulated by the leading professional societies involved in care of patients with DTC, rhTSH can be applied in 3 settings: for remnant ablation, adjuvant treatment, and treatment of known disease. Numerous studies have investigated the effects of rhTSH as a method of TSH stimulation on the thyroid cell, the systemic effects, biokinetics, and clinical outcomes; however, no consensus has been reached about many aspects of its potential use. Recombinant human TSH is able to stimulate sufficient TSH levels (>30 mIU L-1) and is hypothesized to decrease risks of tumor cell proliferation. As rhTSH-use avoids the transiently impaired renal function associated with THW, radioiodine excretion is faster with the former, leading to a lower iodine-131 uptake and a difference in fractional remnant uptake, effective half-life, mean residence time, and dose to the blood. Differences between rhTSH and THW were observed in radioiodine genotoxic effects and endothelial-dependent vasodilation and inflammation. For thyroid remnant ablation, THW and rhTSH lead to similar remnant ablation rates. For adjuvant therapy and treatment of known disease, insufficient trials have been conducted and future prospective studies are recommended. The current review provides a state-of-the-science overview on the issues and debates surrounding TSH stimulation through either rhTSH adminsitration orendogenous TSH production after levothyroxin withdrawal.
    MeSH term(s) Humans ; Thyroid Neoplasms/surgery ; Thyrotropin/therapeutic use ; Iodine Radioisotopes/therapeutic use ; Thyrotropin Alfa ; Prospective Studies ; Thyroid Hormones ; Hypothyroidism/drug therapy ; Recombinant Proteins/therapeutic use ; Treatment Outcome
    Chemical Substances Thyrotropin (9002-71-5) ; Iodine Radioisotopes ; Thyrotropin Alfa ; Thyroid Hormones ; Recombinant Proteins
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1093/ejendo/lvad006
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  5. Article ; Online: The prognostic impact of micrometastases and isolated tumor cells in early oral squamous cell carcinoma.

    de Bree, Remco / Witjes, Max J H / de Keizer, Bart

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2021  Volume 278, Issue 12, Page(s) 5105–5106

    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Head and Neck Neoplasms ; Humans ; Lymph Nodes/pathology ; Mouth Neoplasms/diagnosis ; Neoplasm Micrometastasis/diagnosis ; Neoplasm Staging ; Prognosis ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2021-01-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06500-y
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  6. Article ; Online: Evaluation of a streamlined sentinel lymph-node imaging protocol in early-stage oral cancer.

    Zeeuw, Michiel / Mahieu, Rutger / de Keizer, Bart / de Bree, Remco

    Annals of nuclear medicine

    2021  Volume 35, Issue 12, Page(s) 1353–1360

    Abstract: Objective: Sentinel lymph-node (SLN) mapping for early-stage oral squamous cell carcinoma (OSCC) is comprehensive and consequently time-consuming and costly. This study evaluated the clinical value of several SLN imaging components and analyzed the ... ...

    Abstract Objective: Sentinel lymph-node (SLN) mapping for early-stage oral squamous cell carcinoma (OSCC) is comprehensive and consequently time-consuming and costly. This study evaluated the clinical value of several SLN imaging components and analyzed the accuracy for SLN identification using a streamlined SLN imaging protocol in early-stage OSCC.
    Materials and methods: This retrospective within-patient evaluation study compared both number and localization of identified SLNs between the conventional SLN imaging protocol and a streamlined imaging protocol (dynamic lymphoscintigraphy (LSG) for 10 min directly post-injection and SPECT-CT at ~ 2 h post-injection). LSG and SPECT-CT images of 77 early-stage OSCC patients, scheduled for SLN biopsy, were evaluated by three observers. Identified SLNs using either protocol were related to histopathological assessment of harvested SLNs, complementary neck dissection specimens and follow-up status.
    Results: A total of 200 SLNs were identified using the streamlined protocol, and 12 additional SLNs (n = 212) were identified with the conventional protocol in 10 patients. Of those, 9/12 were identified on early static LSG and 3/12 on late static LSG. None of the additionally identified SLNs contained metastases; none of those in whom additional SLNs were identified developed regional recurrence during follow-up. Only inferior alveolar process carcinoma showed a higher rate of additionally identified SLNs with the conventional protocol (p = 0.006).
    Conclusion: Early dynamic LSG can be reduced to 10 min. Late static LSG may be omitted, except in those with a history of oncological neck treatment or with OSCC featuring slow lymphatic drainage. Early static LSG appeared to be contributory in most OSCC subsites.
    MeSH term(s) Carcinoma, Squamous Cell
    Language English
    Publishing date 2021-09-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-021-01677-6
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    Zs.A 3657: Show issues Location:
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  7. Article ; Online: Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma.

    de Bree, Remco / Mahieu, Rutger / Donders, Dominique N V / de Keizer, Bart

    Clinical & experimental metastasis

    2022  Volume 39, Issue 3, Page(s) 417–419

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/pathology ; Humans ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Mouth Neoplasms/pathology ; Radiopharmaceuticals ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy ; Squamous Cell Carcinoma of Head and Neck/pathology
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2022-02-22
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 604952-7
    ISSN 1573-7276 ; 0262-0898
    ISSN (online) 1573-7276
    ISSN 0262-0898
    DOI 10.1007/s10585-022-10159-6
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    Zs.A 1855: Show issues Location:
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  8. Article: CT Lymphography Using Lipiodol

    Mahieu, Rutger / Donders, Dominique N V / Dankbaar, Jan Willem / de Bree, Remco / de Keizer, Bart

    Journal of clinical medicine

    2022  Volume 11, Issue 17

    Abstract: This study evaluated sentinel lymph node (SLN) identification with CT lymphography (CTL) following peritumoral administration of ... ...

    Abstract This study evaluated sentinel lymph node (SLN) identification with CT lymphography (CTL) following peritumoral administration of Lipiodol
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11175129
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  9. Article: Molecular Theranostics in Radioiodine-Refractory Differentiated Thyroid Cancer.

    Petranović Ovčariček, Petra / Campenni, Alfredo / de Keizer, Bart / Deandreis, Desiree / Kreissl, Michael C / Vrachimis, Alexis / Tuncel, Murat / Giovanella, Luca

    Cancers

    2023  Volume 15, Issue 17

    Abstract: Differentiated thyroid cancer (DTC) is the most common subtype of thyroid cancer and has an excellent overall prognosis. However, metastatic DTC in certain cases may have a poor prognosis as it becomes radioiodine-refractory. Molecular imaging is ... ...

    Abstract Differentiated thyroid cancer (DTC) is the most common subtype of thyroid cancer and has an excellent overall prognosis. However, metastatic DTC in certain cases may have a poor prognosis as it becomes radioiodine-refractory. Molecular imaging is essential for disease evaluation and further management. The most commonly used tracers are [
    Language English
    Publishing date 2023-08-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15174290
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  10. Article ; Online: The EANM guideline on radioiodine therapy of benign thyroid disease.

    Campennì, Alfredo / Avram, Anca M / Verburg, Frederik A / Iakovou, Ioannis / Hänscheid, Heribert / de Keizer, Bart / Petranović Ovčariček, Petra / Giovanella, Luca

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 11, Page(s) 3324–3348

    Abstract: This document provides the new EANM guideline on radioiodine therapy of benign thyroid disease. Its aim is to guide nuclear medicine physicians, endocrinologists, and practitioners in the selection of patients for radioiodine therapy. Its recommendations ...

    Abstract This document provides the new EANM guideline on radioiodine therapy of benign thyroid disease. Its aim is to guide nuclear medicine physicians, endocrinologists, and practitioners in the selection of patients for radioiodine therapy. Its recommendations on patients' preparation, empiric and dosimetric therapeutic approaches, applied radioiodine activity, radiation protection requirements, and patients follow-up after administration of radioiodine therapy are extensively discussed.
    MeSH term(s) Humans ; Iodine Radioisotopes/therapeutic use ; Graves Disease/drug therapy ; Thyroid Diseases/radiotherapy ; Thyroid Diseases/drug therapy ; Radiometry ; Radiation Protection
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2023-07-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06274-5
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    Zs.A 1227: Show issues Location:
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